Current Opinion in Physiology最新文献_第4页

Emerging paracrine functions of the endothelium in the setting of diabetes 糖尿病患者出现的内皮旁分泌功能

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100668

Natalie J Haywood , Mark T Kearney

引用次数: 1

Establishing the optimum use of high-intensity interval training in heart failure: current status and future directions 建立高强度间歇训练在心力衰竭中的最佳应用：现状和未来方向

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100669

Kegan Moneghetti , Graeme Carrick-Ranson , Erin J Howden

引用次数: 0

Endothelial-to-mesenchymal transition: advances and controversies 内皮细胞向间充质细胞转化:进展与争议

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100678

Michael Simons

引用次数: 2

Sex differences in offspring of preeclamptic pregnancies 子痫前期妊娠后代的性别差异

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100688

Nathan Campbell , Dylan Solise , Evangeline Deer , Babbette LaMarca

{"title":"Sex differences in offspring of preeclamptic pregnancies","authors":"Nathan Campbell , Dylan Solise , Evangeline Deer , Babbette LaMarca","doi":"10.1016/j.cophys.2023.100688","DOIUrl":"10.1016/j.cophys.2023.100688","url":null,"abstract":"<div><p><span>A poor uterine environment causes changes in fetal development<span> that affect the health of offspring long-term. Although there are multiple pathways that contribute to the development of cardiovascular and neurological disease, low birth weight or fetal growth restriction (FGR) predisposes offspring to these diseases. There is a link between fetal exposure to adverse influences and hypertension later in life. Many epidemiological studies support the link between fetal life and the risk of disease later in life. Experimental models have sought to provide mechanistic proof of this link while simultaneously investigating potential therapeutics or treatment pathways. Preeclampsia (PE), one of several hypertensive disorders in pregnancy, is a leading cause of morbidity and mortality for both the mother and fetus. Studies have shown that PE is a state of chronic inflammation and there is an imbalance between pro-inflammatory and regulatory </span></span>immune cells<span> and mediators. There is no cure for PE beyond the delivery of the fetal–placental unit, and many PE pregnancies result in FGR and preterm birth. Epidemiological data demonstrate that the sex of the offspring is correlated with the degree of cardiovascular disease that develops with the age of the offspring, yet few studies examine the effect of sex on the development of neurological disorders. Even fewer studies examine the effects of therapeutics on offspring of different genders following a PE pregnancy. Moreover, there remain significant gaps in knowledge concerning the role the immune system plays in FGR offspring developing hypertension or neurovascular disorders later in life. Therefore, the purpose of this review is to highlight current research on sex differences in the developmental programming of hypertension and neurological disorders following a PE pregnancy.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100688"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging roles of non-coding RNAs in endothelial cell function 非编码RNA在内皮细胞功能中的新作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100672

Tijana Mitić, Andrea Caporali

引用次数: 2

Sphingolipids and their carriers 鞘磷脂及其载体

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100671

Ye Zeng , Bingmei M Fu

引用次数: 1

Proteostasis and resilience in the mechanically-stressed vascular endothelium 机械应力下血管内皮的蛋白酶抑制和弹性

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100673

Adam Keen, Feiran Zhang, John S Reader, Ellie Tzima

引用次数: 1

Spatiotemporal regulation of Rho GTPase signaling during endothelial barrier remodeling 内皮屏障重构过程中Rho GTPase信号的时空调控

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100676

Jeffrey MA van der Krogt , Ivanka JE van der Meulen , Jaap D van Buul

{"title":"Spatiotemporal regulation of Rho GTPase signaling during endothelial barrier remodeling","authors":"Jeffrey MA van der Krogt , Ivanka JE van der Meulen , Jaap D van Buul","doi":"10.1016/j.cophys.2023.100676","DOIUrl":"10.1016/j.cophys.2023.100676","url":null,"abstract":"<div><p>The vasculature is characterized by a thin cell layer that comprises the inner wall of all blood vessels, the continuous endothelium. Endothelial cells can also be found in the eye’s cornea. And even though cornea and vascular endothelial (VE) cells differ from each other in structure, they both function as barriers and express similar junctional proteins such as the adherens junction VE-cadherin and tight-junction member claudin-5. How these barriers are controlled to maintain the barrier and thereby its integrity is of major interest in the development of potential therapeutic targets. An important target of endothelial barrier remodeling is the actin cytoskeleton, which is centrally coordinated by Rho GTPases that are in turn regulated by Rho-regulatory proteins. In this review, we give a brief overview of how Rho-regulatory proteins themselves are spatiotemporally regulated during the process of endothelial barrier remodeling. Additionally, we propose a roadmap for the comprehensive dissection of the Rho GTPase signaling network in its entirety.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100676"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of the endothelium in severe acute respiratory syndrome coronavirus 2 infection and pathogenesis 内皮细胞在严重急性呼吸综合征冠状病毒2型感染和发病机制中的作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100670

Rainha Passi , Mairi Brittan , Andrew H Baker

{"title":"The role of the endothelium in severe acute respiratory syndrome coronavirus 2 infection and pathogenesis","authors":"Rainha Passi , Mairi Brittan , Andrew H Baker","doi":"10.1016/j.cophys.2023.100670","DOIUrl":"10.1016/j.cophys.2023.100670","url":null,"abstract":"<div><p>Endothelial cell (EC) dysfunction is a characteristic complication of coronavirus-19 (COVID-19). This review discusses the role of the endothelium during the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with a focus on different vascular beds, possible routes of infectivity and the impact of EC dysfunction across multiple organ systems. It is now known that COVID-19 disease elicits a distinct transcriptomic and molecular profile that is different to other viral infections, such as Influenza A (H1N1). Interestingly, there is also a suggested interplay between the heart and lungs that promotes the amplification of inflammatory cascades, leading to an exacerbation in disease severity. Multiomic studies have informed common pathways that may be responsible for endothelial activation while also highlighting key differences in COVID-19 pathogenesis between organ systems. At a pathological level, endothelialitis is an endpoint result regardless of either a direct viral infection or via indirect effects independent of infection. Understanding if ECs are directly targeted by SARS-CoV-2 or are collaterally damaged amid a cytokine storm originating from other cells and organs can provide novel insights into disease progression and may highlight possible new therapeutic opportunities targeted at the damaged endothelium.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100670"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9808197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Adipose tissue lymphatic endothelial cells: revisited functions in the modulation of adipose biology 脂肪组织淋巴内皮细胞:在脂肪生物学调节中重新审视功能

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100675

Ibrahim AlZaim , Joseph Festa , Joanna Kalucka

引用次数: 1