Current Opinion in Physiology最新文献_第7页

Autophagy at the synapse, an early site of dysfunction in neurodegeneration 突触的自噬，神经退行性疾病的早期功能障碍

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100631

Hilary Grosso Jasutkar , Ai Yamamoto

引用次数: 0

Editorial overview: Autophagy editorial COPHYS special Issue 编辑综述：自噬编辑COPHYS特刊

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100646

Noboru Mizushima, Anne Simonsen

引用次数: 0

Growth restriction in preeclampsia: lessons from animal models 子痫前期的生长限制:来自动物模型的教训

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100647

Jordan H Mallette, Breland F Crudup, Barbara T Alexander

引用次数: 1

Lipids regulated by exercise and phosphoinositide 3-kinase: potential role as biomarkers and therapeutic targets for cardiovascular disease 运动和磷酸肌醇3-激酶调节的脂质：作为心血管疾病生物标志物和治疗靶点的潜在作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100633

Teleah G Belkin , Yow Keat Tham , Julie R McMullen

{"title":"Lipids regulated by exercise and phosphoinositide 3-kinase: potential role as biomarkers and therapeutic targets for cardiovascular disease","authors":"Teleah G Belkin , Yow Keat Tham , Julie R McMullen","doi":"10.1016/j.cophys.2023.100633","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100633","url":null,"abstract":"<div>Lipids are organic biomolecules that provide structural support to cells, but are also important for energy storage and signaling. Lipid profiling has emerged as a new technology with the potential of identifying new biomarkers and therapeutic targets. The lipid composition of cardiomyocyte membranes is altered during the process of cardiac remodeling, including exercise-induced heart enlargement (physiological cardiac hypertrophy) and disease-induced pathological remodeling. Phosphoinositide 3-kinase (PI3K) is an essential regulator of exercise-induced physiological hypertrophy and mediator of cardioprotection in cardiac stress settings. In this review, we first briefly summarize the protective role of exercise and PI3K on the heart. Next, we describe the regulation of lipids in the heart and circulation by exercise or transgenic expression of PI3K (increased or decreased), and contrast this to cardiac disease settings. We also describe studies in which exercise or PI3K-regulated lipids have been associated with cardiorespiratory fitness or cardioprotection, and discuss potential clinical applications.</div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"32 ","pages":"Article 100633"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49818093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial overview: Multiscale and integrative regulators of cardiac muscle and matrix remodeling 编辑综述：心肌和基质重塑的多尺度综合调节因子

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100645

Jennifer Davis, Timothy A McKinsey

引用次数: 0

Interplay between exercise, circadian rhythm, and cardiac metabolism and remodeling 运动、昼夜节律、心脏代谢和重塑之间的相互作用

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100643

Kyle Fulghum , Bradford G Hill

引用次数: 0

Mechanoelectrical transduction-related genetic forms of hearing loss 与机电转导相关的听力损失遗传形式

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100632

Jinsei Jung , Ulrich Müller

引用次数: 0

Exercise and calcium in the heart 运动与心脏中的钙

IF 2.5

Current Opinion in Physiology Pub Date : 2023-04-01 DOI: 10.1016/j.cophys.2023.100644

Ole J Kemi

{"title":"Exercise and calcium in the heart","authors":"Ole J Kemi","doi":"10.1016/j.cophys.2023.100644","DOIUrl":"https://doi.org/10.1016/j.cophys.2023.100644","url":null,"abstract":"<div>Cardiomyocyte Ca2+ dictates cardiac contraction via excitation–contraction coupling (ECC) and excitation–transcription coupling. Adaptation to these processes also majorly contributes to enhanced contractile function and capacity following exercise training. Cytoplasmic Ca2+ release controls sarcomeric contraction, with important modulation by the voltage-sensitive plasma membrane L-type Ca2+ channel and the Ryanodine receptor, as well as the sarcoplasmic reticulum Ca2+ ATPase. Exercise training increases and enhances these ECC subprocesses, in a manner that increases and enhances cardiac contraction. Also, adaptation to exercise training further includes myofilament Ca2+ sensitization. Then, there are several aspects linked to postexercise training cardiomyocyte Ca2+ handling that remains speculative and inconclusive, but could if proven true to be of special importance. This includes Ca2+-linked muscle-specific gene transcription to alter cell architecture and size, and it includes the scenario whereby Ca2+ cycling and adaptations may alter arrhythmogenicity. These aspects of cardiac Ca2+ adaptations to exercise training are discussed in this review article.</div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"32 ","pages":"Article 100644"},"PeriodicalIF":2.5,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49818098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exerkines: opening the way to protecting ischemic heart 运动素:开辟缺血性心脏保护之路

IF 2.5

Current Opinion in Physiology Pub Date : 2023-02-01 DOI: 10.1016/j.cophys.2022.100615

Lili Feng , Bowen Li , Zhenjun Tian

引用次数: 1

Cardiac troponin release in athletes: what do we know and where should we go? 运动员心肌肌钙蛋白释放:我们知道什么，我们应该去哪里?

IF 2.5

Current Opinion in Physiology Pub Date : 2023-02-01 DOI: 10.1016/j.cophys.2022.100629

Sylvan LJE Janssen , Kristian Berge , Tom Luiken , Vincent L Aengevaeren , Thijs MH Eijsvogels

{"title":"Cardiac troponin release in athletes: what do we know and where should we go?","authors":"Sylvan LJE Janssen , Kristian Berge , Tom Luiken , Vincent L Aengevaeren , Thijs MH Eijsvogels","doi":"10.1016/j.cophys.2022.100629","DOIUrl":"https://doi.org/10.1016/j.cophys.2022.100629","url":null,"abstract":"<div>Cardiac troponins (cTn) are proteins that regulate cardiomyocyte contraction. A rise and fall of cTn above the upper reference limit is diagnostic of myocardial injury. Therefore, cTn measurements are part of the routine workup when suspecting acute coronary syndromes.Exercise can also produce cTn elevations. Many studies in the last three decades have advanced our understanding of exercise-induced cTn release. Beyond technical improvements in cTn assays, various predictors of cTn release have been identified, whereas insight into exercise-induced cTn release patterns and its clinical implications have been improved. Whether cTn release in athletes represents a physiological or pathological response remains a topic of debate. This review summarizes our current understanding of exercise-induced cTn release and provides directions for future studies. We address how to 1) discriminate physiological versus pathological cTn release, 2) unravel the underlying mechanisms of exercise-induced cTn release, and 3) determine whether exercise-induced cTn elevation is a novel cardiovascular risk factor.</div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"31 ","pages":"Article 100629"},"PeriodicalIF":2.5,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49861716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4