Nutrition and Cancer-An International Journal最新文献

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The Association between Tea Consumption and Bladder Cancer Risk Based on the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) International Consortium. 茶叶消费与膀胱癌风险之间的关系——基于膀胱癌流行病学和营养决定因素(BLEND)国际联盟。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-04-08 DOI: 10.1080/01635581.2025.2488063
Yan-Xi Zhang, Richard Albers, Ya-Ting Chen, Gunnar Steineck, Eliane Kellen, Kenneth C Johnson, Chih-Ming Lu, Hermann Pohlabeln, Carlo La Vecchia, Stefano Porru, Angela Carta, Jerry Polesel, Cristina Bosetti, Xuejuan Jiang, Li Tang, James Marshall, Margaret R Karagas, Zuo-Feng Zhang, Jack A Taylor, Maurice P A Zeegers, Anke Wesselius, Evan Yi-Wen Yu
{"title":"The Association between Tea Consumption and Bladder Cancer Risk Based on the Bladder Cancer Epidemiology and Nutritional Determinants (BLEND) International Consortium.","authors":"Yan-Xi Zhang, Richard Albers, Ya-Ting Chen, Gunnar Steineck, Eliane Kellen, Kenneth C Johnson, Chih-Ming Lu, Hermann Pohlabeln, Carlo La Vecchia, Stefano Porru, Angela Carta, Jerry Polesel, Cristina Bosetti, Xuejuan Jiang, Li Tang, James Marshall, Margaret R Karagas, Zuo-Feng Zhang, Jack A Taylor, Maurice P A Zeegers, Anke Wesselius, Evan Yi-Wen Yu","doi":"10.1080/01635581.2025.2488063","DOIUrl":"10.1080/01635581.2025.2488063","url":null,"abstract":"<p><strong>Objectives: </strong>Evidence regarding the association between tea consumption and bladder cancer (BC) risk is inconsistent. This study aimed to increase our knowledge of the association by using international data from the Bladder Cancer Epidemiology and Nutritional Determinants Consortium.</p><p><strong>Methods: </strong>Individual data on 2,347 cases and 6,871 controls from 15 case-control studies with information on black, green, herbal, or general tea was pooled. The association was estimated using multilevel multivariable logistic regression analysis adjusted for multiple (non-)dietary factors.</p><p><strong>Results: </strong>Association between tea consumption and BC risk was observed (odds ratio, OR = 0.72, 95% confidence interval, 95% CI = 0.65-0.80) compared to non-tea drinkers. Stratified analyses based on gender and smoking status yielded similar results. Stratified analysis showed no significant association between black or green tea consumption and BC risk across models, while herbal tea consumption was linked to a reduced BC risk (OR = 0.59, 95% CI = 0.36-0.96). As daily tea consumption increased within a suitable range (<5.67 cups/day), BC risk decreased.</p><p><strong>Conclusions: </strong><i>Camellia sinensis</i> tea showed no association with BC risk, while herbal tea was inversely linked to BC incidence. Despite some significant findings in the selected strata, further studies are required to clarify the underlying mechanisms.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"687-698"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin D Supplementation Improves Pathological Complete Response in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Randomized Clinical Trial. 补充维生素D可改善乳腺癌患者接受新辅助化疗的病理完全缓解:一项随机临床试验
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-17 DOI: 10.1080/01635581.2025.2480854
Michelle Sako Omodei, Jackeline Chimicoviaki, Daniel Araujo Brito Buttros, Benedito Souza Almeida-Filho, Carla Priscila Carvalho-Pessoa, Eduardo Carvalho-Pessoa, Heloisa De Luca Vespoli, Eliana Aguiar Petri Nahas
{"title":"Vitamin D Supplementation Improves Pathological Complete Response in Breast Cancer Patients Undergoing Neoadjuvant Chemotherapy: A Randomized Clinical Trial.","authors":"Michelle Sako Omodei, Jackeline Chimicoviaki, Daniel Araujo Brito Buttros, Benedito Souza Almeida-Filho, Carla Priscila Carvalho-Pessoa, Eduardo Carvalho-Pessoa, Heloisa De Luca Vespoli, Eliana Aguiar Petri Nahas","doi":"10.1080/01635581.2025.2480854","DOIUrl":"10.1080/01635581.2025.2480854","url":null,"abstract":"<p><p>This study aimed to evaluate the effect of vitamin D (VD) supplementation on the pathological complete response (pCR) rate in women with breast cancer (BC) undergoing neoadjuvant chemotherapy (NCT). A randomized clinical trial was conducted with 80 women aged ≥45years with BC who were eligible for NCT. Women were randomized into two groups: VD group, daily supplementation with 2,000IU of cholecalciferol (<i>n</i> = 40) or placebo (<i>n</i> = 40), for 6 months. The primary outcome measure was the pCR rate. Serum 25-hydroxyvitamin-D [25(OH)D] levels were measured after BC diagnosis and the end of NCT. Of the 80 randomized women, 75 completed the NCT and underwent surgery. Baseline 25(OH)D values indicated hypovitaminosis D in both groups (VD: 19.6 ± 5.8 ng/mL and placebo: 21 ± 7.9 ng/mL, <i>p</i> = 0.33). After 6 months, 25(OH)D levels increased in the VD group compared to the placebo group (28 ± 8.7 vs. 20.2 ± 6.1 ng/mL, <i>p</i> = 0.03). The pCR rate was higher in women supplemented with VD when compared than the placebo (43% vs. 24%, <i>p</i> = 0.04). Adjusted logistic regression showed that women with 25(OH)D levels ≥20ng/mL were more likely to achieve pCR (OR3.65, 95%CI 1.09-12.8, <i>p</i> = 0.04). Women with BC undergoing NCT who received supplementation with 2,000IU of VD were more likely to achieve a pathological complete response than women in the placebo group.</p><p><strong>Trial registration: </strong>Ensaiosclinicos.gov.br, identifier RBR-10k4gqdg.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"648-657"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CT Derived Measurement of Body Composition: Observations from a Comparative Analysis of Patients with Colorectal and Lung Cancer. CT 导出的身体成分测量:对结直肠癌和肺癌患者的对比分析观察。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-08-23 DOI: 10.1080/01635581.2024.2392913
Tanvir Abbass, Ross D Dolan, Paul G Horgan, Nicholas MacLeod, Richard J Skipworth, Barry J Laird, Donald C McMillan
{"title":"CT Derived Measurement of Body Composition: Observations from a Comparative Analysis of Patients with Colorectal and Lung Cancer.","authors":"Tanvir Abbass, Ross D Dolan, Paul G Horgan, Nicholas MacLeod, Richard J Skipworth, Barry J Laird, Donald C McMillan","doi":"10.1080/01635581.2024.2392913","DOIUrl":"10.1080/01635581.2024.2392913","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;CT-derived measures of body composition have been shown to have prognostic value in patients with cancer. However, few studies have compared these observations across tumor types and stages of disease. The aim of the present study was to compare body composition measures between two types of cancers, i.e. colorectal cancer (CRC), which is less inflammatory and patients maintain body composition over a longitudinal study period, whereas lung cancer (LC) is proinflammatory and patients lose more fat and muscle mass using a standard methodology.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Clinicopathological characteristics, including those pertaining to nutritional risk/status and systemic inflammation in patients with colorectal cancer (CRC, &lt;i&gt;n&lt;/i&gt; = 1047) and lung cancer (LC, &lt;i&gt;n&lt;/i&gt; = 662), were compared. The CT image at L3 was used to assess body composition. Comparison of these cohorts was carried out using the chi-square test. Binary logistic regression analysis was performed to assess the impact of clinico-pathological variables on body composition, and scatter plots were used to examine the relationship between body mass index (BMI) and CT-derived measures of body composition.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;According to CT-derived body composition, high subcutaneous (SFI) and visceral fat index (VFI) were common (&gt;70%) in both CRC and LC. Also, low skeletal muscle index (SMI) and density (SMD) were approximately 40-50% and 60-70% in both CRC and LC. Compared with CRC, patients with LC had a higher American Society of Anaesthesia (ASA) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), Malnutrition Universal Screening Tool (MUST) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), modified frailty index (mFI) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), modified Glasgow Prognostic Score (mGPS) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001), and neutrophil lymphocyte ratio (NLR) (&lt;i&gt;P&lt;/i&gt; &lt; 0.001) scores.On binary logistic regression analysis, MUST, mFI, and NLR were predictors of subcutaneous adiposity (&lt;i&gt;P&lt;/i&gt; &lt; 0.05); type of cancer, MUST, and mFI were predictors of visceral obesity (&lt;i&gt;P&lt;/i&gt; &lt; 0.001); age, type of cancer, MUST, and mGPS were predictors of low SMI (&lt;i&gt;P&lt;/i&gt; &lt; 0.001); and age, type of cancer, mFI, and mGPS were predictors of low SMD (&lt;i&gt;P&lt;/i&gt; &lt; 0.05). There was a similar relationship between BMI and other measures of CT-derived body composition across two types of cancers.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Obesity and low skeletal muscle mass were common in both CRC and LC cohorts despite large differences in comorbidity, nutritional risk, systemic inflammation, and survival, even when normalized for TNM stage. These observations would support the hypothesis that, although prognostic, CT derived body composition analysis primarily reflects patient constitution rather than the effect of tumor stage in patients with cancer. The systemic inflammatory response, as evidenced by mGPS, can be considered as an important therapeutic target and loss of muscle mass in patients with advanced cancer is related to the systemi","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"70-78"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142047499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy of Double-Lumen Biliary-Enteric Tube in Enteral Nutrition for Patients with Malignant Obstructive Jaundice. 双腔胆管-肠内营养管对恶性阻塞性黄疸患者的疗效
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-26 DOI: 10.1080/01635581.2024.2408041
Jian-Hua Cao, Ke-Fu Wu, Gao-Xiang Li, Jie Chen, Zhan-Hu Mu, Hai-Min Li, Jian-Jun Yao, Xue-Wen Yang
{"title":"Efficacy of Double-Lumen Biliary-Enteric Tube in Enteral Nutrition for Patients with Malignant Obstructive Jaundice.","authors":"Jian-Hua Cao, Ke-Fu Wu, Gao-Xiang Li, Jie Chen, Zhan-Hu Mu, Hai-Min Li, Jian-Jun Yao, Xue-Wen Yang","doi":"10.1080/01635581.2024.2408041","DOIUrl":"10.1080/01635581.2024.2408041","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the efficacy of a double-lumen biliary-enteric tube (DBET) for enteral nutrition (EN) in individuals with malignant obstructive jaundice (MOJ).</p><p><strong>Methods: </strong>A retrospective cohort study was conducted using data from a prospectively maintained single-center database, including patients with MOJ. In the intervention group, DBET placement was performed concurrently with percutaneous transhepatic cholangiodrainage and biliary stenting, followed by postoperative EN (DBET-EN). In the control group, deep vein catheterization was undertaken after endoscopic biliary stenting, and parenteral nutrition (PN) was provided. A multivariable generalized linear model was used to assess the association between DBET-EN and 6-month mortality.</p><p><strong>Results: </strong>A total of 74 patients were included in this study, comprising 28 patients in the intervention group (DBET-EN group) and 46 patients in the control group (PN group). Within the 6-month follow-up, 5 patients (17.9%) in the DBET-EN group and 20 (43.5%) in the PN group died. The multivariable generalized linear model demonstrated a significantly reduced 6-month mortality in the DBET-EN group compared to the PN group (adjusted odds ratio [OR]: 0.25, 95% CI: 0.08-0.81, <i>P</i> = 0.020). Secondary outcomes indicated that patients in the DBET-EN group had lower 9-month mortality rates and longer tube retention durations compared to the PN group (all adjusted <i>P</i> < 0.05). Postoperative liver function improved similarly in both groups. At 3, 6, and 9 months postoperatively, patient-generated subjective global assessment (PG-SGA) scores and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-C30 (EORTC QLQ-C30) scores were significantly higher in the DBET-EN group than in the PN group (<i>P</i> < 0.05).</p><p><strong>Conclusion: </strong>The implementation of DBET for EN in patients in the advanced stage of MOJ proved to be a minimally invasive and safe intervention. It significantly improved patients' nutritional status and quality of life while reducing mortality.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"139-148"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early Oral Feeding is Safe and Comfortable in Patients with Gastric Cancer Undergoing Radical Total Gastrectomy. 接受根治性全胃切除术的胃癌患者早期口服喂养既安全又舒适
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-08-27 DOI: 10.1080/01635581.2024.2396150
Bin Cai, Guangen Xu, Zhenxing Zhang, Kelong Tao, Wei Wang
{"title":"Early Oral Feeding is Safe and Comfortable in Patients with Gastric Cancer Undergoing Radical Total Gastrectomy.","authors":"Bin Cai, Guangen Xu, Zhenxing Zhang, Kelong Tao, Wei Wang","doi":"10.1080/01635581.2024.2396150","DOIUrl":"10.1080/01635581.2024.2396150","url":null,"abstract":"<p><p>Data supporting the safety and clinical efficacy of early oral feeding (EOF) after total gastrectomy are limited. The aim of this prospective randomized controlled study was to explore the safety and clinical efficacy of two early enteral nutrition approaches for gastric cancer patients after radical total gastrectomy. The EOF group had faster postoperative recovery of intestinal function than the enteral tube feeding (ETF) group. The times to first flatus and first defecation were shorter in the EOF group (<i>p</i> < 0.05). In addition, the EOF protocol effectively avoided abdominal distension (<i>p</i> < 0.05). The hospitalization cost of the EOF group was lower than that of the ETF group (<i>p</i> < 0.05). Moreover, oral nutrition satisfied the physiological need for oral intake. People were more satisfied with EOF (<i>p</i> < 0.01). Furthermore, it is worth noting that compared with ETF, EOF did not increase the risk of anastomotic complications such as leakage and bleeding. Most obviously, EOF not only avoided the risk of complications during tube insertion, but also avoided the discomfort experience of nasal feeding tube. In summary, compared with ETF, EOF promotes early bowel recovery effectively without increasing the risk of postoperative complications. It is safe and comfortable for gastric cancer patients undergoing radical total gastrectomy.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"79-85"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142074600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Didymin Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cells by Modulating the PI3K/Akt Pathway. Didymin通过调节PI3K/Akt通路抑制胃癌细胞增殖和诱导凋亡。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-01-23 DOI: 10.1080/01635581.2025.2454050
Tong Zhang, Bin Xu
{"title":"Didymin Inhibits Proliferation and Induces Apoptosis in Gastric Cancer Cells by Modulating the PI3K/Akt Pathway.","authors":"Tong Zhang, Bin Xu","doi":"10.1080/01635581.2025.2454050","DOIUrl":"10.1080/01635581.2025.2454050","url":null,"abstract":"<p><p>Gastric cancer (GC) is a malignant tumor with high morbidity and mortality rates worldwide. This study aimed to investigate the effects and mechanisms of action of didymin, a dietary flavonoid glycoside, on GC treatment. Human GC cell lines Hs-746T and AGS were used to assess the effects of didymin on cell viability, cell proliferation, and cell cycle. The results showed that didymin decreased the proliferative capacity of GC cells and blocked cell cycle. Didymin decreased wound healing, invasion, and migration capacities of GC cells. Mitochondrial reactive oxygen species (ROS) levels and mitochondrial membrane potentials were reduced in cells treated with didymin. Network pharmacology analysis revealed that the therapeutic effects of didymin on AGS cells were related to the phosphatidylinositol 3-kinase (PI3K)/Akt pathway. <i>In vivo</i> mouse xenograft studies confirmed that didymin treatment decreased tumor cell proliferation, cell cycle protein levels, and Akt phosphorylation. The present study demonstrated that didymin regulates mitochondrial function and the PI3K/Akt pathway to inhibit cell proliferation and induce apoptosis in GC cells <i>in vitro</i> and <i>in vivo</i>. Therefore, didymin is a promising drug for the treatment of GC.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"537-552"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Protein Energy Malnutrition on Breast Cancer Patients Hospitalized with Acute Decompensated Heart Failure: Insight from NIS Database 2020. 蛋白质能量营养不良对乳腺癌急性失代偿性心力衰竭住院患者的影响:来自NIS数据库2020的见解
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2025-03-12 DOI: 10.1080/01635581.2025.2474262
Elvis Obomanu, Phuuwadith Wattanachayakul, Colton Jones, Karecia Byfield, Akshay Ratnani, Ryan Mayo
{"title":"Impact of Protein Energy Malnutrition on Breast Cancer Patients Hospitalized with Acute Decompensated Heart Failure: Insight from NIS Database 2020.","authors":"Elvis Obomanu, Phuuwadith Wattanachayakul, Colton Jones, Karecia Byfield, Akshay Ratnani, Ryan Mayo","doi":"10.1080/01635581.2025.2474262","DOIUrl":"10.1080/01635581.2025.2474262","url":null,"abstract":"<p><strong>Background: </strong>Breast cancer patients are at risk of acute decompensated heart failure (ADHF) and protein-energy malnutrition (PEM) due to chemoradiation effects or cancer itself. There are no existing studies on the impact of PEM on breast cancer patients hospitalized for ADHF. This study aims to evaluate the effects of PEM on breast cancer patients admitted for ADHF.</p><p><strong>Methods: </strong>Using the 2020 US National Inpatient Sample (NIS), our study analyzed breast cancer patients aged 18 and older. A multivariate logistic and linear regression analysis determined the odds ratio for various outcomes. The primary outcome was inpatient mortality among patients hospitalized for ADHF based on the presence or absence of PEM, while secondary outcomes included cardiogenic shock, anemia, and total hospital charges.</p><p><strong>Results: </strong>Thirty thousand five hundred and fifty-five (30,555) patients were identified, predominantly female (99%) and Caucasian (71.4%). Among them, 6.07% were diagnosed with concurrent PEM. PEM was associated with higher in-hospital mortality risk (aOR 2.61), increased cardiogenic shock (aOR 3.17), anemia (aOR 1.43), more extended hospital stays (b 2.09), and higher hospital charges (average $28,285).</p><p><strong>Conclusions: </strong>The findings indicate that comorbid PEM is associated with increased risks of in-hospital mortality, anemia, cardiogenic shock, prolonged hospital stays and increased overall hospital costs among breast cancer patients admitted for ADHF.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"483-489"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical and Nutritional Aspects and Outcomes of Covid-19 in Cancer and Non-Cancer Pediatric Patients. Covid-19对癌症和非癌症儿科患者的临床和营养影响及结果。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-09-28 DOI: 10.1080/01635581.2024.2408765
Greice Milena Sant'Ana Reis, Heleni Aires Clemente, José Adailton da Silva, João Araújo Barros Neto, Alane Cabral Menezes de Oliveira, Carolina Santos Mello
{"title":"Clinical and Nutritional Aspects and Outcomes of Covid-19 in Cancer and Non-Cancer Pediatric Patients.","authors":"Greice Milena Sant'Ana Reis, Heleni Aires Clemente, José Adailton da Silva, João Araújo Barros Neto, Alane Cabral Menezes de Oliveira, Carolina Santos Mello","doi":"10.1080/01635581.2024.2408765","DOIUrl":"10.1080/01635581.2024.2408765","url":null,"abstract":"<p><p>The SARS-CoV-2 virus has been the subject of study by several researchers worldwide since 2020; however, there are points to be clarified. This study aimed to analyze the clinical and nutritional aspects of hospitalized cancer and non-cancer pediatric patients and the association with COVID-19 outcomes. This is a cohort study of hospitalized children and adolescents with a laboratory diagnosis of COVID-19. Patients were assessed according to the presence or absence of previous oncological diseases. Sociodemographic, clinical and nutritional data were investigated during the course of the infection. Outcomes included Intensive Care Unit (ICU) admission, longer length of stay (14 days), criticality, and death. Oncological disease was found in 16 (19.3%) patients, most of whom had B-type acute lymphoid leukemia. In Poisson regression, adjusted for age and comorbidity, an association was found between oncological disease and length of stay ≥14 days (RR 4.30; 95% CI 1.46 - 15.6; <i>p</i> = 0.013), COVID-19 criticality (RR 3.82; 95% CI 1.66 - 30.9; <i>p</i> = 0.010) and death (RR 3.42; 95% CI 0.94 - 9.96; <i>p</i> = 0.035). The research revealed that cancer patients had longer hospital stays, were more likely to have the severe form of COVID-19, and had a 3.42 times greater risk of dying.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"179-187"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142332564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Novel Nutrition-Related Prognostic Biomarker for Predicting Survival in Patients with Colorectal Cancer. 预测结直肠癌患者生存期的新型营养相关预后生物标记物
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-10-09 DOI: 10.1080/01635581.2024.2412356
Hao Cai, Yu Chen, Jian-Cheng Li, Yu-Xin Wang, An-Kang Chen, Hou-Jun Jia
{"title":"A Novel Nutrition-Related Prognostic Biomarker for Predicting Survival in Patients with Colorectal Cancer.","authors":"Hao Cai, Yu Chen, Jian-Cheng Li, Yu-Xin Wang, An-Kang Chen, Hou-Jun Jia","doi":"10.1080/01635581.2024.2412356","DOIUrl":"10.1080/01635581.2024.2412356","url":null,"abstract":"<p><strong>Background: </strong>Colorectal cancer (CRC) is a prevalent global malignancy with substantial morbidity and mortality. Accurate prognostic evaluation is essential in CRC patient management. This study investigates the prognostic significance of red blood cell count (RBC) and Onodera's prognostic nutritional index (OPNI) in resectable CRC patients.</p><p><strong>Methods: </strong>A retrospective analysis of 210 CRC patients undergoing radical resection (January 2015-January 2017) assessed clinical and hematological factors, including RBC, albumin, hemoglobin, and OPNI. A novel comprehensive biomarker, R-OPNI, combining preoperative RBC with OPNI, was introduced. Correlations with patient survival were analyzed, and R-OPNI's independent prognostic value was assessed through univariate and multivariate Cox models. Predictive ability was compared to other factors using the receiver operating characteristic (ROC) method.</p><p><strong>Results: </strong>Higher RBC levels (≥ 3.9 × 10<sup>12</sup>/L) and elevated OPNI were associated with significantly improved overall survival. Lower R-OPNI scores (0 or 1) indicated notably poorer survival. Multivariate analysis confirmed R-OPNI's independent prognostic significance (HR: 0.273, 95% CI: 0.098-0.763, <i>p</i> = 0.013). R-OPNI (AUC = 0.732) demonstrated superior predictive value compared to individual prognostic factors.</p><p><strong>Conclusion: </strong>R-OPNI emerges as a robust, independent prognostic predictor for resectable CRC patients, emphasizing the importance of assessing preoperative nutritional status.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"221-229"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vitamin B12 Intake and Cancer Risk: Findings from a Case-Control Study in Vietnam. 维生素 B12 摄入量与癌症风险:越南一项病例对照研究的结果。
IF 2 4区 医学
Nutrition and Cancer-An International Journal Pub Date : 2025-01-01 Epub Date: 2024-10-13 DOI: 10.1080/01635581.2024.2415143
Ngoan Tran Le, Yen Thi-Hai Pham, Y-Thanh Lu, Linh Thuy Le, Nhi Yen Ngoc Huynh, Hang Viet Dao, Dai Duc Nguyen, Kathryn Demanelis, Toan H Ha, Suresh V Kuchipudi, Hung N Luu
{"title":"Vitamin B12 Intake and Cancer Risk: Findings from a Case-Control Study in Vietnam.","authors":"Ngoan Tran Le, Yen Thi-Hai Pham, Y-Thanh Lu, Linh Thuy Le, Nhi Yen Ngoc Huynh, Hang Viet Dao, Dai Duc Nguyen, Kathryn Demanelis, Toan H Ha, Suresh V Kuchipudi, Hung N Luu","doi":"10.1080/01635581.2024.2415143","DOIUrl":"10.1080/01635581.2024.2415143","url":null,"abstract":"<p><p>There is inconclusive evidence on the role of dietary intake of vitamin B<sub>12</sub> in cancer. We evaluated the association between vitamin B<sub>12</sub> intake and cancer risk in a hospital-based case-control study, comprising 3,758 cancer cases and 2,995 controls in Vietnam. Vitamin B<sub>12</sub> intake was derived from the validated food frequency questionnaire. Unconditional logistic regression model was used to calculate the odds ratios (ORs), and respective 95% confidence intervals (CIs) for the association between vitamin B<sub>12</sub> and cancer risk. There was a U-shaped association between vitamin B<sub>12</sub> intake and overall risk of cancer. Individuals with intakes lower than the median intake had a 6% (OR = 1.06, 95% CI: 0.86-1.31)-107% (OR = 2.07, 95% CI: 1.58-2.71), increased risk of cancer (<i>P<sub>trend</sub></i><0.001), whereas those with higher intakes than the median intake had a 20% (OR = 1.20, 95% CI: 0.97-1.48)-52% (OR = 1.52, 95% CI: 1.22-1.89) increased risk of cancer (<i>P<sub>trend</sub></i><0.04). The excess risk of cancer associated with low intakes of vitamin B<sub>12</sub> was observed among esophageal, lung, and breast cancer patients, whereas with high intakes of vitamin B<sub>12</sub> among gastric cancer patients. In summary, a U-shaped association between vitamin B<sub>12</sub> intake and increased cancer risk was observed in the Vietnamese population.</p>","PeriodicalId":54701,"journal":{"name":"Nutrition and Cancer-An International Journal","volume":" ","pages":"252-264"},"PeriodicalIF":2.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142481159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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