Turkish Journal of Gastroenterology最新文献

{"title":"Long Non-Coding RNA LINC01123 Facilitates Cholangiocarcinoma Aggravation by Targeting miR-641.","authors":"Xueshuo Wu, Ling Wang, Xiaoming Wang, Deli Kuang, Chunmiao Yuan, Kun Xiao","doi":"10.5152/tjg.2025.24522","DOIUrl":"10.5152/tjg.2025.24522","url":null,"abstract":"<p><strong>Background/aims: </strong>Cholangiocarcinoma (CCA) is a malignant and insidious tumor that is tricky to treat. Long non-coding RNA (LncRNA) LINC01123 is a biomolecule that influences cancer progression by regulating gene expression via influencing the regulatory function of microRNAs in gene expression. Therefore, this study investigated the connection between LINC01123 and CCA and explored the underlying mechanism. The objective of this study was to provide valuable information on the management of CCA.</p><p><strong>Materials and methods: </strong>Tumor and normal paracancer tissue samples in this study were collected from 128 CCA patients. To measure LINC01123 and miR-641 expression characteristics, quantitative reverse transcription-polymerase chain reaction was used. To explore the biological functions of LINC01123 and miR-641 in CCA cells, cell counting Kit-8 (CCK-8) and transwell migration and invasion assays were used. The mechanism was investigated using dual luciferase reporter assays and rescue experiments.</p><p><strong>Results: </strong>This study found that the expression levels of LINC01123 were higher in CCA tissues and cells than in normal tissues and cells. LINC01123 promoted the proliferation, migration and invasion ability of CCA cells and consequently became an indicator of lymph node metastasis and advanced TNM stage in CCA. Moreover, the expression of miR-641 was negatively correlated with the expression of LINC01123. LINC01123 affected CCA progression by downregulating miR-641.</p><p><strong>Conclusion: </strong>There was an upregulation of LINC01123 in CCA tumor tissues and cells. LINC01123 promoted CCA aggravation by targeting miR-641. LINC01123 could be the target of future treatment for CCA.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"183-192"},"PeriodicalIF":1.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HER2 Status in Gastric and Gastroesophageal Carcinomas: Evaluation of Histopathological Fingings, Paired ResectionBiopsy Specimens, and the Effect of Neoadjuvant Therapy: A Single Center Study.","authors":"Resmiye Irmak Yuzuguldu, Ozgul Sagol, Mehtat Unlu, Merve Keskinkilic, Serhan Derici, Hale Akpinar, Sulen Sarioglu","doi":"10.5152/tjg.2025.24488","DOIUrl":"10.5152/tjg.2025.24488","url":null,"abstract":"<p><strong>Background/aims: </strong>Accurately determining the human epidermal growth factor receptor 2 (HER2) status is crucial in identifying suitable candidates for targeted therapy in gastric cancer, considering the cost and potential side effects of anti-HER2 treatments. This study aimed to assess HER2 overexpression/amplification prevalence in gastric and gastroesophageal cancer patients, its correlation with clinicopathological characteristics, and the consistency of HER2 status between biopsy and radical specimens.</p><p><strong>Materials and methods: </strong>We analyzed data from 667 specimens of 600 gastric/gastroesophageal cancer patients at Dokuz Eylül University Faculty of Medicine from 2012 to 2021. The correlation of HER2 expression and amplification status and clinicopathological parameters were assessed. Furthermore, we compared HER2 status concordance between paired biopsy-radical specimens when both endoscopic and radical materials were present. Additionally, we compared HER2 status before and after treatment in patients receiving neoadjuvant chemotherapy.</p><p><strong>Results: </strong>In our study, +3 HER2 immunohistochemistry results were more common in gastroesophageal junction tumors (23%). Human epidermal growth factor receptor 2 immunohistochemistry positivity and HER2 gene amplification were found to be significantly more common in males, people over 65 years of age, and intestinal morphology. Overall concordance of HER2 status between radical and biopsy materials was 95.5%.</p><p><strong>Conclusion: </strong>The high HER2 concordance between the paired biopsy and radical samples holds significant importance in clinical management. This finding is particularly noteworthy since the HER2 assessment can generally be conducted on small/limited biopsy materials in routine practice. Our study is the most extensive series from Türkiye and the Balkans, which will shed light on our country's data by investigating the relationship of HER2 with clinicopathological parameters in gastric/gastroesophageal carcinomas.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"357-370"},"PeriodicalIF":1.4,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12147396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143015876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Gut Microbiota and Gastrointestinal Polyps: A Mendelian Randomization Study.","authors":"Yang Xie, Sheng Chen, Yiling Xiong, Chunyan Zeng, Youxiang Chen","doi":"10.5152/tjg.2025.24347","DOIUrl":"10.5152/tjg.2025.24347","url":null,"abstract":"<p><strong>Background/aims: </strong>Numerous studies have confirmed that intestinal flora is closely linked to the development of gastrointestinal polyps. However, the precise causal link between them has yet to be clarified. This study sought to determine the causal relationship between gut microbiota and gastric, duodenal, colon, and rectal polyps by Mendelian randomization (MR).</p><p><strong>Materials and methods: </strong>We employed publicly available genome-wide association study summary data to conduct MR analysis. Gut microbiota data were sourced from the International MiBioGen Consortium, and gastrointestinal polyp data were obtained from the MRC-IEU Consortium. Instrumental variables were selected based on eligible single-nucleotide polymorphisms. To assess causality, we utilized MR-Egger, weighted median, inverse variance weighting, simple mode, and weighted mode techniques. Heterogeneity and pleiotropy were evaluated through Cochran's Q test, MR-Egger intercept test, and leave-one-out analysis.</p><p><strong>Results: </strong>We determined that Lachnospiraceae UCG004, Erysipelotrichaceae UCG003, and Veillonella increased the risk of colon polyps. However, Dorea and Clostridium innocuum group act as protective factors for colon polyps. Allisonella increases the risk of rectal polyps. In contrast, Christensenellaceae R.7 group, Parasutterella, and Intestinimonas are protective factors for rectal polyps. Lachnospiraceae FCS020 group, Intestinibacter, Ruminococcaceae UCG003, and Parasutterella act as risk factors for stomach and duodenum polyps.</p><p><strong>Conclusions: </strong>Our research establishes a causal link between gut microbiota dysbiosis and the formation of gastrointestinal polyps. Nonetheless, additional studies are necessary to explore the mechanisms through which bacterial taxa influence the development of these polyps.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 5","pages":"302-311"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070428/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Biochemical Characteristics of a Danish and Turkish Cohort of Incident and Prevalent Patients with Primary Biliary Cholangitis.","authors":"Hasan Eruzun, Lars Bossen, Dilara Turan Gökçe, İlkay Ergenç, Zekiye Nur Harput, Neslihan Güneş Aydemir, Meral Akdoğan Kayhan, Hasan Basri Yapıcı, Tugay Doğan, Peter Holland-Fischer, Jesper Bach Hansen, Yusuf Yılmaz, Orhan Sezgin, Haydar Adanır, Ahmet Bektaş, Henning Grønbæk","doi":"10.5152/tjg.2025.24300","DOIUrl":"10.5152/tjg.2025.24300","url":null,"abstract":"<p><strong>Background/aims: </strong>Primary biliary cholangitis (PBC) is a chronic liver disease influenced by environmental, genetic, and epigenetic factors, with varying incidence across populations. This study compared demographic, biochemical, and treatment responses in Danish and Turkish PBC patients.</p><p><strong>Materials and methods: </strong>Four cohorts were analyzed: (1) 101 incident Turkish patients, (2) 77 incident Danish patients, (3) 103 prevalent Turkish patients, and (4) 155 prevalent Danish patients. Demographics, biochemical data, disease severity, and response to ursodeoxycholic acid (UDCA) were assessed. Regression analysis was applied to the entire cohort to identify factors associated with the UDCA response.</p><p><strong>Results: </strong>Female dominance was noted in all cohorts (>90%) except the Danish incident group (75%). Turkish patients in the prevalent cohort were younger than Danish patients. Antimitochondrial antibody (AMA) positivity was higher in Turkish cohorts (92%-97%) compared to Danish cohorts (75%-88%). Biochemical data were similar across groups, with 15% of both populations having cirrhosis. Turkish patients showed a higher complete response to UDCA. Elevated alanine aminotransferase (ALT) levels reduced UDCA response, while Turkish ethnicity and older age improved it.</p><p><strong>Conclusion: </strong>Despite similar disease severity and age at diagnosis between Danish and Turkish PBC patients, Turkish patients had higher AMA positivity and better responses to UDCA treatment. These findings suggest potential genetic or environmental influences on treatment efficacy.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"241-246"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Positioning During Colonoscopy on Efficacy and Post-procedure Comfort.","authors":"Mustafa Ergin, Gülencan Yumuşak Ergin, Fatih Kıvrakoğlu, Mehmet İbiş","doi":"10.5152/tjg.2025.24439","DOIUrl":"10.5152/tjg.2025.24439","url":null,"abstract":"<p><strong>Background/aims: </strong>There are studies with different results on improving effectiveness and patient comfort by increasing lumen distention through positioning during colonoscopy. In our study, we aimed to compare colonoscopy outcomes and post-procedural patient comfort in the left-lateral and right-lateral positions.</p><p><strong>Materials and methods: </strong>A total of 231 patients who underwent screening colonoscopy were included. Patients were randomized to either the left-lateral or the right-lateral position. Patient age, sex, comorbidities, body mass index (BMI) values, times to reach the cecum, ileum intubation rates, total procedure times, and colonoscopy findings were compared. Pain and discomfort after the procedure were evaluated and compared with the visual analog scale (VAS) scores at 30 minutes, 6 hours, and 24 hours.</p><p><strong>Results: </strong>Colonoscopy was performed in the left-lateral position in 129 patients and in the right-lateral position in 102. The distributions of age, sex, comorbidities, and BMI values were similar in both groups. The time to reach the cecum and the total procedure time were similar in both groups. There were no significant differences in the findings detected by colonoscopy. There was no significant difference in the post-procedural VAS scores.</p><p><strong>Conclusion: </strong></p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 3","pages":"174-182"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Potential Functional Modules and Diagnostic Genes for Crohn's Disease Based on Weighted Gene Co-expression Network Analysis and LASSO Algorithm.","authors":"Ruiquan Wang, Hongqi Zhao","doi":"10.5152/tjg.2025.23605","DOIUrl":"10.5152/tjg.2025.23605","url":null,"abstract":"<p><strong>Background/aims: </strong>Accurate diagnosis of Crohn's disease (CD) is paramount due to its resemblance to other inflammatory bowel diseases. Early and precise diagnosis plays a pivotal role in tailoring personalized treatments, thereby enhancing the quality of life for CD patients.</p><p><strong>Materials and methods: </strong>Differential gene expression analysis was conducted to identify genes from the mRNA expression profiles of CD samples, followed by pathway enrichment analysis. The immune cell infiltration levels of each CD patient sample were assessed. Using weighted gene co-expression network analysis, key gene modules linked to CD were found. Hub gene identification was made easier by the construction of protein-protein interaction networks. Next, utilizing the Least Absolute Shrinkage and Selection Operator on the hub genes in the training set, a diagnostic model was created. The accuracy of the model was then confirmed using a different validation set.</p><p><strong>Results: </strong>Our analysis revealed 651 differentially expressed genes, enriched in leukocyte chemotaxis and inflammation-related pathways. Immunization results showed a higher abundance of T cells CD4 memory resting, macrophages M2, and plasma cells in CD patients. Weighted gene co-expression network analysis linked the turquoise module with macrophages M2. Eight hub genes (APOA1, APOA4, CYP2C8, CYP2C9, CYP2J2, EPHX2, HSD3B1, and LPL) formed the diagnostic model, exhibiting excellent diagnostic performance with area under curve values of 0.94 (training set) and 0.941 (validation set).</p><p><strong>Conclusion: </strong>The CD diagnostic model, based on hub genes, shows exceptional diagnostic accuracy, providing a valuable reference for CD diagnosis.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"209-218"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammation and Immune-Based Scores Predict Prognosis for Patients with Hepatocellular Carcinoma: A Pilot Single-Center Study.","authors":"Merve Guzel Dirim, Asli Cifcibasi Ormeci, Bilger Cavus, Arzu Poyanli, Kursat Rahmi Serin, Filiz Akyuz, Kadir Demir, Selman Fatih Besisik, Sabahattin Kaymakoglu","doi":"10.5152/tjg.2025.24407","DOIUrl":"10.5152/tjg.2025.24407","url":null,"abstract":"<p><strong>Background/aims: </strong>Hepatocellular carcinoma (HCC) ranks as a major contributor to cancer-related deaths. Systemic inflammation plays a pivotal role in HCC development and progression. Thus, we aimed to determine the impact of inflammation- and immune-based scores in predicting the prognosis of HCC.</p><p><strong>Materials and methods: </strong>In this retrospective study, patients with HCC were enrolled between 2010 and 2020. The purpose of this retrospective study was to evaluate the impact of various biomarkers, including baseline alpha-fetoprotein (AFP) levels, C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index, neutrophil-to-CRP (N/CRP) ratio, systemic immune-inflammation index (SII), albumin-bilirubin (ALBI) score, neutrophil-to-lymphocyte ratio (NLR), and aspartate aminotransferase (AST)-to-alanine aminotransferase (ALT) (AST/ALT) ratio (AAR), on survival, invasion of vascular tracts, metastasis, and treatment responses.</p><p><strong>Results: </strong>A total of 199 patients with complete (n = 44) and non-complete (n = 145) treatment response groups were enrolled in the study. All scores for the non-complete response group were statistically significant (P < .05). The areas under the curves for predicting a non-complete response group were 0.651, 0.649, 0.636, 0.625, 0.613, 0.609, and 0.600 for AFP, CALLY index, AAR, SII, N/CRP ratio, ALBI score, and NLR, respectively. These results are consistent with the assessment of mortality and HCC progression.</p><p><strong>Conclusion: </strong>Our results indicate that these biomarkers could serve as powerful prognostic tools for HCC.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"219-228"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regulatory Role of IGF2BP2 in Intestinal Mucosal Barrier Dysfunction in Ulcerative Colitis.","authors":"Ruifan Li, Bin Gu, Anli Lv","doi":"10.5152/tjg.2025.24192","DOIUrl":"10.5152/tjg.2025.24192","url":null,"abstract":"<p><strong>Background/aims: </strong>Ulcerative colitis (UC), an idiopathic and chronic inflammatory disease, primarily targets the mucosal lining of the colon. This research endeavors to reveal the mechanism of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and nuclear receptor coactivator-3 (NCOA3) in UC-induced intestinal mucosal barrier dysfunction.</p><p><strong>Materials and methods: </strong>Dextran sodium sulfate (DSS) was used for UC mouse modeling, followed by an assessment of the disease activity index, intestinal barrier integrity, and intestinal permeability assessment through FITC-glucan assay. microRNA (miR)-222-3p, IGF2BP2, and NCOA3 levels in colon tissues of mice were detected. The targeted binding of miR-222-3p to IGF2BP2 was determined using a dual-luciferase assay. The enrichment of IGF2BP2 or N6-methyladenosine (m6A) on NCOA3 mRNA in YAMC cells was tested by RNA immunoprecipitation and m6A RNA immunoprecipitation assays, and the mRNA stability of NCOA3 was determined after actinomycin D treatment.</p><p><strong>Results: </strong>miR-222-3p was increased while IGF2BP2 and NCOA3 were decreased in the colon tissues of UC mice. IGF2BP2 overexpression effectively alleviated intestinal injury and reinstated the functional integrity of the mucosal barrier in DSS mice. IGF2BP2 recognized and bound to the m6A site of NCOA3 and increased mRNA stability, and miR-222-3p negatively regulated IGF2BP2. NCOA3 downregulation abated the beneficial impact of IGF2BP2 overexpression on DSS mice. miR-222-3p downregulation upregulated IGF2BP2/NCOA3 expression to protect against intestinal mucosal barrier dysfunction.</p><p><strong>Conclusion: </strong>IGF2BP2 was repressed by miR-222-3p, yet IGF2BP2 increased the stability of NCOA3 mRNA via an m6A-dependent pathway, ultimately leading to attenuation of UC-related intestinal mucosal barrier impairment and UC progression.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"269-279"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consider Mitochondrial DNA Rearrangements as a Cause of Idiopathic Pancreatitis.","authors":"Josef Finsterer, Sounira Mehri","doi":"10.5152/tjg.2025.24704","DOIUrl":"https://doi.org/10.5152/tjg.2025.24704","url":null,"abstract":"","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"263-264"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.","authors":"Mustafa Şentürk, Volkan İnce, Orhan Üreyen, Kemal Eyvaz, Burak Işık, Brian I Carr, Sezai Yılmaz","doi":"10.5152/tjg.2025.24540","DOIUrl":"10.5152/tjg.2025.24540","url":null,"abstract":"<p><strong>Background/aims: </strong>Mean platelet volume (MPV) reflects platelet activation. Platelets have an important role in tumor progression and metastasis. In this study, we wanted to investigate the effect of MPV on survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC).</p><p><strong>Materials and methods: </strong>All data of 376 patients who underwent LT and pathologically diagnosed with HCC were analyzed. By determining the cut-off of MPV (10.2 fL), 2 groups with high and low MPV were formed. The groups were compared within themselves. Factors affecting survival were determined by univariate and multivariate analysis.</p><p><strong>Results: </strong>When the groups were compared, patients with low MPV had significantly higher platelet counts, larger tumor sizes, lower BMI, and higher recurrence rates. In multivariate analysis, GGT >104, AFP >200 μg/L, largest tumor diameter >5 cm, and lower MPV were found to be independent risk factors that affected the prognosis. Tumor-free survival was significantly worse in the lower MPV group (P = .002).</p><p><strong>Conclusion: </strong>Pre-transplant low MPV may be useful in predicting poor prognosis and a high rate of tumor recurrence in patients with HCC after liver transplantation.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 3","pages":"169-173"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}