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Circadian rhythms in metabolism and mental health: a reciprocal regulatory network with implications for metabolic and neuropsychiatric disorders 代谢和心理健康中的昼夜节律：一个与代谢和神经精神疾病相关的互惠调节网络
IF 2.5
Current Opinion in Physiology Pub Date : 2025-09-01 Epub Date: 2025-06-02 DOI: 10.1016/j.cophys.2025.100836
Matthew Lloyd , Brooke A Prakash , Lucy Zhao, Guohao Ni, Yining Ru, Sridhar R Vasudevan
{"title":"Circadian rhythms in metabolism and mental health: a reciprocal regulatory network with implications for metabolic and neuropsychiatric disorders","authors":"Matthew Lloyd ,&nbsp;Brooke A Prakash ,&nbsp;Lucy Zhao,&nbsp;Guohao Ni,&nbsp;Yining Ru,&nbsp;Sridhar R Vasudevan","doi":"10.1016/j.cophys.2025.100836","DOIUrl":"10.1016/j.cophys.2025.100836","url":null,"abstract":"<div><div>Circadian rhythms orchestrate metabolism and brain function, aligning internal physiological processes with the 24-hour day–night cycle. Growing evidence highlights a reciprocal relationship between circadian regulation, metabolism, and neurobiological processes. Circadian disruption impairs glucose and lipid homeostasis, alters neurotransmitter and endocrine signalling, and triggers stress response, forming a feedback loop that impacts metabolism and brain function. These disturbances are implicated in many conditions, such as obesity, diabetes, depression, and bipolar disorder. This review examines recent advances in the interplay between circadian regulation, metabolism, and mental health, emphasising shared molecular mechanisms and their role in disease progression. Understanding these connections may ultimately inform therapeutic strategies that integrate circadian-based approaches to improve treatments for metabolic and psychiatric disorders.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"45 ","pages":"Article 100836"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144364617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of microRNA trafficking to mitochondria in the heart microRNA转运至心脏线粒体的机制
IF 1.9
Current Opinion in Physiology Pub Date : 2025-09-01 Epub Date: 2025-08-08 DOI: 10.1016/j.cophys.2025.100848
Diego Quiroga , Rachel Daniel , Samarjit Das
{"title":"Mechanisms of microRNA trafficking to mitochondria in the heart","authors":"Diego Quiroga ,&nbsp;Rachel Daniel ,&nbsp;Samarjit Das","doi":"10.1016/j.cophys.2025.100848","DOIUrl":"10.1016/j.cophys.2025.100848","url":null,"abstract":"<div><div>MicroRNAs (miRNAs) are essential post-transcriptional regulators of gene expression, and accumulating evidence supports their presence and function within mitochondria. These mitochondrial microRNAs (MitomiRs) modulate key processes such as oxidative phosphorylation, ATP production, calcium homeostasis, and reactive oxygen species balance in cardiac tissue. Despite growing recognition of their importance, the mechanisms governing miRNA trafficking to mitochondria remain incompletely understood. This review explores the current knowledge on miRNA biogenesis, mitochondrial import pathways — including the roles of Argonaute 2 (AGO2), the Translocase of the Outer/Inner Mitochondrial Membrane (TOM/TIM) complexes, and Polynucleotide Phosphorylase (PNPase) — and the regulatory impact of specific MitomiRs, such as miR-181c, miR-210, miR-378, let-7b, and miR-1. Understanding how these molecules influence mitochondrial function provides insight into their therapeutic potential in cardiovascular disease.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"45 ","pages":"Article 100848"},"PeriodicalIF":1.9,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144917866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Circadian control of cellular constituent turnover and growth 细胞成分周转和生长的昼夜节律控制
IF 2.5
Current Opinion in Physiology Pub Date : 2025-09-01 Epub Date: 2025-05-27 DOI: 10.1016/j.cophys.2025.100837
Jeffrey J Kelu
{"title":"Circadian control of cellular constituent turnover and growth","authors":"Jeffrey J Kelu","doi":"10.1016/j.cophys.2025.100837","DOIUrl":"10.1016/j.cophys.2025.100837","url":null,"abstract":"<div><div>The circadian clock synchronises biological processes with environmental cues, optimising fitness and energy efficiency. Among these, cell growth regulation is a critical yet underexplored area. While primarily linked to rhythmic cell division, cell growth also arises from the cyclic accumulation of cellular components driving volume expansion. This review highlights advances in understanding how the circadian clock regulates the synthesis and degradation of key cellular constituents, particularly RNAs and proteins, in both homeostatic and growing cells. These processes are essential for maintaining cellular homeostasis and supporting tissue development and regeneration. Further exploration of circadian turnover and its integration with cellular growth pathways could pave the way for chronotherapeutic strategies.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"45 ","pages":"Article 100837"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noncoding RNA in cancer: pathogenesis to therapeutic targets 非编码RNA在癌症中的作用：发病机制和治疗靶点
IF 2.5
Current Opinion in Physiology Pub Date : 2025-09-01 Epub Date: 2025-06-30 DOI: 10.1016/j.cophys.2025.100847
Arpita Ghosh Mitra
{"title":"Noncoding RNA in cancer: pathogenesis to therapeutic targets","authors":"Arpita Ghosh Mitra","doi":"10.1016/j.cophys.2025.100847","DOIUrl":"10.1016/j.cophys.2025.100847","url":null,"abstract":"<div><div>In the human genome, most transcribed RNA does not translate into protein, yet it plays a crucial role in gene expression regulation. This ‘dark matter of the genome’ is called noncoding RNAs (ncRNAs), which are involved in the pathogenesis of different diseases, viz., cancer. According to the length of nucleotides, ncRNAs are categorised into long ncRNAs (lncRNAs) or small ncRNAs. Recent emerging studies are exploring the massive role of ncRNAs behind pathophysiology and the scope of utilising these huge segments as diagnostic and prognostic indicators, as well as therapeutic targets of cancer. This brief and succinct review will focus on recent publications on the status and major contribution of ncRNAs in cancer, ranging from pathogenesis and diagnosis to prognosis and therapy.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"45 ","pages":"Article 100847"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144655697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial ncRNAs beyond the mitochondrion: coordinators of organelle crosstalk 线粒体外的线粒体ncrna：细胞器串扰的协调者
IF 2.5
Current Opinion in Physiology Pub Date : 2025-09-01 Epub Date: 2025-05-08 DOI: 10.1016/j.cophys.2025.100831
Sidhant Khatri, Anna Blumental-Perry
{"title":"Mitochondrial ncRNAs beyond the mitochondrion: coordinators of organelle crosstalk","authors":"Sidhant Khatri,&nbsp;Anna Blumental-Perry","doi":"10.1016/j.cophys.2025.100831","DOIUrl":"10.1016/j.cophys.2025.100831","url":null,"abstract":"<div><div>The mitochondrion contains its own genome that encodes subunits of respiratory complexes, components of the translation machinery, and numerous noncoding RNAs (ncRNAs). Some of these ncRNAs are antisense transcripts of their respective genes, regulating their maturation within mitochondria. Others facilitate mitochondria-to-nucleus communication, conveying mitochondrial status to the nucleus and coordinating synergy between the genomes. The first known mito-ncRNAs that exit mitochondria were those generated from the control regions of the mitochondrial genome. Recent evidence suggests that this phenomenon is broader, encompassing multiple mitochondrial sense and antisense transcripts and mito-tRNAs. mito-ncRNAs are regulated by the proliferative state of the cell, physiological stresses, and viral infections. Both within and outside the organelle, mito-ncRNAs serve as scaffolds for protein complex assembly, as modulators of promoter occupancy, heterochromatin states, nucleolar functions, and spliceosome selectivity, and as precursors and regulators of miRNA networks. Here, we summarize and discuss current knowledge regarding mito-ncRNA-mediated signaling pathways.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"45 ","pages":"Article 100831"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144107859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intersection of sex and circadian biology 性别与昼夜生物学的交叉
IF 2.5
Current Opinion in Physiology Pub Date : 2025-09-01 Epub Date: 2025-05-30 DOI: 10.1016/j.cophys.2025.100834
Georgios K Paschos, Ronan Lordan, Garret A FitzGerald
{"title":"Intersection of sex and circadian biology","authors":"Georgios K Paschos,&nbsp;Ronan Lordan,&nbsp;Garret A FitzGerald","doi":"10.1016/j.cophys.2025.100834","DOIUrl":"10.1016/j.cophys.2025.100834","url":null,"abstract":"<div><div>The circadian clock aligns behavior and physiology with environmental rhythms, and its disruption has been associated with increased risk of metabolic and neurological diseases. This review examines the emerging trends and mounting evidence demonstrating that there are sex-specific differences in circadian physiology relevant to health. Preclinical and clinical studies indicate that females exhibit greater circadian resilience, robust transcriptional rhythms, and resistance to clock perturbation compared to males. These influences affect susceptibility to metabolic conditions and responses to circadian perturbations like shift work. Notably, sex differences in response to alcohol consumption and cancer chronotherapy have emerged as fields of significant interest. Future research must consider both sexes to refine existing interventions and uncover the complex mechanisms of circadian physiology for more inclusive therapeutic strategies.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"45 ","pages":"Article 100834"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144269989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
SHP2 happens, just sail with it: the role of the protein tyrosine phosphatase SHP2 in autoimmune and autoinflammatory diseases 蛋白酪氨酸磷酸酶SHP2在自身免疫性和自身炎症性疾病中的作用
IF 2.5
Current Opinion in Physiology Pub Date : 2025-09-01 Epub Date: 2025-05-26 DOI: 10.1016/j.cophys.2025.100833
Samantha Le Sommer , Maria I Kontaridis
{"title":"SHP2 happens, just sail with it: the role of the protein tyrosine phosphatase SHP2 in autoimmune and autoinflammatory diseases","authors":"Samantha Le Sommer ,&nbsp;Maria I Kontaridis","doi":"10.1016/j.cophys.2025.100833","DOIUrl":"10.1016/j.cophys.2025.100833","url":null,"abstract":"<div><div>Autoimmune and autoinflammatory diseases are a diverse group of disorders that stem from aberrant immune responses against self. While autoimmune disorders are characterized by lymphocyte-driven antigen-specific responses, autoinflammatory diseases are driven by chronic activation of the innate immune system. However, to date, both groups of disorders lack clear understanding for their onset and the functional mechanisms conducive to their pathology and have few efficacious, safe, and/or curative treatment options for patients. The SH2 domain–containing protein tyrosine phosphatase (SHP2), the protein encoded by the <em>PTPN11</em> gene, is a nodal enzyme involved in embryogenesis, development, proliferation, differentiation, and survival of cells. Mutations in <em>PTPN11</em> are associated with the development of congenital disorders as well as several types of cancers. Recently, links between autoimmunity and genetic developmental disorders have also revealed a key role for SHP2 activity in autoimmune–autoinflammatory pathophysiology. Its association with these disorders has begun to unravel the molecular mechanisms that contribute to the onset of autoimmunity. In this review, we will discuss the emergent role of SHP2 in autoimmunity and the current known and unknown molecular mechanisms of its regulation in these processes and propose the translational impact it may have as a therapeutic in the near future.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"45 ","pages":"Article 100833"},"PeriodicalIF":2.5,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144230197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitochondrial connection to Alzheimer’s disease and heart failure 线粒体与阿尔茨海默病和心力衰竭有关
IF 2.5
Current Opinion in Physiology Pub Date : 2025-06-01 Epub Date: 2025-05-02 DOI: 10.1016/j.cophys.2025.100830
Anupriya Sinha , Natasha Jaiswal , Pooja Jadiya , Dhanendra Tomar
{"title":"Mitochondrial connection to Alzheimer’s disease and heart failure","authors":"Anupriya Sinha ,&nbsp;Natasha Jaiswal ,&nbsp;Pooja Jadiya ,&nbsp;Dhanendra Tomar","doi":"10.1016/j.cophys.2025.100830","DOIUrl":"10.1016/j.cophys.2025.100830","url":null,"abstract":"<div><div>The brain and heart are intricately linked, with dysfunction in one organ often affecting the other. Cardiovascular diseases (CVDs), particularly heart failure, impair cerebral blood flow, contributing to cognitive decline and increasing dementia risk. Conversely, Alzheimer’s disease (AD), marked by amyloid-beta plaques and tau tangles, impacts cardiac function. A shared mechanism between AD and CVDs is mitochondrial dysfunction, which disrupts energy production and oxidative balance, worsening both neurodegeneration and heart health. This interdependence underscores the potential for mitochondria-targeted therapies to address both conditions. With an aging population facing rising incidences of AD and CVDs, understanding these interconnected pathways and the central role of mitochondria could inform new therapeutic strategies and improve outcomes in both neurodegenerative and cardiovascular diseases.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"44 ","pages":"Article 100830"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Current advances in protein phosphatases in kidney disease 蛋白质磷酸酶在肾脏疾病中的研究进展
IF 2.5
Current Opinion in Physiology Pub Date : 2025-06-01 Epub Date: 2025-04-20 DOI: 10.1016/j.cophys.2025.100828
Marina Rousseau, Pedro Geraldes
{"title":"Current advances in protein phosphatases in kidney disease","authors":"Marina Rousseau,&nbsp;Pedro Geraldes","doi":"10.1016/j.cophys.2025.100828","DOIUrl":"10.1016/j.cophys.2025.100828","url":null,"abstract":"<div><div>Chronic kidney disease (CKD) affects a large portion of the global population and is characterized by alterations in kidney function. Unfortunately, patients who progress to end-stage kidney disease have little chance of kidney function reversal and will ultimately need dialysis or a kidney transplant. Therefore, understanding the underlying mechanisms of CKD progression is critical for developing new therapies. Protein phosphatases are essential regulators of signal transduction in the normal function of cells. The deregulation of different protein phosphatases has been associated with kidney disease onset and progression. This review aims to highlight the recent advances in the role of protein phosphatases in kidney health and disease. Mainly, attention will be brought to three of the four main families of protein phosphatases (serine/threonine, protein tyrosine, and dual-specificity phosphatases). Since kidney disease encompasses a wide range of pathologies, this review will focus on glomerulopathies, diabetic kidney disease, acute kidney injury, and advanced CKD/fibrosis.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"44 ","pages":"Article 100828"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143892203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Noncoding RNAs in myocardial ischemia/reperfusion injury and repair 非编码rna在心肌缺血/再灌注损伤及修复中的作用
IF 2.5
Current Opinion in Physiology Pub Date : 2025-06-01 Epub Date: 2025-03-21 DOI: 10.1016/j.cophys.2025.100825
Mingliang Pan , Zhixin Li , Xiaohong Wang , Liying Zhan , Guo-Chang Fan
{"title":"Noncoding RNAs in myocardial ischemia/reperfusion injury and repair","authors":"Mingliang Pan ,&nbsp;Zhixin Li ,&nbsp;Xiaohong Wang ,&nbsp;Liying Zhan ,&nbsp;Guo-Chang Fan","doi":"10.1016/j.cophys.2025.100825","DOIUrl":"10.1016/j.cophys.2025.100825","url":null,"abstract":"<div><div>Myocardial ischemia/reperfusion (I/R) usually triggers a series of molecular and cellular changes, which yield excessive oxidative stress and massive cardiomyocyte death, leading to sterile inflammation, cardiac fibrosis, and, eventually, heart failure. Over the past two decades, numerous studies have demonstrated that noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), involve almost every aspect of adverse cardiac remodeling induced by I/R. They have emerged as key regulators in the process of cardiac cell death (i.e<em>.</em> apoptosis, necroptosis, ferroptosis, pyroptosis, and PANoptosis), fibrosis, angiogenesis, and immune responses during myocardial I/R. Herein, this review summarizes recent advancements on ncRNA-mediated regulation of cardiac cell death, cardiac angiogenesis, fibrosis, and macrophage function as well as intercellular communication following myocardial I/R. Finally, the therapeutic potential of ncRNAs for treating myocardial I/R injury and future research directions are also discussed.</div></div>","PeriodicalId":52156,"journal":{"name":"Current Opinion in Physiology","volume":"44 ","pages":"Article 100825"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143808564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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