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Current Opinion in Physiology最新文献

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Revolutionizing therapeutics: unleashing the power of extracellular vesicles for disease intervention
IF 2.5
Current Opinion in Physiology Pub Date : 2025-01-21 DOI: 10.1016/j.cophys.2025.100815
Sayam Ghosal , Bernadett R Bodnár , Brachyahu M Kestecher , Ákos Nagy , Tamás László , Bora Yilmaz , Yixuan Zeng , Adrienn Szabó , Csaba Bödör , Edit I Buzás , Xabier Osteikoetxea
{"title":"Revolutionizing therapeutics: unleashing the power of extracellular vesicles for disease intervention","authors":"Sayam Ghosal ,&nbsp;Bernadett R Bodnár ,&nbsp;Brachyahu M Kestecher ,&nbsp;Ákos Nagy ,&nbsp;Tamás László ,&nbsp;Bora Yilmaz ,&nbsp;Yixuan Zeng ,&nbsp;Adrienn Szabó ,&nbsp;Csaba Bödör ,&nbsp;Edit I Buzás ,&nbsp;Xabier Osteikoetxea","doi":"10.1016/j.cophys.2025.100815","DOIUrl":"10.1016/j.cophys.2025.100815","url":null,"abstract":"<div><div>Extracellular vesicles (EVs) have emerged as a significant tool in therapeutic applications, exhibiting low immunogenicity and the ability to traverse biological barriers. EV-based treatments show great potential in various diseases, including oncology, neurodegeneration, and cardiovascular conditions. In cancer research, EVs play a role in tumor growth, spread, and resistance to chemotherapy, with modified EVs showing promise in improving drug delivery to challenging cancers such as glioblastoma. For neurodegeneration, EVs aid in protecting neurons and restoring motor function. Likewise, in cardiovascular diseases, EVs participate in tissue repair and heart protection. The effectiveness of EV-based vaccines, exemplified by a clinically approved meningococcal serogroup B MenB-4C vaccine, further underscores the therapeutic value of this approach. This review examines the progress in EV-based therapeutics and their future potential.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"43 ","pages":"Article 100815"},"PeriodicalIF":2.5,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143149275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific effects of environmental pollutants on pulmonary immune responses
IF 2.5
Current Opinion in Physiology Pub Date : 2025-01-17 DOI: 10.1016/j.cophys.2025.100813
Sylvia S Sanchez, Fenna CM Sillé
{"title":"Sex-specific effects of environmental pollutants on pulmonary immune responses","authors":"Sylvia S Sanchez,&nbsp;Fenna CM Sillé","doi":"10.1016/j.cophys.2025.100813","DOIUrl":"10.1016/j.cophys.2025.100813","url":null,"abstract":"<div><div>Environmental pollutants can adversely impact various physiological processes, affecting systems such as the respiratory and immune systems. Immune responses are influenced by various factors, including age, hormonal status, genetic background, and, notably, sex, with effects extending to both innate and adaptive immunity. External factors, like environmental pollutants, can also disrupt innate and/or adaptive immunity and compromise pathogen recognition and memory against future infections. Furthermore, environmental pollutants can play a pivotal role in the development and exacerbation of many chronic respiratory diseases. It is becoming increasingly evident that environmental pollutants elicit sex-specific effects across different species. This review highlights recent findings on the intricate interplay between sex differences and immune-related effects induced by environmental pollutants, with a particular focus on the dysregulation of pulmonary immune responses.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"43 ","pages":"Article 100813"},"PeriodicalIF":2.5,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143349036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian rhythms in renal metabolism
IF 2.5
Current Opinion in Physiology Pub Date : 2025-01-16 DOI: 10.1016/j.cophys.2025.100814
Yohan Bignon, Dmitri Firsov
{"title":"Circadian rhythms in renal metabolism","authors":"Yohan Bignon,&nbsp;Dmitri Firsov","doi":"10.1016/j.cophys.2025.100814","DOIUrl":"10.1016/j.cophys.2025.100814","url":null,"abstract":"<div><div>The kidney has one of the highest resting metabolic rates among human tissues. Most of the produced ATP is used for solutes and water reabsorption along the renal tubule. However, circadian rhythmicity in the glomerular filtration rate results in substantial circadian variations in the amounts of solutes and water to be reabsorbed at a given circadian time. Moreover, circadian rhythmicity in the renal blood flow causes circadian oscillations in available oxygen and metabolic substrates in kidney tissue. Collectively, this suggests that processes involved in energy consumption and energy production in the kidney follow circadian rhythms that parallel those in tubular reabsorption. In this review, we summarize recent progress in the identification of rhythmic renal metabolic pathways that are entrained by the intrinsic tubular circadian clock.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"43 ","pages":"Article 100814"},"PeriodicalIF":2.5,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143149274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular vesicles released by Trypanosoma cruzi and Leishmania spp.: protozoan parasite–host interaction mechanism
IF 2.5
Current Opinion in Physiology Pub Date : 2024-11-22 DOI: 10.1016/j.cophys.2024.100792
Patricia Xander , Mariana O Gonçalves, Ana C Torrecilhas
{"title":"Extracellular vesicles released by Trypanosoma cruzi and Leishmania spp.: protozoan parasite–host interaction mechanism","authors":"Patricia Xander ,&nbsp;Mariana O Gonçalves,&nbsp;Ana C Torrecilhas","doi":"10.1016/j.cophys.2024.100792","DOIUrl":"10.1016/j.cophys.2024.100792","url":null,"abstract":"<div><div>Extracellular vesicles (EVs) released by the protozoa parasites <em>Trypanosoma cruzi</em> and <em>Leishmania</em> spp. and host communication have received increased attention and achieved greater significance in recent years. This review focuses on the operation and consequences of the communication channel, which provides important insights into a variety of infectious disease characteristics and host immune responses. We highlight the most important discoveries, explain the underlying mechanisms, and discuss the implications for basic science and potential treatments. These EVs play a critical role in the parasite's ability to spread infection and alter the host’s immune response. However, there are some gaps in the research in this field, particularly in functional biological features that could help us understand the conditions and mechanisms underlying protozoan EV release. Therefore, more research is needed, as understanding the mechanisms underlying pathogen–host interaction is critical to treating endemic parasitic diseases. Given that EVs are promising candidates for vaccination, diagnosis, and therapy, this could lay the groundwork for the development of novel therapeutic approaches. Furthermore, there is no vaccine available for Chagas disease, which is extremely difficult to treat and manage.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"43 ","pages":"Article 100792"},"PeriodicalIF":2.5,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143149305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The two-sided impact of beta-adrenergic receptor ligands on inflammation 肾上腺素能受体配体对炎症的双面影响
IF 2.5
Current Opinion in Physiology Pub Date : 2024-10-01 DOI: 10.1016/j.cophys.2024.100779
Paulina Dragan, Dorota Latek
{"title":"The two-sided impact of beta-adrenergic receptor ligands on inflammation","authors":"Paulina Dragan,&nbsp;Dorota Latek","doi":"10.1016/j.cophys.2024.100779","DOIUrl":"10.1016/j.cophys.2024.100779","url":null,"abstract":"<div><div>Beta-adrenergic receptors (β-ARs) encompass three distinct subtypes, which participate in modulating inflammatory responses. Both agonists and antagonists of these receptors are used to treat numerous diseases and have often been observed to have a protective role on different kinds of tissues. β-AR antagonists are used to treat cardiovascular diseases and chronic obstructive pulmonary disease but may worsen inflammation in neurodegenerative disorders. However, two β-AR antagonists, carvedilol and nebivolol, can attenuate the formation of the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome. Many β-AR agonists have proved to mediate anti-inflammatory signals, especially in regard to suppressing the inflammatory response of macrophages or providing protective effects in cases of hypoxia. The activation of beta-adrenergic receptors can, however, be a double-edged sword, as their overactivation may result in cardiac inflammation. Here, we aim to provide an overview of recent advances in studying the connection between β-ARs and inflammation.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"41 ","pages":"Article 100779"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adrenergic modulation of neutrophil and macrophage functions: pathophysiological cues 肾上腺素能调节中性粒细胞和巨噬细胞的功能：病理生理学线索
IF 2.5
Current Opinion in Physiology Pub Date : 2024-10-01 DOI: 10.1016/j.cophys.2024.100780
Carmen Vida , Yadileiny Portilla , Cristina Murga
{"title":"Adrenergic modulation of neutrophil and macrophage functions: pathophysiological cues","authors":"Carmen Vida ,&nbsp;Yadileiny Portilla ,&nbsp;Cristina Murga","doi":"10.1016/j.cophys.2024.100780","DOIUrl":"10.1016/j.cophys.2024.100780","url":null,"abstract":"<div><div>In this review, we will summarize current and past findings on the adrenergic regulation of myeloid cell functions and dynamics, with special emphasis on the pathophysiological impact of such modulation. Adrenergic signaling has traditionally been described to be immunosuppressive, but some recent results are challenging this paradigm, in particular those related to <em>in vivo</em> models of stress and findings in human patients. Also, cumulative evidence reveals that the final pro- or anti-inflammatory outcome of adrenergic inputs in myeloid cells appears to be very dependent on the experimental setup utilized or on the cellular context (resting vs stimulated conditions, <em>in vivo</em> vs <em>in vitro</em> settings, mice vs human cells, health vs pathology). Varying doses and/or time points may result in seemingly contradictory results that depend on the nature of receptor engaged (α or β adrenergic receptor subtypes), the downstream cascades involved, the presence of additional stimulatory or inhibitory signals, and the actual kinetics of the process studied. We will thus address some of these apparently paradoxical findings, review several pathological settings in which adrenergic modulation of neutrophil or macrophage-mediated immunity is relevant, and discuss open questions that still remain unanswered.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"41 ","pages":"Article 100780"},"PeriodicalIF":2.5,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142416297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Overview: Adrenergic signaling in cellular physiology and disease 社论概述：细胞生理学和疾病中的肾上腺素能信号传导
IF 2.5
Current Opinion in Physiology Pub Date : 2024-08-23 DOI: 10.1016/j.cophys.2024.100778
Anastasios Lymperopoulos , Walter J Koch
{"title":"Editorial Overview: Adrenergic signaling in cellular physiology and disease","authors":"Anastasios Lymperopoulos ,&nbsp;Walter J Koch","doi":"10.1016/j.cophys.2024.100778","DOIUrl":"10.1016/j.cophys.2024.100778","url":null,"abstract":"","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"42 ","pages":"Article 100778"},"PeriodicalIF":2.5,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142122773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Sex differences in personalized medicine and beyond 编辑综述：个性化医学及其他领域的性别差异
IF 2.5
Current Opinion in Physiology Pub Date : 2024-08-22 DOI: 10.1016/j.cophys.2024.100777
Mark J Kohr, Susan E Howlett, Licy Yanes Cardozo
{"title":"Editorial overview: Sex differences in personalized medicine and beyond","authors":"Mark J Kohr,&nbsp;Susan E Howlett,&nbsp;Licy Yanes Cardozo","doi":"10.1016/j.cophys.2024.100777","DOIUrl":"10.1016/j.cophys.2024.100777","url":null,"abstract":"","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"42 ","pages":"Article 100777"},"PeriodicalIF":2.5,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142098079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unheralded adrenergic receptor signaling in cellular oxidative stress and death 细胞氧化应激和死亡中不为人知的肾上腺素能受体信号传导
IF 2.5
Current Opinion in Physiology Pub Date : 2024-06-24 DOI: 10.1016/j.cophys.2024.100766
Lilly Underwood, Chun-sun Jiang, Joo-Yeun Oh, Priscila Y Sato
{"title":"Unheralded adrenergic receptor signaling in cellular oxidative stress and death","authors":"Lilly Underwood,&nbsp;Chun-sun Jiang,&nbsp;Joo-Yeun Oh,&nbsp;Priscila Y Sato","doi":"10.1016/j.cophys.2024.100766","DOIUrl":"https://doi.org/10.1016/j.cophys.2024.100766","url":null,"abstract":"<div><p>Catecholamines (CAs) bind and activate adrenergic receptors (ARs), thus exuding a key role in cardiac adaptations to global physiological queues. Prolonged exposure to high levels of CAs promotes deleterious effects on the cardiovascular system, leading to organ dysfunction and heart failure (HF). In addition to the prominent role of ARs in inotropic and chronotropic responses, recent studies have delved into elucidating mechanisms contributing to CA toxicity and cell death. Central to this process is understanding the involvement of α1AR and βAR in cardiac remodeling and mechanisms of cellular survival. Here, we highlight the complexity of AR signaling and the fundamental need for a better understanding of its contribution to oxidative stress and cell death. This crucial informational nexus remains a barrier to the development of new therapeutic strategies for cardiovascular diseases.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"40 ","pages":"Article 100766"},"PeriodicalIF":2.5,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141541905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biogenesis and secretion of mitovesicles, small extracellular vesicles of mitochondrial origin at the crossroads between brain health and disease 线粒体小泡的生物生成与分泌--线粒体来源的细胞外小泡是大脑健康与疾病的交叉点
IF 2.5
Current Opinion in Physiology Pub Date : 2024-06-11 DOI: 10.1016/j.cophys.2024.100765
Yohan Kim , Pasquale D’Acunzo , Efrat Levy
{"title":"Biogenesis and secretion of mitovesicles, small extracellular vesicles of mitochondrial origin at the crossroads between brain health and disease","authors":"Yohan Kim ,&nbsp;Pasquale D’Acunzo ,&nbsp;Efrat Levy","doi":"10.1016/j.cophys.2024.100765","DOIUrl":"10.1016/j.cophys.2024.100765","url":null,"abstract":"<div><p>In the brain, mitochondrial components are released into the extracellular space via several mechanisms, including a recently identified type of extracellular vesicles called mitovesicles. While vesiculation of neuronal mitochondria yields various intracellular types of vesicles, with either a single or a double membrane, mitovesicles secreted into the extracellular space are a unique subtype of these mitochondria-derived vesicles, with a double membrane and a specific set of mitochondrial DNA, RNA, proteins, and lipids. Based on the most relevant literature describing mitochondrial vesiculation and mitochondrial exocytosis, we propose a model for their secretion when the amphisomes, a hybrid endosome–autophagosome organelle, fuse with the plasma membrane, releasing mitovesicles and exosomes into the extracellular space. In aging and neurodegenerative disorders, mitochondrial dysfunction, in association with endolysosomal abnormalities, alter mitovesicle number and content, with downstream effect on brain health.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"40 ","pages":"Article 100765"},"PeriodicalIF":2.5,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141402063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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