膳食脂肪酸与膀胱癌风险:来自PLCO癌症筛选试验的见解。

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Gao Li, Wenjie Zheng, Xin Zhang, Yuanhao Chen
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引用次数: 0

摘要

本研究旨在评估不同膳食脂肪酸的摄入与膀胱癌风险之间的关系。定量分析使用了前列腺、肺、结直肠和卵巢(PLCO)癌症筛查试验的数据,其中包括101,731名参与者。采用Cox比例风险模型计算膀胱癌风险与膳食脂肪酸摄入量的关系的风险比(HR)和95%置信区间(CI)。在中位11.3年的随访期间,发现了861例膀胱癌病例。在多变量Cox回归模型中充分调整潜在混杂因素后,未发现饮食脂肪酸摄入与膀胱癌风险之间存在显著关联。亚组分析显示与性别有显著的交互作用(p p p -trend = 0.028)。然而,限制性三次样条分析显示,在整体组或性别特定亚组中,MUFA摄入量与膀胱癌风险之间没有线性关系。膳食脂肪酸与膀胱癌风险之间的关系受到性别和吸烟状况等因素的影响。在女性中,适量摄入MUFA可能会降低膀胱癌的风险,但较高的摄入量并没有提供额外的好处。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dietary Fatty Acids and Bladder Cancer Risk: Insights from the PLCO Cancer Screening Trial.

This study aimed to evaluate the relationship between the consumption of different dietary fatty acids and the risk of bladder cancer. A quantitative analysis was conducted using data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, which included 101,731 participants. The Cox proportional hazards model was used to calculate hazard ratios (HR) and 95% confidence intervals (CI) for bladder cancer risk in relation to dietary fatty acid intake. During a median follow-up of 11.3 years, 861 bladder cancer cases were identified. After fully adjusting for potential confounders in a multivariate Cox regression model, no significant association was found between dietary fatty acid consumption and bladder cancer risk. Subgroup analysis revealed significant interactions with gender (p < 0.001) and smoking status (p < 0.001). Gender-specific analysis showed that a higher intake of monounsaturated fatty acids (MUFAs) was linked to a reduced risk of bladder cancer in females (HR: 0.62; 95% CI: 0.39-0.99, P-trend = 0.028). However, restricted cubic spline analysis revealed no linear relationship between MUFA intake and bladder cancer risk in the overall group or gender-specific subgroups. The association between dietary fatty acids and bladder cancer risk is influenced by factors like gender and smoking status. In females, moderate MUFA intake may reduce bladder cancer risk, but higher intake does not provide additional benefits.

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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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