韩国胆道-胰腺癌患者醋酸甲地孕酮处方8年趋势及其影响

IF 2 4区医学 Q3 NUTRITION & DIETETICS

Nutrition and Cancer-An International Journal Pub Date : 2025-05-26 DOI:10.1080/01635581.2025.2508536

Hoonji Oh, Ju Won Kim

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引用次数: 0

摘要

背景：化疗引起的厌食症和恶病质是胆道癌（BTC）和胰管腺癌（PDAC）患者面临的重大挑战。用于治疗厌食症的醋酸甲地孕酮（MA）有副作用，并可能在癌症治疗中引发处方级联反应。本研究分析了BTC或PDAC患者的MA处方趋势和相关效果。方法：使用韩国健康保险和评估服务数据库的数据，对BTC或PDAC患者的MA处方率进行检查。我们调查了同期的血栓和抗凝处方率。结果：对2009年至2016年诊断为BTC或PDAC的31114例患者的分析显示，MA处方显著增加：BTC患者从4.42%增加到44.62%，PDAC患者从7.56%增加到63.15% (p结论：BTC或PDAC患者的MA处方在8年内显著增加。长期服用MA的患者抗凝处方率高于未服用MA的患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Eight-Year Trends in Megestrol Acetate Prescription Among Korean Patients with Biliary-Pancreatic Cancer and Their Impact.

Background: Chemotherapy-induced anorexia and cachexia are significant challenges for patients with biliary tract cancer (BTC) and pancreatic ductal adenocarcinoma (PDAC). Megestrol acetate (MA), used to manage anorexia, has side effects and may trigger prescription cascades in cancer treatment. This study analyzed MA prescription trends and associated effects in BTC or PDAC patients.

Methods: MA prescription rates among BTC or PDAC patients were examined using data from the Health Insurance and Review Assessment Service database in Korea. We investigated thrombosis and anti-coagulant prescription rates during the same period.

Results: Analysis of 31,114 patients diagnosed with BTC or PDAC between 2009 and 2016 revealed significant increases in MA prescriptions: from 4.42% to 44.62% in BTC patients and from 7.56% to 63.15% in PDAC patients (p < 0.0001). In 2009, thrombosis was diagnosed in 5.58% of BTC patients and 6.83% of PDAC patients, rising to 7.62% and 12.47% by 2016. Anticoagulant prescriptions also increased, from 0.84% to 16.97% for BTC patients and from 2.37% to 15.96% for PDAC patients.

Conclusion: MA prescriptions for BTC or PDAC patients increased significantly over 8 years. Patients on long-term MA had higher anticoagulant prescription rates compared to those not on long-term MA.

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来源期刊

Nutrition and Cancer-An International Journal 医学-营养学

CiteScore

5.80

自引率

3.40%

发文量

172

审稿时长

3 months

期刊介绍： This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.