Current Medical Imaging Reviews最新文献

{"title":"Prediction of Monosodium Urate Crystal Deposits in the First Metatarsophalangeal Joint Using a Decision Tree Model.","authors":"Jiachun Zhuang, Lin Liu, Yingyi Zhu, Yunyan Zi, Hongjing Leng, Bei Weng, Lina Chen, Haijun Wu","doi":"10.2174/0115734056355443250505051813","DOIUrl":"https://doi.org/10.2174/0115734056355443250505051813","url":null,"abstract":"<p><strong>Background: </strong>Despite the increasing prevalence of hyperuricemia and gout, there remains a relative paucity of research focused on the use of straightforward clinical and laboratory markers to predict urate crystal formation. The identification of such predictive markers is crucial, as they would greatly enhance the ability of clinicians to make timely and accurate diagnoses, leading to more effective and targeted therapeutic interventions.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the diagnostic value of various easily obtainable clinical and laboratory indicators and to establish a decision tree (DT) model to analyze their predictive significance for monosodium urate (MSU) deposition in the first metatarsophalangeal (MTP) joint.</p><p><strong>Methods: </strong>A retrospective study was conducted on 317 patients who presented to the outpatient clinic with a gout flare between January 2023 and June 2024 (181 cases with MSU deposition in the first MTP joint and 136 cases without such deposition). Clinical and laboratory indicators included gender, age, disease course, serum uric acid (SUA), glomerular filtration rate (GFR), serum creatinine (SCR), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Statistical analysis methods, including T-test, logistic regression and decision tree, were used to analyze the predictors of MSU deposition in the first MTP joint. The performance of the DT model was evaluated using receiver operating characteristic (ROC) curves and a 5-fold cross-validation method was used to ensure the robustness of the study results.</p><p><strong>Results: </strong>Disease course, GFR, SUA, age, and SCR emerged as significant predictors of MSU deposition in the first MTP joint in both LR and DT analyses. The DT model exhibited superior diagnostic performance compared to the LR model, with a sensitivity of 83.4% (151/181), specificity of 56.6% (77/136), and overall accuracy of 71.9% (228/317). The importance of predictive variables in the DT model showed disease course, GFR, SUA, age, and SCR as 53.36%, 21.51%, 15.1%, 5.5% and 4.53%, respectively. The area under the ROC curve predicted by the DT model was 0.752 (95% CI: 0.700~0.800).</p><p><strong>Conclusion: </strong>The DT model demonstrates strong predictive capability. Disease duration, GFR, SUA, age, and SCR are pivotal factors for predicting MSU deposition at the first MTP joint, with disease course being the most critical factor.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Myocardial Infarction on Routine Non-Gated Thoracic Computed Tomography.","authors":"Mehrad Rokni, Yasser G Abdelhafez, Lorenzo Nardo, Mohammad H Madani","doi":"10.2174/0115734056363863250509093505","DOIUrl":"https://doi.org/10.2174/0115734056363863250509093505","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study is to assess the identification of incidental myocardial infarction on non-electrocardiogram-gated computed tomographic scans of the chest and its prognostic significance.</p><p><strong>Background: </strong>The increased utilization and abundance of thoracic computed tomographic (CT) scans have provided a substrate for potential screening purposes.</p><p><strong>Objective: </strong>The objective of this study was to evaluate the detection of incidental myocardial infarction on routine non-gated thoracic CT performed for noncardiac reasons and its associated major cardiovascular events and survival.</p><p><strong>Methods: </strong>We retrospectively assessed routine non-gated thoracic CT scans of all consecutive individuals aged 18 or above who underwent thoracic CT scans as outpatients at the University of California Davis from January 2015 to December 2015. We evaluated the presence and location of incidental MI on non-gated thoracic CT and compared major adverse cardiac events (MACE) and overall survival in CT-positive infarct individuals with a CTnegative infarct control group.</p><p><strong>Results: </strong>We reviewed routine thoracic CT scans of 1157 individuals and identified 12 individuals with incidental MI. The mean age of individuals with infarction was 71.4 ± 14.1 years, and 50% were female. All individuals with incidental MI had coronary calcification. Individuals with incidental MI had a higher rate of MACE endpoint (92% vs. 28%, p=0.0001), number of MACE events (1.1 vs. 0.3, p<0.001), and lower overall survival (median survival of 67 months vs. not reached, p=0.023) compared with age and sex-matched controls without incidental MI.</p><p><strong>Conclusion: </strong>Although small in number relative to the total number of individuals evaluated, subjects with incidental MI on routine non-gated thoracic CT scans have worse cardiovascular outcomes and survival compared with controls without infarction. This study highlights the potential opportunistic screening utility of routine thoracic CTs, which could lead to improved risk stratification and intervention.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Enterography of Phlebosclerotic Colitis: A Case Report.","authors":"Yu-Xuan Kho, Chien-Ming Chen, Sung-Yu Chu","doi":"10.2174/0115734056382571250509114555","DOIUrl":"https://doi.org/10.2174/0115734056382571250509114555","url":null,"abstract":"<p><strong>Background: </strong>Phlebosclerotic colitis is a rare type of chronic ischemic colitis, with most documented cases occurring in Asians. Plain-film and computed tomography findings of pericolonic vascular calcifications are diagnostic. However, Magnetic Resonance Enterography (MRE) findings of phlebosclerotic colitis have not yet been reported, and its diagnosis might be overlooked without awareness of this disease.</p><p><strong>Case report: </strong>A 70-year-old female patient without prior systemic disease presented with a 3-month history of nausea, vomiting, abdominal pain, and diarrhea. Personal history was unremarkable except for long-term use of herbal medicine. She was initially investigated at a regional hospital with a colonoscopy and biopsy. Due to the presence of stenosis at the transverse colon and biopsy results suggestive of Inflammatory Bowel Disease (IBD), she was referred to our hospital for further investigation and treatment. MRE was performed as part of the IBD workup, which showed a thickened ascending and transverse colonic wall that was fibrotic, non-edematous, and with triangular projections on the mesenteric aspect. Owing to findings that were inconsistent with IBD, subsequent abdominal plain-film radiography confirmed characteristic linear dendritic serpiginous radiopaque opacities alongside the ascending and transverse colon. Re-biopsy of the affected colon confirmed the diagnosis of phlebosclerotic colitis. The patient's symptoms improved after conservative treatment.</p><p><strong>Conclusion: </strong>MRE of phlebosclerotic colitis appears as symmetrical non-edematous bowel wall thickening with triangular signal voids indicative of venous calcifications.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and Reliability of Multimodal Imaging in Diagnosing Knee Sports Injuries.","authors":"Di Zhu, Zitong Zhang, Wenji Li","doi":"10.2174/0115734056360665250506115221","DOIUrl":"https://doi.org/10.2174/0115734056360665250506115221","url":null,"abstract":"<p><strong>Background: </strong>Due to differences in subjective experience and professional level among doctors, as well as inconsistent diagnostic criteria, there are issues with the accuracy and reliability of single imaging diagnosis results for knee joint injuries.</p><p><strong>Objective: </strong>To address these issues, magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound (US) are adopted in this article for ensemble learning, and deep learning (DL) is combined for automatic analysis.</p><p><strong>Methods: </strong>By steps such as image enhancement, noise elimination, and tissue segmentation, the quality of image data is improved, and then convolutional neural networks (CNN) are used to automatically identify and classify injury types. The experimental results show that the DL model exhibits high sensitivity and specificity in the diagnosis of different types of injuries, such as anterior cruciate ligament tear, meniscus injury, cartilage injury, and fracture.</p><p><strong>Results: </strong>The diagnostic accuracy of anterior cruciate ligament tear exceeds 90%, and the highest diagnostic accuracy of cartilage injury reaches 95.80%. In addition, compared with traditional manual image interpretation, the DL model has significant advantages in time efficiency, with a significant reduction in average interpretation time per case. The diagnostic consistency experiment shows that the DL model has high consistency with doctors' diagnosis results, with an overall error rate of less than 2%.</p><p><strong>Conclusion: </strong>The model has high accuracy and strong generalization ability when dealing with different types of joint injuries. These data indicate that combining multiple imaging technologies and the DL algorithm can effectively improve the accuracy and efficiency of diagnosing sports injuries of knee joints.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Challenges and Insights in Optic Nerve Hemangioblastoma Using Magnetic Resonance Imaging: A Case Report.","authors":"Wenwen Wang, Fajin Lv, Tianyou Luo, Mengqi Liu","doi":"10.2174/0115734056359483250502063550","DOIUrl":"https://doi.org/10.2174/0115734056359483250502063550","url":null,"abstract":"<p><strong>Background: </strong>Optic nerve hemangioblastoma (ONH) is a rare benign tumor. It can be sporadic or associated with Von-Hippel Lindau (VHL) syndrome. Magnetic resonance imaging (MRI) is the most commonly used diagnostic technique for the tumor. However, an accurate diagnosis can be challenging due to the rarity of ONH and its similarity to glioma and meningioma.</p><p><strong>Case report: </strong>A 49-year-old female experienced progressive vision loss for ten years in the right eye, accompanied by proptosis over two years. The ophthalmological examination found her visual acuity of the right eye to have no light perception. Optical coherence tomography showed decreased thickness of the right retinal ganglion cell layer. MRI revealed an oval solid mass within the right retrobulbar space, with isointensity on T₁-weighted (T₁WI) imaging and heterogeneous hyperintensity on T₂-weighted imaging (T₂WI). Heterogeneous enhancement was found on gadolinium-enhanced T₁WI and dynamic contrast-enhanced MRI. At internal and marginal areas of the mass, multiple flow voids were observed on various sequences, especially on T₂WI. Furthermore, the superior, inferior, medial, and lateral rectus muscles of the right eye distinctly atrophied, showing a lower signal intensity on T₂WI and less apparent enhancement than the left normal ones. Postoperative pathological diagnosis was hemangioblastoma of the right optic nerve.</p><p><strong>Conclusion: </strong>Hemangioblastoma should be considered as a differential diagnosis for the space-occupying mass of the optic nerve if there is the presence of flow voids, vivid enhancement, and absence of a dural attachment, regardless of VHL syndrome. Of note, this is the first reported case to consider altered extraocular muscles as a potential point to prompt the diagnosis on MRI.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Quantitative Ultrasound Elastography in the Assessment of Non-Alcoholic Fatty Liver Disease in Children.","authors":"Xu Cao, Jianbo Liu, Jing Li, Kexin Shi, Shuang Zheng, Dongna Di, Peng Tian","doi":"10.2174/0115734056373132250507141342","DOIUrl":"https://doi.org/10.2174/0115734056373132250507141342","url":null,"abstract":"<p><strong>Objective: </strong>This preliminary investigation aimed to assess the value of two elastography techniques, sound touch elastography (STE) and sound touch quantification (STQ), in measuring liver stiffness in children with non-fatty versus fatty livers.</p><p><strong>Methods: </strong>This study used a case-control design. The STE and STQ were used to measure and compare liver stiffness in 121 children with fatty livers and 251 children with non-fatty livers, respectively.</p><p><strong>Results: </strong>In this study, we found that, compared to children with non-fatty liver disease, children with fatty liver disease had lower Young's modulus values in STE and STQ in the left lobe of the liver, and the difference was statistically significant (P < 0.05). However, after multifactorial analysis, no association was found between liver Young's modulus values measured by STE and STQ and the presence of fatty liver in children. In the present study, significantly higher Young's modulus values were observed in the left lobe compared to the right lobe of the liver in children with non-fatty liver (P < 0.05). In contrast, no significant difference was found between the left and right lobes in children with fatty liver (P > 0.05). The optimal diagnostic threshold for detecting steatohepatitis in the left lobe was 5.890 kPa using STE and 8.050 kPa using STQ.</p><p><strong>Conclusion: </strong>STE and STQ, as the latest ultrasound diagnostic techniques based on shear wave elastography, can quantitatively assess fatty liver in children. In this study, some liver elasticity measurements in the fatty liver group differed from those in the non-fatty liver group.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiple Gastric Schwannoma: A Case Report.","authors":"Bin Huang, Mingtai Cao, Xiaoying Zheng, Tuanyue Ma, Yuntai Cao","doi":"10.2174/0115734056365968250422110814","DOIUrl":"https://doi.org/10.2174/0115734056365968250422110814","url":null,"abstract":"<p><strong>Background: </strong>Gastric schwannoma is a rare gastrointestinal mesenchymal tumor with Schwann cell differentiation. In the past, most of the published cases were single gastric schwannoma. Multiple gastric schwannoma is exceedingly rare. We herein report a case of multiple gastric schwannomas.</p><p><strong>Case presentation: </strong>A 55-year-old male presented with postprandial vomiting of unclear etiology, accompanied by epigastric pain and bloating. Computed tomography revealed marked thickening of the gastric wall at the fundus-body junction along the greater curvature and gastric angle, with intraluminal nodular projections. Multiphase contrast-enhanced computed tomography demonstrated moderate progressive enhancement. The patient was misdiagnosed as having a gastric stromal tumor before the operation and subsequently underwent laparoscopic partial gastrectomy. However, pathological and immunohistochemical analysis confirmed multiple gastric schwannomas. The patient recovered uneventfully and was discharged without complications.</p><p><strong>Conclusion: </strong>Gastric schwannoma is rare in clinical practice, especially gastric multiple schwannomas, which are easily confused with gastric stromal tumors, as illustrated in this case, where a preoperative misdiagnosis occurred. Clinicians should enhance their recognition of characteristic imaging features (including Computed tomography, Magnetic resonance imaging, and Positron emission tomography) and employ multimodal diagnostic approaches to optimize preoperative diagnosis.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Small Cell Neuroendocrine Carcinoma of the Ureter: A Case Evaluated by ¹⁸FFDG- PET/CT and Literature Review.","authors":"Rong Yang, Liqin Gu, Chengzhou Li, Qiong Song, Yanfang Bao, Lan Lin, Juan Chen","doi":"10.2174/0115734056353458250429063852","DOIUrl":"https://doi.org/10.2174/0115734056353458250429063852","url":null,"abstract":"<p><strong>Introduction: </strong>Small cell neuroendocrine carcinoma (SCNEC) of the ureter is extremely rare, and tends to show a mixed histologic profile. Literature on its imaging features is limited.</p><p><strong>Case presentation: </strong>We herein report the case of a 68-year-old woman who presented with two days of left flank pain. Ultrasound and CT scan revealed a lesion in the left distal ureter. The lesion exhibited intensive tracer activity on ¹⁸F-FDG PET/CT scan, corresponding to a malignant tumor, most likely a high-grade urothelial carcinoma, and no metastases were observed. Then, the patient underwent a radical left nephroureterectomy. Pathology revealed a carcinoma composed of SCNEC (approximately 83%) and urothelial carcinoma (approximately 17%). During one year of follow-up, the patient underwent six cycles of adjuvant chemotherapy (etoposide 100mgd 1-3 + cisplatin 30mgd 1-3, q3w), and no recurrence or metastases were found on the CT scan.</p><p><strong>Conclusion: </strong>This case report has presented a case of ureteral SCNEC and explored the value of ¹⁸F-FDG PET/CT in the diagnosis and staging of the disease.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Classification and Hemodynamic Characteristics of Uterine Artery Blood Flow in Recurrent Spontaneous Abortion.","authors":"Yunyun Cao, Guanjie Wang, Haifei Wang, Ping Chen, Xiaoping Gong","doi":"10.2174/0115734056367096250508073203","DOIUrl":"https://doi.org/10.2174/0115734056367096250508073203","url":null,"abstract":"<p><strong>Introduction: </strong>Recurrent spontaneous abortion (RSA) demonstrates a complex pathogenesis. The uterine artery (UtA) Doppler ultrasound monitoring is clinically valuable for predicting RSA risk.</p><p><strong>Objective: </strong>This study aimed to assess the type of blood flow velocity waveform (FVW) and the hemodynamic characteristics of the UtA between the RSA and control groups.</p><p><strong>Method: </strong>This retrospective study included 203 patients with RSA and 121 without RSA. All participants underwent transvaginal Doppler ultrasonography during the mid-luteal phase to assess the type of FVW and the hemodynamic parameters of the UtA.</p><p><strong>Results and discussion: </strong>The C type was the most prevalent in both the control and RSA groups, with incidences of 80.16% and 63.04%, respectively. The single type was more predominant in the control group than in the RSA group (83.47% vs. 73.89%). Notably, the compound type was more frequent in the RSA group than in the control group (26.11% vs. 15.26%). The compound type exhibited significantly higher circulatory resistance than the single type, with significant statistical differences observed in the mean pulsatility index (mPI) and mean resistance index (mRI) between the two types (P < 0.001). Further, mPI and mRI values of the UtA were higher in the RSA group than in the control group, with significant statistical differences between the two groups (P < 0.001). If abnormal UtA hemodynamic parameters and FVW are detected, early clinical intervention should be implemented to improve adverse pregnancy outcomes.</p><p><strong>Conclusion: </strong>UtA FVW varies, indicating differences in blood resistance. Prepregnancy monitoring of high-resistance FVW and hemodynamic parameters effectively assessed uterine perfusion status and may provide a foundation for early clinical intervention and potential personalized treatment strategies.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation Between Bone Mineral Density And Different Types of Modic Changes in Lumbar Spine.","authors":"Xiaoling Zhong, Yinghui Tang, Guohua Zeng, Lixiang Zhang, Minjie Yang, Yu Chen","doi":"10.2174/0115734056368021250428060738","DOIUrl":"https://doi.org/10.2174/0115734056368021250428060738","url":null,"abstract":"<p><strong>Introduction: </strong>Modic changes (MCs) are a common manifestation of lumbar degenerative disease, classified into three types. However, the relationship between Bone Mineral Density (BMD) and each type of MC at the vertebral lesion sites remains unclear.</p><p><strong>Methods: </strong>This study included 144 patients who had both lumbar MR and CT images. The classification and grading of MCs were evaluated using MR images. On the CT images, BMD values, T-scores, and Z-scores were obtained from the normal T12 vertebrae, the corresponding lumbar Modic lesion sites, and the adjacent healthy regions at the same vertebra on the axial plane.</p><p><strong>Results: </strong>A total of 370 vertebrae (226 MCs and 144 normal T12 vertebrae) were assessed. No significant difference was found in the BMD of normal T12 vertebrae between males and females in the study. MCs were more commonly found in the lumbar 4 and 5 vertebrae. Of the MCs, 80 (36%) were classified as type I, 130 (57%) as type II, and 16 (7%) as type III. The BMD value, T-score, and Z-score of each Modic type lesion site were higher than those of adjacent healthy regions and normal T12 vertebrae. A strong correlation was found between the different Modic types, though no significant differences were observed between grades within the same Modic type.</p><p><strong>Conclusion: </strong>The presence of any MCs was significantly associated with an increase in BMD in the corresponding lesion sites, with more severe MCs showing a stronger association with higher BMD. This is the first study to explore the relationship between all types of MCs and their BMD values.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}