Current Opinion in Physiology最新文献_第10页

Coordination of mitochondrial and nuclear gene-expression regulation in health, evolution, and disease 线粒体和核基因表达调控在健康、进化和疾病中的协调作用

IF 2.5

Current Opinion in Physiology Pub Date : 2022-06-01 DOI: 10.1016/j.cophys.2022.100554

Omer Papier , Gavriel Minor , Hadar Medini, Dan Mishmar

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引用次数: 1

Mitochondrial dynamics: roles in exercise physiology and muscle mass regulation 线粒体动力学:在运动生理学和肌肉质量调节中的作用

IF 2.5

Current Opinion in Physiology Pub Date : 2022-06-01 DOI: 10.1016/j.cophys.2022.100550

Andre Djalalvandi , Luca Scorrano

引用次数: 2

Remodeling of cardiac metabolism in heart failure with preserved ejection fraction 保留射血分数的心力衰竭患者心脏代谢的重构

IF 2.5

Current Opinion in Physiology Pub Date : 2022-06-01 DOI: 10.1016/j.cophys.2022.100559

Akira Yoshii, Rong Tian

引用次数: 1

Mitochondrial lysine acylation and cardiometabolic stress: truth or consequence? 线粒体赖氨酸酰化与心脏代谢应激:真相还是后果?

IF 2.5

Current Opinion in Physiology Pub Date : 2022-06-01 DOI: 10.1016/j.cophys.2022.100551

Deborah M Muoio , Ashley S Williams , Paul A Grimsrud

引用次数: 1

The integrated stress response as a key pathway downstream of mitochondrial dysfunction 综合应激反应是线粒体功能障碍下游的关键途径

IF 2.5

Current Opinion in Physiology Pub Date : 2022-06-01 DOI: 10.1016/j.cophys.2022.100555

Maria Bilen , Sara Benhammouda , Ruth S Slack , Marc Germain

{"title":"The integrated stress response as a key pathway downstream of mitochondrial dysfunction","authors":"Maria Bilen , Sara Benhammouda , Ruth S Slack , Marc Germain","doi":"10.1016/j.cophys.2022.100555","DOIUrl":"10.1016/j.cophys.2022.100555","url":null,"abstract":"<div><p><span>Mitochondrial function is fundamental to maintaining metabolic homeostasis. Alterations in </span>mitochondrial biogenesis<span><span>, energy production, and dynamics are behind many metabolic diseases affecting particularly the muscular and nervous systems. Therefore, synchronized coordination between organelles is required to sustain homeostasis. The integrated stress response (ISR) is a heavily investigated pathway that allows for communication between organelles, including the mitochondria and the nucleus among others. The ISR slows down protein synthesis in the cytoplasm and modifies the </span>transcriptome<span> in the nucleus following mitochondrial stress. With the help of the ATF4<span> transcription factor, it promotes metabolic rewiring, amino acid, and antioxidant synthesis to counteract cellular stress. Under chronic stress, the ISR leads to apoptotic cell death. However, the mechanisms as to how the ISR can coordinate cell death and survival depending on the type of insult remain unclear. In this review, we will discuss the mechanisms of activation of the ISR under different mitochondrial dysfunctions. We propose a few mechanisms and factors that contribute to the cell-specific response. Finally, we discuss the role of the ISR in neurodegenerative diseases given the important implications of the mitochondria in maintaining healthy neurological function.</span></span></span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82165525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Therapeutic mitochondrial transplantation 治疗性线粒体移植

IF 2.5

Current Opinion in Physiology Pub Date : 2022-06-01 DOI: 10.1016/j.cophys.2022.100558

James D McCully , Pedro J del Nido , Sitaram M Emani

引用次数: 5

Heat and mitochondrial bioenergetics 热与线粒体生物能量学

IF 2.5

Current Opinion in Physiology Pub Date : 2022-06-01 DOI: 10.1016/j.cophys.2022.100553

Alex T Von Schulze , Paige C Geiger

{"title":"Heat and mitochondrial bioenergetics","authors":"Alex T Von Schulze , Paige C Geiger","doi":"10.1016/j.cophys.2022.100553","DOIUrl":"10.1016/j.cophys.2022.100553","url":null,"abstract":"<div><p>Recurrent heat treatment (HT) is known to improve mitochondrial respiratory function<span><span> and reduce mitochondrial reactive oxygen species (mROS) production over time. Counterintuitively, HT results in acute mitochondrial stress characterized by impaired mitochondrial respiratory function and increased mROS production. The combination of reduced adenosine triphosphate (ATP) synthesis and elevated mROS production leads to the activation of the adenosine monophosphate (AMP)-activated protein kinase, nuclear factor erythroid-2-related factor 2, proliferator-activated receptor gamma coactivator 1-alpha, and nuclear respiratory factor-1 signaling cascades, as well as the heat-shock response via activation of heat-shock factor 1. The coordinated transcriptional control of these proteins leads to the chronological induction of mitochondrial quality-control mechanisms, such as mitophagy and chaperone-mediated autophagy, and mitochondrial biogenesis/remodeling. Taken together, the </span>acute stress imposed by HT leads to positive adaptations in mitochondrial health and function over time — making HT an attractive, nonpharmacologic treatment option for conditions characterized by mitochondrial dysfunction.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":null,"pages":null},"PeriodicalIF":2.5,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73678965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Editorial overview: Mitochondrial physiology 编辑概述:线粒体生理学

IF 2.5

Current Opinion in Physiology Pub Date : 2022-06-01 DOI: 10.1016/j.cophys.2022.100538

Iain Scott, Kelsey Fisher-Wellman

引用次数: 0

Integrating Sex and Gender in Mitochondrial Science 整合性与性别在线粒体科学

IF 2.5

Current Opinion in Physiology Pub Date : 2022-04-01 DOI: 10.1016/j.cophys.2022.100536

A. Junker, R. Juster, M. Picard

引用次数: 1

How chromatin stiffens fibroblasts 染色质如何使成纤维细胞变硬