营养状况对胸部肿瘤放疗患者症状性放射性肺炎的预测价值。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Xiaoxuan Xie, Meng Chen, Ming Pei, Xiangyang Li, Yun Zhou, Yongzhong Guo
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引用次数: 0

摘要

在接受放射治疗的胸椎癌患者中,营养状况与放射性肺炎(RP)风险之间的关系尚不清楚,值得进一步研究。回顾性分析2021年1月至2024年6月的一般临床资料。根据不良事件通用术语标准(第5版)对RP进行诊断和分级,症状性RP定义为≥2级。RP的预测因素被确定使用最小的绝对收缩和选择算子和多变量逻辑回归分析,其次是一个正态图的发展。利用受试者工作特性曲线下面积(AUC)、校准曲线和决策曲线分析来评价nomogram预测性能。控制营养状态(CONUT)评分和V5被确定为症状性RP的独立预测因子,并纳入预测模型。nomogram具有较好的预测能力(AUC: 0.851;95%可信区间:0.801-0.902),具有良好的准确性和临床应用价值。营养状况与症状性RP的发展有关。放疗前CONUT评分可作为症状性RP的预测指标,将其纳入CONUT- v5模型具有更好的判别能力。改善营养状况可能是预防症状性RP发展的一种简单方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Predictive Value of Nutritional Status for Symptomatic Radiation Pneumonitis in Patients with Thoracic Cancer Undergoing Radiotherapy.

The association between nutritional status and the risk of radiation pneumonitis (RP) in patients with thoracic cancer undergoing radiotherapy remains unclear and warrants further investigation. General clinical data between January 2021 and June 2024 were retrospectively analyzed. RP was diagnosed and graded according to the Common Terminology Criteria for Adverse Events (version 5), with symptomatic RP defined as grade ≥2. Predictive factors for RP were identified using least absolute shrinkage and selection operator and multivariate logistic regression analyses, followed by the development of a nomogram. The predictive performance of the nomogram was evaluated using the area under the curve (AUC) of receiver operating characteristic, calibration curve, and decision curve analysis. Controlling Nutritional Status (CONUT) scores and V5 were identified as independent predictors of symptomatic RP and incorporated into the predictive model. The nomogram demonstrated excellent predictive capability (AUC: 0.851; 95% confidence interval: 0.801-0.902), with good accuracy and clinical application utility. Nutritional status is associated with the development of symptomatic RP. The pre-radiotherapy CONUT score can serve as a predictor of symptomatic RP, and its incorporation into the CONUT-V5 model achieves better discriminative capacity. Improving nutritional status may be a simple way to prevent the development of symptomatic RP.

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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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