Effect of Creatine Supplementation on Body Composition in Cancer Patients: A Systematic Review.

IF 2 4区 医学 Q3 NUTRITION & DIETETICS
Asier Del Arco, Saioa Aguirre-Elordui, Jurgi Olasagasti-Ibargoien, Arkaitz Castañeda-Babarro
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Abstract

Creatine is a naturally occurring compound stored in muscles, obtainable through diet and supplementation, known to enhance strength, exercise capacity, and recovery. Recent research suggests it may aid in treating some chronic diseases. This review analyzed the effects of creatine supplementation (CrS) on body composition in cancer patients or survivors. Following PRISMA guidelines, five databases were searched for studies up to September 12, reviewing seven articles with 463 participants (316 men, 147 women; average age 62.95 years). Five studies assessed CrS effects on body weight: three found no changes, while two reported increases. For lean body mass, three trials noted increases in both creatine and placebo groups, but differences were not significant. Fat mass results varied, showing reductions, no changes, or mitigated increases during hormone therapy. Although CrS showed potential improvements, evidence of significant effects on body composition in cancer patients remains limited. CrS appears safe and might be more beneficial with less aggressive treatments or in non-metastatic cases. Further research is needed to clarify its role in this context.

补充肌酸对癌症患者体成分的影响:一项系统综述。
肌酸是一种储存在肌肉中的天然化合物,可通过饮食和补充获得,已知可增强力量,运动能力和恢复能力。最近的研究表明,它可能有助于治疗一些慢性疾病。这篇综述分析了补充肌酸(CrS)对癌症患者或幸存者身体成分的影响。按照PRISMA指南,截至9月12日,检索了5个数据库的研究,审查了7篇文章,463名参与者(316名男性,147名女性;平均年龄62.95岁)。五项研究评估了CrS对体重的影响:三项研究发现没有变化,而两项研究报告增加了。在瘦体重方面,有三项试验指出,肌酸组和安慰剂组的体重都有所增加,但差异并不显著。脂肪量的结果各不相同,在激素治疗期间显示减少,没有变化,或减轻增加。尽管CrS显示出潜在的改善,但对癌症患者身体成分有显著影响的证据仍然有限。CrS似乎是安全的,并且在较少的积极治疗或非转移性病例中可能更有益。需要进一步的研究来阐明其在这方面的作用。
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来源期刊
CiteScore
5.80
自引率
3.40%
发文量
172
审稿时长
3 months
期刊介绍: This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.
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