Turkish Journal of Gastroenterology最新文献

{"title":"Familial Low-Phospholipid-Associated Cholelithiasis Syndrome Presenting with Recurrent Intrahepatic Stones After Cholecystectomy with a Heterozygous ABCB4 Variant.","authors":"Gupse Adali, Mustafahan Kose, Berkay Dertsiz, Metin Eser, Ismail Kirbas, Erkan Parlak","doi":"10.5152/tjg.2026.26254","DOIUrl":"10.5152/tjg.2026.26254","url":null,"abstract":"<p><p></p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"915-917"},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148594286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Steatosis: Innocent Bystander or Silent Culprit?","authors":"Ahmet Sukru Alparslan, Ruhsen Ocal, Osman Cagin Buldukoglu, Serdar Akca, Berna Ozcanoglu, Mert Van, Galip Egemen Atar, Serkan Ocal, Ayhan Hilmi Cekin","doi":"10.5152/tjg.2026.26091","DOIUrl":"10.5152/tjg.2026.26091","url":null,"abstract":"<p><strong>Background/aims: </strong>Pancreatic steatosis (PS) is characterized by fat accumulation within the pancreas and is associated with chronic low-grade inflammation. Migraine, the third most commonly seen disease worldwide, is an established risk factor for white matter lesions (WMLs). Given the shared inflammatory background of these conditions, it was hypothesized that the presence of PS in patients with migraine may contribute to the development of WMLs.</p><p><strong>Materials and methods: </strong>This cross-sectional study included patients with migraine who attended the outpatient clinic and had undergone cranial magnetic resonance imaging (MRI) scan for any indication within the last 6 months. Following MRI, patients were referred to the radiology department for transabdominal ultrasonography to assess the presence of PS and hepatosteatosis.</p><p><strong>Results: </strong>Among the 78 patients with migraine included in the study, 35 (44.9%) had cranial WMLs. PS was significantly more prevalent among patients with WMLs than among those without WMLs (57.4% vs. 16.7%, P < .001). In multivariable logistic regression analysis adjusted for age, body mass index, and low-density lipoprotein/high-density lipoprotein ratio, PS remained independently associated with cranial WMLs (odds ratio (OR) 5.79, 95% CI 1.004-33.41; P = .049). Increasing age was also independently associated with WMLs (OR 1.095 per year, 95% CI 1.018-1.179; P = .015).</p><p><strong>Conclusion: </strong>This study demonstrated that the presence of PS may contribute to disease burden in patients with migraine. Evaluation of PS in this population may help identify a potentially modifiable metabolic condition and provide additional insight into the management of this common and debilitating disorder.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148609512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Processing Status, Rather Than Meat Source, Is Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease Among US Adults.","authors":"Shan Qin, Zhaowei Li, Fuman Yang, Qian Feng, Rui Wang, Zhong Chen","doi":"10.5152/tjg.2026.26294","DOIUrl":"10.5152/tjg.2026.26294","url":null,"abstract":"<p><strong>Background/aims: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is one of the most common chronic liver diseases worldwide and is closely related to modifiable dietary factors. The authors aimed to examine whether the association between meat intake and MASLD is more closely related to meat source or processing status.</p><p><strong>Materials and methods: </strong>The current study analyzed data from 1828 adults in the 2017 2018 National Health and Nutrition Examination Survey (NHANES). Meat intake was assessed using 24-hour dietary recalls and classified into processed red meat, processed poultry, unprocessed red meat, and unprocessed poultry. The presence of MASLD was determined using the controlled attenuation parameter measured by vibration-controlled transient elastography.</p><p><strong>Results: </strong>In fully adjusted models, each 1 oz-eq/day increase in processed meat was associated with 27% higher odds of MASLD (odds ratio (OR) 1.27, 95% CI 1.10-1.46, P = .003). Patients in the highest tertile had 2.46 times higher odds of MASLD than those in the lowest tertile (P = .002), with a robust linear trend (P for nonlinearity = .817). This association was observed for both processed red meat and processed poultry. In contrast, neither total unprocessed meat nor its specific subtypes (unprocessed red meat and unprocessed poultry) was significantly associated with MASLD. Iso-serving substitution analysis indicated that replacing 1 oz-eq/day of processed meat with unprocessed meat was associated with a 24% reduction in the odds of MASLD (OR 0.76, 95% CI 0.66-0.88; P = .001).</p><p><strong>Conclusion: </strong>The observed association with MASLD appeared to be more closely related to processing status than to meat source.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discriminative Role of Interleukin-6, Neuropilin-1, and Amphiregulin for Cirrhosis in Patients with Chronic Hepatitis B Infection.","authors":"Fatma Karakoc Ozudogru, Banu Karaca, Nesrin Turker, Bahar Ormen, Sezgin Vatansever, Huriye Erbak Yılmaz, Furkan Oguzhan Karalar, Fulya Gunsar, Alper Sener","doi":"10.5152/tjg.2026.26143","DOIUrl":"10.5152/tjg.2026.26143","url":null,"abstract":"<p><strong>Background/aims: </strong>The roles of inflammatory and fibrogenic biomarkers in chronic hepatitis B (CHB) infection and hepatitis B virüs (HBV)-related cirrhosis remain incompletely understood. The current study investigated the diagnostic and discriminative ability of amphiregulin (AREG), interleukin-6 (IL-6), and neuropilin-1 (Nrp-1) as biomarkers of HBV-related cirrhosis.</p><p><strong>Materials and methods: </strong>This cross-sectional analytical study included 70 patients with CHB (43 without cirrhosis and 27 with HBVrelated cirrhosis) and 60 healthy controls. Clinical and laboratory data were obtained from hospital records. Serum IL-6, Nrp-1, and AREG levels collected during outpatient visits were measured using enzyme-linked immunosorbent assay. Group differences were analyzed using the Kruskal-Wallis test, discriminative performance was evaluated using receiver operating characteristic (ROC) analysis, and factors independently associated with cirrhosis were identified using logistic regression.</p><p><strong>Results: </strong>IL-6 and Nrp-1 levels were higher in patients with noncirrhotic and HBV-related cirrhotic CHB than in healthy controls (P < .001), with no significant difference between the patient subgroups. AREG levels were lower in the overall CHB cohort than in controls (P < .001) but higher in patients with cirrhosis than in those without cirrhosis (P = .001). ROC analysis showed that AREG had moderate discriminative ability for HBV-related cirrhosis (area under the curve (AUC) = 0.749). The optimal Youden-derived cutoff value was 2.29 ng/mL, with a sensitivity of 74% and a specificity of 65%. In logistic regression, AREG was independently associated with HBV-related cirrhosis (P = .012). Addition of ln-transformed AREG to age- and sex-adjusted aspartate aminotransferase-to-platelet ratio index (APRI)- and Fibrosis-4 index (FIB-4)-based models increased the AUC from 0.923 to 0.970 and from 0.938 to 0.980, respectively.</p><p><strong>Conclusion: </strong>AREG may serve as a complementary biomarker with moderate discriminative value for HBV-related cirrhosis but is unlikely to be useful as a standalone diagnostic or prognostic marker. Although IL-6 and Nrp-1 reflected underlying inflammatory activity, their ability to distinguish cirrhosis was limited.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Intravenous Lidocaine on Duodenal Peristalsis and Sedation Quality During Endoscopic Retrograde Cholangiopancreatography: A Randomized Controlled Trial.","authors":"Mehmet Şahap, Önder Aydemir, Kerem Kenarlı, Bülent Ödemiş, Abdulkadir But","doi":"10.5152/tjg.2026.26266","DOIUrl":"10.5152/tjg.2026.26266","url":null,"abstract":"<p><strong>Background/aims: </strong>The current study aimed to evaluate the effects of intravenous (IV) lidocaine on sedative requirements, duodenal peristalsis, and procedural outcomes in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP) under deep sedation.</p><p><strong>Materials and methods: </strong>In this prospective, randomized, double-blind, placebo controlled study, 120 patients with ASA I-III who were scheduled for elective ERCP were enrolled. Participants were randomized to 2 groups: the lidocaine group (n = 60) received a 1 mg/kg bolus followed by a 2 mg/kg/h infusion, whereas the control group (n = 60) received an equivalent volume of 0.9% saline. Sedation was maintained with propofol and titrated to a Bispectral Index of 60-80. Duodenal peristalsis was assessed using a predefined semiquantitative peristalsis scoring system.</p><p><strong>Results: </strong>Demographic characteristics were similar between groups. Total propofol consumption was significantly lower in the lidocaine group (P < .001). Recovery and discharge times were significantly shorter in the lidocaine group than in the control group (P < .001 for both). Clinically adequate inhibition of duodenal peristalsis was observed more frequently in the lidocaine group (90.0% vs. 75.0%; P = .031), and the requirement for rescue antispasmodics was lower (P = .018). Complication rates, cannulation time, primary success rate, and endoscopist satisfaction were similar between groups.</p><p><strong>Conclusion: </strong>IV lidocaine may serve as a supportive anesthetic-sparing adjunct during ERCP, reducing propofol requirements and facilitating shorter recovery times. Although lidocaine was associated with greater inhibition of duodenal peristalsis and reduced use of rescue antispasmodic, major procedural outcomes were comparable between groups; therefore, these findings should be interpreted cautiously.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559901/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Simple and Effective Method for Endoscopic Fragmentation of Gastric Bezoars.","authors":"Haijun Liang, Tao Yin, Zhenyu Liu","doi":"10.5152/tjg.2026.26208","DOIUrl":"10.5152/tjg.2026.26208","url":null,"abstract":"<p><p>Cite this article as: Liang H, Yin T, Liu Z. A simple and effective method for endoscopic fragmentation of gastric bezoars. Turk J Gastroenterol. 2026;37(8):912-914.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"912-914"},"PeriodicalIF":2.3,"publicationDate":"2026-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pregnancy in Primary Biliary Cholangitis: A Single-Center Experience Emphasizing the Need for Postpartum Monitoring.","authors":"Ersin Batıbay, Mahmut Polat, Akın Kaya, Ahmet Tay","doi":"10.5152/tjg.2026.26054","DOIUrl":"10.5152/tjg.2026.26054","url":null,"abstract":"<p><p>Cite this article as: Batıbay E, Polat M, Kaya A, Tay A. Pregnancy in primary biliary cholangitis: A single-center experience emphasizing the need for postpartum monitoring. Turk J Gastroenterol. 2026;37(8):915-917.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"915-917"},"PeriodicalIF":2.3,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148563402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrosis-4 and Aspartate Aminotransferase-to-Platelet Ratio Index as Predictors of Relapse in Autoimmune Hepatitis: A Retrospective Single-Center Study.","authors":"İlyas Ethem Şenocak, Yunus Günegül, Yunus Emre Demiral, Talha Ercan, Ahmet Tarık Eminler","doi":"10.5152/tjg.2026.26177","DOIUrl":"10.5152/tjg.2026.26177","url":null,"abstract":"<p><strong>Background/aims: </strong>Autoimmune hepatitis (AIH) is associated with a high rate of relapse following treatment withdrawal. Identifying noninvasive markers that predict disease recurrence is crucial for long-term management. This study evaluated the prognostic performance of the Fibrosis-4 (FIB-4) Index and the Aspartate Aminotransferase-to-Platelet Ratio Index (APRI) in predicting post-treatment relapse in AIH.</p><p><strong>Materials and methods: </strong>This retrospective, single-center cohort study included 65 patients with AIH between January 2010 and October 2025 who achieved sustained normalization of transaminase under corticosteroid based therapy and were followed up for at least 12 months. Baseline demographic, laboratory, and noninvasive fibrosis parameters were analyzed. Relapse was defined as alanine aminotransferase or aspartate aminotransferase elevation ≥2 times the upper limit of normal and/or serum immunoglobulin G (IgG) above the upper limit, occurring after complete discontinuation of immunosuppressive therapy. Receiver operating characteristic (ROC) curve analysis and logistic regression were performed.</p><p><strong>Results: </strong>Relapse occurred in 26 patients (40.0%). Patients with relapse had higher baseline serum IgG (P < .001), lower platelet counts (P = .004), and higher APRI and FIB-4 scores (P < .001 for both). ROC analysis identified optimal cutoff values of APRI >1.54 (area under the curve (AUC) = 0.81) and FIB-4 > 3.84 (AUC = 0.80). In multivariate analysis, baseline IgG (odds ratio (OR) = 1.09; 95% CI = 1.00-1.18; P = .049) and FIB-4 > 3.84 (OR = 6.68; 95% CI = 2.02-22.10; P = .002) remained independent predictors.</p><p><strong>Conclusion: </strong>Baseline FIB-4 and serum IgG independently predict relapse following discontinuation of immunosuppressive therapy in AIH and may support individualized follow-up strategies. Cite this article as: Şenocak İE, Günegül Y, Demiral YE, Ercan T, Eminler AT. Fibrosis-4 and Aspartate Aminotransferase-to-Platelet Ratio Index as predictors of relapse in autoimmune hepatitis: A retrospective single center study. Turk J Gastroenterol. 2026;37(8):900-908.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"900-908"},"PeriodicalIF":2.3,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Randomized Controlled Trial Comparing Low-FODMAP and Gluten-Free Diets on Gastrointestinal Symptoms, Nutritional Status, and Quality of Life in Irritable Bowel Syndrome.","authors":"Adeviye Eda Somtaş, Aslı Gizem Çapar","doi":"10.5152/tjg.2026.26147","DOIUrl":"10.5152/tjg.2026.26147","url":null,"abstract":"<p><strong>Background/aims: </strong>Irritable bowel syndrome (IBS) is a common chronic gastrointestinal disorder that requires a symptom-based treatment approach, in which dietary and lifestyle modifications play a central role in reducing symptoms and improving quality of life. Therefore, dietary strategies should be individualized. This study compared the short term effects of low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) and gluten-free diets on symptom severity, health-related quality of life, dietary intake, and anthropometric measurements in individuals with IBS.</p><p><strong>Materials and methods: </strong>In this 3-arm, parallel-group randomized controlled trial, 63 adults diagnosed with IBS according to the Rome IV criteria were enrolled. Participants were randomly assigned to a low-FODMAP diet (n = 21), a gluten-free diet (n = 21), or a control group (n = 21). The intervention period lasted 4 weeks. Assessments were conducted at baseline and after the intervention using the IBS Symptom Severity Score (IBS-SSS), IBS Quality of Life questionnaire (IBS-QOL), IBS Visual Analog Scale, 3-day dietary intake records, and anthropometric measurements.</p><p><strong>Results: </strong>Both intervention groups demonstrated reductions in IBS-SSS scores and improvements in IBS-QOL scores (P < .001). After adjustment for baseline values, a significant between-group difference was observed in quality of life (P < .001), whereas no significant difference was found in symptom severity (P > .05). Significant between-group differences were also observed in body weight, body mass index, waist circumference, waist-to-hip ratio, and carbohydrate intake.</p><p><strong>Conclusion: </strong>Low-FODMAP and gluten-free diets may improve quality of life in individuals with IBS in the short term. After adjustment for baseline values, a between-group difference was observed only in quality of life, whereas no difference was found in symptom severity. These findings suggest that both dietary interventions may represent effective nutritional strategies for the management of IBS.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting TARDBP to Restore Colonic Barrier Integrity in Ulcerative Colitis via NFATC1 mRNA Destabilization.","authors":"Yin Jiang, JingLin Gao, YaLi Huang, XingHui Song, GuangTing Li, Yuan Jiang, XiuHua Liu, DaGui Chen","doi":"10.5152/tjg.2026.25318","DOIUrl":"10.5152/tjg.2026.25318","url":null,"abstract":"<p><strong>Background/aims: </strong>Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by limited understanding of post-transcriptional mechanisms governing intestinal barrier integrity. This study investigated the role of NFATC1 in modulating barrier function during colitis and identified RNA-binding proteins regulating its expression.</p><p><strong>Materials and methods: </strong>An experimental model of UC was established in mice using dextran sulfate sodium (DSS). Adeno-associated virus vectors were used for in vivo knockdown of NFATC1 or overexpression of TARDBP. Colonic pathology was evaluated by histologic analysis and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays for apoptosis. Inflammatory cytokines, oxidative stress markers, and intestinal permeability were quantified using enzyme-linked immunosorbent assay (ELISA) and commercial kits. The expression levels of NFATC1, TARDBP, TLR4/p-p65, Zonula occludens-1 (ZO-1), and occludin were assessed by reverse transcription quantitative polymerase chain reaction (RT-qPCR), western blotting, and immunofluorescence staining. The molecular interaction between TARDBP and NFATC1 was investigated using coimmunoprecipitation, actinomycin D chase assays, and RNA immunoprecipitation.</p><p><strong>Results: </strong>DSS administration impaired colonic barrier integrity in mice and was associated with increased NFATC1 and decreased TARDBP expression. Notably, NFATC1 knockdown or TARDBP overexpression independently ameliorated DSS-induced colonic barrier damage. In contrast, the protective effects of TARDBP overexpression were abrogated by simultaneous NFATC1 overexpression. Mechanistically, TARDBP directly bound to NFATC1 mRNA, thereby promoting its degradation and reducing its stability rather than interacting at the protein level.</p><p><strong>Conclusion: </strong>This study identified a novel post-transcriptional regulatory mechanism by which TARDBP attenuates colonic inflammation through destabilization of NFATC1 mRNA. These findings highlight the TARDBP-NFATC1 axis as a potential therapeutic target for restoring intestinal barrier function in UC. Cite this article as: Jiang Y, Gao J, Huang Y, et al. Targeting TARDBP to restore colonic barrier integrity in ulcerative colitis via NFATC1 mRNA destabilization. Turk J Gastroenterol. 2026;37(8):869-886.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"869-886"},"PeriodicalIF":2.3,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}