Turkish Journal of Gastroenterology最新文献_第4页

Unraveling the Heterogeneity of Tumor Immune Microenvironment in Hepatocellular Carcinoma by SingleCell RNA Sequencing and its Implications for Prognosis and Therapeutic Response. 单细胞RNA测序揭示肝癌肿瘤免疫微环境的异质性及其对预后和治疗反应的影响

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-28 DOI: 10.5152/tjg.2024.24118

Ying Han, Lele Song, Lingna Lv, Chunlei Fan, Huiguo Ding

{"title":"Unraveling the Heterogeneity of Tumor Immune Microenvironment in Hepatocellular Carcinoma by SingleCell RNA Sequencing and its Implications for Prognosis and Therapeutic Response.","authors":"Ying Han, Lele Song, Lingna Lv, Chunlei Fan, Huiguo Ding","doi":"10.5152/tjg.2024.24118","DOIUrl":"10.5152/tjg.2024.24118","url":null,"abstract":"Tumor immune microenvironment (TIME) has become a new hotspot in cancer research over the past few years. Tumor immune microenvironment of hepatocellular carcinoma (HCC) is especially intriguing as HCC is reported to be highly heterogeneous by previous genomic and cytological studies. It is also closely related to patient prognosis and therapeutic outcome. The recently emerged single-cell RNA sequencing (scRNAseq) technique provides a new tool for TIME study, and current studies have made great advances in defining the roles of TIME in HCC pathogenesis and therapy. Current evidence suggests that heterogeneity is a key player influencing therapeutic response, drug resistance, and prognosis. However, our understanding is limited on the roles of TIME heterogeneity in HCC development, prognosis, and therapeutic response, especially in the era of immunotherapy. This review aims to unravel the heterogeneity of TIME in HCC by scRNAseq, with specific focuses on the cellular, transcriptional, and marker perspectives of TIME heterogeneity in HCC, as well as assessing prognostic and therapeutic response by heterogeneity markers. By summarizing current discoveries regarding TIME heterogeneity, we hope to provide clues on the crucial roles of various cellular components in the development and progression of HCC. We also hope to identify potential markers and therapeutic targets for prognosis assessment and personalized treatment to improve patient outcomes. Combined therapies from multiple dimensions regarding heterogeneity may provide new opportunities to treat HCC more effectively.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"35 12","pages":"876-888"},"PeriodicalIF":1.4,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11639598/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142787677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Mysteries of Autoimmune Gastritis. 揭示自身免疫性胃炎的奥秘。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-25 DOI: 10.5152/tjg.2024.24563

İrfan Soykan, Ramazan Erdem Er, Yigit Baykara, Cağdaş Kalkan

{"title":"Unraveling the Mysteries of Autoimmune Gastritis.","authors":"İrfan Soykan, Ramazan Erdem Er, Yigit Baykara, Cağdaş Kalkan","doi":"10.5152/tjg.2024.24563","DOIUrl":"https://doi.org/10.5152/tjg.2024.24563","url":null,"abstract":"Autoimmune gastritis is an immune-mediated disease characterized by the destruction of parietal cells and atrophy of the oxyntic mucosa due to anti-parietal cell antibodies. It may lead to serious conditions including iron/vitamin B12 and micronutrient deficiencies, neurological disorders, and gastric malignancies. The exact mechanism of this disease is not exactly understood; however, dysregulated immunological mechanisms appear to be major contributors. Patients with this disease are often asymptomatic but may present with gastrointestinal symptoms and/or iron/vitamin B12 deficiencies. Although important serological markers are available and despite advanced endoscopic techniques, the definitive diagnosis relies on histopathological examination of gastric corporal biopsy specimens. Autoimmune gastritis is closely related with increased risk of gastric neuroendocrine tumors and gastric adenocarcinoma. Patients with autoimmune gastritis do not benefit from specific treatments, thus, management is directed to restore micronutrient deficiencies and to prevent occurrence of neoplastic transformation with appropriate endoscopic surveillance.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessment of Serum Dynamic Thiol/Disulfide Homeostasis and Oxidative/Nitrosative Stress in Patients with Crohn's Disease. 克罗恩病患者血清动态硫醇/二硫稳态和氧化/亚硝化应激的评估

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-25 DOI: 10.5152/tjg.2024.23519

Ancel Aysun Bağdaş, Sezgin Barutçu, Ahmet Saracaloğlu, Abdullah Tuncay Demiryürek

{"title":"Assessment of Serum Dynamic Thiol/Disulfide Homeostasis and Oxidative/Nitrosative Stress in Patients with Crohn's Disease.","authors":"Ancel Aysun Bağdaş, Sezgin Barutçu, Ahmet Saracaloğlu, Abdullah Tuncay Demiryürek","doi":"10.5152/tjg.2024.23519","DOIUrl":"10.5152/tjg.2024.23519","url":null,"abstract":"Background/aims: Crohn's disease (CD) is a major subtype of chronic relapsing inflammatory gastrointestinal disorders. In this study, we assessed the possible contributions of serum oxidative/nitrosative stress and dynamic thiol/disulfide homeostasis to CD pathogenesis.Materials and methods: Patients with active CD (A-CD) at onset (n = 38), CD patients in the remission (R-CD) (n = 38), and healthy controls (n = 38) were prospectively included in this study. Serum oxidative/nitrosative parameters as well as total thiol and native thiol levels were analyzed.Results: We observed significant augmentation in nitric oxide (NO) levels in both A-CD and R-CD patients compared to healthy controls. We detected marked reductions in the 3-nitrotyrosine levels in the patient groups. Glutathione, glutathione peroxidase, and myeloperoxidase levels were observed to be significantly lower in both the active and remission groups (P < .001). In the A-CD group, native thiol (P < .001) and total thiol (P < .01) levels were lower, and disulfide levels were higher than those of the control group (P < .01), while the native thiol/total thiol ratio was reduced and disulfide/total thiol (P < .001) and disulfide/native thiol (P < .001) ratios were elevated. Remarkably, no change in dynamic thiol/disulfide homeostasis was found in the R-CD group.Conclusion: Our results showed increased serum NO levels and decreased antioxidant enzymes, particularly during the active phase of CD. Determination of thiol/disulfide homeostasis could help differentiate between the active and remission phases of the disease. Thiol/ disulfide parameters can be used as biomarkers for A-CD.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"114-123"},"PeriodicalIF":1.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Dysfunction Associated Fatty Liver Disease in Long-Term Cholecystectomy Patients: A Cross-Sectional Study. 长期胆囊切除术患者代谢功能障碍相关脂肪肝：一项横断面研究

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-25 DOI: 10.5152/tjg.2024.24337

Semih Sezer, Selim Demirci, Murat Kara

{"title":"Metabolic Dysfunction Associated Fatty Liver Disease in Long-Term Cholecystectomy Patients: A Cross-Sectional Study.","authors":"Semih Sezer, Selim Demirci, Murat Kara","doi":"10.5152/tjg.2024.24337","DOIUrl":"https://doi.org/10.5152/tjg.2024.24337","url":null,"abstract":"Background/aims: Cholecystectomy, while generally safe with low perioperative morbidity and mortality, has been linked to an increase in metabolic disorders. Metabolic dysfunction-associated fatty liver disease (MAFLD) is a globally prevalent condition that leads to both hepatic and systemic complications. This study aimed to investigate the association between cholecystectomy and MAFLD.Materials and methods: This cross-sectional study was designed to evaluate the relationship between cholecystectomy and MAFLD. Metabolic dysfunction-associated fatty liver disease was defined by the presence of hepatic steatosis in combination with any of the following conditions: diabetes mellitus (fasting plasma glucose ≥126 mg/dL), overweight (body mass index (BMI) ≥25 kg/m2), or metabolic dysregulation.Results: A total of 163 participants with BMI ≥25 kg/m2, including consecutive cholecystectomized (N = 83) and non-cholecystectomized (N = 80) subjects, were included. The prevalence of MAFLD was found in 64 out of 83 (77.1%) cholecystectomized patients and in 30 out of 80 (37.5%) non-cholecystectomized subjects (P < .001). When age, gender, BMI, exercise habits, hypertension, diabetes mellitus, and cholecystectomy status were included in regression analyses, we found that only BMI [odds ratio (OR) = 1.155 (95% CI: 1.040-1.283)] and cholecystectomy [OR = 4.540 (95% CI: 2.200-9.370)] were independently associated with MAFLD (both P < .01). ROC analysis identified 10 years as the cut-off, with MAFLD risk being 2.7-7.3 times higher in patients with cholecystectomy for ≤10 and >10 years.Conclusion: In our study, MAFLD was found to be 4.5 times more likely in cholecystectomized patients compared to those without cholecystectomy, with a significant increase in frequency observed after 10 years. These results suggest that cholecystectomized patients should be monitored for MAFLD.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic Cancer: Current Concepts, Trends, and Future Directions. 胰腺癌：当前概念、趋势和未来方向。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-18 DOI: 10.5152/tjg.2024.24544

Patrick Wenzel, Carolin Mogler, Kıvanç Görgülü, Hana Algül

{"title":"Pancreatic Cancer: Current Concepts, Trends, and Future Directions.","authors":"Patrick Wenzel, Carolin Mogler, Kıvanç Görgülü, Hana Algül","doi":"10.5152/tjg.2024.24544","DOIUrl":"10.5152/tjg.2024.24544","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PC) ranks among the deadliest cancers, with a less than 15% 5-year survival rate. Epidemiological studies project that it will become the second leading cause of cancer-associated mortalities in the following decades. The hallmarks of pancreatic cancer lead to tumor aggressiveness and therapeutic resistance. For this reason, the field has been focusing on multiple dimensions to generate better therapeutic approaches, including new adjuvant, neoadjuvant, and palliative concepts to extend the survival of PC patients. Over the last 2 decades, clinical trials have significantly improved disease prognosis and patient survival. To achieve better outcomes and to deeply understand the therapeutic approaches, molecular tumor boards have become crucial for deeper exploitation of tumor genetics and tumor biology, providing better stratification markers for therapeutic regimens. Using recently developed targeted therapies, such as KRAS inhibitors, the field has gathered momentum and been tooled up with the help of new sequencing technologies. Therefore, researchers and clinicians have geared up for the battle against PC. This review will systematically discuss recent developments in adjuvant, neoadjuvant, and palliative treatment modalities. Moreover, the paradigm-shifting importance of genetic profiling on pancreatic cancer. will be explained through a showcase to frame future directions.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"69-81"},"PeriodicalIF":1.4,"publicationDate":"2024-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China. 无柄锯齿状病变：寻找中国的真实患病率和危险因素。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-11 DOI: 10.5152/tjg.2024.24188

Bing-Yue Yao, Li Zhang, Chuan-Xia Wu, Liang Zheng, Ben-Song Duan, Qin-Wei Xu, Jing-Jing Lian, Hai-Bin Zhang, Yu Wang, Jia Cao

{"title":"Sessile Serrated Lesions: Searching for the True Prevalence and Risk Factors in China.","authors":"Bing-Yue Yao, Li Zhang, Chuan-Xia Wu, Liang Zheng, Ben-Song Duan, Qin-Wei Xu, Jing-Jing Lian, Hai-Bin Zhang, Yu Wang, Jia Cao","doi":"10.5152/tjg.2024.24188","DOIUrl":"10.5152/tjg.2024.24188","url":null,"abstract":"Background/aims: Growing recognition identifies sessile serrated lesions (SSL) as colorectal cancer (CRC) precursors. However, the SSL detection rate remains debatable and lacks a definitive consensus. Additionally, understanding the influencing factors in SSL development is limited. We aim to retrospectively analyze the true prevalence and risk factors of SSL in China.Materials and methods: This retrospective study collected medical data from patients who underwent colonoscopy at the Endoscopy Center of Shanghai East Hospital affiliated with Tongji University between March 1, 2019 and February 28, 2022. Data were sourced through the electronic medical record system and included information such as age, sex, lesion location, number, and pathology. This study predominantly focused on the detection rate and the clinical and endoscopic features of SSL.Results: Of 72 287 colonoscopies in 3 years, 3905 cases were histologically confirmed as SSL. Among them, 2290 (58.6%) were male, and 1615 (41.4%) were female. The overall SSL detection rate was 5.40%, slightly surpassing Asian/Chinese averages but lower than Western rates. Males had a higher SSL detection rate (6.1%) than females (4.6%). Univariate analysis revealed a significant association between SSL with dysplasia/adenocarcinoma (SSL-D/AD) and obesity (Body Mass Index, BMI ≥ 24), CRC family history, and hypertension. After multivariable logistic regression, only obesity (BMI ≥ 24) remained a statistically significant independent risk factor for SSL-D/AD.Conclusions: The SSL detection rate at our center is 5.4% and increases with age. Males have a significantly higher detection rate than females. Our findings suggest that endoscopists should consider risk factors for SSL-D/AD, such as obesity, CRC family history, and hypertension.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"15-23"},"PeriodicalIF":1.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736866/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multidisciplinary Approach to Perihilar and Intrahepatic Cholangiocarcinoma: A Single-Center Experience. 肝门周围和肝内胆管癌的多学科方法：单中心经验。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-11 DOI: 10.5152/tjg.2024.24301

Adnan Gundogdu, Taha Anil Kodalak, Hakan Kucukaslan, Serdar Topaloglu, Ummuhan Turali, Sukru Oguz, Davut Dohman, Hasan Dinc, Feyyaz Ozdemir, Mehmet Arslan, Umit Cobanoglu, Erdem Karabulut, Adnan Calik, Mehmet Halil Ozturk

{"title":"Multidisciplinary Approach to Perihilar and Intrahepatic Cholangiocarcinoma: A Single-Center Experience.","authors":"Adnan Gundogdu, Taha Anil Kodalak, Hakan Kucukaslan, Serdar Topaloglu, Ummuhan Turali, Sukru Oguz, Davut Dohman, Hasan Dinc, Feyyaz Ozdemir, Mehmet Arslan, Umit Cobanoglu, Erdem Karabulut, Adnan Calik, Mehmet Halil Ozturk","doi":"10.5152/tjg.2024.24301","DOIUrl":"10.5152/tjg.2024.24301","url":null,"abstract":"Background/aims: Treatment of perihilar cholangiocarcinoma (PHCC) and intrahepatic cholangiocarcinoma (IHCC) is a challenging issue. We aimed to investigate the clinical characteristics of both tumors and the outcome of our treatment policy.Material and methods: We retrospectively analyzed data of 117 patients who were diagnosed with PHCC or IHCC between January 2007 and September 2023. Postoperative outcomes and the effects of prognostic factors on overall survival (OS) were investigated.Results: Surgical resection was performed on 47 patients (PHCC, n = 33 and IHCC, n = 14). Preoperative biliary drainage was applied in 32 of 33 cases with PHCC and 2 of 14 cases with IHCC. The mortality rate was 8.5% (n = 4). The complication rate was 68.1%. The R0 resection rate was 73% in PHCC. The mean OS time of PHCC cases that underwent R0 resection was 26.5 ± 24.8 months. The mean OS time of patients who underwent resection for IHCC was 28.7 ± 35.5 months. The OS was poorly affected by high CA19-9 levels (≥37 U/mL) (P = .005), the presence of lymphovascular invasion (P = .049), positive surgical margins after resection (P < .001), and the development of postoperative acute renal failure (P = .078). The OS of patients receiving adjuvant chemotherapy was significantly longer (P = .071). CA19-9 levels of more than 37 U/mL (P = .027) and positive surgical margin (P < .001) were independent factors for poor OS.Conclusion: Surgical resection is the mainstay of multidisciplinary treatment for PHCC and IHCC. In advanced stages of IHCC, the combination of loco-regional therapies and repeat surgery, along with the enhanced efficacy of systemic chemotherapy, plays a significant role in a patient's survival.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"34-44"},"PeriodicalIF":1.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report. 土耳其胃肠病学会：胰腺工作组，急性胰腺炎委员会共识报告。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-11 DOI: 10.5152/tjg.2024.24392

Deniz Öğütmen Koç, Göksel Bengi, Özlem Gül, Yeşim Özen Alahdab, Engin Altıntaş, Sezgin Barutçu, Yılmaz Bilgiç, Birol Bostancı, Mehmet Cindoruk, Kadri Çolakoğlu, Deniz Duman, Nergiz Ekmen, Ahmet Tarık Eminler, Yasemin Gökden, Süleyman Günay, Gözde Derviş Hakim, Kader Irak, Sabite Kacar, İsmail Hakkı Kalkan, Elmas Kasap, Aydın Şeref Köksal, Sedef Kuran, Nevin Oruç, Osman Özdoğan, Burak Özşeker, Erkan Parlak, Murat Saruç, İlker Şen, Gürhan Şişman, Mukaddes Tozlu, Nurettin Tunç, Nalan Gülşen Ünal, Hakan Ümit Ünal, Serkan Yaraş, Abdullah Emre Yıldırım, Müjde Soytürk, Dilek Oğuz, Orhan Sezgin

{"title":"Turkish Society of Gastroenterology: Pancreas Working Group, Acute Pancreatitis Committee Consensus Report.","authors":"Deniz Öğütmen Koç, Göksel Bengi, Özlem Gül, Yeşim Özen Alahdab, Engin Altıntaş, Sezgin Barutçu, Yılmaz Bilgiç, Birol Bostancı, Mehmet Cindoruk, Kadri Çolakoğlu, Deniz Duman, Nergiz Ekmen, Ahmet Tarık Eminler, Yasemin Gökden, Süleyman Günay, Gözde Derviş Hakim, Kader Irak, Sabite Kacar, İsmail Hakkı Kalkan, Elmas Kasap, Aydın Şeref Köksal, Sedef Kuran, Nevin Oruç, Osman Özdoğan, Burak Özşeker, Erkan Parlak, Murat Saruç, İlker Şen, Gürhan Şişman, Mukaddes Tozlu, Nurettin Tunç, Nalan Gülşen Ünal, Hakan Ümit Ünal, Serkan Yaraş, Abdullah Emre Yıldırım, Müjde Soytürk, Dilek Oğuz, Orhan Sezgin","doi":"10.5152/tjg.2024.24392","DOIUrl":"10.5152/tjg.2024.24392","url":null,"abstract":"Acute pancreatitis (AP) is a clinical condition that arises acutely in the pancreas through various inflammatory pathways due to multiple causes. Turkish Society of Gastroenterology Pancreas Working Group developed comprehensive guidance statements regarding the management of AP that include its epidemiology, etiology, clinical presentation, diagnostic criteria, disease severity, treatment, prognosis, local and systemic complications. The statements were developed through literature review, deliberation, and consensus opinion. These statements were ultimately used to develop a conceptual framework for the multidisciplinary management of AP.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"35 Suppl 1","pages":"S1-S44"},"PeriodicalIF":1.4,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142734412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NOP2/Sun RNA Methyltransferase 4 Regulates the Mammalian Target of Rapamycin Signaling Pathway to Promote Hepatocellular Carcinoma Progression. NOP2/Sun RNA甲基转移酶4调控哺乳动物雷帕霉素信号通路靶点促进肝细胞癌进展

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-04 DOI: 10.5152/tjg.2024.23684

Congren Wang, Shaoying Ke, Shaoze Lin, Conglin Lin, Zhibing Cai, Lingju Hong, Qunxiong Pan

{"title":"NOP2/Sun RNA Methyltransferase 4 Regulates the Mammalian Target of Rapamycin Signaling Pathway to Promote Hepatocellular Carcinoma Progression.","authors":"Congren Wang, Shaoying Ke, Shaoze Lin, Conglin Lin, Zhibing Cai, Lingju Hong, Qunxiong Pan","doi":"10.5152/tjg.2024.23684","DOIUrl":"10.5152/tjg.2024.23684","url":null,"abstract":"Background/aims: NOP2/Sun RNA methyltransferase 4 (NSUN4) is a prognostic indicator for hepatocellular carcinoma (HCC). However, the mechanism of NSUN4 in HCC is still unexplored. This project mainly focuses on the function and mechanism of NSUN4 in HCC malignant progression.Materials and methods: The relation between the expression level of NSUN4 and the prognosis of HCC was measured by the means of bioinformatics. The expression level of NSUN4 was assessed by quantitative reverse transcription polymerase chain reaction. The western blot was utilized to determine the protein expression level of NSUN4 and mammalian target of rapamycin (mTOR) pathway-related proteins in cells and mouse tumor tissues. Cell counting kit-8 and colony formation assays were employed to measure cell proliferation ability. The wound healing assay and Transwell experiment were conducted to measure the cells' migration and invasion abilities. Flow cytometry was applied to determine the cell cycle.Results: NSUN4 was overexpressed in HCC tissues and cells, enhancing cell migration, proliferation, and invasion. The influence that NSUN4 exerted on HCC malignant progression could be reduced by the inhibitor of the mTOR pathway.Conclusion: The study explained the mechanism and influence of NSUN4 on HCC progression by regulating the mTOR signaling pathway through in vitro and in vivo experiments, providing the theoretical basis and a new research direction for clinical prognostic prediction and treatment.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"24-33"},"PeriodicalIF":1.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning. 肝移植治疗蘑菇中毒急性肝衰竭。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-11-04 DOI: 10.5152/tjg.2024.24226

Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz

{"title":"Liver Transplantation for Acute Liver Failure due to Mushroom Poisoning.","authors":"Hayri Canbaz, Attila Bestemir, Sami Akbulut, Sezai Yilmaz, Yusuf Yavuz","doi":"10.5152/tjg.2024.24226","DOIUrl":"10.5152/tjg.2024.24226","url":null,"abstract":"Background/aims: Liver transplantation is a life-saving approach in some cases of mushroom poisoning, which is one of the important causes of acute liver failure. However, debate continues regarding the timing of liver transplantation. The aim of this study is to retrospectively evaluate the results of patients who underwent liver transplantation due to mushroom poisoning.Materials and methods: In this descriptive and observational study, the demographic and clinical data of 26 patients who presented to emergency units due to clinical features of acute hepatic failure secondary to mushroom poisoning between October 2008 and November 2023 and who underwent emergent liver transplantation were retrospectively reviewed.Results: A total of 26 patients with a median (IQR) age of 39 (36) years were included in this study. The patients were divided into two groups: alive (n = 18) and dead (n = 8). No statistically significant differences were found between groups in terms of age, BMI, blood groups, hepatic encephalopathy grade, biochemical analysis obtained on the first days of hospital admission (AST, ALT, creatinine, ammonia, PTT, INR, albumin, platelets, HGB), ICU stay, cold ischemia time (CIT) and warm ischemia time (WIT), total bilirubin (P = .052), and time from poisoning to admission (P = .051). On the other hand, there were statistically significant differences between the alive and dead groups in terms of MELD score (P = .016; 23 vs. 34), re-transplantation (P = .022; 0% vs. 37.5%), hospital stay (P = .004; 24 vs. 6 days), and follow up (P < .001; 3423 vs. 5 days).Conclusions: This study showed that mortality was higher in patients with high MELD scores and patients who underwent re-transplantation. However, this study needs to be supported by multicenter prospective studies.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"107-113"},"PeriodicalIF":1.4,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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