Nutrition and Cancer-An International Journal最新文献

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Dietitian-Provided Interventions for Adults with Cancer: An Umbrella Review of Systematic Reviews. 成人癌症患者的营养干预:系统综述综述。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-19 DOI: 10.1080/01635581.2025.2480317
M Rozga, L Moloney, D Handu
{"title":"Dietitian-Provided Interventions for Adults with Cancer: An Umbrella Review of Systematic Reviews.","authors":"M Rozga, L Moloney, D Handu","doi":"10.1080/01635581.2025.2480317","DOIUrl":"10.1080/01635581.2025.2480317","url":null,"abstract":"<p><p>Malnutrition is common in adults with cancer and is associated with lower quality of life and higher risk of mortality. A comprehensive picture of dietitian efficacy in cancer care is needed to inform payers and policymakers about effective care options. The objective of this umbrella review of systematic reviews (SRs) is to examine the impact of dietitian interventions, compared to no intervention or usual care, on nutrition-related outcomes in adults with all types and stages of cancer. MEDLINE, CINAHL, Cochrane Database of SRs, Food Science Source, and SPORTSDiscus databases were searched for SRs and meta-analyses published from 2018 to September 2024. The GRADE method was used to rate evidence certainty. There were 2,087 articles identified in the search, 125 full texts were examined for eligibility, and seven SRs were included in this umbrella review, representing 25 randomized controlled trials and six observational studies. Interventions provided by dietitians may improve nutrition status, protein and energy intake, length of stay, and quality of life, but evidence certainty was low, primarily due to the risk of bias in primary studies, heterogeneity, and lack of precise effect size. Providing dietitian-led interventions for adults with cancer may improve a wide range of nutrition-related outcomes.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"575-589"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of Early Oral Feeding on Quality of Life Following Esophagectomy: A Systematic Review and Meta-Analysis. 食管切除术后早期口服喂养对生活质量的影响:系统回顾与元分析》。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-11-07 DOI: 10.1080/01635581.2024.2422636
Ming Shi, Mengjie Li, Manyi Fu, Guijuan He
{"title":"Effects of Early Oral Feeding on Quality of Life Following Esophagectomy: A Systematic Review and Meta-Analysis.","authors":"Ming Shi, Mengjie Li, Manyi Fu, Guijuan He","doi":"10.1080/01635581.2024.2422636","DOIUrl":"10.1080/01635581.2024.2422636","url":null,"abstract":"<p><strong>Background: </strong>The role of early oral feeding (EOF) following esophagectomy remains debated. This study evaluates whether postoperative EOF improves patients' quality of life.</p><p><strong>Methods: </strong>A comprehensive search was performed across eight databases to identify relevant studies. The effects of continuous variables were assessed using the mean difference (MD). The effects of dichotomous variables were assessed using the relative risk (RR).</p><p><strong>Results: </strong>Seven studies were included in the analysis. EOF significantly improved postoperative overall quality of life [MD = 9.64, 95% CI (6.11, 13.16), <i>p</i> < 0.001], dysphagia [MD = -7.37, 95% CI (-14.32, -0.42), <i>p</i> = 0.040], and eating difficulty [MD = -6.72, 95% CI (-10.62, -2.82), <i>p</i> < 0.001]. However, no significant differences were observed in postoperative reflux [MD = -5.90, 95% CI (-12.52, 0.73), <i>p</i> = 0.080], esophageal pain [MD = -1.86, 95% CI (-5.51, 1.78), <i>p</i> = 0.320], anastomotic leakage [RR = 0.70, 95% CI (0.37, 1.35), <i>p</i> = 0.290], and pulmonary infection [RR = 0.44, 95% CI (0.15, 1.35), <i>p</i> = 0.150].</p><p><strong>Conclusion: </strong>EOF after esophagectomy appears to improve patients' quality of life; however, these findings are constrained by the limited number and quality of studies. Further research is needed to validate these results.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"324-333"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142604322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Combined Exercise and Nutrition Interventions During Inpatient Chemotherapy in Acute Leukemia and Malignant Lymphoma Patients: A Randomized Controlled Trial. 急性白血病和恶性淋巴瘤患者住院化疗期间运动和营养联合干预的效果:随机对照试验
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-19 DOI: 10.1080/01635581.2024.2406043
Ryuichi Kasahara, Shinichiro Morishita, Takaaki Fujita, Ryohei Jinbo, Junko Kubota, Aya Takano, Shoko Takahashi, Sayaka Kisara, Kazumi Jinbo, Yuichi Yamamoto, Masae Kakuta, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Shigehira Saji
{"title":"Effect of Combined Exercise and Nutrition Interventions During Inpatient Chemotherapy in Acute Leukemia and Malignant Lymphoma Patients: A Randomized Controlled Trial.","authors":"Ryuichi Kasahara, Shinichiro Morishita, Takaaki Fujita, Ryohei Jinbo, Junko Kubota, Aya Takano, Shoko Takahashi, Sayaka Kisara, Kazumi Jinbo, Yuichi Yamamoto, Masae Kakuta, Tatsuyuki Kai, Yutaka Shiga, Hideo Kimura, Miki Furukawa, Shigehira Saji","doi":"10.1080/01635581.2024.2406043","DOIUrl":"10.1080/01635581.2024.2406043","url":null,"abstract":"<p><p>The aim of the present study was to determine the effectiveness of combined exercise and nutrition interventions on physical function and quality of life (QOL) in patients with acute leukemia or malignant lymphoma (ML) during inpatient chemotherapy. The study was a randomized controlled trial where patients with acute leukemia or ML who were receiving inpatient chemotherapy and exercise therapy were divided into an intervention group (IG) and a control group (CG). Both groups underwent resistance training and aerobic exercise. The patients in the IG were instructed to take nutritional supplements twice a day. Assessment items were muscle strength (handgrip strength and knee extension strength), 6-min walking test, skeletal muscle mass, QOL, nutritional status, and fatigue. Two-way analysis of variance showed a significant interaction for bilateral handgrip strength and knee extension strength. No significant interactions were found for the other items. The results of the present study showed improved muscle strength in the IG compared to the CG, indicating the effectiveness of combined exercise and nutrition interventions during inpatient chemotherapy in patients with acute leukemia or ML.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"115-123"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142301172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safe Threshold Rate of Indocyanine Green Retention and Intervention of Nutrition Management After Hepatectomy. 肝切除术后吲哚菁绿潴留的安全阈值率和营养管理干预。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-11-21 DOI: 10.1080/01635581.2024.2431348
Junping Gao, Zhan Lu, Wanqiang Liang, Jie Zhang, Shangdong Qin, Juntao Huang, Wenfeng Gong, Bangde Xiang
{"title":"Safe Threshold Rate of Indocyanine Green Retention and Intervention of Nutrition Management After Hepatectomy.","authors":"Junping Gao, Zhan Lu, Wanqiang Liang, Jie Zhang, Shangdong Qin, Juntao Huang, Wenfeng Gong, Bangde Xiang","doi":"10.1080/01635581.2024.2431348","DOIUrl":"10.1080/01635581.2024.2431348","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the safe indocyanine green retention rate at the 15-minute (ICG-R15) threshold for hepatectomy and the effect of nutritional management on ICG-R15 and posthepatectomy liver failure (PHLF).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted on 70 hepatectomy patients with chronic liver disease, divided into routine care and nutrition intervention groups. ICG-R15 was measured pre- and postoperatively, along with PHLF occurrence and other health metrics.</p><p><strong>Results: </strong>Seventy patients with chronic liver disease were divided into two groups: one received routine care, while the other followed a nutrition plan based on Omaha theory. The intervention group showed a significantly lower incidence of PHLF (15.8% vs 41.2%, <i>p</i> = 0.009) and clinically relevant PHLF (5.3% vs 19.6%, <i>p</i> = 0.031), along with shorter hospital stays (11.3 ± 6.4 days vs 21.5 ± 15.5 days, <i>p</i> = 0.012) and fewer complications (26.3% vs 47.1%, <i>p</i> = 0.020). The optimal ICG-R15 threshold for predicting PHLF was 4.5%, with 8.5% being critical.</p><p><strong>Conclusion: </strong>ICG-R15 is a reliable predictor of PHLF, with 4.5% being safe and 8.5% critical. Nutritional management based on Omaha theory improves outcomes and quality of life. Further validation is needed.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"372-379"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Intermittent Fasting with a Ketogenic Diet on AMPK Levels in Breast Cancer Patients Receiving Chemotherapy. 间歇禁食加生酮饮食对接受化疗的乳腺癌患者AMPK水平的影响
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-04-08 DOI: 10.1080/01635581.2025.2488065
Ahsan Raza Khan Lughmani, Nouman Ibrahim, Wasiq Ali, Yasmeen Bibi, Adnan Afzal, Mizna Javed, Ammara Hameed, Wania Shahzadi, Saba Saddique, Maria Ahmed
{"title":"Impact of Intermittent Fasting with a Ketogenic Diet on AMPK Levels in Breast Cancer Patients Receiving Chemotherapy.","authors":"Ahsan Raza Khan Lughmani, Nouman Ibrahim, Wasiq Ali, Yasmeen Bibi, Adnan Afzal, Mizna Javed, Ammara Hameed, Wania Shahzadi, Saba Saddique, Maria Ahmed","doi":"10.1080/01635581.2025.2488065","DOIUrl":"10.1080/01635581.2025.2488065","url":null,"abstract":"<p><p>Adenosine monophosphate-activated protein kinase (AMPK), a metabolic sensor activated by nutrient starvation, plays a multifaceted role in cancer. Whether AMPK is beneficial or malevolent is controversial. This study aimed to investigate AMPK levels in breast cancer patients receiving chemotherapy and compare the effects of intermittent fasting combined with different diets on these levels. Forty-five breast cancer patients were divided into three groups: a control, a group practicing 23:1-h intermittent fasting (IF) with a routine diet (RD), and another with a ketogenic diet (KD) over 4 weeks. Body mass index (BMI), Carbohydrate Antigen 15-3 (CA 15-3) levels, and serum AMPK levels were measured pre and post-intervention. Results showed a significant increase in AMPK levels in both the fasting groups and no significant difference in the non-fasting group, with the keto diet group showing the most significant growth. CA 15-3 levels were reduced in all the groups but significantly reduced in the KD group as compared to the RD group. This study shows that intermittent fasting with the keto diet improves AMPK levels and may serve as a valuable non-pharmacological complementary strategy for reducing or eliminating the tumor and, simultaneously, preventing the healthy cells from the toxic side effects of chemotherapy.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"699-705"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143804541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Association between Tea Consumption and Bladder Cancer Risk Based on the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) International Consortium. 茶叶消费与膀胱癌风险之间的关系——基于膀胱癌流行病学和营养决定因素(BLEND)国际联盟。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-04-08 DOI: 10.1080/01635581.2025.2488063
Yan-Xi Zhang, Richard Albers, Ya-Ting Chen, Gunnar Steineck, Eliane Kellen, Kenneth C Johnson, Chih-Ming Lu, Hermann Pohlabeln, Carlo La Vecchia, Stefano Porru, Angela Carta, Jerry Polesel, Cristina Bosetti, Xuejuan Jiang, Li Tang, James Marshall, Margaret R Karagas, Zuo-Feng Zhang, Jack A Taylor, Maurice P A Zeegers, Anke Wesselius, Evan Yi-Wen Yu
{"title":"The Association between Tea Consumption and Bladder Cancer Risk Based on the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) International Consortium.","authors":"Yan-Xi Zhang, Richard Albers, Ya-Ting Chen, Gunnar Steineck, Eliane Kellen, Kenneth C Johnson, Chih-Ming Lu, Hermann Pohlabeln, Carlo La Vecchia, Stefano Porru, Angela Carta, Jerry Polesel, Cristina Bosetti, Xuejuan Jiang, Li Tang, James Marshall, Margaret R Karagas, Zuo-Feng Zhang, Jack A Taylor, Maurice P A Zeegers, Anke Wesselius, Evan Yi-Wen Yu","doi":"10.1080/01635581.2025.2488063","DOIUrl":"10.1080/01635581.2025.2488063","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence regarding the association between tea consumption and bladder cancer (BC) risk is inconsistent. This study aimed to increase our knowledge of the association by using international data from the Bladder Cancer Epidemiology and Nutritional Determinants Consortium.</p><p><strong>Methods: </strong>Individual data on 2,347 cases and 6,871 controls from 15 case-control studies with information on black, green, herbal, or general tea was pooled. The association was estimated using multilevel multivariable logistic regression analysis adjusted for multiple (non-)dietary factors.</p><p><strong>Results: </strong>Association between tea consumption and BC risk was observed (odds ratio, OR = 0.72, 95% confidence interval, 95% CI = 0.65-0.80) compared to non-tea drinkers. Stratified analyses based on gender and smoking status yielded similar results. Stratified analysis showed no significant association between black or green tea consumption and BC risk across models, while herbal tea consumption was linked to a reduced BC risk (OR = 0.59, 95% CI = 0.36-0.96). As daily tea consumption increased within a suitable range (<5.67 cups/day), BC risk decreased.</p><p><strong>Conclusions: </strong><i>Camellia sinensis</i> tea showed no association with BC risk, while herbal tea was inversely linked to BC incidence. Despite some significant findings in the selected strata, further studies are required to clarify the underlying mechanisms.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"687-698"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D Supplementation Improves Pathological Complete Response in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Randomized Clinical Trial. 补充维生素D可改善乳腺癌患者接受新辅助化疗的病理完全缓解:一项随机临床试验
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI: 10.1080/01635581.2025.2480854
Michelle Sako Omodei, Jackeline Chimicoviaki, Daniel Araujo Brito Buttros, Benedito Souza Almeida-Filho, Carla Priscila Carvalho-Pessoa, Eduardo Carvalho-Pessoa, Heloisa De Luca Vespoli, Eliana Aguiar Petri Nahas
{"title":"Vitamin D Supplementation Improves Pathological Complete Response in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Randomized Clinical Trial.","authors":"Michelle Sako Omodei, Jackeline Chimicoviaki, Daniel Araujo Brito Buttros, Benedito Souza Almeida-Filho, Carla Priscila Carvalho-Pessoa, Eduardo Carvalho-Pessoa, Heloisa De Luca Vespoli, Eliana Aguiar Petri Nahas","doi":"10.1080/01635581.2025.2480854","DOIUrl":"10.1080/01635581.2025.2480854","url":null,"abstract":"<p><p>This study aimed to evaluate the effect of vitamin D (VD) supplementation on the pathological complete response (pCR) rate in women with breast cancer (BC) undergoing neoadjuvant chemotherapy (NCT). A randomized clinical trial was conducted with 80 women aged ≥45years with BC who were eligible for NCT. Women were randomized into two groups: VD group, daily supplementation with 2,000IU of cholecalciferol (<i>n</i> = 40) or placebo (<i>n</i> = 40), for 6 months. The primary outcome measure was the pCR rate. Serum 25-hydroxyvitamin-D [25(OH)D] levels were measured after BC diagnosis and the end of NCT. Of the 80 randomized women, 75 completed the NCT and underwent surgery. Baseline 25(OH)D values indicated hypovitaminosis D in both groups (VD: 19.6 ± 5.8 ng/mL and placebo: 21 ± 7.9 ng/mL, <i>p</i> = 0.33). After 6 months, 25(OH)D levels increased in the VD group compared to the placebo group (28 ± 8.7 vs. 20.2 ± 6.1 ng/mL, <i>p</i> = 0.03). The pCR rate was higher in women supplemented with VD when compared than the placebo (43% vs. 24%, <i>p</i> = 0.04). Adjusted logistic regression showed that women with 25(OH)D levels ≥20ng/mL were more likely to achieve pCR (OR3.65, 95%CI 1.09-12.8, <i>p</i> = 0.04). Women with BC undergoing NCT who received supplementation with 2,000IU of VD were more likely to achieve a pathological complete response than women in the placebo group.</p><p><strong>Trial registration: </strong>Ensaiosclinicos.gov.br, identifier RBR-10k4gqdg.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"648-657"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CT Derived Measurement of Body Composition: Observations from a Comparative Analysis of Patients with Colorectal and Lung Cancer. CT 导出的身体成分测量:对结直肠癌和肺癌患者的对比分析观察。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-08-23 DOI: 10.1080/01635581.2024.2392913
Tanvir Abbass, Ross D Dolan, Paul G Horgan, Nicholas MacLeod, Richard J Skipworth, Barry J Laird, Donald C McMillan
{"title":"CT Derived Measurement of Body Composition: Observations from a Comparative Analysis of Patients with Colorectal and Lung Cancer.","authors":"Tanvir Abbass, Ross D Dolan, Paul G Horgan, Nicholas MacLeod, Richard J Skipworth, Barry J Laird, Donald C McMillan","doi":"10.1080/01635581.2024.2392913","DOIUrl":"10.1080/01635581.2024.2392913","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;CT-derived measures of body composition have been shown to have prognostic value in patients with cancer. However, few studies have compared these observations across tumor types and stages of disease. The aim of the present study was to compare body composition measures between two types of cancers, i.e. colorectal cancer (CRC), which is less inflammatory and patients maintain body composition over a longitudinal study period, whereas lung cancer (LC) is proinflammatory and patients lose more fat and muscle mass using a standard methodology.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Clinicopathological characteristics, including those pertaining to nutritional risk/status and systemic inflammation in patients with colorectal cancer (CRC, &lt;i&gt;n&lt;/i&gt; = 1047) and lung cancer (LC, &lt;i&gt;n&lt;/i&gt; = 662), were compared. The CT image at L3 was used to assess body composition. Comparison of these cohorts was carried out using the chi-square test. Binary logistic regression analysis was performed to assess the impact of clinico-pathological variables on body composition, and scatter plots were used to examine the relationship between body mass index (BMI) and CT-derived measures of body composition.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;According to CT-derived body composition, high subcutaneous (SFI) and visceral fat index (VFI) were common (&gt;70%) in both CRC and LC. Also, low skeletal muscle index (SMI) and density (SMD) were approximately 40-50% and 60-70% in both CRC and LC. Compared with CRC, patients with LC had a higher American Society of Anaesthesia (ASA) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), Malnutrition Universal Screening Tool (MUST) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), modified frailty index (mFI) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), modified Glasgow Prognostic Score (mGPS) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), and neutrophil lymphocyte ratio (NLR) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001) scores.On binary logistic regression analysis, MUST, mFI, and NLR were predictors of subcutaneous adiposity (&lt;i&gt;P&lt;/i&gt; &lt; 0.05); type of cancer, MUST, and mFI were predictors of visceral obesity (&lt;i&gt;P&lt;/i&gt; &lt; 0.001); age, type of cancer, MUST, and mGPS were predictors of low SMI (&lt;i&gt;P&lt;/i&gt; &lt; 0.001); and age, type of cancer, mFI, and mGPS were predictors of low SMD (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). There was a similar relationship between BMI and other measures of CT-derived body composition across two types of cancers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Obesity and low skeletal muscle mass were common in both CRC and LC cohorts despite large differences in comorbidity, nutritional risk, systemic inflammation, and survival, even when normalized for TNM stage. These observations would support the hypothesis that, although prognostic, CT derived body composition analysis primarily reflects patient constitution rather than the effect of tumor stage in patients with cancer. The systemic inflammatory response, as evidenced by mGPS, can be considered as an important therapeutic target and loss of muscle mass in patients with advanced cancer is related to the systemi","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"70-78"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Double-Lumen Biliary-Enteric Tube in Enteral Nutrition for Patients with Malignant Obstructive Jaundice. 双腔胆管-肠内营养管对恶性阻塞性黄疸患者的疗效
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-26 DOI: 10.1080/01635581.2024.2408041
Jian-Hua Cao, Ke-Fu Wu, Gao-Xiang Li, Jie Chen, Zhan-Hu Mu, Hai-Min Li, Jian-Jun Yao, Xue-Wen Yang
{"title":"Efficacy of Double-Lumen Biliary-Enteric Tube in Enteral Nutrition for Patients with Malignant Obstructive Jaundice.","authors":"Jian-Hua Cao, Ke-Fu Wu, Gao-Xiang Li, Jie Chen, Zhan-Hu Mu, Hai-Min Li, Jian-Jun Yao, Xue-Wen Yang","doi":"10.1080/01635581.2024.2408041","DOIUrl":"10.1080/01635581.2024.2408041","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the efficacy of a double-lumen biliary-enteric tube (DBET) for enteral nutrition (EN) in individuals with malignant obstructive jaundice (MOJ).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using data from a prospectively maintained single-center database, including patients with MOJ. In the intervention group, DBET placement was performed concurrently with percutaneous transhepatic cholangiodrainage and biliary stenting, followed by postoperative EN (DBET-EN). In the control group, deep vein catheterization was undertaken after endoscopic biliary stenting, and parenteral nutrition (PN) was provided. A multivariable generalized linear model was used to assess the association between DBET-EN and 6-month mortality.</p><p><strong>Results: </strong>A total of 74 patients were included in this study, comprising 28 patients in the intervention group (DBET-EN group) and 46 patients in the control group (PN group). Within the 6-month follow-up, 5 patients (17.9%) in the DBET-EN group and 20 (43.5%) in the PN group died. The multivariable generalized linear model demonstrated a significantly reduced 6-month mortality in the DBET-EN group compared to the PN group (adjusted odds ratio [OR]: 0.25, 95% CI: 0.08-0.81, <i>P</i> = 0.020). Secondary outcomes indicated that patients in the DBET-EN group had lower 9-month mortality rates and longer tube retention durations compared to the PN group (all adjusted <i>P</i> < 0.05). Postoperative liver function improved similarly in both groups. At 3, 6, and 9 months postoperatively, patient-generated subjective global assessment (PG-SGA) scores and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) scores were significantly higher in the DBET-EN group than in the PN group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The implementation of DBET for EN in patients in the advanced stage of MOJ proved to be a minimally invasive and safe intervention. It significantly improved patients' nutritional status and quality of life while reducing mortality.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"139-148"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Oral Feeding is Safe and Comfortable in Patients with Gastric Cancer Undergoing Radical Total Gastrectomy. 接受根治性全胃切除术的胃癌患者早期口服喂养既安全又舒适
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-08-27 DOI: 10.1080/01635581.2024.2396150
Bin Cai, Guangen Xu, Zhenxing Zhang, Kelong Tao, Wei Wang
{"title":"Early Oral Feeding is Safe and Comfortable in Patients with Gastric Cancer Undergoing Radical Total Gastrectomy.","authors":"Bin Cai, Guangen Xu, Zhenxing Zhang, Kelong Tao, Wei Wang","doi":"10.1080/01635581.2024.2396150","DOIUrl":"10.1080/01635581.2024.2396150","url":null,"abstract":"<p><p>Data supporting the safety and clinical efficacy of early oral feeding (EOF) after total gastrectomy are limited. The aim of this prospective randomized controlled study was to explore the safety and clinical efficacy of two early enteral nutrition approaches for gastric cancer patients after radical total gastrectomy. The EOF group had faster postoperative recovery of intestinal function than the enteral tube feeding (ETF) group. The times to first flatus and first defecation were shorter in the EOF group (<i>p</i> < 0.05). In addition, the EOF protocol effectively avoided abdominal distension (<i>p</i> < 0.05). The hospitalization cost of the EOF group was lower than that of the ETF group (<i>p</i> < 0.05). Moreover, oral nutrition satisfied the physiological need for oral intake. People were more satisfied with EOF (<i>p</i> < 0.01). Furthermore, it is worth noting that compared with ETF, EOF did not increase the risk of anastomotic complications such as leakage and bleeding. Most obviously, EOF not only avoided the risk of complications during tube insertion, but also avoided the discomfort experience of nasal feeding tube. In summary, compared with ETF, EOF promotes early bowel recovery effectively without increasing the risk of postoperative complications. It is safe and comfortable for gastric cancer patients undergoing radical total gastrectomy.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"79-85"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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