Current Opinion in Physiology最新文献_第6页

The role of the endothelium in severe acute respiratory syndrome coronavirus 2 infection and pathogenesis 内皮细胞在严重急性呼吸综合征冠状病毒2型感染和发病机制中的作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100670

Rainha Passi , Mairi Brittan , Andrew H Baker

{"title":"The role of the endothelium in severe acute respiratory syndrome coronavirus 2 infection and pathogenesis","authors":"Rainha Passi , Mairi Brittan , Andrew H Baker","doi":"10.1016/j.cophys.2023.100670","DOIUrl":"10.1016/j.cophys.2023.100670","url":null,"abstract":"<div><p>Endothelial cell (EC) dysfunction is a characteristic complication of coronavirus-19 (COVID-19). This review discusses the role of the endothelium during the pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), with a focus on different vascular beds, possible routes of infectivity and the impact of EC dysfunction across multiple organ systems. It is now known that COVID-19 disease elicits a distinct transcriptomic and molecular profile that is different to other viral infections, such as Influenza A (H1N1). Interestingly, there is also a suggested interplay between the heart and lungs that promotes the amplification of inflammatory cascades, leading to an exacerbation in disease severity. Multiomic studies have informed common pathways that may be responsible for endothelial activation while also highlighting key differences in COVID-19 pathogenesis between organ systems. At a pathological level, endothelialitis is an endpoint result regardless of either a direct viral infection or via indirect effects independent of infection. Understanding if ECs are directly targeted by SARS-CoV-2 or are collaterally damaged amid a cytokine storm originating from other cells and organs can provide novel insights into disease progression and may highlight possible new therapeutic opportunities targeted at the damaged endothelium.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100670"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10066588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9808197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Adipose tissue lymphatic endothelial cells: revisited functions in the modulation of adipose biology 脂肪组织淋巴内皮细胞:在脂肪生物学调节中重新审视功能

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100675

Ibrahim AlZaim , Joseph Festa , Joanna Kalucka

引用次数: 1

Hyperpolarization and the endothelium 超极化与内皮

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100674

Christopher J Garland , Kim A Dora

引用次数: 1

The role of endothelial cells in pulmonary hypertension: old concepts and new science 内皮细胞在肺动脉高压中的作用：旧概念与新科学

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100667

Maike Haensel , Beata Wojciak-Stothard

引用次数: 2

Environmental stressors and the endothelium 环境压力源与内皮

IF 2.5

Current Opinion in Physiology Pub Date : 2023-08-01 DOI: 10.1016/j.cophys.2023.100677

Thomas Münzel , Marin Kuntic , Andreas Daiber

{"title":"Environmental stressors and the endothelium","authors":"Thomas Münzel , Marin Kuntic , Andreas Daiber","doi":"10.1016/j.cophys.2023.100677","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100677","url":null,"abstract":"<div><p>Dysfunction of the endothelium, a monolayer of cells in the lumen of all vessels, is found near-universally in the context of cardiovascular risk factors and diseases (CVD). Because of its crucial role in regulating vascular tone, hemostatic functions, inflammation, adhesion, and platelet activity, normalizing endothelial function is an attractive target in therapeutic approaches to CVD with prognostic implications. We will review the mechanisms leading to endothelial dysfunction in response to traditional and novel cardiovascular risk factors noise and air pollution with focus on oxidative stress and inflammation. A cardiac and vasoactive medication might attenuate vascular dysfunction based on the pathophysiology leading to the environment-induced endothelial dysfunction. The most promising approach, however, represents reductions of particulate matter with a diameter ≤2.5µm (PM<sub>2.5</sub>) concentrations via improvements in air quality and marked reductions in transportation noise day and night levels as indicated by the World Health Organization (WHO), thereby markedly reducing the cardiovascular burden induced by noise and air pollution.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"34 ","pages":"Article 100677"},"PeriodicalIF":2.5,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49816143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Noncoding RNAs: a new frontier in regulation of exercise-induced physiological cardiac hypertrophy 非编码RNA：运动性生理性心肌肥大调控的新前沿

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100653

Lijun Wang , Xuan Zhao , Yi Lu , Junjie Xiao

引用次数: 0

Cardiovascular disease and feminizing gender-affirming hormone therapy: implications for the provision of safe and lifesaving care 心血管疾病和女性化的性别肯定激素治疗:对提供安全和救生护理的影响

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100650

Abby M Pribish , Sean J Iwamoto

{"title":"Cardiovascular disease and feminizing gender-affirming hormone therapy: implications for the provision of safe and lifesaving care","authors":"Abby M Pribish , Sean J Iwamoto","doi":"10.1016/j.cophys.2023.100650","DOIUrl":"10.1016/j.cophys.2023.100650","url":null,"abstract":"<div><p>Sex recorded at birth, gender identity, and feminizing gender-affirming hormone therapy (fGAHT) likely contribute to cardiovascular disease (CVD) risk in transgender women. Understanding the interplay of these factors is necessary for the provision of safe, affirming, and lifesaving care. Among transgender women taking fGAHT, data show increases in CVD mortality and rates of myocardial infarction, stroke, and venous thromboembolism compared to reference populations, depending on study design and comparators. However, most studies are observational with a paucity of contextualizing information (e.g. dosing, route of administration, gonadectomy status), which makes it difficult to parse adverse fGAHT effects from confounders and interaction with known CVD risk factors (e.g. obesity, smoking, psychosocial and gender minority stressors). Increased CVD risk in transgender women points toward a need for greater attention to CVD management in this population including cardiology referral when indicated and additional research on the mechanisms and mediators of CVD risk.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100650"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10035588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9635267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

MicroRNAs regulating pathophysiological processes in obesity: the impact of exercise training 调节肥胖病理生理过程的微小RNA：运动训练的影响

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100648

Alex C Improta-Caria, Úrsula PR Soci, Luis F Rodrigues, Tiago Fernandes, Edilamar M Oliveira

引用次数: 1

Dynamics of exercise training and detraining induced cardiac adaptations 运动训练动力学和去训练诱导的心脏适应

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100657

Attila Oláh, Alex A Sayour, Mihály Ruppert, Bálint A Barta, Béla Merkely, Attila Kovács, Tamás Radovits

{"title":"Dynamics of exercise training and detraining induced cardiac adaptations","authors":"Attila Oláh, Alex A Sayour, Mihály Ruppert, Bálint A Barta, Béla Merkely, Attila Kovács, Tamás Radovits","doi":"10.1016/j.cophys.2023.100657","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100657","url":null,"abstract":"<div><p>The effect of regular physical activity has been provided by numerous investigations in cardiology: both its role in primary and secondary cardiovascular prevention, as well as exercise-induced cardiac hypertrophy in athletes have already been well characterized. In this short review, we would summarize the rate of development and regression of the cardiac adaptations induced by long-term, regular training and its cessation. While most of the cross-sectional studies in sports cardiology compared athletes to healthy controls, we investigated longitudinal follow-up studies, those also have baseline data before regular exercise and/or detraining period. Intense exercise training induces significant improvement in functional characteristics after approximately two weeks, while the first marked alterations in sinus bradycardia<span> and left ventricular (LV) hypertrophy have been observed after two months of regular physical activity. Similar tendency with some earlier reports of morphological alterations has been observed in small animal studies. Both human and experimental data imply rapid morphological, functional, and electrical regression after cessation of exercise stimulus. These information suggest that exercise-associated cardiac functional improvements (early diastolic filling, maximal oxygen uptake) of the heart manifests earlier than the morphological and electrical alterations. The increased functional properties might be the primer alteration while the morphological and electrical adaptation might be a secondary consequence of the regular hemodynamic overload of the heart and systemic circulation. The regression of exercise-induced alterations seems to be an accelerated process compared to its development.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"33 ","pages":"Article 100657"},"PeriodicalIF":2.5,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49817091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex differences in healthspan and lifespan responses to geroprotective dietary interventions in preclinical models 临床前模型中性别差异对性别保护性饮食干预的健康寿命和寿命反应

IF 2.5

Current Opinion in Physiology Pub Date : 2023-06-01 DOI: 10.1016/j.cophys.2023.100651

Michael R MacArthur , Sarah J Mitchell

引用次数: 0