Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.

IF 1.4 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Turkish Journal of Gastroenterology Pub Date : 2025-01-06 DOI:10.5152/tjg.2025.24540

Mustafa Şentürk, Volkan İnce, Orhan Üreyen, Kemal Eyvaz, Burak Işık, Brian I Carr, Sezai Yılmaz

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引用次数: 0

Abstract

Background/aims: Mean platelet volume (MPV) reflects platelet activation. Platelets have an important role in tumor progression and metastasis. In this study, we wanted to investigate the effect of MPV on survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC).

Materials and methods: All data of 376 patients who underwent LT and pathologically diagnosed with HCC were analyzed. By determining the cut-off of MPV (10.2 fL), 2 groups with high and low MPV were formed. The groups were compared within themselves. Factors affecting survival were determined by univariate and multivariate analysis.

Results: When the groups were compared, patients with low MPV had significantly higher platelet counts, larger tumor sizes, lower BMI, and higher recurrence rates. In multivariate analysis, GGT >104, AFP >200 μg/L, largest tumor diameter >5 cm, and lower MPV were found to be independent risk factors that affected the prognosis. Tumor-free survival was significantly worse in the lower MPV group (P = .002).

Conclusion: Pre-transplant low MPV may be useful in predicting poor prognosis and a high rate of tumor recurrence in patients with HCC after liver transplantation.

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平均血小板体积是肝细胞癌肝移植患者预后不良的因素。

背景/目的：平均血小板体积（MPV）反映血小板活化。血小板在肿瘤进展和转移中起重要作用。在这项研究中，我们想要研究MPV对肝细胞癌（HCC）肝移植（LT）患者生存的影响。材料与方法：对376例行肝移植并病理诊断为HCC的患者资料进行分析。通过测定MPV的截止值（10.2 fL），将MPV分为高、低两组。两组之间进行了内部比较。通过单因素和多因素分析确定影响生存的因素。结果：当两组比较时，MPV低的患者血小板计数明显较高，肿瘤大小较大，BMI较低，复发率较高。多因素分析发现GGT >04、AFP >200 μg/L、最大肿瘤直径>5 cm、MPV较低是影响预后的独立危险因素。低MPV组无瘤生存期明显较差（P = 0.002）。结论：移植前低MPV可用于预测肝移植后肝癌患者的不良预后和高肿瘤复发率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Turkish Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

1.90

自引率

0.00%

发文量

127

审稿时长

6 months

期刊介绍： The Turkish Journal of Gastroenterology (Turk J Gastroenterol) is the double-blind peer-reviewed, open access, international publication organ of the Turkish Society of Gastroenterology. The journal is a bimonthly publication, published on January, March, May, July, September, November and its publication language is English. The Turkish Journal of Gastroenterology aims to publish international at the highest clinical and scientific level on original issues of gastroenterology and hepatology. The journal publishes original papers, review articles, case reports and letters to the editor on clinical and experimental gastroenterology and hepatology.