Circadian control of cellular constituent turnover and growth

Abstract

The circadian clock synchronises biological processes with environmental cues, optimising fitness and energy efficiency. Among these, cell growth regulation is a critical yet underexplored area. While primarily linked to rhythmic cell division, cell growth also arises from the cyclic accumulation of cellular components driving volume expansion. This review highlights advances in understanding how the circadian clock regulates the synthesis and degradation of key cellular constituents, particularly RNAs and proteins, in both homeostatic and growing cells. These processes are essential for maintaining cellular homeostasis and supporting tissue development and regeneration. Further exploration of circadian turnover and its integration with cellular growth pathways could pave the way for chronotherapeutic strategies.