Current Opinion in Physiology最新文献_第2页

Cardiac adrenergic receptors and GRKs: mitochondrial modulation in the heart 心脏肾上腺素能受体和 GRKs：心脏线粒体调节

IF 2.5

Current Opinion in Physiology Pub Date : 2023-12-07 DOI: 10.1016/j.cophys.2023.100733

Gizem Kayki-Mutlu, Ebru Arioglu-Inan

{"title":"Cardiac adrenergic receptors and GRKs: mitochondrial modulation in the heart","authors":"Gizem Kayki-Mutlu, Ebru Arioglu-Inan","doi":"10.1016/j.cophys.2023.100733","DOIUrl":"10.1016/j.cophys.2023.100733","url":null,"abstract":"<div><p><span><span>The cellular ‘powerhouse’, mitochondria play vital roles in cardiac cells, including the modulation of contractility. Among the various mechanisms, the modulation of cardiac mitochondria by adrenergic signaling stands out as a crucial component in orchestrating cardiac function. Adrenergic system serving as the primary regulator of </span>cardiac contractility, exerts its effects through α- and ß-adrenoceptors, which are regulated by G-protein-coupled receptor kinase 2 (GRK2) and ß-arrestin. In recent years, it has been revealed that these components of adrenergic signaling interact with mitochondria in diverse ways. α- and ß-adrenoceptors are reported to contribute to </span>mitochondrial biogenesis<span>, dynamics, and function. Besides, GRK2 is known to be localized to mitochondria, following oxidative stress or ischemic injury, and exerts negative metabolic effects. In this review, we outlined the contributions of these pivotal elements of adrenergic signaling to mitochondrial function. The better understanding of this delicate relationship holds crucial implications for novel therapeutic options to treat cardiovascular pathologies.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"37 ","pages":"Article 100733"},"PeriodicalIF":2.5,"publicationDate":"2023-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138625464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of endothelial cells in autoimmune rheumatic disease 内皮细胞在自身免疫性风湿病中的作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-12-01 DOI: 10.1016/j.cophys.2023.100732

Medha Kanitkar, Christopher P Denton

{"title":"The role of endothelial cells in autoimmune rheumatic disease","authors":"Medha Kanitkar, Christopher P Denton","doi":"10.1016/j.cophys.2023.100732","DOIUrl":"10.1016/j.cophys.2023.100732","url":null,"abstract":"<div><p>Vasculopathy is a generic feature of autoimmune rheumatic disease and there is substantial evidence that endothelial cell dysfunction has a role in pathogenesis and clinical manifestations of this challenging group of diseases. Endothelial cells (EC) are a target for injury and through their essential functional role in vascular homoeostasis, this has significant impact. In addition, the emerging recognition that EC are important regulators of other cell types and can differentiate into other relevant cell types has direct relevance. These aspects are reviewed with a focus on recent published evidence regarding the importance of EC in development, progression and treatment of autoimmune rheumatic disease. The potential role of the adaptive and innate immune system in causing endothelial cell damage, including anti-endothelial cell autoantibodies, will be reviewed. Recent advances in understanding how EC may differentiate into mesenchymal lineages and the interplay between physiological roles in healing or tissue repair and dysfunctional responses in acquired connective tissue disease will be reviewed.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"37 ","pages":"Article 100732"},"PeriodicalIF":2.5,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867323001037/pdfft?md5=ac0864dcb763bc6948a89da29e1475ed&pid=1-s2.0-S2468867323001037-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138621862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure 由β-阿司匹林介导的β-肾上腺素能受体信号转导及其在心力衰竭中的潜在作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-11-18 DOI: 10.1016/j.cophys.2023.100723

Preston C Nibley , Sudha K Shenoy

{"title":"β-adrenergic receptor signaling mediated by β-arrestins and its potential role in heart failure","authors":"Preston C Nibley , Sudha K Shenoy","doi":"10.1016/j.cophys.2023.100723","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100723","url":null,"abstract":"<div><p>The lethality of heart failure, particularly in the context of post-acute sequelae SARS-CoV-2 infection-related myocarditis, necessitates the discovery of the cellular pathways implicated in cardiovascular disease. We summarize the signaling mechanisms of the catecholamine-binding β-adrenergic receptors (β-ARs), with an emphasis on the role of β-arrestins. β-ARs, a subset of G protein-coupled receptors (GPCRs), canonically propagate signals through heterotrimeric G proteins. However, since their discovery in the late 1980s, β-arrestins have been shown to both (i) quench G protein signaling and (ii) initiate their own independent signaling cascades, which is influenced by posttranslational modifications<span>. β-arrestin-biased agonism by the beta-blocker carvedilol and its allosteric modulation can serve a cardioprotective role. The increasingly labyrinthine nature of GPCR signaling suggests that ligand-dependent β-AR signaling, either stimulated by an agonist or blocked by an antagonist, is selectively enhanced or suppressed by allosteric modulations, which are orchestrated by novel drugs or endogenous posttranslational modifications.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"37 ","pages":"Article 100723"},"PeriodicalIF":2.5,"publicationDate":"2023-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138548833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenergic signaling in cardiovascular aging 心血管衰老过程中的肾上腺素能信号传导

IF 2.5

Current Opinion in Physiology Pub Date : 2023-11-13 DOI: 10.1016/j.cophys.2023.100722

Ioannis D Kyriazis , Claudio de Lucia

引用次数: 0

Adrenergic receptors in endothelial and vascular smooth muscle cells 内皮细胞和血管平滑肌细胞中的肾上腺素能受体

IF 2.5

Current Opinion in Physiology Pub Date : 2023-10-12 DOI: 10.1016/j.cophys.2023.100721

Jessica Gambardella , Antonella Fiordelisi , Roberta Avvisato , Antonietta Buonaiuto , Federica A Cerasuolo , Daniela Sorriento , Guido Iaccarino

引用次数: 0

The stress connection in cancer: the adrenergic fuelling of breast tumors 癌症中的压力关系:乳腺肿瘤的肾上腺素能燃料

IF 2.5

Current Opinion in Physiology Pub Date : 2023-10-06 DOI: 10.1016/j.cophys.2023.100720

Angela Albitre , Clara Reglero , Teresa González-Muñoz , Petronila Penela

{"title":"The stress connection in cancer: the adrenergic fuelling of breast tumors","authors":"Angela Albitre , Clara Reglero , Teresa González-Muñoz , Petronila Penela","doi":"10.1016/j.cophys.2023.100720","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100720","url":null,"abstract":"<div><p>Cancer progression involves complex interactions between tumor cells and the surrounding microenvironment. Chronic psychosocial stress and sympathetic nervous system activation lead to abnormal catecholamine release, impacting tumor cells directly and indirectly and fuelling cancer-promoting effects. However, the same adrenergic Receptor (AR) that mediate these effects could also convey exercise-related beneficial changes. Epidemiological studies show conflicting associations between stress, AR inhibitors, and breast cancer (BC) metastatic progression. Adrenergic sympathetic stress triggers sustained inflammatory and hypoxic-related signaling pathways, alters function and distribution of immune cell populations, and remodels blood vessels, leading to immunosuppression and premetastatic site formation. Activated AR initiate feedback loops with tyrosine kinase receptors and chemokine receptors, affecting stem-related transcription factors, pro-inflammatory mediators, angiogenic factors, and energy metabolism regulators, promoting tumor growth and invasion. Understanding molecular mechanisms of agonistic and antagonistic AR ligands and crosstalk with other signaling pathways is crucial for developing effective therapies targeting adrenergic-driven BC progression.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"36 ","pages":"Article 100720"},"PeriodicalIF":2.5,"publicationDate":"2023-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2468867323000913/pdfft?md5=aed2a106f616954c94deb047200e5e28&pid=1-s2.0-S2468867323000913-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92073581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of non-coding RNAs in physiological and pathological angiogenesis 非编码RNA在生理和病理血管生成中的作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-10-01 DOI: 10.1016/j.cophys.2023.100690

Nihay Laham-Karam , Isidore Mushimiyimana , Krista Hokkanen , Seppo Ylä-Herttuala

引用次数: 1

Endothelial cell senescence — understanding aging and disease 内皮细胞衰老——理解衰老与疾病

IF 2.5

Current Opinion in Physiology Pub Date : 2023-10-01 DOI: 10.1016/j.cophys.2023.100702

Paul R Coleman , Ka K Ting , Yanfei Qi , Mathew A Vadas , Jennifer R Gamble

引用次数: 0

Membrane force reception: mechanosensation in G protein-coupled receptors and tools to address it 膜受力：G蛋白偶联受体的机械感觉及其解决方法

IF 2.5

Current Opinion in Physiology Pub Date : 2023-10-01 DOI: 10.1016/j.cophys.2023.100689

Katie Hardman , Adrian Goldman , Christos Pliotas

{"title":"Membrane force reception: mechanosensation in G protein-coupled receptors and tools to address it","authors":"Katie Hardman , Adrian Goldman , Christos Pliotas","doi":"10.1016/j.cophys.2023.100689","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100689","url":null,"abstract":"<div><p>To survive, all organisms must detect and respond to mechanical cues in their environment. Cells are subjected to a plethora of mechanical forces, such as hydrostatic pressure, cell-cell contact, stretch, compression, and shear stress. Mechanosensitive (MS) membrane proteins have evolved across all life kingdoms to sense and respond to forces in the membrane. Bacterial MS ion channels provide a blueprint for understanding the fundamental mechanisms that underpin cellular responses to mechanical signals. Recently, the identification of eukaryotic force transducers, which includes membrane proteins other than channels, has led to the recognition of common structural hallmarks and unified biophysical mechanisms that could potentially link these diverse proteins. Accumulating evidence suggests G protein-coupled receptors (GPCRs) are candidates for pressure sensing in mammals. This review summarises the current knowledge on MS GPCRs, describes the tools used to assess their mechanosensitivity, and aims to highlight the key characteristics that link these receptors to established mechanosensors.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"35 ","pages":"Article 100689"},"PeriodicalIF":2.5,"publicationDate":"2023-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49787173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in coronavirus disease 2019 myocarditis 2019冠状病毒病心肌炎的性别差异

IF 2.5

Current Opinion in Physiology Pub Date : 2023-10-01 DOI: 10.1016/j.cophys.2023.100704

Danielle J Beetler , DeLisa Fairweather

引用次数: 0