Adrenergic signaling in cardiovascular aging

Abstract

The average lifespan of humans is increasing worldwide, and the percentage of older adults is substantially growing. The adrenergic system is a crucial determinant for the cardiovascular homeostasis during aging. In this short review, we discuss the new insights that emerged concerning the role of adrenergic receptors and relative signaling in the aging of the heart and vasculature with particular emphasis on molecular mechanisms involved. We also examine specific therapeutic interventions that modulate the adrenergic system feasibly counteracting and delaying age-induced pathophysiological changes in cardiovascular function and structure.