Ahsan Raza Khan Lughmani, Nouman Ibrahim, Wasiq Ali, Yasmeen Bibi, Adnan Afzal, Mizna Javed, Ammara Hameed, Wania Shahzadi, Saba Saddique, Maria Ahmed
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引用次数: 0
摘要
腺苷单磷酸活化蛋白激酶(Adenosine monophospate -activated protein kinase, AMPK)是一种由营养饥饿激活的代谢传感器,在癌症中起着多方面的作用。AMPK是有益的还是有害的是有争议的。本研究旨在调查接受化疗的乳腺癌患者的AMPK水平,并比较间歇性禁食结合不同饮食对这些水平的影响。45名乳腺癌患者被分为三组:对照组,一组采用23:1小时间歇性禁食(IF)和常规饮食(RD),另一组采用生酮饮食(KD)超过4周。测量干预前后体重指数(BMI)、糖类抗原15-3 (CA 15-3)水平和血清AMPK水平。结果显示,禁食组和非禁食组的AMPK水平均显著升高,而非禁食组的AMPK水平无显著差异,其中以生酮饮食组的AMPK水平增长最为显著。CA 15-3水平在所有组中均降低,但KD组与RD组相比显著降低。这项研究表明,断断续续的禁食与酮饮食可以提高AMPK水平,可能是一种有价值的非药物补充策略,可以减少或消除肿瘤,同时防止健康细胞免受化疗毒副作用的影响。
Impact of Intermittent Fasting with a Ketogenic Diet on AMPK Levels in Breast Cancer Patients Receiving Chemotherapy.
Adenosine monophosphate-activated protein kinase (AMPK), a metabolic sensor activated by nutrient starvation, plays a multifaceted role in cancer. Whether AMPK is beneficial or malevolent is controversial. This study aimed to investigate AMPK levels in breast cancer patients receiving chemotherapy and compare the effects of intermittent fasting combined with different diets on these levels. Forty-five breast cancer patients were divided into three groups: a control, a group practicing 23:1-h intermittent fasting (IF) with a routine diet (RD), and another with a ketogenic diet (KD) over 4 weeks. Body mass index (BMI), Carbohydrate Antigen 15-3 (CA 15-3) levels, and serum AMPK levels were measured pre and post-intervention. Results showed a significant increase in AMPK levels in both the fasting groups and no significant difference in the non-fasting group, with the keto diet group showing the most significant growth. CA 15-3 levels were reduced in all the groups but significantly reduced in the KD group as compared to the RD group. This study shows that intermittent fasting with the keto diet improves AMPK levels and may serve as a valuable non-pharmacological complementary strategy for reducing or eliminating the tumor and, simultaneously, preventing the healthy cells from the toxic side effects of chemotherapy.
期刊介绍:
This timely publication reports and reviews current findings on the effects of nutrition on the etiology, therapy, and prevention of cancer. Etiological issues include clinical and experimental research in nutrition, carcinogenesis, epidemiology, biochemistry, and molecular biology. Coverage of therapy focuses on research in clinical nutrition and oncology, dietetics, and bioengineering. Prevention approaches include public health recommendations, preventative medicine, behavior modification, education, functional foods, and agricultural and food production policies.