Current Opinion in Physiology最新文献_第5页

Proteostasis and resilience in the mechanically-stressed vascular endothelium 机械应力下血管内皮的蛋白酶抑制和弹性

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100673

Adam Keen, Feiran Zhang, John S Reader, Ellie Tzima

引用次数: 1

Spatiotemporal regulation of Rho GTPase signaling during endothelial barrier remodeling 内皮屏障重构过程中Rho GTPase信号的时空调控

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100676

Jeffrey MA van der Krogt , Ivanka JE van der Meulen , Jaap D van Buul

{"title":"Spatiotemporal regulation of Rho GTPase signaling during endothelial barrier remodeling","authors":"Jeffrey MA van der Krogt , Ivanka JE van der Meulen , Jaap D van Buul","doi":"10.1016/j.cophys.2023.100676","DOIUrl":"10.1016/j.cophys.2023.100676","url":null,"abstract":"<div><p>The vasculature is characterized by a thin cell layer that comprises the inner wall of all blood vessels, the continuous endothelium. Endothelial cells can also be found in the eye’s cornea. And even though cornea and vascular endothelial (VE) cells differ from each other in structure, they both function as barriers and express similar junctional proteins such as the adherens junction VE-cadherin and tight-junction member claudin-5. How these barriers are controlled to maintain the barrier and thereby its integrity is of major interest in the development of potential therapeutic targets. An important target of endothelial barrier remodeling is the actin cytoskeleton, which is centrally coordinated by Rho GTPases that are in turn regulated by Rho-regulatory proteins. In this review, we give a brief overview of how Rho-regulatory proteins themselves are spatiotemporally regulated during the process of endothelial barrier remodeling. Additionally, we propose a roadmap for the comprehensive dissection of the Rho GTPase signaling network in its entirety.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100676"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10398679/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10309317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The role of the endothelium in severe acute respiratory syndrome coronavirus 2 infection and pathogenesis 内皮细胞在严重急性呼吸综合征冠状病毒2型感染和发病机制中的作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100670

Rainha Passi , Mairi Brittan , Andrew H Baker

{"title":"The role of the endothelium in severe acute respiratory syndrome coronavirus 2 infection and pathogenesis","authors":"Rainha Passi , Mairi Brittan , Andrew H Baker","doi":"10.1016/j.cophys.2023.100670","DOIUrl":"10.1016/j.cophys.2023.100670","url":null,"abstract":"<div><p>Endothelial cell (EC) dysfunction is a characteristic complication of coronavirus-19 (COVID-19). This review discusses the role of the endothelium during the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with a focus on different vascular beds, possible routes of infectivity and the impact of EC dysfunction across multiple organ systems. It is now known that COVID-19 disease elicits a distinct transcriptomic and molecular profile that is different to other viral infections, such as Influenza A (H1N1). Interestingly, there is also a suggested interplay between the heart and lungs that promotes the amplification of inflammatory cascades, leading to an exacerbation in disease severity. Multiomic studies have informed common pathways that may be responsible for endothelial activation while also highlighting key differences in COVID-19 pathogenesis between organ systems. At a pathological level, endothelialitis is an endpoint result regardless of either a direct viral infection or via indirect effects independent of infection. Understanding if ECs are directly targeted by SARS-CoV-2 or are collaterally damaged amid a cytokine storm originating from other cells and organs can provide novel insights into disease progression and may highlight possible new therapeutic opportunities targeted at the damaged endothelium.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100670"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9808197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Adipose tissue lymphatic endothelial cells: revisited functions in the modulation of adipose biology 脂肪组织淋巴内皮细胞:在脂肪生物学调节中重新审视功能

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100675

Ibrahim AlZaim , Joseph Festa , Joanna Kalucka

引用次数: 1

Hyperpolarization and the endothelium 超极化与内皮

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100674

Christopher J Garland , Kim A Dora

引用次数: 1

The role of endothelial cells in pulmonary hypertension: old concepts and new science 内皮细胞在肺动脉高压中的作用：旧概念与新科学

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100667

Maike Haensel , Beata Wojciak-Stothard

引用次数: 2

Environmental stressors and the endothelium 环境压力源与内皮

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100677

Thomas Münzel , Marin Kuntic , Andreas Daiber

{"title":"Environmental stressors and the endothelium","authors":"Thomas Münzel , Marin Kuntic , Andreas Daiber","doi":"10.1016/j.cophys.2023.100677","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100677","url":null,"abstract":"<div><p>Dysfunction of the endothelium, a monolayer of cells in the lumen of all vessels, is found near-universally in the context of cardiovascular risk factors and diseases (CVD). Because of its crucial role in regulating vascular tone, hemostatic functions, inflammation, adhesion, and platelet activity, normalizing endothelial function is an attractive target in therapeutic approaches to CVD with prognostic implications. We will review the mechanisms leading to endothelial dysfunction in response to traditional and novel cardiovascular risk factors noise and air pollution with focus on oxidative stress and inflammation. A cardiac and vasoactive medication might attenuate vascular dysfunction based on the pathophysiology leading to the environment-induced endothelial dysfunction. The most promising approach, however, represents reductions of particulate matter with a diameter ≤2.5µm (PM<sub>2.5</sub>) concentrations via improvements in air quality and marked reductions in transportation noise day and night levels as indicated by the World Health Organization (WHO), thereby markedly reducing the cardiovascular burden induced by noise and air pollution.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100677"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noncoding RNAs: a new frontier in regulation of exercise-induced physiological cardiac hypertrophy 非编码RNA：运动性生理性心肌肥大调控的新前沿

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100653

Lijun Wang , Xuan Zhao , Yi Lu , Junjie Xiao

引用次数: 0

Cardiovascular disease and feminizing gender-affirming hormone therapy: implications for the provision of safe and lifesaving care 心血管疾病和女性化的性别肯定激素治疗:对提供安全和救生护理的影响

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100650

Abby M Pribish , Sean J Iwamoto

{"title":"Cardiovascular disease and feminizing gender-affirming hormone therapy: implications for the provision of safe and lifesaving care","authors":"Abby M Pribish , Sean J Iwamoto","doi":"10.1016/j.cophys.2023.100650","DOIUrl":"10.1016/j.cophys.2023.100650","url":null,"abstract":"<div><p>Sex recorded at birth, gender identity, and feminizing gender-affirming hormone therapy (fGAHT) likely contribute to cardiovascular disease (CVD) risk in transgender women. Understanding the interplay of these factors is necessary for the provision of safe, affirming, and lifesaving care. Among transgender women taking fGAHT, data show increases in CVD mortality and rates of myocardial infarction, stroke, and venous thromboembolism compared to reference populations, depending on study design and comparators. However, most studies are observational with a paucity of contextualizing information (e.g. dosing, route of administration, gonadectomy status), which makes it difficult to parse adverse fGAHT effects from confounders and interaction with known CVD risk factors (e.g. obesity, smoking, psychosocial and gender minority stressors). Increased CVD risk in transgender women points toward a need for greater attention to CVD management in this population including cardiology referral when indicated and additional research on the mechanisms and mediators of CVD risk.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100650"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9635267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MicroRNAs regulating pathophysiological processes in obesity: the impact of exercise training 调节肥胖病理生理过程的微小RNA：运动训练的影响

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100648

Alex C Improta-Caria, Úrsula PR Soci, Luis F Rodrigues, Tiago Fernandes, Edilamar M Oliveira

引用次数: 1