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Physiological functions of mitophagy 线粒体自噬的生理功能
IF 2.5
Current Opinion in Physiology Pub Date : 2022-12-01 DOI: 10.1016/j.cophys.2022.100612
Milos Stanojlovic , Aniketh Bishnu , Francois Singh , Ian G Ganley
{"title":"Physiological functions of mitophagy","authors":"Milos Stanojlovic ,&nbsp;Aniketh Bishnu ,&nbsp;Francois Singh ,&nbsp;Ian G Ganley","doi":"10.1016/j.cophys.2022.100612","DOIUrl":"10.1016/j.cophys.2022.100612","url":null,"abstract":"<div><p>Mitochondria are vitally important organelles within our cells. In addition to being the key energy provider, they perform numerous other essential roles ranging from calcium homeostasis to iron metabolism. Therefore, these mitochondrial functions are dependent on the quality and number of mitochondria, which needs to be dynamic in response to a cell’s changing needs. Mitochondrial numbers themselves are controlled by mitochondrial biogenesis and turnover. Multiple pathways exist that result in the turnover of mitochondria, but the focus of this review will be on mitophagy (the autophagy of mitochondria). Here, we will touch on the basic mechanisms of mitophagy and how this has been translated from cell-based studies to complex mammalian systems. We will then examine the tasks that mitophagy serves in vivo. While mitochondrial quality control is a critical function of mitophagy, we will also discuss the recent roles that mitophagy plays in metabolic remodeling.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"30 ","pages":"Article 100612"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867322001304/pdfft?md5=35046883309369ec7c0e3a0b3a5929bb&pid=1-s2.0-S2468867322001304-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76421789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Chaperone-mediated autophagy: mechanisms and physiological relevance 伴侣介导的自噬:机制和生理相关性
IF 2.5
Current Opinion in Physiology Pub Date : 2022-12-01 DOI: 10.1016/j.cophys.2022.100597
Maryam Jafari , Mericka McCabe , Ana M Cuervo
{"title":"Chaperone-mediated autophagy: mechanisms and physiological relevance","authors":"Maryam Jafari ,&nbsp;Mericka McCabe ,&nbsp;Ana M Cuervo","doi":"10.1016/j.cophys.2022.100597","DOIUrl":"10.1016/j.cophys.2022.100597","url":null,"abstract":"<div><p><span><span>A fraction of the cellular proteome can be selectively targeted to </span>lysosomes for degradation within this organelle by a process known as chaperone-mediated autophagy (CMA). A dedicated network of genes and their protein products contribute to CMA execution and regulation. Here, we describe the most recent advances on the molecular dissection of CMA and on the understanding of the lysosomal and cellular components that contribute to its regulation, both under physiological conditions and in response to different stressors. The recent development of experimental mouse models to track, upregulate, or downregulate CMA </span><em>in vivo</em> has helped identify that, besides the role of CMA in cellular protein quality control, this type of autophagy also contributes to timely remodeling of the cellular functional proteome to modulate a variety of cellular processes. We review some of the novel regulatory roles of CMA and the consequences of CMA failure on physiology and cellular functioning.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"30 ","pages":"Article 100597"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90606506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Role of autophagy in male and female fertility 自噬在男性和女性生育中的作用
IF 2.5
Current Opinion in Physiology Pub Date : 2022-12-01 DOI: 10.1016/j.cophys.2022.100611
Chao Liu , Bingbing Wu , Wenwen Liu , Wei Li
{"title":"Role of autophagy in male and female fertility","authors":"Chao Liu ,&nbsp;Bingbing Wu ,&nbsp;Wenwen Liu ,&nbsp;Wei Li","doi":"10.1016/j.cophys.2022.100611","DOIUrl":"10.1016/j.cophys.2022.100611","url":null,"abstract":"<div><p>Autophagy is an important cellular homoeostatic process that transports cytoplasmic constituents to lysosomes<span> and participates in various physiological processes. Recent findings have revealed novel functional roles of autophagy in the reproductive process, and dysfunctional autophagy has been reported to be associated with male and female infertility. In this review, we summarise the recent progress regarding autophagy in fertility and discuss important concerns in this field.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"30 ","pages":"Article 100611"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89819879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent insights concerning autophagy and endothelial cell nitric oxide generation 关于自噬和内皮细胞一氧化氮生成的最新见解
IF 2.5
Current Opinion in Physiology Pub Date : 2022-12-01 DOI: 10.1016/j.cophys.2022.100614
Seul-Ki Park , Jae Min Cho , Sohom Mookherjee , Paulo W. Pires , John David Symons
{"title":"Recent insights concerning autophagy and endothelial cell nitric oxide generation","authors":"Seul-Ki Park ,&nbsp;Jae Min Cho ,&nbsp;Sohom Mookherjee ,&nbsp;Paulo W. Pires ,&nbsp;John David Symons","doi":"10.1016/j.cophys.2022.100614","DOIUrl":"10.1016/j.cophys.2022.100614","url":null,"abstract":"<div><p>Although endothelial cell (EC) dysfunction contributes to the etiology of more diseases than any other tissue in the body, EC metabolism is an understudied therapeutic target. Evidence regarding the important role of autophagy in maintaining EC homeostasis<span> is accumulating rapidly. Here, we focus on advances over the past two years regarding how EC autophagy mediates EC nitric oxide generation in the context of aging and cardiovascular complications, including coronary artery disease, aneurysm, and stroke. In addition, insight concerning the efficacy of maneuvers designed to boost EC autophagy in an effort to combat cardiovascular complications associated with repressed EC autophagy is discussed.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"30 ","pages":"Article 100614"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78777407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of autophagy in liver diseases 自噬在肝脏疾病中的作用
IF 2.5
Current Opinion in Physiology Pub Date : 2022-12-01 DOI: 10.1016/j.cophys.2022.100594
Hideaki Morishita , Masaaki Komatsu
{"title":"Role of autophagy in liver diseases","authors":"Hideaki Morishita ,&nbsp;Masaaki Komatsu","doi":"10.1016/j.cophys.2022.100594","DOIUrl":"10.1016/j.cophys.2022.100594","url":null,"abstract":"<div><p><span>Since the initial discovery of autophagy in rat liver over 60 years ago, studies on hepatic autophagy have provided insight into the mechanisms and physiological functions of autophagy. These findings include the essential role of starvation-induced autophagy in supplying nutrients such as amino acids, glucose, and </span>free fatty acids<span> for energy production and the synthesis of macromolecules. Furthermore, it has been established that autophagy selectively degrades intracellular components such as p62/SQSTM1- and ubiquitin-containing droplets, as well as damaged organelles for intracellular quality control in hepatic cells. Dysfunction of hepatic autophagy can lead to several liver diseases, including hepatic tumors. In this review, we describe the physiological role of hepatic autophagy and its pathophysiological significance in several chronic liver disorders.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"30 ","pages":"Article 100594"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74766775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glycophagy — the physiological perspective on a newly characterized glycogen-selective autophagy 糖吞噬——一种新发现的糖原选择性自噬的生理学视角
IF 2.5
Current Opinion in Physiology Pub Date : 2022-12-01 DOI: 10.1016/j.cophys.2022.100598
Lea MD Delbridge , Parisa Koutsifeli , Sarah PT Fong , Marco Annandale , Kate L Weeks , James R Bell , Kimberley M Mellor
{"title":"Glycophagy — the physiological perspective on a newly characterized glycogen-selective autophagy","authors":"Lea MD Delbridge ,&nbsp;Parisa Koutsifeli ,&nbsp;Sarah PT Fong ,&nbsp;Marco Annandale ,&nbsp;Kate L Weeks ,&nbsp;James R Bell ,&nbsp;Kimberley M Mellor","doi":"10.1016/j.cophys.2022.100598","DOIUrl":"10.1016/j.cophys.2022.100598","url":null,"abstract":"<div><p><span>Degradation of intracellular components through autophagy is a fundamental process to maintain cellular integrity and homeostasis. Recently, a glycogen-selective autophagy pathway has been described, termed ‘glycophagy’. Glycogen is a primary storage depot and regulator of glucose availability, and glycophagy is emerging as a critical physiological process involved in energy metabolism. Glycophagy-mediated degradation of glycogen appears to operate in parallel with the well-described canonical pathway of </span>glycogenolysis<span> involving glycogen phosphorylase. Evidence suggests that starch-binding domain protein 1 (Stbd1) is a key glycogen-binding protein involved in tagging glycogen for glycophagy, and that GABA Type A Receptor Protein Like 1 is primarily involved as the Atg8 family protein recruiting the Stbd1–glycogen complex into the forming glycophagosome. The nuances of glycophagy protein machinery, regulation, and lysosomal glucose release are yet to be fully elucidated. In this mini-review, we critically analyze the current evidence base for glycophagy as a selective-autophagy process of physiological importance and highlight areas where further investigation is warranted.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"30 ","pages":"Article 100598"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84198417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms and physiological functions of ER-phagy er吞噬的机制和生理功能
IF 2.5
Current Opinion in Physiology Pub Date : 2022-12-01 DOI: 10.1016/j.cophys.2022.100613
Pablo Sanz-Martinez, Alexandra Stolz
{"title":"Mechanisms and physiological functions of ER-phagy","authors":"Pablo Sanz-Martinez,&nbsp;Alexandra Stolz","doi":"10.1016/j.cophys.2022.100613","DOIUrl":"10.1016/j.cophys.2022.100613","url":null,"abstract":"<div><p>The endoplasmic reticulum (ER) is the largest cellular organelle that undergoes constant turnover upon diverse functional demands and cellular signals. Removal of nonfunctional or superfluous subdomains is balanced by the parallel expansion and formation of ER membranes, leading to the dynamic exchange of ER components. In recent years, selective autophagy of the ER, termed ER-phagy, has emerged as a predominant process involved in ER degradation and maintenance of ER homeostasis. Identification of multiple ER-phagy receptors, many with additional ER-shaping functions, paved the way for our molecular understanding of ER turnover in different cells and organs. In this review, we describe the molecular principles underling the physiological functions of ER-phagy in maintaining ER homeostasis via receptor-mediated macroautophagy and elaborate current focus points of the field.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"30 ","pages":"Article 100613"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867322001316/pdfft?md5=cf09e9008cea36c94368138e2e807db3&pid=1-s2.0-S2468867322001316-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87986052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of autophagy in the eye: from physiology to disease 自噬在眼睛中的作用:从生理到疾病
IF 2.5
Current Opinion in Physiology Pub Date : 2022-12-01 DOI: 10.1016/j.cophys.2022.100592
Hideaki Morishita
{"title":"Role of autophagy in the eye: from physiology to disease","authors":"Hideaki Morishita","doi":"10.1016/j.cophys.2022.100592","DOIUrl":"10.1016/j.cophys.2022.100592","url":null,"abstract":"<div><p>Autophagy is a conserved catabolic process that delivers cytoplasmic materials to the lysosome for degradation. Recent studies indicate that autophagy is essential for maintaining vision by regulating intracellular homeostasis in various structures of the eye, including the lens, retina, cornea, and trabecular meshwork. Dysregulated autophagy causes ocular diseases such as cataract, glaucoma, retinitis pigmentosa, and age-related macular degeneration. Autophagy-independent degradation pathways such as LC3-associated phagocytosis in the retina and cytosolic PLAAT phospholipase-mediated organelle degradation in the lens are also physiologically important. Here, I summarize recent findings on the role of autophagy and related pathways in ocular physiology and disease.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"30 ","pages":"Article 100592"},"PeriodicalIF":2.5,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867322001109/pdfft?md5=5188e5de08a826206a6d97dae4def8f4&pid=1-s2.0-S2468867322001109-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84985948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Transcriptional regulation of autophagy in aging 衰老过程中自噬的转录调控
IF 2.5
Current Opinion in Physiology Pub Date : 2022-10-01 DOI: 10.1016/j.cophys.2022.100591
Tatiana M Moreno , Caitlin M Lange , Caroline Kumsta
{"title":"Transcriptional regulation of autophagy in aging","authors":"Tatiana M Moreno ,&nbsp;Caitlin M Lange ,&nbsp;Caroline Kumsta","doi":"10.1016/j.cophys.2022.100591","DOIUrl":"10.1016/j.cophys.2022.100591","url":null,"abstract":"<div><p><span>Macroautophagy, hereafter autophagy, is a cellular recycling process that degrades damaged cellular components. Autophagy is important for maintaining cellular homeostasis and has been reported to decline with age. This age-related reduction in autophagy function has been associated with the development of age-related diseases. A network of </span>signaling pathways<span> that sense nutrient status and cellular stress regulate autophagy via post-translational, transcriptional, and epigenetic mechanisms, but the molecular mechanisms that lead to autophagy decline with age remain unclear. Here, we review links between autophagy and aging and focus on the hypothesis that transcriptional dysregulation of key autophagy genes contributes to the age-related decline in autophagy. We outline how transcription factors TFEB (transcription factor EB) and FOXOs ( forkhead box-O family proteins) facilitate appropriate transcriptional regulation of autophagy in healthy organisms, and summarize recent advances characterizing age-related changes in the regulation of transcription-factor function that could contribute to transcriptional dysregulation of autophagy.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"29 ","pages":"Article 100591"},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84743344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division Drp1和细胞骨架：线粒体分裂的机制联系。
IF 2.5
Current Opinion in Physiology Pub Date : 2022-10-01 DOI: 10.1016/j.cophys.2022.100574
Jason A Mears , Rajesh Ramachandran
{"title":"Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division","authors":"Jason A Mears ,&nbsp;Rajesh Ramachandran","doi":"10.1016/j.cophys.2022.100574","DOIUrl":"10.1016/j.cophys.2022.100574","url":null,"abstract":"<div><p>Dynamin-related protein 1 (Drp1), the master regulator of mitochondrial division (MD), interacts with the cytoskeletal elements, namely filamentous actin, microtubules, and septins<span> that coincidentally converge at MD sites. However, the mechanistic contributions of these critical elements to, and their cooperativity in, MD remain poorly characterized. Emergent data indicate that the cytoskeleton plays combinatorial modulator, mediator, and effector roles in MD by ‘priming’ and ‘channeling’ Drp1 for mechanoenzymatic membrane remodeling. In this brief review, we will outline our current understanding of Drp1–cytoskeleton interactions, focusing on recent progress in the field and a plausible ‘diffusion barrier’ role for the cytoskeleton in MD.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"29 ","pages":"Article 100574"},"PeriodicalIF":2.5,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10427167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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