Turkish Journal of Gastroenterology最新文献_第10页

Clinical Characteristics and Etiology of Terminal Ileum Ulcers: A Retrospective Study. 回肠末端溃疡的临床特征和病因：一项回顾性研究

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-24 DOI: 10.5152/tjg.2024.23589

Nomingerel Tseveldorj, Cemre Gündüz, Yaşar Ozan Saraçoğlu, Ülkü Dağlı

{"title":"Clinical Characteristics and Etiology of Terminal Ileum Ulcers: A Retrospective Study.","authors":"Nomingerel Tseveldorj, Cemre Gündüz, Yaşar Ozan Saraçoğlu, Ülkü Dağlı","doi":"10.5152/tjg.2024.23589","DOIUrl":"10.5152/tjg.2024.23589","url":null,"abstract":"Terminal ileal ulcers can have various etiologies, including Crohn's disease (CD), infections, and medication-related causes. This study aims to investigate the incidence of terminal ileal ulcers detected during colonoscopies, explore their underlying causes, and analyze their clinical, endoscopic, and histopathological characteristics. Additionally, the study aims to identify predictive factors that indicate the need for follow-up. Medical records of all patients who underwent colonoscopies, between 2009 and 2019 were retrospectively reviewed. Patients with terminal ileal ulcers, with or without ileocecal valve involvement, were included in the study. Demographic information, medication usage, symptoms, colonoscopy findings, and histopathological data of these patients were analyzed. A total of 398 patients were included in the study. Histopathological examination revealed that 243 patients (61%) had active ileitis, and 69 patients (17.4%) had chronic active ileitis. The final diagnoses for ulcers were: nonspecific ulcers in 212 patients (53.3%), CD in 66 patients (16.6%), and non-steroidal anti-inflammatory drug-induced ulcers in 58 patients (14.6%). In the multivariate analysis, the parameters predicting CD included the presence of 10 or more ulcers (odds ratio (OR) = 7.305), deep ulcers (OR = 7.431), and edematous surrounding tissue (OR = 5.174), all of which were statistically significant (P < .001). Upon final evaluation, only 66 patients (16.6%) were diagnosed with CD, while 212 patients (53.3%) had nonspecific ulcers. The majority of patients with healed ulcers exhibited pathological findings consistent with active ileitis. Therefore, it can be concluded that not all terminal ileal ulcers are indicative of CD. In those cases with active ileitis, repetitive colonoscopies should be reconsidered.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"35 8","pages":"609-617"},"PeriodicalIF":1.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IL6ST: A Novel Therapeutic Target for Managing and Treating Colorectal Cancer Via Ferroptosis. IL6ST：通过铁凋亡管理和治疗结直肠癌的新治疗靶点。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-06 DOI: 10.5152/tjg.2024.23353

Kun Zhao, Baoguo He, Kuijin Xue, Bin Cao, Keyu Ren, Yanchun Jin, Shanwei Rong, Liangzhou Wei, Hongyun Wei

{"title":"IL6ST: A Novel Therapeutic Target for Managing and Treating Colorectal Cancer Via Ferroptosis.","authors":"Kun Zhao, Baoguo He, Kuijin Xue, Bin Cao, Keyu Ren, Yanchun Jin, Shanwei Rong, Liangzhou Wei, Hongyun Wei","doi":"10.5152/tjg.2024.23353","DOIUrl":"10.5152/tjg.2024.23353","url":null,"abstract":"Inflammation is an essential driver of colorectal cancer (CRC). Identifying phenotypes and targets associated with inflammation and cancer may be an effective way to treat CRC. R was used to analyze interleukin 6 cytokine family signal transducer (IL6ST) expression in The Cancer Genome Atlas Colon Adenocarcinoma database. Immunohistochemistry, western blotting, and quantitative PCR were used to detect IL6ST and ferroptosis-related genes expression in our cohort. Receiver operating characteristic curves evaluated the specificity and sensitivity of IL6ST to predict CRC. Cell counting kit-8 investigated cell viability. Mitochondrial morphology, total iron, and reactive oxygen species (ROS) levels were evaluated to assess cell ferroptosis. The correlation of IL6ST and immune cells filtration were also analyzed based on R. IL6ST was significantly upregulated in CRC tissues (P < .05). The specificity and sensitivity of IL6ST for predicting CRC were high (area under the curve (AUC): 0.919, CI: 0.896-0.942). IL6ST was significantly associated with ferroptosis-related genes. IL6ST knockdown decreased SW480 cells viability (knockdown vs. vector, P = .004), promoted the ferroptosis phenotype, and increased iron accumulation (knockdown vs. vector P = .014) and ROS production (knockdown vs. vector P = .005). IL6ST upregulation increased SW620 cells viability (overexpression vs. blank, P = .001), inhibited the ferroptosis phenotype, and decreased iron accumulation (overexpression vs. vector P = 0.006) and ROS production (overexpression vs. vector P = .05). IL6ST increased FTH1 and GPX4 expression and reduced PTGS2, NOX1, and ACSL4 expression (P < .01). Additionally, IL6ST level is linked to immune cell infiltration. A higher enrichment score of T cells was observed in IL6ST up-regulated group. IL6ST inhibits ferroptosis and may be a potential novel therapeutic target in CRC via the modulation of ferroptosis.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"35 9","pages":"690-698"},"PeriodicalIF":1.4,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11391227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142331960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Dysfunction-Associated Fatty Liver Disease and Fibrosis Status in Patients with Type 2 Diabetes Treated at Internal Medicine Clinics: Türkiye DAHUDER Awareness of Fatty Liver Disease (TR-DAFLD) Study. 在内科诊所接受治疗的 2 型糖尿病患者的代谢功能障碍相关脂肪肝和纤维化状况：Türkiye DAHUDER 脂肪肝认知（TR-DAFLD）研究。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-06 DOI: 10.5152/tjg.2024.24045

Yasin Şahintürk, Gökhan Köker, Nizameddin Koca, Hilmi Erdem Sümbül, İsmail Demir, Havva Keskin, Selçuk Yaylacı, İhsan Solmaz, Banu Açmaz, Hamit Yıldız, Sibel Ocak Serin, Şükriye Taşçı, Teslime Ayaz, Eşref Araç, Hasan Sözel, Ali Kırık, Attila Önmez, Seher Kır, Hacer Şen, Alihan Oral, Fatih Necip Arıcı, Mustafa Kanat, Ayhan Hilmi Çekin, Seyit Uyar

{"title":"Metabolic Dysfunction-Associated Fatty Liver Disease and Fibrosis Status in Patients with Type 2 Diabetes Treated at Internal Medicine Clinics: Türkiye DAHUDER Awareness of Fatty Liver Disease (TR-DAFLD) Study.","authors":"Yasin Şahintürk, Gökhan Köker, Nizameddin Koca, Hilmi Erdem Sümbül, İsmail Demir, Havva Keskin, Selçuk Yaylacı, İhsan Solmaz, Banu Açmaz, Hamit Yıldız, Sibel Ocak Serin, Şükriye Taşçı, Teslime Ayaz, Eşref Araç, Hasan Sözel, Ali Kırık, Attila Önmez, Seher Kır, Hacer Şen, Alihan Oral, Fatih Necip Arıcı, Mustafa Kanat, Ayhan Hilmi Çekin, Seyit Uyar","doi":"10.5152/tjg.2024.24045","DOIUrl":"10.5152/tjg.2024.24045","url":null,"abstract":"This awareness study aimed to determine the ultrasound (US) examination rates in relation to US-confirmed metabolic dysfunction-associated fatty liver disease (MAFLD) diagnosis in internal medicine outpatients with type 2 diabetes (T2D) across Türkiye. A total of 6283 T2D patients were included in this multicenter retrospective cohort study conducted at 17 internal medicine clinics across Türkiye. The presence and indications for US performed within the last 3 years were recorded along with US-confirmed MAFLD rates, laboratory findings on the day of US, and referral rates. Fibrosis-4 (FIB-4) index was calculated to estimate the risk of advanced liver fibrosis (FIB-4 index ≥ 1.3). Overall, 1731 (27.6%) of 6283 patients had US examination, which revealed MAFLD diagnosis in 69.9% of cases. In addition, 24.4% of patients with US-confirmed MAFLD were at risk of advanced fibrosis (FIB-4 index ≥ 1.3), and the referral rate was 15.5%. In conclusion, our findings emphasize an insufficient MAFLD awareness among clinicians and the likelihood of most of T2D patients to be at risk of living with an unknown status regarding their MAFLD and advanced fibrosis risk.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"35 8","pages":"643-650"},"PeriodicalIF":1.4,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver Stiffness and Steatosis Measurements with iLivTouch and FibroScan: A Comparative Study. 使用 iLivTouch 和 FibroScan 测量肝脏硬度和脂肪变性：比较研究

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-06 DOI: 10.5152/tjg.2024.23531

Mübin Özercan, Zeynep Melekoğlu Ellik, Ayhan Parmaksız, Mesut Gümüşsoy, Serkan Duman, Necati Örmeci

{"title":"Liver Stiffness and Steatosis Measurements with iLivTouch and FibroScan: A Comparative Study.","authors":"Mübin Özercan, Zeynep Melekoğlu Ellik, Ayhan Parmaksız, Mesut Gümüşsoy, Serkan Duman, Necati Örmeci","doi":"10.5152/tjg.2024.23531","DOIUrl":"10.5152/tjg.2024.23531","url":null,"abstract":"The presence of liver fibrosis is the most important indicator of progression to cirrhosis. Noninvasive measurement of liver stiffness is crucial for detecting fibrosis. Vibration-controlled transient elastography is one of the most useful methods for this purpose. We aimed to compare the liver stiffness and steatosis measurements with iLivTouch© and the FibroScan© elastography devices Two hundred thirty-seven consecutive adult patients with chronic hepatitis were included in the study. The liver stiffness and steatosis were measured with iLivTouch and FibroScan on the same day. Thirty-one patients had liver biopsies on the same day with elastography procedures. The diagnostic performances of iLivTouch and FibroScan were compared to aspartate aminotransferase to platelet ratio index (APRI), Fibrosis-4 (FIB-4), and nonalcoholic fatty liver disease fibrosis score (NFS). The liver stiffness measurements obtained using iLivTouch and FibroScan had median value of 10.3 (ranging from 2.9 to 46.3) and 7.2 (ranging from 2.5 to 75), respectively. The mean steatosis measurements using ultrasound attenuation parameter with iLivTouch were 245.51 ± 45.79, while the mean controlled attenuation parameter measurements using FibroScan were 259.37 ± 75.0. In subgroup analysis, the AUC of iLivTouch on detecting signiicant fibrosis [0.83, (P = .002)] was minimally higher than other noninvasive methods [0.82 for NFS (P = .003), 0.80 for FibroScan (P = .006), 0.68 for FIB-4 (P = .089), and 0.53 for APRI (P = .76)]. The stiffness and steatosis measurements with iLivTouch and FibroScan were not similar. The accuracy of iLivTouch in detecting significant and advanced fibrosis was minimally higher. Large clinical trials are necessary to support these findings.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"35 8","pages":"634-642"},"PeriodicalIF":1.4,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11363179/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141989492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rupture of Hepatic Artery Aneurysm as a Cause of Severe Upper Gastrointestinal Bleeding and Cholangitis in a Liver Transplanted Patient. 肝动脉瘤破裂导致肝移植患者严重上消化道出血和胆管炎

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-06 DOI: 10.5152/tjg.2024.24039

Cumali Efe, Ersin Batıbay, Osman Yüksekyayla, Mehmet Kolu

引用次数: 0

Direct Clipping for Active Colonic Diverticular Bleeding Using an Endoclip with Re-grasping Function. 使用具有再夹持功能的内夹直接夹闭活动性结肠憩室出血。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-06 DOI: 10.5152/tjg.2024.24004

Takaaki Kishino, Maiko Yamakawa

引用次数: 0

Impact of Dialysis Method on Colon Postpolypectomy Bleeding in Patients with End-stage Renal Disease. 透析方法对终末期肾病患者结肠息肉切除术后出血的影响

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-06 DOI: 10.5152/tjg.2024.23640

Hsueh-Chien Chiang, Chiang Chien-Ming, Lin Xi-Zhang, Chen Po-Jun

引用次数: 0

Selective Immunoglobulin M Deficiency in Patients with Autoimmune Liver Diseases. 自身免疫性肝病患者的选择性免疫球蛋白 M 缺乏症

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-01 DOI: 10.5152/tjg.2024.23413

Yasemin H Balaban, Mohamed İsmail, Şefika Nur Ayar

引用次数: 0

Functional Bowel Disorder Management in Routine Practice with Tips for Hot Topics: Expert Opinion Review. 功能性肠病的常规治疗与热点话题提示：专家意见回顾。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-01 DOI: 10.5152/tjg.2024.24029

Filiz Akyüz, Altay Çelebi, İbrahim Doğan, Yusuf Erzin, Taylan Kav, Müjde Soytürk, Dilek Oğuz, Birol Özer, Sabahattin Kaymakoğlu

{"title":"Functional Bowel Disorder Management in Routine Practice with Tips for Hot Topics: Expert Opinion Review.","authors":"Filiz Akyüz, Altay Çelebi, İbrahim Doğan, Yusuf Erzin, Taylan Kav, Müjde Soytürk, Dilek Oğuz, Birol Özer, Sabahattin Kaymakoğlu","doi":"10.5152/tjg.2024.24029","DOIUrl":"10.5152/tjg.2024.24029","url":null,"abstract":"Functional gastrointestinal system disorders are common problems in practice. The most common symptoms are abdominal pain, gas, bloating, diarrhea, constipation, and a mixture of these, and similar symptoms can be seen in conditions such as inflammatory bowel disease, colorectal cancer, and celiac disease depending on the age of the patient, indicating the importance of differential diagnosis. The importance of patient management is shown by making a symptom-based diagnosis and making cost-effective, that is, limited advanced examinations. The pathophysiology of irritable bowel syndrome (IBS) is multifactorial, and stress is one of the leading triggers of IBS symptoms. Therefore, terminology will change to gut-brain interaction disorders in the future, and the patient-physician relationship has a special place in the treatment of functional bowel disorder. Dietary recommendation and medical treatment in IBS should be determined according to the predominant symptom and symptom severity. In addition to diet, some lifestyle changes can also be helpful in reducing IBS symptoms. Antispasmodics and antidepressants are not fast-acting. These drugs should be used for at least 2-4 weeks to see the efficacy of treatment. Drugs should be used according to the standard recommended duration and dose in intermittent treatments.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"35 6","pages":"423-439"},"PeriodicalIF":1.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232060/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Efficacy and Acceptability of Endoscopic Methods for Rectal Neuroendocrine Neoplasms with Low Malignant Potential: A Network Meta-analysis. 低恶性潜能直肠神经内分泌肿瘤内窥镜方法的疗效和可接受性比较：网络 Meta 分析

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-06-01 DOI: 10.5152/tjg.2024.23477

Shun-Tao Zhang, Qi Chen, Yuan-Meng Zhang, Qiao-Yu Li, Yu-Chen Gao, Wen-Jun Meng, Lie-Wang Qiu, Bo Zeng

{"title":"Comparative Efficacy and Acceptability of Endoscopic Methods for Rectal Neuroendocrine Neoplasms with Low Malignant Potential: A Network Meta-analysis.","authors":"Shun-Tao Zhang, Qi Chen, Yuan-Meng Zhang, Qiao-Yu Li, Yu-Chen Gao, Wen-Jun Meng, Lie-Wang Qiu, Bo Zeng","doi":"10.5152/tjg.2024.23477","DOIUrl":"10.5152/tjg.2024.23477","url":null,"abstract":"Background/aims: Although endoscopic resection is an effective treatment of rectal neuroendocrine neoplasms (R-NENs) with low malignant potential, there is no consensus on the most recommended endoscopic method. This study aimed to assess the efficacy and acceptability of different endoscopic treatments for R-NENs with low malignant potential.Materials and methods: We searched databases for studies on treatments of R-NENs using endoscopic resection. These studies comprised techniques such as endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), modified endoscopic mucosal resection (EMRM), modified endoscopic submucosal dissection (ESDM), and transanal endoscopic microsurgery (TEM). The primary outcomes assessed were histological complete resection (HCR).Results: Overall, 38 retrospective studies (3040 R-NENs) were identified. Endoscopic mucosal resection with a cap (EMRC), endoscopic mucosal resection with ligation (EMRL), ESD, ESDM, and TEM demonstrated higher resectability than did EMR in achieving HCR. Endoscopic mucosal resection, EMRC, EMRL, EMRP, EMRD, and EMRU required shorter operation times than did ESD. Endoscopic mucosal resection, EMRC, ESDM, and TEM incurred lower risks than did ESD.Conclusion: Regarding R-NENs <20 mm with low malignant potential, ESD could be used as the primary treatment. However, TEM may be more effective if supported by economic conditions and hospital facility. With respect to R-NENs <16 mm with low malignant potential, EMRL could be used as the primary treatment. In regard to R-NENs <10 mm with low malignant potential, EMRL, EMRC, and ESD could be used as the primary treatment. However, EMRL and EMRC might be better when operational difficulties and economic conditions were considered.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"35 6","pages":"440-452"},"PeriodicalIF":1.4,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11232080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0