Current Opinion in Physiology最新文献_第6页

Noncoding RNAs: a new frontier in regulation of exercise-induced physiological cardiac hypertrophy 非编码RNA：运动性生理性心肌肥大调控的新前沿

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100653

Lijun Wang , Xuan Zhao , Yi Lu , Junjie Xiao

引用次数: 0

Cardiovascular disease and feminizing gender-affirming hormone therapy: implications for the provision of safe and lifesaving care 心血管疾病和女性化的性别肯定激素治疗:对提供安全和救生护理的影响

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100650

Abby M Pribish , Sean J Iwamoto

{"title":"Cardiovascular disease and feminizing gender-affirming hormone therapy: implications for the provision of safe and lifesaving care","authors":"Abby M Pribish , Sean J Iwamoto","doi":"10.1016/j.cophys.2023.100650","DOIUrl":"10.1016/j.cophys.2023.100650","url":null,"abstract":"<div><p>Sex recorded at birth, gender identity, and feminizing gender-affirming hormone therapy (fGAHT) likely contribute to cardiovascular disease (CVD) risk in transgender women. Understanding the interplay of these factors is necessary for the provision of safe, affirming, and lifesaving care. Among transgender women taking fGAHT, data show increases in CVD mortality and rates of myocardial infarction, stroke, and venous thromboembolism compared to reference populations, depending on study design and comparators. However, most studies are observational with a paucity of contextualizing information (e.g. dosing, route of administration, gonadectomy status), which makes it difficult to parse adverse fGAHT effects from confounders and interaction with known CVD risk factors (e.g. obesity, smoking, psychosocial and gender minority stressors). Increased CVD risk in transgender women points toward a need for greater attention to CVD management in this population including cardiology referral when indicated and additional research on the mechanisms and mediators of CVD risk.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100650"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9635267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MicroRNAs regulating pathophysiological processes in obesity: the impact of exercise training 调节肥胖病理生理过程的微小RNA：运动训练的影响

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100648

Alex C Improta-Caria, Úrsula PR Soci, Luis F Rodrigues, Tiago Fernandes, Edilamar M Oliveira

引用次数: 1

Dynamics of exercise training and detraining induced cardiac adaptations 运动训练动力学和去训练诱导的心脏适应

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100657

Attila Oláh, Alex A Sayour, Mihály Ruppert, Bálint A Barta, Béla Merkely, Attila Kovács, Tamás Radovits

{"title":"Dynamics of exercise training and detraining induced cardiac adaptations","authors":"Attila Oláh, Alex A Sayour, Mihály Ruppert, Bálint A Barta, Béla Merkely, Attila Kovács, Tamás Radovits","doi":"10.1016/j.cophys.2023.100657","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100657","url":null,"abstract":"<div><p>The effect of regular physical activity has been provided by numerous investigations in cardiology: both its role in primary and secondary cardiovascular prevention, as well as exercise-induced cardiac hypertrophy in athletes have already been well characterized. In this short review, we would summarize the rate of development and regression of the cardiac adaptations induced by long-term, regular training and its cessation. While most of the cross-sectional studies in sports cardiology compared athletes to healthy controls, we investigated longitudinal follow-up studies, those also have baseline data before regular exercise and/or detraining period. Intense exercise training induces significant improvement in functional characteristics after approximately two weeks, while the first marked alterations in sinus bradycardia<span> and left ventricular (LV) hypertrophy have been observed after two months of regular physical activity. Similar tendency with some earlier reports of morphological alterations has been observed in small animal studies. Both human and experimental data imply rapid morphological, functional, and electrical regression after cessation of exercise stimulus. These information suggest that exercise-associated cardiac functional improvements (early diastolic filling, maximal oxygen uptake) of the heart manifests earlier than the morphological and electrical alterations. The increased functional properties might be the primer alteration while the morphological and electrical adaptation might be a secondary consequence of the regular hemodynamic overload of the heart and systemic circulation. The regression of exercise-induced alterations seems to be an accelerated process compared to its development.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100657"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in healthspan and lifespan responses to geroprotective dietary interventions in preclinical models 临床前模型中性别差异对性别保护性饮食干预的健康寿命和寿命反应

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100651

Michael R MacArthur , Sarah J Mitchell

引用次数: 0

Exercising heart failure patients: cardiac protection through preservation of mitochondrial function and substrate utilization? 锻炼心力衰竭患者：通过保护线粒体功能和底物利用来保护心脏？

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100656

Kirsten T Nijholt , Suzanne N Voorrips , Pablo I Sánchez-Aguilera, Berend Daan Westenbrink

{"title":"Exercising heart failure patients: cardiac protection through preservation of mitochondrial function and substrate utilization?","authors":"Kirsten T Nijholt , Suzanne N Voorrips , Pablo I Sánchez-Aguilera, Berend Daan Westenbrink","doi":"10.1016/j.cophys.2023.100656","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100656","url":null,"abstract":"<div><p>Current heart failure (HF) therapy remains unable to substantially improve exercise capacity. Studies have shown that exercise training has beneficial effects on the heart in both health and disease. How mitochondria respond to exercise in this setting has, however, received less attention in literature. These beneficial effects may include protective changes in mitochondrial function and adaptations in substrate utilization. This review describes exercise-induced changes in cardiac metabolism, including changes in mitochondrial function and substrate utilization and their effects on cardiac function. We conclude that exercising HF patients can improve mitochondrial function and optimize substrate utilization, eventually improving or restoring cardiac function. This suggests that exercise itself should be incorporated in the HF treatment plan, to improve cardiac function and in term exercise capacity. Extending knowledge on mechanisms by which exercise exerts protective effects could potentially lead to development of therapies directed at improving mitochondrial function and substrate utilization in HF.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100656"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The genetic basis of exercise and cardiorespiratory fitness – relation to cardiovascular disease 运动和心肺健康的遗传基础——与心血管疾病的关系

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100649

Marie Klevjer , Ada N Nordeidet , Anja Bye

引用次数: 3

Sex-biased and sex hormone-dependent regulation of apolipoprotein A1 载脂蛋白A1的性别偏向性和性激素依赖性调控

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100654

Anja Angelov , Paul J Connelly , Christian Delles , Georgios Kararigas

{"title":"Sex-biased and sex hormone-dependent regulation of apolipoprotein A1","authors":"Anja Angelov , Paul J Connelly , Christian Delles , Georgios Kararigas","doi":"10.1016/j.cophys.2023.100654","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100654","url":null,"abstract":"<div><p><span><span>Pronounced sex differences in the development and outcome of cardiovascular diseases (CVD) exist. Apolipoprotein A1 (APOA1), the basic </span>structural protein of high-density lipoprotein (HDL), is involved in key metabolic processes. However, its role in the pathogenesis of CVD is incompletely understood. The effects of biological sex on factors influencing the APOA1-lipid balance and the underlying mechanisms are also poorly understood. Here, we summarize evidence supporting sex-biased and sex hormone-dependent regulation of APOA1. In particular, we discuss sex-biased </span><em>APOA1</em> genetic variation, sex differences in APOA1 regulation and cardiovascular physiology, and sex hormone-dependent regulation of APOA1 in cis- and transgender individuals. We put forward that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. Importantly, in situations of sex hormone therapy or inhibition, more sex-stratified data are required to inform clinical management of APOA1-related cardiovascular risk in a sex-dependent manner.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100654"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular and renal mechanisms of preeclampsia 子痫前期的血管和肾脏机制

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100655

Xi Wang , Corbin A Shields , Ubong Ekperikpe , Lorena M Amaral , Jan M Williams , Denise C Cornelius

引用次数: 1

The respiratory physiology of exercise: age and sex considerations 运动的呼吸生理：年龄和性别因素

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100652

Michael G Leahy , Shalaya Kipp, Andrew William Sheel

引用次数: 0