发布求助
文献互助 智能选刊 最新文献

Current Opinion in Physiology最新文献

筛选
英文 中文
Editorial overview: Exercise-induced cardiac protection: Mechanisms and clinical implications 编辑概述:运动诱导的心脏保护:机制和临床意义
IF 2.5
Current Opinion in Physiology Pub Date : 2023-09-09 DOI: 10.1016/j.cophys.2023.100716
Kate L Weeks, Junjie Xiao, Julie R McMullen
{"title":"Editorial overview: Exercise-induced cardiac protection: Mechanisms and clinical implications","authors":"Kate L Weeks, Junjie Xiao, Julie R McMullen","doi":"10.1016/j.cophys.2023.100716","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100716","url":null,"abstract":"","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"36 ","pages":"Article 100716"},"PeriodicalIF":2.5,"publicationDate":"2023-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49778661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Recent insights into the multifaceted physiology of the endothelial cell and its modulated functions in pathology 编辑综述：内皮细胞的多方面生理学及其在病理学中的调节功能的最新见解
IF 2.5
Current Opinion in Physiology Pub Date : 2023-09-01 DOI: 10.1016/j.cophys.2023.100715
Paul C Evans, Jeremy Pearson
{"title":"Editorial overview: Recent insights into the multifaceted physiology of the endothelial cell and its modulated functions in pathology","authors":"Paul C Evans, Jeremy Pearson","doi":"10.1016/j.cophys.2023.100715","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100715","url":null,"abstract":"","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"36 ","pages":"Article 100715"},"PeriodicalIF":2.5,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49819283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular insights into the force-from-lipids gating of mechanosensitive channels 机械敏感通道中脂质力门控的分子洞察
IF 2.5
Current Opinion in Physiology Pub Date : 2023-08-21 DOI: 10.1016/j.cophys.2023.100706
Navid Bavi , Charles D Cox , Yury A Nikolaev , Boris Martinac
{"title":"Molecular insights into the force-from-lipids gating of mechanosensitive channels","authors":"Navid Bavi ,&nbsp;Charles D Cox ,&nbsp;Yury A Nikolaev ,&nbsp;Boris Martinac","doi":"10.1016/j.cophys.2023.100706","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100706","url":null,"abstract":"<div><p>It is well-established that mechanosensitive (MS) ion channels differentially respond to membrane tension, bilayer thinning, and curvature. The thesis that the lipid bilayer acted as the terminal transducer of force directly to the channel became known as the force-from-lipids gating paradigm (also less frequently referred to as the ‘bilayer model’). This principle allows cells to detect and respond to mechanical forces in their environment, which is important for various physiological processes, including blood pressure regulation, touch sensation, and many others. Our understanding of how mechanical force drives MS channel gating has been greatly enhanced by new insights into the molecular interactions between the lipid bilayer and channel proteins. In this short review, we revisit the role of the force-from-lipids principle within the current understanding of MS channel gating and focus on its molecular underpinnings.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"36 ","pages":"Article 100706"},"PeriodicalIF":2.5,"publicationDate":"2023-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49778662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer 高内皮微静脉在体内平衡、炎症和癌症中的调节、维持和重塑
IF 2.5
Current Opinion in Physiology Pub Date : 2023-08-18 DOI: 10.1016/j.cophys.2023.100705
Nancy H Ruddle
{"title":"Regulation, maintenance, and remodeling of high endothelial venules in homeostasis, inflammation, and cancer","authors":"Nancy H Ruddle","doi":"10.1016/j.cophys.2023.100705","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100705","url":null,"abstract":"<div><p>High endothelial venules (HEVs), high-walled cuboidal blood vessels, through their expression of adhesion molecules and chemokines, allow the entrance of lymphoid cells into primary, secondary, and tertiary lymphoid structures (TLSs) (aka tertiary lymphoid organs). HEV heterogeneity exists between various lymphoid organs in their expression of peripheral node addressin and mucosal vascular addressin adhesion molecule 1. Transcriptomic analyses reveal extensive heterogeneity, plasticity, and regulation of HEV gene expression in ontogeny, acute inflammation, and chronic inflammation within and between lymphoid organs. Rules regulating HEV development are flexible in inflammation. HEVs in tumor TLSs are diagnostic of favorable clinical outcome and response to immunotherapy, including immune checkpoint blockade. Immunotherapy induces HEVs and provides an entrance for naive, central memory, and effector cells and a niche for stem-like precursor cells. Understanding HEV regulation will permit their exploitation as routes for drug delivery to autoimmune lesions, rejecting organs, and tumors.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"36 ","pages":"Article 100705"},"PeriodicalIF":2.5,"publicationDate":"2023-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49819282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Emerging paracrine functions of the endothelium in the setting of diabetes 糖尿病患者出现的内皮旁分泌功能
IF 2.5
Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100668
Natalie J Haywood , Mark T Kearney
{"title":"Emerging paracrine functions of the endothelium in the setting of diabetes","authors":"Natalie J Haywood ,&nbsp;Mark T Kearney","doi":"10.1016/j.cophys.2023.100668","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100668","url":null,"abstract":"<div><p>The endothelium was originally described and viewed as an inert simple barrier layer lining the vasculature, however, further research exposed the endothelium as an active organ, which contributes not only to normal physiology but also the pathophysiology of several diseases. More recently, evidence is emerging demonstrating that the endothelium can act as a paracrine organ that can dynamically respond to circulating changes depending upon its location and stimuli, including changes in the whole-body metabolic environment. Over the last few decades, changes in human lifestyle have contributed to a pandemic of nutritional obesity, leading to a significant increase in the prevalence of type-2 diabetes mellitus. Therefore, understanding the paracrine actions of the endothelium, especially in the setting of metabolic imbalance, will provide novel therapeutic avenues.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100668"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Establishing the optimum use of high-intensity interval training in heart failure: current status and future directions 建立高强度间歇训练在心力衰竭中的最佳应用：现状和未来方向
IF 2.5
Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100669
Kegan Moneghetti , Graeme Carrick-Ranson , Erin J Howden
{"title":"Establishing the optimum use of high-intensity interval training in heart failure: current status and future directions","authors":"Kegan Moneghetti ,&nbsp;Graeme Carrick-Ranson ,&nbsp;Erin J Howden","doi":"10.1016/j.cophys.2023.100669","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100669","url":null,"abstract":"<div><p>High-intensity interval training (HIIT) is increasingly employed in a variety of clinical settings due to the growing evidence of increased efficacy compared with moderate-intensity exercise for a range of health and physical function and exercise outcomes. In this brief review, we highlight the recent findings from randomized trials, discuss the evidence and rationale for the greater physiological adaptations to HIIT, and identify future areas of research that will aid in the optimization of HIIT as an adjunctive therapy in the management of heart failure.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100669"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endothelial-to-mesenchymal transition: advances and controversies 内皮细胞向间充质细胞转化:进展与争议
IF 2.5
Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100678
Michael Simons
{"title":"Endothelial-to-mesenchymal transition: advances and controversies","authors":"Michael Simons","doi":"10.1016/j.cophys.2023.100678","DOIUrl":"10.1016/j.cophys.2023.100678","url":null,"abstract":"<div><p>Endothelial-to-mesenchymal transition (EndMT) is a physiological process that is equally important during development and under certain pathological conditions in adult tissues. The last decade has witnessed a remarkable explosion of information about EndMT from molecular mechanisms responsible for its development to its role in various disease processes. The emerging picture is that of a complex set of interactions that underlie the pathophysiological basis of some of the most deadly and intractable diseases. This mini review brings together recent advances and attempts to present a unified view of this complex field.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100678"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9629684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Sex differences in offspring of preeclamptic pregnancies 子痫前期妊娠后代的性别差异
IF 2.5
Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100688
Nathan Campbell , Dylan Solise , Evangeline Deer , Babbette LaMarca
{"title":"Sex differences in offspring of preeclamptic pregnancies","authors":"Nathan Campbell ,&nbsp;Dylan Solise ,&nbsp;Evangeline Deer ,&nbsp;Babbette LaMarca","doi":"10.1016/j.cophys.2023.100688","DOIUrl":"10.1016/j.cophys.2023.100688","url":null,"abstract":"<div><p><span>A poor uterine environment causes changes in fetal development<span> that affect the health of offspring long-term. Although there are multiple pathways that contribute to the development of cardiovascular and neurological disease, low birth weight or fetal growth restriction (FGR) predisposes offspring to these diseases. There is a link between fetal exposure to adverse influences and hypertension later in life. Many epidemiological studies support the link between fetal life and the risk of disease later in life. Experimental models have sought to provide mechanistic proof of this link while simultaneously investigating potential therapeutics or treatment pathways. Preeclampsia (PE), one of several hypertensive disorders in pregnancy, is a leading cause of morbidity and mortality for both the mother and fetus. Studies have shown that PE is a state of chronic inflammation and there is an imbalance between pro-inflammatory and regulatory </span></span>immune cells<span> and mediators. There is no cure for PE beyond the delivery of the fetal–placental unit, and many PE pregnancies result in FGR and preterm birth. Epidemiological data demonstrate that the sex of the offspring is correlated with the degree of cardiovascular disease that develops with the age of the offspring, yet few studies examine the effect of sex on the development of neurological disorders. Even fewer studies examine the effects of therapeutics on offspring of different genders following a PE pregnancy. Moreover, there remain significant gaps in knowledge concerning the role the immune system plays in FGR offspring developing hypertension or neurovascular disorders later in life. Therefore, the purpose of this review is to highlight current research on sex differences in the developmental programming of hypertension and neurological disorders following a PE pregnancy.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100688"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9618026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Emerging roles of non-coding RNAs in endothelial cell function 非编码RNA在内皮细胞功能中的新作用
IF 2.5
Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100672
Tijana Mitić, Andrea Caporali
{"title":"Emerging roles of non-coding RNAs in endothelial cell function","authors":"Tijana Mitić,&nbsp;Andrea Caporali","doi":"10.1016/j.cophys.2023.100672","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100672","url":null,"abstract":"<div><p>Nearly 98% of the human genome is transcriptionally active but does not encode proteins, reflecting a wide range of noncoding genomes with essential regulatory and structural roles. Understanding the endothelial cell (EC) function in vascular biology has been pivotal for grasping the repair mechanisms in ischaemic tissue and during cardiovascular diseases. However, only a tiny portion of the human genome's noncoding region has been studied to understand its role in new mechanisms in EC biology. Herein, we provide an overview of the non-coding RNAs (ncRNAs) in endothelium. We also discuss the latest research focusing on canonical and noncanonical aspects in ncRNA biology, ncRNA, cell-to-cell communication and transcriptional and epigenetic regulation by ncRNA in the endothelium.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100672"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Sphingolipids and their carriers 鞘磷脂及其载体
IF 2.5
Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100671
Ye Zeng , Bingmei M Fu
{"title":"Sphingolipids and their carriers","authors":"Ye Zeng ,&nbsp;Bingmei M Fu","doi":"10.1016/j.cophys.2023.100671","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100671","url":null,"abstract":"<div><p><span>Bioactive sphingolipids have emerged as critical players in inflammation and metabolic diseases. The major metabolites of sphingolipids, including </span>ceramides<span><span> and sphingosine-1-phosphate (S1P), are often elevated in blood plasma and injured tissues. But they do not freely exist. Instead, they are carried by so-called chaperone molecules such as high-density lipoprotein (HDL), low-density lipoproteins (LDL), and serum albumin, as well as by recently emerging carriers, extracellular vesicles. In this short review, we briefly summarize the current knowledge about the role of sphingolipids in various diseases and describe how sphingolipids are associated with their carriers for their functions. Some issues are highlighted such as S1P negatively correlated with </span>apolipoprotein M of HDL in obesity, adaptive immune responses driven by native LDLs rather than oxidized LDLs, and sphingolipid exchange between HDL and LDL or albumin. This review aims to show the importance of sphingolipid carriers in disease processes and in the development of effective therapeutics.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100671"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：481959085
Book学术官方微信