Current Medical Imaging Reviews最新文献

{"title":"Clinical and Imaging Characteristics of Non-Gestational Ovarian Choriocarcinoma: A Case Report.","authors":"Xiaofeng Fu, Wei Chen, Jiang Zhu","doi":"10.2174/0115734056386021250520043409","DOIUrl":"https://doi.org/10.2174/0115734056386021250520043409","url":null,"abstract":"<p><strong>Background: </strong>Non-gestational Ovarian Choriocarcinoma (NGOC) is an extremely rare and highly malignant ovarian germ cell tumor with nonspecific clinical manifestations, making early diagnosis challenging. At present, detailed reports on the clinical and imaging characteristics of NGOC are scarce. This case report discusses a rare instance of NGOC in a prepubertal adolescent, complemented by a literature review to enhance clinicians' understanding of its presentation, diagnosis, and treatment.</p><p><strong>Case presentation: </strong>A 10-year-old female with no history of menstruation or sexual activity presented with persistent lower abdominal pain and vaginal bleeding. Preoperative imaging revealed a large pelvic mass with heterogeneous echogenicity and vascularity. Serum Human Chorionic Gonadotropin (hCG) levels were markedly elevated (>297,000 IU/L). Preoperative Imaging: Ultrasonography and CT demonstrated a large, heterogeneous, hypervascular adnexal mass with features of necrosis and cystic changes, suggesting malignancy. Surgical and Pathological Findings: The mass, originating from the right adnexa, was removed <i>via</i> laparotomy. Histopathology confirmed NGOC, supported by immunohistochemistry, showing strong positivity for markers like CD146, CK18, HCG, and HPL, along with a high Ki-67 index (>90%).</p><p><strong>Conclusion: </strong>In young females with no sexual life, significantly elevated HCG levels and imaging findings of a large heterogeneous adnexal mass should raise suspicion for NGOC. Early recognition and multimodal diagnostic approaches, including imaging, biochemical, and pathological assessments, are essential for timely intervention, reducing metastatic risk and improving prognosis. This report contributes to the understanding of NGOC and emphasizes the importance of accurate diagnosis for better patient outcomes.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144181034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Imaging of Mediastinal Epithelioid Hemangioendothelioma: Two Case Reports.","authors":"Tong Chen, Yapeng Sun, Mengsu Zeng, Mingliang Wang","doi":"10.2174/0115734056360811250516114535","DOIUrl":"https://doi.org/10.2174/0115734056360811250516114535","url":null,"abstract":"<p><strong>Introduction: </strong>Epithelioid Hemangioendothelioma (EHE) is a rare vascular neoplasm that typically occurs in the bone, soft tissue, liver, and lung but rarely in the mediastinum. Multimodal imaging of EHE is poorly understood, often leading to misdiagnosis as other mediastinal tumors.</p><p><strong>Case presentation: </strong>Two female cases with incidental mediastinal masses were retrospectively analysed, focusing on multimodal presentations. For both cases, CT studies showed well-defined, low-density oval masses in the right anterior superior mediastinum with the Superior Vena Cava (SVC) invasion. Intralesional punctate calcifications were observed in Case 2. MRI revealed hypointense masses on T1WI and slightly hyperintense on T2WI, with partial diffusion restriction on DWI. Case 1 had mild enhancement, while Case 2 had significant enhancement. PET-CT showed significant FDG uptake with maximum standardized uptake values (SUVmax) of 9.2 and 5.1, respectively. Both patients underwent surgical resection, with pathology confirming mediastinal EHEs.</p><p><strong>Conclusion: </strong>Mediastinal EHE presents as a well-defined soft-tissue mass with punctate calcifications and heterogeneous enhancement, typically located in the anterior mediastinum with invasion into medium or large veins. Moreover, it should be considered in the differential diagnosis of mediastinal tumors.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144182809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning for Automated Prediction of Sphenoid Sinus Pneumatization in Computed Tomography.","authors":"Ali Alamer, Omar Salim, Fawaz Alharbi, Fahd Alsaleem, Afnan Almuqbil, Khaled Alhassoon, Fahad Alsunaydih","doi":"10.2174/0115734056363158250429101521","DOIUrl":"https://doi.org/10.2174/0115734056363158250429101521","url":null,"abstract":"<p><strong>Background: </strong>The sphenoid sinus is an important access point for trans-sphenoidal surgeries, but variations in its pneumatization may complicate surgical safety. Deep learning can be used to identify these anatomical variations.</p><p><strong>Methods: </strong>We developed a convolutional neural network (CNN) model for the automated prediction of sphenoid sinus pneumatization patterns in computed tomography (CT) scans. This model was tested on mid-sagittal CT images. Two radiologists labeled all CT images into four pneumatization patterns: Conchal (type I), presellar (type II), sellar (type III), and postsellar (type IV). We then augmented the training set to address the limited size and imbalanced nature of the data.</p><p><strong>Results: </strong>The initial dataset included 249 CT images, divided into training (n = 174) and test (n = 75) datasets. The training dataset was augmented to 378 images. Following augmentation, the overall diagnostic accuracy of the model improved from 76.71% to 84%, with an area under the curve (AUC) of 0.84, indicating very good diagnostic performance. Subgroup analysis showed excellent results for type IV, with the highest AUC of 0.93, perfect sensitivity (100%), and an F1-score of 0.94. The model also performed robustly for type I, achieving an accuracy of 97.33% and high specificity (99%). These metrics highlight the model's potential for reliable clinical application.</p><p><strong>Conclusion: </strong>The proposed CNN model demonstrates very good diagnostic accuracy in identifying various sphenoid sinus pneumatization patterns, particularly excelling in type IV, which is crucial for endoscopic sinus surgery due to its higher risk of surgical complications. By assisting radiologists and surgeons, this model enhances the safety of transsphenoidal surgery, highlighting its value, novelty, and applicability in clinical settings.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive Correlation between Lipin-1 and Lipin-2 Expressions and Hepatic T1 Values in IUGR Rats.","authors":"Tao Wang, MingZhu Deng, Alpha Kalonda Mutamba, XiaoRi He, Jing Bian, DuJun Bian","doi":"10.2174/0115734056296733250514081236","DOIUrl":"https://doi.org/10.2174/0115734056296733250514081236","url":null,"abstract":"<p><strong>Background: </strong>Intrauterine growth restriction (IUGR) is associated with long-term metabolic disturbances, including obesity. Changes in hepatic lipid metabolism and adipose tissue function, mediated by lipin-1 and lipin-2, may contribute to these outcomes.</p><p><strong>Aim: </strong>This study aimed to investigate the correlation between lipin-1 in visceral adipose tissues (VATs) and lipin-2 in the liver. It also examined hepatic T1 values using T1 mapping in IUGR rats.</p><p><strong>Objective: </strong>The objective of this study was to explore the metabolic mechanisms linking IUGR and adult obesity by analyzing molecular and imaging markers.</p><p><strong>Methods: </strong>Pregnant rats were fed either a low-protein diet (10%) to induce IUGR or a normal-protein diet (21%) as a control. Male offspring underwent conventional magnetic resonance imaging and native T1 mapping using a 3.0 T whole-body MR scanner at days 21, 56, and 84 post-birth. Liver tissues and VATs were collected for analysis. Lipin-1 and lipin-2 expression levels were measured using Western blot and real-time quantitative PCR.</p><p><strong>Results: </strong>The IUGR group exhibited significantly higher mRNA and protein expression levels of lipin-1 and lipin-2 compared to the control group at days 21, 56, and 84 after birth. Additionally, the IUGR group demonstrated significantly higher hepatic T1 values than the control group at the corresponding time points. Positive correlations were observed between the protein and mRNA expression levels of lipin-1 and hepatic T1 values. Similarly, the protein and mRNA expression levels of lipin-2 were positively correlated with hepatic T1 values. All results were statistically significant (P<0.05).</p><p><strong>Conclusion: </strong>The upregulation of lipin-1 and lipin-2 expressions was found to be linked to elevated hepatic T1 values, potentially contributing to adult obesity in IUGR rats.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144183401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of Monosodium Urate Crystal Deposits in the First Metatarsophalangeal Joint Using a Decision Tree Model.","authors":"Jiachun Zhuang, Lin Liu, Yingyi Zhu, Yunyan Zi, Hongjing Leng, Bei Weng, Lina Chen, Haijun Wu","doi":"10.2174/0115734056355443250505051813","DOIUrl":"https://doi.org/10.2174/0115734056355443250505051813","url":null,"abstract":"<p><strong>Background: </strong>Despite the increasing prevalence of hyperuricemia and gout, there remains a relative paucity of research focused on the use of straightforward clinical and laboratory markers to predict urate crystal formation. The identification of such predictive markers is crucial, as they would greatly enhance the ability of clinicians to make timely and accurate diagnoses, leading to more effective and targeted therapeutic interventions.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the diagnostic value of various easily obtainable clinical and laboratory indicators and to establish a decision tree (DT) model to analyze their predictive significance for monosodium urate (MSU) deposition in the first metatarsophalangeal (MTP) joint.</p><p><strong>Methods: </strong>A retrospective study was conducted on 317 patients who presented to the outpatient clinic with a gout flare between January 2023 and June 2024 (181 cases with MSU deposition in the first MTP joint and 136 cases without such deposition). Clinical and laboratory indicators included gender, age, disease course, serum uric acid (SUA), glomerular filtration rate (GFR), serum creatinine (SCR), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR). Statistical analysis methods, including T-test, logistic regression and decision tree, were used to analyze the predictors of MSU deposition in the first MTP joint. The performance of the DT model was evaluated using receiver operating characteristic (ROC) curves and a 5-fold cross-validation method was used to ensure the robustness of the study results.</p><p><strong>Results: </strong>Disease course, GFR, SUA, age, and SCR emerged as significant predictors of MSU deposition in the first MTP joint in both LR and DT analyses. The DT model exhibited superior diagnostic performance compared to the LR model, with a sensitivity of 83.4% (151/181), specificity of 56.6% (77/136), and overall accuracy of 71.9% (228/317). The importance of predictive variables in the DT model showed disease course, GFR, SUA, age, and SCR as 53.36%, 21.51%, 15.1%, 5.5% and 4.53%, respectively. The area under the ROC curve predicted by the DT model was 0.752 (95% CI: 0.700~0.800).</p><p><strong>Conclusion: </strong>The DT model demonstrates strong predictive capability. Disease duration, GFR, SUA, age, and SCR are pivotal factors for predicting MSU deposition at the first MTP joint, with disease course being the most critical factor.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidental Myocardial Infarction on Routine Non-Gated Thoracic Computed Tomography.","authors":"Mehrad Rokni, Yasser G Abdelhafez, Lorenzo Nardo, Mohammad H Madani","doi":"10.2174/0115734056363863250509093505","DOIUrl":"https://doi.org/10.2174/0115734056363863250509093505","url":null,"abstract":"<p><strong>Aims: </strong>The aim of this study is to assess the identification of incidental myocardial infarction on non-electrocardiogram-gated computed tomographic scans of the chest and its prognostic significance.</p><p><strong>Background: </strong>The increased utilization and abundance of thoracic computed tomographic (CT) scans have provided a substrate for potential screening purposes.</p><p><strong>Objective: </strong>The objective of this study was to evaluate the detection of incidental myocardial infarction on routine non-gated thoracic CT performed for noncardiac reasons and its associated major cardiovascular events and survival.</p><p><strong>Methods: </strong>We retrospectively assessed routine non-gated thoracic CT scans of all consecutive individuals aged 18 or above who underwent thoracic CT scans as outpatients at the University of California Davis from January 2015 to December 2015. We evaluated the presence and location of incidental MI on non-gated thoracic CT and compared major adverse cardiac events (MACE) and overall survival in CT-positive infarct individuals with a CTnegative infarct control group.</p><p><strong>Results: </strong>We reviewed routine thoracic CT scans of 1157 individuals and identified 12 individuals with incidental MI. The mean age of individuals with infarction was 71.4 ± 14.1 years, and 50% were female. All individuals with incidental MI had coronary calcification. Individuals with incidental MI had a higher rate of MACE endpoint (92% vs. 28%, p=0.0001), number of MACE events (1.1 vs. 0.3, p<0.001), and lower overall survival (median survival of 67 months vs. not reached, p=0.023) compared with age and sex-matched controls without incidental MI.</p><p><strong>Conclusion: </strong>Although small in number relative to the total number of individuals evaluated, subjects with incidental MI on routine non-gated thoracic CT scans have worse cardiovascular outcomes and survival compared with controls without infarction. This study highlights the potential opportunistic screening utility of routine thoracic CTs, which could lead to improved risk stratification and intervention.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Resonance Enterography of Phlebosclerotic Colitis: A Case Report.","authors":"Yu-Xuan Kho, Chien-Ming Chen, Sung-Yu Chu","doi":"10.2174/0115734056382571250509114555","DOIUrl":"https://doi.org/10.2174/0115734056382571250509114555","url":null,"abstract":"<p><strong>Background: </strong>Phlebosclerotic colitis is a rare type of chronic ischemic colitis, with most documented cases occurring in Asians. Plain-film and computed tomography findings of pericolonic vascular calcifications are diagnostic. However, Magnetic Resonance Enterography (MRE) findings of phlebosclerotic colitis have not yet been reported, and its diagnosis might be overlooked without awareness of this disease.</p><p><strong>Case report: </strong>A 70-year-old female patient without prior systemic disease presented with a 3-month history of nausea, vomiting, abdominal pain, and diarrhea. Personal history was unremarkable except for long-term use of herbal medicine. She was initially investigated at a regional hospital with a colonoscopy and biopsy. Due to the presence of stenosis at the transverse colon and biopsy results suggestive of Inflammatory Bowel Disease (IBD), she was referred to our hospital for further investigation and treatment. MRE was performed as part of the IBD workup, which showed a thickened ascending and transverse colonic wall that was fibrotic, non-edematous, and with triangular projections on the mesenteric aspect. Owing to findings that were inconsistent with IBD, subsequent abdominal plain-film radiography confirmed characteristic linear dendritic serpiginous radiopaque opacities alongside the ascending and transverse colon. Re-biopsy of the affected colon confirmed the diagnosis of phlebosclerotic colitis. The patient's symptoms improved after conservative treatment.</p><p><strong>Conclusion: </strong>MRE of phlebosclerotic colitis appears as symmetrical non-edematous bowel wall thickening with triangular signal voids indicative of venous calcifications.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and Reliability of Multimodal Imaging in Diagnosing Knee Sports Injuries.","authors":"Di Zhu, Zitong Zhang, Wenji Li","doi":"10.2174/0115734056360665250506115221","DOIUrl":"https://doi.org/10.2174/0115734056360665250506115221","url":null,"abstract":"<p><strong>Background: </strong>Due to differences in subjective experience and professional level among doctors, as well as inconsistent diagnostic criteria, there are issues with the accuracy and reliability of single imaging diagnosis results for knee joint injuries.</p><p><strong>Objective: </strong>To address these issues, magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound (US) are adopted in this article for ensemble learning, and deep learning (DL) is combined for automatic analysis.</p><p><strong>Methods: </strong>By steps such as image enhancement, noise elimination, and tissue segmentation, the quality of image data is improved, and then convolutional neural networks (CNN) are used to automatically identify and classify injury types. The experimental results show that the DL model exhibits high sensitivity and specificity in the diagnosis of different types of injuries, such as anterior cruciate ligament tear, meniscus injury, cartilage injury, and fracture.</p><p><strong>Results: </strong>The diagnostic accuracy of anterior cruciate ligament tear exceeds 90%, and the highest diagnostic accuracy of cartilage injury reaches 95.80%. In addition, compared with traditional manual image interpretation, the DL model has significant advantages in time efficiency, with a significant reduction in average interpretation time per case. The diagnostic consistency experiment shows that the DL model has high consistency with doctors' diagnosis results, with an overall error rate of less than 2%.</p><p><strong>Conclusion: </strong>The model has high accuracy and strong generalization ability when dealing with different types of joint injuries. These data indicate that combining multiple imaging technologies and the DL algorithm can effectively improve the accuracy and efficiency of diagnosing sports injuries of knee joints.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Challenges and Insights in Optic Nerve Hemangioblastoma Using Magnetic Resonance Imaging: A Case Report.","authors":"Wenwen Wang, Fajin Lv, Tianyou Luo, Mengqi Liu","doi":"10.2174/0115734056359483250502063550","DOIUrl":"https://doi.org/10.2174/0115734056359483250502063550","url":null,"abstract":"<p><strong>Background: </strong>Optic nerve hemangioblastoma (ONH) is a rare benign tumor. It can be sporadic or associated with Von-Hippel Lindau (VHL) syndrome. Magnetic resonance imaging (MRI) is the most commonly used diagnostic technique for the tumor. However, an accurate diagnosis can be challenging due to the rarity of ONH and its similarity to glioma and meningioma.</p><p><strong>Case report: </strong>A 49-year-old female experienced progressive vision loss for ten years in the right eye, accompanied by proptosis over two years. The ophthalmological examination found her visual acuity of the right eye to have no light perception. Optical coherence tomography showed decreased thickness of the right retinal ganglion cell layer. MRI revealed an oval solid mass within the right retrobulbar space, with isointensity on T₁-weighted (T₁WI) imaging and heterogeneous hyperintensity on T₂-weighted imaging (T₂WI). Heterogeneous enhancement was found on gadolinium-enhanced T₁WI and dynamic contrast-enhanced MRI. At internal and marginal areas of the mass, multiple flow voids were observed on various sequences, especially on T₂WI. Furthermore, the superior, inferior, medial, and lateral rectus muscles of the right eye distinctly atrophied, showing a lower signal intensity on T₂WI and less apparent enhancement than the left normal ones. Postoperative pathological diagnosis was hemangioblastoma of the right optic nerve.</p><p><strong>Conclusion: </strong>Hemangioblastoma should be considered as a differential diagnosis for the space-occupying mass of the optic nerve if there is the presence of flow voids, vivid enhancement, and absence of a dural attachment, regardless of VHL syndrome. Of note, this is the first reported case to consider altered extraocular muscles as a potential point to prompt the diagnosis on MRI.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Value of Quantitative Ultrasound Elastography in the Assessment of Non-Alcoholic Fatty Liver Disease in Children.","authors":"Xu Cao, Jianbo Liu, Jing Li, Kexin Shi, Shuang Zheng, Dongna Di, Peng Tian","doi":"10.2174/0115734056373132250507141342","DOIUrl":"https://doi.org/10.2174/0115734056373132250507141342","url":null,"abstract":"<p><strong>Objective: </strong>This preliminary investigation aimed to assess the value of two elastography techniques, sound touch elastography (STE) and sound touch quantification (STQ), in measuring liver stiffness in children with non-fatty versus fatty livers.</p><p><strong>Methods: </strong>This study used a case-control design. The STE and STQ were used to measure and compare liver stiffness in 121 children with fatty livers and 251 children with non-fatty livers, respectively.</p><p><strong>Results: </strong>In this study, we found that, compared to children with non-fatty liver disease, children with fatty liver disease had lower Young's modulus values in STE and STQ in the left lobe of the liver, and the difference was statistically significant (P < 0.05). However, after multifactorial analysis, no association was found between liver Young's modulus values measured by STE and STQ and the presence of fatty liver in children. In the present study, significantly higher Young's modulus values were observed in the left lobe compared to the right lobe of the liver in children with non-fatty liver (P < 0.05). In contrast, no significant difference was found between the left and right lobes in children with fatty liver (P > 0.05). The optimal diagnostic threshold for detecting steatohepatitis in the left lobe was 5.890 kPa using STE and 8.050 kPa using STQ.</p><p><strong>Conclusion: </strong>STE and STQ, as the latest ultrasound diagnostic techniques based on shear wave elastography, can quantitatively assess fatty liver in children. In this study, some liver elasticity measurements in the fatty liver group differed from those in the non-fatty liver group.</p>","PeriodicalId":54215,"journal":{"name":"Current Medical Imaging Reviews","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}