Current Opinion in Physiology最新文献_第7页

Lipids regulated by exercise and phosphoinositide 3-kinase: potential role as biomarkers and therapeutic targets for cardiovascular disease 运动和磷酸肌醇3-激酶调节的脂质：作为心血管疾病生物标志物和治疗靶点的潜在作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100633

Teleah G Belkin , Yow Keat Tham , Julie R McMullen

{"title":"Lipids regulated by exercise and phosphoinositide 3-kinase: potential role as biomarkers and therapeutic targets for cardiovascular disease","authors":"Teleah G Belkin , Yow Keat Tham , Julie R McMullen","doi":"10.1016/j.cophys.2023.100633","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100633","url":null,"abstract":"<div><p><span>Lipids are organic biomolecules that provide structural support to cells, but are also important for energy storage and signaling. Lipid profiling has emerged as a new technology with the potential of identifying new biomarkers and therapeutic targets. The </span>lipid composition<span> of cardiomyocyte membranes is altered during the process of cardiac remodeling, including exercise-induced heart enlargement (physiological cardiac hypertrophy) and disease-induced pathological remodeling. Phosphoinositide 3-kinase (PI3K) is an essential regulator of exercise-induced physiological hypertrophy and mediator of cardioprotection in cardiac stress settings. In this review, we first briefly summarize the protective role of exercise and PI3K on the heart. Next, we describe the regulation of lipids in the heart and circulation by exercise or transgenic expression of PI3K (increased or decreased), and contrast this to cardiac disease settings. We also describe studies in which exercise or PI3K-regulated lipids have been associated with cardiorespiratory fitness or cardioprotection, and discuss potential clinical applications.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"32 ","pages":"Article 100633"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49818093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial overview: Multiscale and integrative regulators of cardiac muscle and matrix remodeling 编辑综述：心肌和基质重塑的多尺度综合调节因子

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100645

Jennifer Davis, Timothy A McKinsey

引用次数: 0

Interplay between exercise, circadian rhythm, and cardiac metabolism and remodeling 运动、昼夜节律、心脏代谢和重塑之间的相互作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100643

Kyle Fulghum , Bradford G Hill

引用次数: 0

Mechanoelectrical transduction-related genetic forms of hearing loss 与机电转导相关的听力损失遗传形式

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100632

Jinsei Jung , Ulrich Müller

引用次数: 0

Exercise and calcium in the heart 运动与心脏中的钙

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100644

Ole J Kemi

{"title":"Exercise and calcium in the heart","authors":"Ole J Kemi","doi":"10.1016/j.cophys.2023.100644","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100644","url":null,"abstract":"<div><p>Cardiomyocyte Ca<sup>2+</sup> dictates cardiac contraction via excitation–contraction coupling (ECC) and excitation–transcription coupling. Adaptation to these processes also majorly contributes to enhanced contractile function and capacity following exercise training. Cytoplasmic Ca<sup>2+</sup> release controls sarcomeric contraction, with important modulation by the voltage-sensitive plasma membrane <span>L</span>-type Ca<sup>2+</sup> channel and the Ryanodine receptor, as well as the sarcoplasmic reticulum Ca<sup>2+</sup> ATPase. Exercise training increases and enhances these ECC subprocesses, in a manner that increases and enhances cardiac contraction. Also, adaptation to exercise training further includes myofilament Ca<sup>2+</sup> sensitization. Then, there are several aspects linked to postexercise training cardiomyocyte Ca<sup>2+</sup> handling that remains speculative and inconclusive, but could if proven true to be of special importance. This includes Ca<sup>2+</sup>-linked muscle-specific gene transcription to alter cell architecture and size, and it includes the scenario whereby Ca<sup>2+</sup> cycling and adaptations may alter arrhythmogenicity. These aspects of cardiac Ca<sup>2+</sup> adaptations to exercise training are discussed in this review article.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"32 ","pages":"Article 100644"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49818098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exerkines: opening the way to protecting ischemic heart 运动素:开辟缺血性心脏保护之路

IF 2.5

Current Opinion in Physiology Pub Date : 2023-02-01 DOI: 10.1016/j.cophys.2022.100615

Lili Feng , Bowen Li , Zhenjun Tian

引用次数: 1

Cardiac troponin release in athletes: what do we know and where should we go? 运动员心肌肌钙蛋白释放:我们知道什么，我们应该去哪里?

IF 2.5

Current Opinion in Physiology Pub Date : 2023-02-01 DOI: 10.1016/j.cophys.2022.100629

Sylvan LJE Janssen , Kristian Berge , Tom Luiken , Vincent L Aengevaeren , Thijs MH Eijsvogels

{"title":"Cardiac troponin release in athletes: what do we know and where should we go?","authors":"Sylvan LJE Janssen , Kristian Berge , Tom Luiken , Vincent L Aengevaeren , Thijs MH Eijsvogels","doi":"10.1016/j.cophys.2022.100629","DOIUrl":"https://doi.org/10.1016/j.cophys.2022.100629","url":null,"abstract":"<div><p>Cardiac troponins (cTn) are proteins that regulate cardiomyocyte contraction. A rise and fall of cTn above the upper reference limit is diagnostic of myocardial injury. Therefore, cTn measurements are part of the routine workup when suspecting acute coronary syndromes.</p><p>Exercise can also produce cTn elevations. Many studies in the last three decades have advanced our understanding of exercise-induced cTn release. Beyond technical improvements in cTn assays, various predictors of cTn release have been identified, whereas insight into exercise-induced cTn release patterns and its clinical implications have been improved. Whether cTn release in athletes represents a physiological or pathological response remains a topic of debate. This review summarizes our current understanding of exercise-induced cTn release and provides directions for future studies. We address how to 1) discriminate physiological versus pathological cTn release, 2) unravel the underlying mechanisms of exercise-induced cTn release, and 3) determine whether exercise-induced cTn elevation is a novel cardiovascular risk factor.</p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"31 ","pages":"Article 100629"},"PeriodicalIF":2.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49861716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Advances and recent insights into the gating mechanisms of the mechanically activated ion channels PIEZO1 and PIEZO2 机械活化离子通道PIEZO1和PIEZO2的门控机制的进展和最新见解

IF 2.5

Current Opinion in Physiology Pub Date : 2023-02-01 DOI: 10.1016/j.cophys.2022.100625

Clement Verkest, Stefan G Lechner

{"title":"Advances and recent insights into the gating mechanisms of the mechanically activated ion channels PIEZO1 and PIEZO2","authors":"Clement Verkest, Stefan G Lechner","doi":"10.1016/j.cophys.2022.100625","DOIUrl":"https://doi.org/10.1016/j.cophys.2022.100625","url":null,"abstract":"<div><p><span>PIEZO1 and PIEZO2 are mechanically gated ion channels that confer mechanosensitivity to a variety of cell types and are thus essential for numerous </span>physiological processes<span>, including touch, pain, blood-pressure regulation, cell migration, or immune function. Recently published cryo-electron microscopy structures of PIEZO1 and PIEZO2 have enabled the structure-guided examination of PIEZO channel function, which has significantly improved our understanding of the cellular and molecular mechanisms underlying the mechanogating of PIEZOs. Here, we summarize evidence suggesting that forces acting in and on cells are transmitted to PIEZOs via both membrane tension (force-from-lipids) and by cytoskeletal strain (force-from-filament) and propose that the two force-transmission pathways act in parallel or synergistically to activate PIEZOs. Moreover, we discuss the role of different protein domains in the detection of mechanical forces from different origins and propose that PIEZOs are polymodal mechanosensors that detect different types of mechanical stimuli via different intramolecular force-coupling mechanisms.</span></p></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"31 ","pages":"Article 100625"},"PeriodicalIF":2.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49773930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Feeling the tension: the bacterial mechanosensitive channel of large conductance as a model system and drug target 感受张力:以大电导的细菌机械敏感通道为模型系统和药物靶点

IF 2.5

Current Opinion in Physiology Pub Date : 2023-02-01 DOI: 10.1016/j.cophys.2022.100627

Junmei Wang , Paul Blount

引用次数: 2

Exercise-induced intertissue communication: adipose tissue and the heart 运动诱导的组织间通讯:脂肪组织和心脏

IF 2.5

Current Opinion in Physiology Pub Date : 2023-02-01 DOI: 10.1016/j.cophys.2022.100626

Jade A Blackwell , Kristin I Stanford

引用次数: 1