Sayam Ghosal , Bernadett R Bodnár , Brachyahu M Kestecher , Ákos Nagy , Tamás László , Bora Yilmaz , Yixuan Zeng , Adrienn Szabó , Csaba Bödör , Edit I Buzás , Xabier Osteikoetxea
{"title":"革命性的治疗方法：释放细胞外囊泡对疾病干预的力量","authors":"Sayam Ghosal , Bernadett R Bodnár , Brachyahu M Kestecher , Ákos Nagy , Tamás László , Bora Yilmaz , Yixuan Zeng , Adrienn Szabó , Csaba Bödör , Edit I Buzás , Xabier Osteikoetxea","doi":"10.1016/j.cophys.2025.100815","DOIUrl":null,"url":null,"abstract":"<div><div>Extracellular vesicles (EVs) have emerged as a significant tool in therapeutic applications, exhibiting low immunogenicity and the ability to traverse biological barriers. EV-based treatments show great potential in various diseases, including oncology, neurodegeneration, and cardiovascular conditions. In cancer research, EVs play a role in tumor growth, spread, and resistance to chemotherapy, with modified EVs showing promise in improving drug delivery to challenging cancers such as glioblastoma. For neurodegeneration, EVs aid in protecting neurons and restoring motor function. Likewise, in cardiovascular diseases, EVs participate in tissue repair and heart protection. The effectiveness of EV-based vaccines, exemplified by a clinically approved meningococcal serogroup B MenB-4C vaccine, further underscores the therapeutic value of this approach. This review examines the progress in EV-based therapeutics and their future potential.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"43 ","pages":"Article 100815"},"PeriodicalIF":2.5000,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Revolutionizing therapeutics: unleashing the power of extracellular vesicles for disease intervention\",\"authors\":\"Sayam Ghosal , Bernadett R Bodnár , Brachyahu M Kestecher , Ákos Nagy , Tamás László , Bora Yilmaz , Yixuan Zeng , Adrienn Szabó , Csaba Bödör , Edit I Buzás , Xabier Osteikoetxea\",\"doi\":\"10.1016/j.cophys.2025.100815\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Extracellular vesicles (EVs) have emerged as a significant tool in therapeutic applications, exhibiting low immunogenicity and the ability to traverse biological barriers. EV-based treatments show great potential in various diseases, including oncology, neurodegeneration, and cardiovascular conditions. In cancer research, EVs play a role in tumor growth, spread, and resistance to chemotherapy, with modified EVs showing promise in improving drug delivery to challenging cancers such as glioblastoma. For neurodegeneration, EVs aid in protecting neurons and restoring motor function. Likewise, in cardiovascular diseases, EVs participate in tissue repair and heart protection. The effectiveness of EV-based vaccines, exemplified by a clinically approved meningococcal serogroup B MenB-4C vaccine, further underscores the therapeutic value of this approach. This review examines the progress in EV-based therapeutics and their future potential.</div></div>\",\"PeriodicalId\":52156,\"journal\":{\"name\":\"Current Opinion in Physiology\",\"volume\":\"43 \",\"pages\":\"Article 100815\"},\"PeriodicalIF\":2.5000,\"publicationDate\":\"2025-01-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Opinion in Physiology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468867325000033\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Physiology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468867325000033","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
Revolutionizing therapeutics: unleashing the power of extracellular vesicles for disease intervention
Extracellular vesicles (EVs) have emerged as a significant tool in therapeutic applications, exhibiting low immunogenicity and the ability to traverse biological barriers. EV-based treatments show great potential in various diseases, including oncology, neurodegeneration, and cardiovascular conditions. In cancer research, EVs play a role in tumor growth, spread, and resistance to chemotherapy, with modified EVs showing promise in improving drug delivery to challenging cancers such as glioblastoma. For neurodegeneration, EVs aid in protecting neurons and restoring motor function. Likewise, in cardiovascular diseases, EVs participate in tissue repair and heart protection. The effectiveness of EV-based vaccines, exemplified by a clinically approved meningococcal serogroup B MenB-4C vaccine, further underscores the therapeutic value of this approach. This review examines the progress in EV-based therapeutics and their future potential.
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