The surface proteomic profile of serum extracellular vesicles as a diagnostic and prognostic tool in breast cancer

IF 2.5 Q2 PHYSIOLOGY

Current Opinion in Physiology Pub Date : 2023-12-12 DOI:10.1016/j.cophys.2023.100734

Giada Corti , Rene Buchet , Andrea Magrini , Pietro Ciancaglini , Saida Mebarek , Massimo Bottini

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Abstract

The diagnosis of breast cancer in the early stage is essential for a favorable prognosis. Extracellular vesicles isolated from body fluids have a central role in breast cancer development due to their biochemical components. Among the biochemical components, surface proteins mediate vesicle interactions with elements of the extracellular milieu, the extracellular matrix, and neighboring cells. The identification of specific surface proteomic profile has been regarded as an easy and reproducible means to define cancer parameters, identify markers for a diagnosis, and determine targets for therapeutical treatments. In this review, we will focus on annexins, tetraspanins, integrins, immune checkpoint proteins, and growth factor receptors that have been identified on the surface of extracellular vesicles isolated from the serum of patients with breast cancer and that have been found to be relevant diagnostic and prognostic biomarkers.

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作为乳腺癌诊断和预后工具的血清细胞外囊泡表面蛋白质组图谱

乳腺癌的早期诊断对于获得良好的预后至关重要。从体液中分离出的细胞外囊泡因其生化成分而在乳腺癌的发展中发挥着核心作用。在这些生化成分中，表面蛋白介导了囊泡与细胞外环境、细胞外基质和邻近细胞的相互作用。特异性表面蛋白质组概况的鉴定被认为是定义癌症参数、确定诊断标记和确定治疗目标的一种简便且可重复的方法。在这篇综述中，我们将重点讨论从乳腺癌患者血清中分离出来的细胞外囊泡表面已被鉴定为相关诊断和预后生物标志物的附件蛋白、四泛蛋白、整合素、免疫检查点蛋白和生长因子受体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Physiology Medicine-Physiology (medical)

CiteScore

5.80

自引率

0.00%

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