The Value of Quantitative Ultrasound Elastography in the Assessment of Non-Alcoholic Fatty Liver Disease in Children.

IF 1.1 4区医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Current Medical Imaging Reviews Pub Date : 2025-05-15 DOI:10.2174/0115734056373132250507141342

Xu Cao, Jianbo Liu, Jing Li, Kexin Shi, Shuang Zheng, Dongna Di, Peng Tian

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引用次数: 0

Abstract

Objective: This preliminary investigation aimed to assess the value of two elastography techniques, sound touch elastography (STE) and sound touch quantification (STQ), in measuring liver stiffness in children with non-fatty versus fatty livers.

Methods: This study used a case-control design. The STE and STQ were used to measure and compare liver stiffness in 121 children with fatty livers and 251 children with non-fatty livers, respectively.

Results: In this study, we found that, compared to children with non-fatty liver disease, children with fatty liver disease had lower Young's modulus values in STE and STQ in the left lobe of the liver, and the difference was statistically significant (P < 0.05). However, after multifactorial analysis, no association was found between liver Young's modulus values measured by STE and STQ and the presence of fatty liver in children. In the present study, significantly higher Young's modulus values were observed in the left lobe compared to the right lobe of the liver in children with non-fatty liver (P < 0.05). In contrast, no significant difference was found between the left and right lobes in children with fatty liver (P > 0.05). The optimal diagnostic threshold for detecting steatohepatitis in the left lobe was 5.890 kPa using STE and 8.050 kPa using STQ.

Conclusion: STE and STQ, as the latest ultrasound diagnostic techniques based on shear wave elastography, can quantitatively assess fatty liver in children. In this study, some liver elasticity measurements in the fatty liver group differed from those in the non-fatty liver group.

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定量超声弹性成像在评估儿童非酒精性脂肪肝中的价值。

目的：本初步研究旨在评估两种弹性成像技术，声触弹性成像（STE）和声触量化（STQ），在测量非脂肪肝和脂肪肝儿童肝脏硬度方面的价值。方法：本研究采用病例-对照设计。采用STE和STQ分别测量和比较121例脂肪肝患儿和251例非脂肪肝患儿的肝脏硬度。结果：本研究中我们发现，与非脂肪肝患儿相比，脂肪肝患儿肝左叶STE和STQ的杨氏模量值较低，差异有统计学意义（P < 0.05）。然而，经过多因素分析，STE和STQ测量的肝脏杨氏模量值与儿童脂肪肝的存在没有关联。在本研究中，非脂肪肝患儿左肝的杨氏模量值明显高于右肝（P < 0.05）。相比之下，脂肪肝患儿左右叶无显著性差异（P < 0.05）。左叶脂肪性肝炎的最佳诊断阈值STE为5.890 kPa， STQ为8.050 kPa。结论：STE和STQ是基于横波弹性成像的最新超声诊断技术，可定量评价儿童脂肪肝。在本研究中，脂肪肝组的一些肝脏弹性测量值与非脂肪肝组不同。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Medical Imaging Reviews 医学-核医学

CiteScore

2.60

自引率

0.00%

发文量

246

审稿时长

1 months

期刊介绍： Current Medical Imaging Reviews publishes frontier review articles, original research articles, drug clinical trial studies and guest edited thematic issues on all the latest advances on medical imaging dedicated to clinical research. All relevant areas are covered by the journal, including advances in the diagnosis, instrumentation and therapeutic applications related to all modern medical imaging techniques. The journal is essential reading for all clinicians and researchers involved in medical imaging and diagnosis.