Nutrition and Cancer-An International Journal最新文献

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Nutritional Strategies in Oncology: A Narrative Review of Advances in Folate-Targeted Therapeutic Approaches for Cancer Treatment. 肿瘤中的营养策略:叶酸靶向治疗方法在癌症治疗中的进展述评。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-04-28 DOI: 10.1080/01635581.2025.2497096
Pouya Saraei, Morteza Ghasemi, Athar Talebi, Arefe Vafaeinezhad, Jamileh Saberzadeh
{"title":"Nutritional Strategies in Oncology: A Narrative Review of Advances in Folate-Targeted Therapeutic Approaches for Cancer Treatment.","authors":"Pouya Saraei, Morteza Ghasemi, Athar Talebi, Arefe Vafaeinezhad, Jamileh Saberzadeh","doi":"10.1080/01635581.2025.2497096","DOIUrl":"https://doi.org/10.1080/01635581.2025.2497096","url":null,"abstract":"<p><p>Folate, a water-soluble B vitamin crucial for DNA synthesis and repair, is internalized by cells through specific folate receptors (FRs), which are frequently overexpressed in various types of cancers. In this comprehensive study, we conducted a review of the literature from Google Scholar, PubMed, and Science Direct, focusing on research published between 1980 and 2024 to evaluate folate-targeted therapeutic strategies in oncology. Our study design involved a rigorous review of both preclinical and clinical research, emphasizing strategies such as folate-drug conjugates, antibody-drug conjugates, and folate-targeted nanoparticles. Key findings indicate that targeting FRs in cancers such as ovarian, breast, cervical, renal, and colorectal enhances drug delivery specificity to tumors, increases therapeutic efficacy, and decreases systemic toxicity compared to traditional chemotherapy. Several clinical trials reported improved progression-free survival and overall response rates among patients receiving folate-targeted therapies. In conclusion, our review highlights the significant potential of folate-targeted strategies in advancing precision oncology while these approaches provide substantial benefits in terms of efficacy and safety, further research is essential to refine drug design and expand clinical applications. Such initiatives will facilitate the development of more personalized cancer treatment protocols that maximize therapeutic outcomes while minimizing adverse effects.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-23"},"PeriodicalIF":2.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Nutritional Intervention and Exercise on Anthropometric and Metabolic Parameters in Moroccan Women with Breast Cancer: A Pilot Study. 营养干预和运动对摩洛哥乳腺癌妇女人体测量和代谢参数的影响:一项试点研究
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-04-26 DOI: 10.1080/01635581.2025.2494294
Abdellah Moukal, Abdallah El-Farouqi, Mohamed Aghrouch, Abderrahmane Zekhnini, El-Hassan Izaabel
{"title":"Effects of Nutritional Intervention and Exercise on Anthropometric and Metabolic Parameters in Moroccan Women with Breast Cancer: A Pilot Study.","authors":"Abdellah Moukal, Abdallah El-Farouqi, Mohamed Aghrouch, Abderrahmane Zekhnini, El-Hassan Izaabel","doi":"10.1080/01635581.2025.2494294","DOIUrl":"https://doi.org/10.1080/01635581.2025.2494294","url":null,"abstract":"<p><p>This study examines the effects of a dietary and physical activity intervention on body composition and metabolic parameters in Moroccan women with breast cancer. Conducted as a pilot cohort study, 37 women with breast cancer were recruited between 2017 and 2019 at the Hassan II Regional Hospital Center and the Agadir Regional Oncology Center. Participants completed a 12-month nutrition and physical activity intervention. The mean age was 47.92 ± 8.56 years. At the end of the intervention, participants experienced a mean weight loss of 11%, resulting in a significant reduction in normal weight and obesity rates from 35.14% and 32.43% to 57% and 5%, respectively (<i>p</i> < 0.05). Waist and hip circumferences were reduced by 10%, and there were significant reductions in body fat and visceral fat. Improvements were also seen in metabolic markers, with significant reductions in total cholesterol, LDL-C, blood glucose and HbA1c levels (<i>p</i> < 0.05). Lean mass was preserved and HDL-C showed a significant increase (<i>p</i> < 0.001).</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-13"},"PeriodicalIF":2.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143996525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Fatty Acids and Bladder Cancer Risk: Insights from the PLCO Cancer Screening Trial. 膳食脂肪酸与膀胱癌风险:来自PLCO癌症筛选试验的见解。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-04-16 DOI: 10.1080/01635581.2025.2492138
Gao Li, Wenjie Zheng, Xin Zhang, Yuanhao Chen
{"title":"Dietary Fatty Acids and Bladder Cancer Risk: Insights from the PLCO Cancer Screening Trial.","authors":"Gao Li, Wenjie Zheng, Xin Zhang, Yuanhao Chen","doi":"10.1080/01635581.2025.2492138","DOIUrl":"https://doi.org/10.1080/01635581.2025.2492138","url":null,"abstract":"<p><p>This study aimed to evaluate the relationship between the consumption of different dietary fatty acids and the risk of bladder cancer. A quantitative analysis was conducted using data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, which included 101,731 participants. The Cox proportional hazards model was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for bladder cancer risk in relation to dietary fatty acid intake. During a median follow-up of 11.3 years, 861 bladder cancer cases were identified. After fully adjusting for potential confounders in a multivariate Cox regression model, no significant association was found between dietary fatty acid consumption and bladder cancer risk. Subgroup analysis revealed significant interactions with gender (<i>p</i> < 0.001) and smoking status (<i>p</i> < 0.001). Gender-specific analysis showed that a higher intake of monounsaturated fatty acids (MUFAs) was linked to a reduced risk of bladder cancer in females (HR: 0.62; 95% CI: 0.39-0.99, <i>P</i>-trend = 0.028). However, restricted cubic spline analysis revealed no linear relationship between MUFA intake and bladder cancer risk in the overall group or gender-specific subgroups. The association between dietary fatty acids and bladder cancer risk is influenced by factors like gender and smoking status. In females, moderate MUFA intake may reduce bladder cancer risk, but higher intake does not provide additional benefits.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-11"},"PeriodicalIF":2.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Causal Effects of Valine on Ovarian Cancer: A Bidirectional Mendelian Randomization Analysis. 缬氨酸对卵巢癌的因果效应:双向孟德尔随机化分析。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-01-02 DOI: 10.1080/01635581.2024.2445870
Xinyan Gao, Yanling Lin, Jun Zhang, Xiaoxiang Jiang, Riping Wu, Dongta Zhong
{"title":"Causal Effects of Valine on Ovarian Cancer: A Bidirectional Mendelian Randomization Analysis.","authors":"Xinyan Gao, Yanling Lin, Jun Zhang, Xiaoxiang Jiang, Riping Wu, Dongta Zhong","doi":"10.1080/01635581.2024.2445870","DOIUrl":"10.1080/01635581.2024.2445870","url":null,"abstract":"<p><strong>Background: </strong>Ovarian cancer is a lethal female cancer with a rising incidence that is often diagnosed late due to a lack of symptoms, affecting survival and quality of life. Studies suggest that dietary factors, especially the levels of branched-chain amino acids such as valine, may influence its development. While valine is essential for metabolism, its specific role in ovarian cancer remains unclear, necessitating further research.</p><p><strong>Methods: </strong>This study aimed to elucidate the causal relationship between valine and OC through a bidirectional Mendelian randomization (MR) approach. Data were sourced from the IEU OpenGWAS project, encompassing genome-wide association statistics for valine (<i>N</i> = 115,048) and OC (Ncase = 1,218, Ncontrol = 198,523) among European participants. Independent genetic variants associated with each phenotype at genome-wide significance were employed as instrumental variables (IVs). The primary analysis utilized the inverse variance weighted (IVW) method for two-sample MR analysis. MR‒Egger regression was applied to adjust for potential pleiotropy, whereas the weighted median method provided robust causal estimates under the assumption of valid IVs. Sensitivity analyses, including leave-one-out (LOO) analysis, heterogeneity tests, and horizontal pleiotropy assessments, were conducted to ensure the robustness of the findings.</p><p><strong>Results: </strong>The results revealed a significant causal relationship between valine and OC, identifying valine as a risk factor for OC (<i>p</i> = 0.043, 95% CI = 1.00008-1.00491, OR = 1.00249) in the forward MR analysis. Sensitivity analyses confirmed the absence of heterogeneity (Q_p value >0.05) and horizontal pleiotropy (<i>p</i> > 0.05), and LOO analysis validated the stability of the results. Conversely, reverse MR analysis revealed no causal effect of OC on valine levels (<i>p</i> = 0.875, 95% CI = 0.34125-2.51495, OR = 1.08528).</p><p><strong>Conclusions: </strong>These findings reveal a causal link between high valine levels and an increased OC risk. This research highlights the monitoring of valine levels as a preventive strategy and the significance of valine metabolism in OC. Future studies are needed to investigate the mechanisms and interventions for reducing risk, offering insights for clinical practice and public health initiatives in OC prevention.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"405-413"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142916165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary Counseling Interventions During Radiation Therapy: A Systematic Review of Feasibility, Safety, and Efficacy. 放射治疗期间的饮食咨询干预:关于可行性、安全性和有效性的系统回顾。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-28 DOI: 10.1080/01635581.2024.2406999
Alexie Oppermann, Shalet James, Mackenzie M Minotti, Kaitlin M Schotz, Martha E Francis, Ian R Kleckner, Melissa A L Vyfhuis, Matthew J Ferris, Brenton J Baguley, Amber S Kleckner
{"title":"Dietary Counseling Interventions During Radiation Therapy: A Systematic Review of Feasibility, Safety, and Efficacy.","authors":"Alexie Oppermann, Shalet James, Mackenzie M Minotti, Kaitlin M Schotz, Martha E Francis, Ian R Kleckner, Melissa A L Vyfhuis, Matthew J Ferris, Brenton J Baguley, Amber S Kleckner","doi":"10.1080/01635581.2024.2406999","DOIUrl":"10.1080/01635581.2024.2406999","url":null,"abstract":"<p><p>Radiotherapy is a common cancer treatment, and concurrent nutritional interventions can maintain nutritional status and improve clinical and supportive care outcomes. However, optimal nutritional interventions during radiotherapy are not firmly established. Herein, we assessed the feasibility, safety, and efficacy of dietary counseling interventions without oral nutrition supplements on health outcomes in adults receiving radiotherapy for cancer in a systematic review. Prospective clinical trials that implemented nutritional counseling interventions during radiotherapy were identified from four databases from inception through December 2023. Feasibility, safety, and efficacy were extracted from 32 articles that described 23 randomized and 4 non-randomized clinical trials. The interventions included individualized nutritional counseling (<i>n</i> = 14 articles), nutritional counseling plus exercise (<i>n</i> = 4), and nutritional counseling focused on increasing or reducing intake of specific nutrients (<i>n</i> = 9). Trials targeted head and neck (<i>n</i> = 12), pelvic cancers (<i>n</i> = 14), and/or breast (<i>n</i> = 5) cancers. Control groups had variable designs and included general nutrition education and intervention as needed. Studies recruited 120 ± 104 participants (range 26-468). Interventions tended to be feasible regarding retention and attendance at sessions, though feasibility metrics varied among different interventions. Most interventions were safe with no studies reporting adverse events attributable to dietary intervention. Individualized dietary counseling interventions tended to lead to between-group differences favoring the intervention group in regard to improved nutritional status, maintenance or attenuation of loss of body mass, improved quality of life, and reduced radiation-induced toxicities. Diets that encouraged/discouraged specific nutrients tended to recruit patients receiving radiation to the pelvic area and resulted in positive or neutral effects on gastrointestinal symptoms. In conclusion, nutritional interventions appear to be feasible, safe, and effective during radiotherapy for various symptom outcomes.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"26-50"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Rate of Postoperative Decline in Parathyroid Hormone Levels Can Predict Symptomatic Hypocalcemia Following Thyroid Cancer Surgery with Neck Lymph Node Dissection. 甲状旁腺激素水平术后下降率可预测甲状腺癌颈淋巴结切除手术后的症状性低钙血症
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-23 DOI: 10.1080/01635581.2024.2401179
Yi-Hsuan Lee, Zhijian Liu, LuLu Zheng, Junlan Qiu, Jianfeng Sang, Wenxian Guan
{"title":"The Rate of Postoperative Decline in Parathyroid Hormone Levels Can Predict Symptomatic Hypocalcemia Following Thyroid Cancer Surgery with Neck Lymph Node Dissection.","authors":"Yi-Hsuan Lee, Zhijian Liu, LuLu Zheng, Junlan Qiu, Jianfeng Sang, Wenxian Guan","doi":"10.1080/01635581.2024.2401179","DOIUrl":"10.1080/01635581.2024.2401179","url":null,"abstract":"<p><strong>Objective: </strong>Identifying early predictive indicators of symptomatic hypocalcemia in patients after thyroidectomy with neck lymph node dissection can help to identify high-risk patients, provide timely intervention, and improve prognosis.</p><p><strong>Methods: </strong>A retrospective analysis of all relevant information was conducted for patients who underwent total thyroidectomy with neck lymph node dissection at our hospital between April 2021 and September 2022. The primary outcome measure was symptomatic hypocalcemia.</p><p><strong>Results: </strong>Of the 210 patients who underwent total thyroidectomy with l neck lymph node dissection, 76 patients (36%) experienced symptoms of hypocalcemia. The analysis confirmed that the rate of parathyroid hormone (PTH) decline (OR = 238.414, 95%CI: 51.904-1095.114, <i>P</i> = 0.000) was an independent risk factor for symptomatic hypocalcemia after total thyroidectomy with neck lymph node dissection. The ROC curve indicated that a PTH decline cutoff value of 0.7425 was significantly correlated with symptoms of hypocalcemia, with a sensitivity of 89% and specificity of 69%, which could effectively predict symptomatic hypocalcemia.</p><p><strong>Conclusion: </strong>A PTH decline rate greater than the cutoff value of 0.7425 is a predictive factor for symptomatic hypocalcemia in adults and may be considered as a high-risk patient and actively managed to supplement calcium as soon as possible to ensure patient safety.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"1-8"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acupuncture's Emergence as A Promising Non-Pharmacological Therapy for Appetite Management in Cancer Chemotherapy. 针灸作为非药物疗法在癌症化疗中调理食欲方面的应用前景广阔。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-10-13 DOI: 10.1080/01635581.2024.2413717
Xu Zhang, Wenjing Yang, Junliang Shang, Lin Shi, Lu Yang, Chi Zhang, Yuyi Chen, Zishen Liu, Bo Li, Xinghan Zhang, Li Tong, Guowang Yang
{"title":"Acupuncture's Emergence as A Promising Non-Pharmacological Therapy for Appetite Management in Cancer Chemotherapy.","authors":"Xu Zhang, Wenjing Yang, Junliang Shang, Lin Shi, Lu Yang, Chi Zhang, Yuyi Chen, Zishen Liu, Bo Li, Xinghan Zhang, Li Tong, Guowang Yang","doi":"10.1080/01635581.2024.2413717","DOIUrl":"10.1080/01635581.2024.2413717","url":null,"abstract":"<p><strong>Objective: </strong>The primary objective of this investigation was to assess the impact of acupuncture intervention and explore the intricacies of acupoint selection as a therapeutic strategy for chemotherapy-induced Anorexia (CIA).</p><p><strong>Method: </strong>Eight electronic databases were searched to identify relevant studies on the use of acupuncture for the treatment of CIA to conduct a comprehensive meta-analysis. Following this, the Apriori algorithm, correlation analysis, and cluster analysis were performed to identify correlations between the selection of acupoints.</p><p><strong>Results: </strong>Acupuncture significantly reduced the incidence of anorexia (RR = 0.76, 95%CI: 0.65, 0.90; <i>I</i><sup>2</sup>=63%; <i>p</i> = 0.001; <i>n</i> = 503) and anorexia score (SMD=-0.33, 95%CI: -0.53, -0.14; <i>I</i><sup>2</sup>=22%; <i>p</i> = 0.0008; <i>n</i> = 419), as well as preserved body mass (MD = 2.70, 95%CI: 1.08, 4.32; <i>I</i><sup>2</sup>=0%; <i>p</i> = 0.001; <i>n</i> = 187) and enhanced physical strength (MD = 4.23, 95%CI: 1.90, 6.55; <i>I</i><sup>2</sup>=58%; <i>p</i> = 0.0004; <i>n</i> = 377). Moreover, subgroup analysis highlighted its efficacy in managing anorexia associated with non-gastrointestinal tumors and mitigating the severity of cisplatin-induced anorexia. Meanwhile, Zusanli (ST36), Neiguan (PC6), Tianshu (ST25), Zhongwan (RN12), and Qihai (RN6) were identified as crucial acupoints in CIA management.</p><p><strong>Conclusion: </strong>Acupuncture holds promise as a potential non-pharmacological approach for managing anorexia during cancer chemotherapy. To provide robust evidence of its effectiveness, well-designed Randomized Controlled Trials (RCTs) with larger participant cohorts, and consistent core outcome measures are essential.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"230-243"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Serum Aflatoxin B1-Lysine Adduct Concentration and Gallbladder Cancer: A Case-Control Study. 血清黄曲霉毒素b1 -赖氨酸加合物浓度与胆囊癌:一项病例对照研究。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1080/01635581.2025.2475545
Ratnakar Shukla, Toshikazu Ikoma, Yasuo Tsuchiya, Takao Asai, Anand Nagar, Vinay Kumar Kapoor
{"title":"Serum Aflatoxin B1-Lysine Adduct Concentration and Gallbladder Cancer: A Case-Control Study.","authors":"Ratnakar Shukla, Toshikazu Ikoma, Yasuo Tsuchiya, Takao Asai, Anand Nagar, Vinay Kumar Kapoor","doi":"10.1080/01635581.2025.2475545","DOIUrl":"10.1080/01635581.2025.2475545","url":null,"abstract":"<p><p>Aflatoxin B1 (AFB1) may be associated with not only developing liver cancer but also gallbladder cancer (GBC). We aimed to investigate whether serum AFB1 level of GBC patients is higher than chronic cholecystitis (CC) patients or healthy subjects (HS). Serum was collected from 45 GBC patients (18 men, 27 women), 57 CC patients (22 men, 35 women), and 55 HS (20 men, 35 women) from May 2021 to February 2024. Serum AFB1-lysine adduct level was measured using a commercial ELISA kit. Detection frequency (≥0.1 ng/ml), median and mean levels of serum AFB1-lysine adduct were compared among three groups. The detection rate was 71% (35/45) in GBC patients, 39% (22/57) in CC, and 7% (4/55) in HS (<i>p</i> < 0.001). Age- and gender-adjusted odds ratios of AFB1 detection in GBC patients were 4.1 and 16.8 times higher than in CC patients and HS, respectively. The median levels were 5.0 ng/mL in GBC patients and < 0.1 ng/mL in CC patients and HS. The mean level in GBC patients (7.9 ± 8.4 ng/mL) was significantly higher than that in CC patients (2.7 ± 4.5 ng/mL) or HS (0.3 ± 1.1 ng/mL). Our findings show direct evidence that AFB1 exposure may be associated with risk of developing GBC in India.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"619-625"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143659734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emodin Decreases Tumor-Associated Macrophages Accumulation and Suppresses Bladder Cancer Development by Inhibiting CXCL1 Secretion from Cancer-Associated Fibroblasts. 大黄素通过抑制癌症相关成纤维细胞分泌 CXCL1 减少肿瘤相关巨噬细胞的聚集并抑制膀胱癌的发展
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-20 DOI: 10.1080/01635581.2025.2480309
Fang Yu, Nan Yu, Lei Zhang, Xiaona Xu, Yan Zhao, Zipeng Cao, Feng Wang
{"title":"Emodin Decreases Tumor-Associated Macrophages Accumulation and Suppresses Bladder Cancer Development by Inhibiting CXCL1 Secretion from Cancer-Associated Fibroblasts.","authors":"Fang Yu, Nan Yu, Lei Zhang, Xiaona Xu, Yan Zhao, Zipeng Cao, Feng Wang","doi":"10.1080/01635581.2025.2480309","DOIUrl":"10.1080/01635581.2025.2480309","url":null,"abstract":"<p><p>Tumor-associated macrophages (TAMs) and cancer-associated fibroblasts (CAFs) are the most abundant stromal cells in the bladder cancer (BC) microenvironment (TME). However, the detailed mechanisms underlying TAM-CAF communication and their contributions to BC progression remain incompletely understood. Emerging evidence shows that Emodin exerts anti-tumor effect on several tumor models by targeting TME. To date, the impact of Emodin on BC has not been previously reported. Our study firstly demonstrated that Emodin significantly inhibited tumor growth and reduced TAM accumulation in a murine BC model. Emodin markedly decreased serum levels of multiple chemokines in tumor-bearing mice, with CXCL1 showing the most pronounced reduction. Strikingly, Emodin selectively suppressed CXCL1 secretion in CAFs but not in TAMs or tumor cells. Furthermore, the decrease in TAM migration induced by Emodin was dependent on CAF-derived CXCL1. Using a subcutaneous tumor model, we found that Emodin failed to inhibit tumor growth when CXCL1-deficient CAFs were co-injected with tumor cells, underscoring the critical role of CXCL1 in this process. Bioinformatics analysis further revealed that elevated CXCL1 levels correlated negatively with invasive/metastatic potential and overall survival in BC patients. In conclusion, our findings establish that Emodin delays BC progression by disrupting CXCL1-mediated crosstalk between CAFs and TAMs.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"706-721"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143671818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Nutritional Intervention on Chemotherapy Tolerance and Quality of Life in Patients with Colorectal Cancer Undergoing Postoperative Chemotherapy: A Randomized Controlled Study. 营养干预对结直肠癌术后化疗患者化疗耐受性和生活质量的影响:一项随机对照研究
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-01-09 DOI: 10.1080/01635581.2025.2449719
Jiwei Wang, Yong Huang, Xilan Zheng, Ming Xie, Yin Wu, Li Yang, Chunmei Yin
{"title":"Effect of Nutritional Intervention on Chemotherapy Tolerance and Quality of Life in Patients with Colorectal Cancer Undergoing Postoperative Chemotherapy: A Randomized Controlled Study.","authors":"Jiwei Wang, Yong Huang, Xilan Zheng, Ming Xie, Yin Wu, Li Yang, Chunmei Yin","doi":"10.1080/01635581.2025.2449719","DOIUrl":"10.1080/01635581.2025.2449719","url":null,"abstract":"<p><p>This study explored the effect of symptom-based individualized nutritional intervention on chemotherapy tolerance and quality of life (QOL) in patients with colorectal cancer (CRC) undergoing postoperative chemotherapy. Postoperative patients with CRC (<i>n</i> = 88) were randomly assigned to the control group (CG, <i>n</i> = 45) and intervention group (IG, <i>n</i> = 43) receiving conventional diet counseling and symptom-based individualized nutritional intervention, respectively, and chemotherapy tolerance, adverse effects, and QOL were compared. Participants in the IG exhibited better nutritional status at the last chemotherapy cycle, with lower Nutrition Risk Screening 2002 (2.37 ± 0.65 vs. 3.78 ± 0.65, <i>p</i> < 0.01) and Patient-Generated Subjective Global Assessment (6.26 ± 0.76 vs. 7.78 ± 0.70, <i>p</i> < 0.01) scores. Compared with CG, relative dose intensity reduction (9.3% vs. 25.89%, <i>p</i> = 0.02), chemotherapy regimen change (25.58% vs. 53.33%, <i>p</i> < 0.01), and chemotherapy delay (13.95% vs. 35.56%, <i>p</i> = 0.019) were lower in the IG. Nausea/vomiting (2.33% vs. 17.78%, <i>p</i> = 0.017), thrombocytopenia (2.33% vs. 28.89%, <i>p</i> < 0.01), and hand-foot syndrome (4.65% vs. 22.22%, <i>p</i> = 0.03) were less frequent in the IG. Participants in the IG had better QOL, with higher physical function scores at cycles 4 (67.91 ± 5.22 vs. 62.22 ± 4.02, <i>p</i> < 0.01) and 8 (72.71 ± 6.31 vs. 57.63 ± 4.75, <i>p</i> < 0.01). Individualized nutritional interventions improved chemotherapy tolerance and QOL and reduced adverse effects in this patient cohort.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"414-423"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142959097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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