Current Opinion in Physiology最新文献_第2页

The emerging role of extracellular vesicle RNAs as mediators of cardiometabolic diseases: from pathophysiology to clinical applications 细胞外囊泡 RNA 作为心脏代谢疾病介质的新作用：从病理生理学到临床应用

IF 2.5

Current Opinion in Physiology Pub Date : 2024-05-31 DOI: 10.1016/j.cophys.2024.100764

Worawan B Limpitikul , Marta Garcia-Contreras , Saumya Das

{"title":"The emerging role of extracellular vesicle RNAs as mediators of cardiometabolic diseases: from pathophysiology to clinical applications","authors":"Worawan B Limpitikul , Marta Garcia-Contreras , Saumya Das","doi":"10.1016/j.cophys.2024.100764","DOIUrl":"https://doi.org/10.1016/j.cophys.2024.100764","url":null,"abstract":"<div><p>Cardiometabolic diseases (CMDs) are a leading contributor to worldwide morbidity and mortality. Recent insights into the pathogenesis of CMDs reveal crucial roles of intercellular crosstalk between metabolically active organs and cardiac cells. In this context, extracellular vesicles (EVs), lipid membrane-delimited particles containing diverse cargo (including small and long RNAs, proteins, lipids, and metabolites), and nonvesicular extracellular particles (NVEPs) have emerged as key mediators of cell-to-cell communications. EV cargo can reflect the metabolic state of their cells of origin and affect the function of their target cells. Understanding EV cargo content and function is essential for unraveling the pathophysiology of CMDs. This mini-review describes recent studies on EV-mediated local and interorgan crosstalk in CMDs, focusing on those that lead to atrial and ventricular myopathy, which are hallmarks of atrial fibrillation and heart failure, respectively. Lastly, this review discusses the potential applications of EVs in the diagnostics and therapeutics of these CMDs.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"40 ","pages":"Article 100764"},"PeriodicalIF":2.5,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141240112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engineered extracellular vesicles for cancer drug delivery and therapeutics 用于癌症药物输送和治疗的工程电动生物体

IF 2.5

Current Opinion in Physiology Pub Date : 2024-04-23 DOI: 10.1016/j.cophys.2024.100755

Marina Pérez-Capó , Antònia Obrador-Hevia , Diego de Miguel-Perez , Christian Rolfo

引用次数: 0

Functional and potency assays for mesenchymal stromal cell–extracellular vesicles in kidney disease 间充质基质细胞-细胞外囊泡在肾脏疾病中的功能和效力测定

IF 2.5

Current Opinion in Physiology Pub Date : 2024-02-28 DOI: 10.1016/j.cophys.2024.100746

Sergio G. Garcia , Marta Clos-Sansalvador , Marta Sanroque-Muñoz , Linrong Pan , Marcella Franquesa

引用次数: 0

The surface proteomic profile of serum extracellular vesicles as a diagnostic and prognostic tool in breast cancer 作为乳腺癌诊断和预后工具的血清细胞外囊泡表面蛋白质组图谱

IF 2.5

Current Opinion in Physiology Pub Date : 2023-12-12 DOI: 10.1016/j.cophys.2023.100734

Giada Corti , Rene Buchet , Andrea Magrini , Pietro Ciancaglini , Saida Mebarek , Massimo Bottini

{"title":"The surface proteomic profile of serum extracellular vesicles as a diagnostic and prognostic tool in breast cancer","authors":"Giada Corti , Rene Buchet , Andrea Magrini , Pietro Ciancaglini , Saida Mebarek , Massimo Bottini","doi":"10.1016/j.cophys.2023.100734","DOIUrl":"10.1016/j.cophys.2023.100734","url":null,"abstract":"<div><p>The diagnosis of breast cancer in the early stage is essential for a favorable prognosis. Extracellular vesicles isolated from body fluids have a central role in breast cancer development due to their biochemical components. Among the biochemical components, surface proteins mediate vesicle interactions with elements of the extracellular milieu, the extracellular matrix, and neighboring cells. The identification of specific surface proteomic profile has been regarded as an easy and reproducible means to define cancer parameters, identify markers for a diagnosis, and determine targets for therapeutical treatments. In this review, we will focus on annexins, tetraspanins, integrins, immune checkpoint proteins, and growth factor receptors that have been identified on the surface of extracellular vesicles isolated from the serum of patients with breast cancer and that have been found to be relevant diagnostic and prognostic biomarkers.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"37 ","pages":"Article 100734"},"PeriodicalIF":2.5,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867323001050/pdfft?md5=8fa9d5e9fec9ceaa07efb361c2b98d35&pid=1-s2.0-S2468867323001050-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139017764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiac adrenergic receptors and GRKs: mitochondrial modulation in the heart 心脏肾上腺素能受体和 GRKs：心脏线粒体调节

IF 2.5

Current Opinion in Physiology Pub Date : 2023-12-07 DOI: 10.1016/j.cophys.2023.100733

Gizem Kayki-Mutlu, Ebru Arioglu-Inan

{"title":"Cardiac adrenergic receptors and GRKs: mitochondrial modulation in the heart","authors":"Gizem Kayki-Mutlu, Ebru Arioglu-Inan","doi":"10.1016/j.cophys.2023.100733","DOIUrl":"10.1016/j.cophys.2023.100733","url":null,"abstract":"<div><p><span><span>The cellular ‘powerhouse’, mitochondria play vital roles in cardiac cells, including the modulation of contractility. Among the various mechanisms, the modulation of cardiac mitochondria by adrenergic signaling stands out as a crucial component in orchestrating cardiac function. Adrenergic system serving as the primary regulator of </span>cardiac contractility, exerts its effects through α- and ß-adrenoceptors, which are regulated by G-protein-coupled receptor kinase 2 (GRK2) and ß-arrestin. In recent years, it has been revealed that these components of adrenergic signaling interact with mitochondria in diverse ways. α- and ß-adrenoceptors are reported to contribute to </span>mitochondrial biogenesis<span>, dynamics, and function. Besides, GRK2 is known to be localized to mitochondria, following oxidative stress or ischemic injury, and exerts negative metabolic effects. In this review, we outlined the contributions of these pivotal elements of adrenergic signaling to mitochondrial function. The better understanding of this delicate relationship holds crucial implications for novel therapeutic options to treat cardiovascular pathologies.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"37 ","pages":"Article 100733"},"PeriodicalIF":2.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138625464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of endothelial cells in autoimmune rheumatic disease 内皮细胞在自身免疫性风湿病中的作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-12-01 DOI: 10.1016/j.cophys.2023.100732

Medha Kanitkar, Christopher P Denton

{"title":"The role of endothelial cells in autoimmune rheumatic disease","authors":"Medha Kanitkar, Christopher P Denton","doi":"10.1016/j.cophys.2023.100732","DOIUrl":"10.1016/j.cophys.2023.100732","url":null,"abstract":"<div><p>Vasculopathy is a generic feature of autoimmune rheumatic disease and there is substantial evidence that endothelial cell dysfunction has a role in pathogenesis and clinical manifestations of this challenging group of diseases. Endothelial cells (EC) are a target for injury and through their essential functional role in vascular homoeostasis, this has significant impact. In addition, the emerging recognition that EC are important regulators of other cell types and can differentiate into other relevant cell types has direct relevance. These aspects are reviewed with a focus on recent published evidence regarding the importance of EC in development, progression and treatment of autoimmune rheumatic disease. The potential role of the adaptive and innate immune system in causing endothelial cell damage, including anti-endothelial cell autoantibodies, will be reviewed. Recent advances in understanding how EC may differentiate into mesenchymal lineages and the interplay between physiological roles in healing or tissue repair and dysfunctional responses in acquired connective tissue disease will be reviewed.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"37 ","pages":"Article 100732"},"PeriodicalIF":2.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867323001037/pdfft?md5=ac0864dcb763bc6948a89da29e1475ed&pid=1-s2.0-S2468867323001037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure 由β-阿司匹林介导的β-肾上腺素能受体信号转导及其在心力衰竭中的潜在作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-11-18 DOI: 10.1016/j.cophys.2023.100723

Preston C Nibley , Sudha K Shenoy

{"title":"β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure","authors":"Preston C Nibley , Sudha K Shenoy","doi":"10.1016/j.cophys.2023.100723","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100723","url":null,"abstract":"<div><p>The lethality of heart failure, particularly in the context of post-acute sequelae SARS-CoV-2 infection-related myocarditis, necessitates the discovery of the cellular pathways implicated in cardiovascular disease. We summarize the signaling mechanisms of the catecholamine-binding β-adrenergic receptors (β-ARs), with an emphasis on the role of β-arrestins. β-ARs, a subset of G protein-coupled receptors (GPCRs), canonically propagate signals through heterotrimeric G proteins. However, since their discovery in the late 1980s, β-arrestins have been shown to both (i) quench G protein signaling and (ii) initiate their own independent signaling cascades, which is influenced by posttranslational modifications<span>. β-arrestin-biased agonism by the beta-blocker carvedilol and its allosteric modulation can serve a cardioprotective role. The increasingly labyrinthine nature of GPCR signaling suggests that ligand-dependent β-AR signaling, either stimulated by an agonist or blocked by an antagonist, is selectively enhanced or suppressed by allosteric modulations, which are orchestrated by novel drugs or endogenous posttranslational modifications.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"37 ","pages":"Article 100723"},"PeriodicalIF":2.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138548833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenergic signaling in cardiovascular aging 心血管衰老过程中的肾上腺素能信号传导

IF 2.5

Current Opinion in Physiology Pub Date : 2023-11-13 DOI: 10.1016/j.cophys.2023.100722

Ioannis D Kyriazis , Claudio de Lucia

引用次数: 0

Adrenergic receptors in endothelial and vascular smooth muscle cells 内皮细胞和血管平滑肌细胞中的肾上腺素能受体

IF 2.5

Current Opinion in Physiology Pub Date : 2023-10-12 DOI: 10.1016/j.cophys.2023.100721

Jessica Gambardella , Antonella Fiordelisi , Roberta Avvisato , Antonietta Buonaiuto , Federica A Cerasuolo , Daniela Sorriento , Guido Iaccarino

引用次数: 0

The stress connection in cancer: the adrenergic fuelling of breast tumors 癌症中的压力关系:乳腺肿瘤的肾上腺素能燃料

IF 2.5

Current Opinion in Physiology Pub Date : 2023-10-06 DOI: 10.1016/j.cophys.2023.100720

Angela Albitre , Clara Reglero , Teresa González-Muñoz , Petronila Penela

{"title":"The stress connection in cancer: the adrenergic fuelling of breast tumors","authors":"Angela Albitre , Clara Reglero , Teresa González-Muñoz , Petronila Penela","doi":"10.1016/j.cophys.2023.100720","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100720","url":null,"abstract":"<div><p>Cancer progression involves complex interactions between tumor cells and the surrounding microenvironment. Chronic psychosocial stress and sympathetic nervous system activation lead to abnormal catecholamine release, impacting tumor cells directly and indirectly and fuelling cancer-promoting effects. However, the same adrenergic Receptor (AR) that mediate these effects could also convey exercise-related beneficial changes. Epidemiological studies show conflicting associations between stress, AR inhibitors, and breast cancer (BC) metastatic progression. Adrenergic sympathetic stress triggers sustained inflammatory and hypoxic-related signaling pathways, alters function and distribution of immune cell populations, and remodels blood vessels, leading to immunosuppression and premetastatic site formation. Activated AR initiate feedback loops with tyrosine kinase receptors and chemokine receptors, affecting stem-related transcription factors, pro-inflammatory mediators, angiogenic factors, and energy metabolism regulators, promoting tumor growth and invasion. Understanding molecular mechanisms of agonistic and antagonistic AR ligands and crosstalk with other signaling pathways is crucial for developing effective therapies targeting adrenergic-driven BC progression.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"36 ","pages":"Article 100720"},"PeriodicalIF":2.5,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867323000913/pdfft?md5=aed2a106f616954c94deb047200e5e28&pid=1-s2.0-S2468867323000913-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92073581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0