Turkish Journal of Gastroenterology最新文献

{"title":"Long-Term Serum Amyloid A Profile in Clinically Stable Pediatric Liver Transplant Recipients.","authors":"Sezin Aydemir, İlgin ÖzdeN, Zerrin Önal, Serdar Cantez, Özlem Durmaz","doi":"10.5152/tjg.2026.26525","DOIUrl":"https://doi.org/10.5152/tjg.2026.26525","url":null,"abstract":"<p><strong>Background/aims: </strong>Serum amyloid A (SAA) is an acute-phase protein whose sustained elevation is required for AA amyloid fibril formation. Although AA amyloidosis is a rare complication of solid organ transplantation, the long term SAA profile of clinically stable pediatric liver transplant recipients remains unknown. This study aimed to characterize long-term SAA concentrations in this population.</p><p><strong>Materials and methods: </strong>This observational study included 51 pediatric liver transplant recipients and 50 children with acute febrile infections. Cross-sectional SAA measurements were obtained in clinically stable recipients at least 6 months after transplantation. Children with acute febrile infections served as a high-inflammation reference group. In addition, 7 recipients underwent serial SAA measurements before transplantation and at 1 week, 1 month, and 6 months after transplantation.</p><p><strong>Results: </strong>Median SAA concentrations were significantly lower in clinically stable transplant recipients than in children with acute infection (4.2 mg/L [0.7-71.8] vs. 172 mg/L [1.5-961], P < .001). SAA concentrations ≥10 mg/L were observed in 14% of transplant recipients and 96% of children with acute infections. In the longitudinal subgroup, SAA concentrations increased during the early postoperative period and declined toward baseline by 6 months (P = .014).</p><p><strong>Conclusion: </strong>SAA concentrations were generally low in clinically stable pediatric liver transplant recipients during long-term follow-up but were substantially higher in children with acute infections. These findings provide insight into long-term SAA concentrations in this population and address an important gap in the literature.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic Ultrasound in the Risk Stratification of Pancreatic Cystic Lesions.","authors":"Süleyman Yildirim","doi":"10.5152/tjg.2026.26579","DOIUrl":"https://doi.org/10.5152/tjg.2026.26579","url":null,"abstract":"","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atypical Pancreatic Head Hemangioma Eroding into the Duodenum: A Rare Cause of Massive Upper Gastrointestinal Bleeding.","authors":"K Manoj Kumar, R Prabhakaran","doi":"10.5152/tjg.2026.26392","DOIUrl":"https://doi.org/10.5152/tjg.2026.26392","url":null,"abstract":"","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149118142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic Double-Balloon Enteroscopy Findings in Hookworm-Induced Jejunal Mucosal Bleeding: A Video Case Report.","authors":"Tian He, Changjian He, Zan Zuo, Min Tang, Wen Zhang, Ping Wan","doi":"10.5152/tjg.2026.26395","DOIUrl":"https://doi.org/10.5152/tjg.2026.26395","url":null,"abstract":"","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving the Early Detection of Hepatocellular Carcinoma in Patients with Chronic Liver Disease: An Integrated C-GALAD Model and Cell-Free DNA Approach.","authors":"JianSheng Chen, BaoQuan Yan, XiaoMei Liu, Wei Qiu, JiPing Yang","doi":"10.5152/tjg.2026.26170","DOIUrl":"https://doi.org/10.5152/tjg.2026.26170","url":null,"abstract":"<p><strong>Background/aims: </strong>Chronic liver disease (CLD) confers an increased risk of hepatocellular carcinoma (HCC), but individual biomarkers have limited diagnostic performance, necessitating a combined approach. The study aimed to evaluate the value of a combined strategy integrating the C-GALAD (gender, age, lens culinaris agglutinin-reactive alpha fetoprotein [AFP-L3], and des-gamma-carboxy prothrombin [DCP]) model with circulating cell-free DNA (cfDNA) for the early detection of progression from CLD to HCC.</p><p><strong>Materials and methods: </strong>A total of 226 patients (HCC, n = 57; CLD without HCC, n = 169) were enrolled. Pretreatment blood samples were collected, and AFP, AFP-L3, and DCP levels were measured; C-GALAD scores were calculated. Plasma cfDNA was extracted and quantified. Baseline clinical characteristics (age, sex, etiology, and cirrhosis) and laboratory parameters (platelet count, total bilirubin, serum albumin [ALB], AFP, AFP-L3, and DCP) were compared between groups. Multivariate logistic regression and receiver operating characteristic curve analysis were performed to identify independent diagnostic factors and evaluated diagnostic performance.</p><p><strong>Results: </strong>The HCC group had a higher prevalence of cirrhosis, lower ALB levels, and higher AFP, AFP-L3, and DCP levels than the CLD group. Median C-GALAD scores were 51 (interquartile range [IQR], 43-57) in the HCC group and 51 (IQR, 46-58) in the CLD group, whereas cfDNA concentrations were 40.25 (IQR, 33.41-48.19) and 31.62 (25.90-35.45) ng/mL, respectively (both P < .001). Multivariable logistic regression identified cirrhosis (adjusted odds ratio [OR], 3.14; 95% CI, 1.18-8.37; P = .022), C-GALAD score (adjusted OR, 2.32; 95% CI, 1.73-3.10; P < .001), and cfDNA concentration (adjusted OR, 1.20; 95% CI, 1.12 1.30; P < .001) as independent predictors of HCC. The area under the curve (AUC) was 0.850 for C-GALAD (sensitivity, 66.67%; specificity, 89.94%) and 0.799 for cfDNA. The combined model achieved an AUC of 0.917, with a sensitivity of 82.46%, specificity of 91.72%, accuracy of 89.38%, positive predictive value of 77.05%, and negative predictive value of 93.94%.</p><p><strong>Conclusion: </strong>The combined C-GALAD and cfDNA strategy significantly improves the accuracy of early HCC detection in patients with CLD, demonstrating excellent diagnostic performance.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Recurrent Acute Pancreatitis Induced by Intragastric Balloon Compression.","authors":"Zekiye Nur Harput, İlyas Gödelek, Mehmet Kasim Aydin, Oktay Bayraktar, Engin Altintaş, Orhan Sezgin","doi":"10.5152/tjg.2026.26350","DOIUrl":"10.5152/tjg.2026.26350","url":null,"abstract":"","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Microbiota-Gut-Brain Axis in Disorders of Gut-Brain Interaction: Mechanisms and Emerging Therapeutic Strategies.","authors":"Cong Yu, Xiu Wang, Shuzhu Chen","doi":"10.5152/tjg.2026.25517","DOIUrl":"https://doi.org/10.5152/tjg.2026.25517","url":null,"abstract":"<p><p>Disorders of gut-brain interaction (DGBIs), traditionally termed functional gastrointestinal disorders, affect approximately 15% of adults worldwide and are characterized by chronic digestive symptoms without identifiable structural abnormalities. According to the recently updated Rome V framework, DGBIs are characterized by pathogenic dysregulation of bidirectional communication among the central nervous system, enteric nervous system, and intestinal microbiota. This review examines the anatomical and molecular foundations of gut-brain axis (GBA) communication, emphasizing the roles of microbial metabolites (e.g., short-chain fatty acids and tryptophan derivatives) in neuroimmune modulation and visceral sensitivity. The authors analyze GBA dysfunction across major DGBIs subtypes (irritable bowel syndrome, functional dyspepsia, and functional abdominal pain syndrome), highlighting microbiota dysbiosis, barrier dysfunction, and central sensitization. Current therapies include psychological interventions, neuromodulation, microbiota-targeted approaches, dietary management, and pharmacotherapy; however, treatment responses remain highly heterogeneous across patient populations, highlighting the potential value of biomarker-guided and mechanism based therapeutic approaches. Future paradigms will require multiomics profiling, artificial intelligence, and precision medicine to develop mechanism-based diagnostics and individualized treatments, advancing care from symptom-focused to mechanism-targeted approaches.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Creeping Fat in Crohn's Disease: Association or Prognostic Factor?","authors":"Melek Balamir","doi":"10.5152/tjg.2026.26548","DOIUrl":"https://doi.org/10.5152/tjg.2026.26548","url":null,"abstract":"","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Intensive Care Unit Admission and Mortality in Acute Pancreatitis.","authors":"Mehmet Yildiz, Mustafa Tosun, Engin Altınkaya, Hilmi Ataseven","doi":"10.5152/tjg.2026.26313","DOIUrl":"https://doi.org/10.5152/tjg.2026.26313","url":null,"abstract":"<p><strong>Background/aims: </strong>Early identification of patients at risk for severe acute pancreatitis (AP) remains challenging. The authors compared the performance of albumin-based ratios in predicting intensive care unit (ICU) admission and mortality among patients with AP.</p><p><strong>Materials and methods: </strong>This retrospective cohort study included 499 patients with AP. The C-reactive protein (CRP)/albumin ratio (CAR), glucose/albumin ratio (GAR), lactate dehydrogenase/albumin ratio (LAR), and red cell distribution width/albumin ratio (RAR) were calculated at admission and during the early phase of hospitalization. The need for ICU admission was the primary outcome.</p><p><strong>Results: </strong>Eleven patients (2.2%) required ICU admission, and 5 (1.0%) died. At admission, CAR was elevated in patients requiring ICU admission (14.27 vs. 3.31, P = .022). At 48 hours, CAR was significantly higher in patients requiring ICU admission (88.86 vs. 13.24, P < .001) and demonstrated high discriminative ability (area under the curve [AUC], 0.921; 95% CI, 0.85-0.98), comparable with that of CRP (AUC = 0.922, P = .964). GAR and RAR demonstrated more modest associations. Exploratory mortality analyses suggested that earlyphase CAR at 48 hours and admission RAR were higher among nonsurvivors.</p><p><strong>Conclusion: </strong>Early-phase (48 hours) CAR is a reliable predictor of ICU admission in patients with AP, with predictive performance comparable with that of CRP while incorporating albumin status. It may serve as a simple adjunctive tool for early risk stratification.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149026785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing the Noninvasive Diagnosis of Cytomegalovirus Gastrointestinal Disease: Perspectives on Plasma Cytomegalovirus DNA and Clinical Prediction Models.","authors":"Selçuk Candan","doi":"10.5152/tjg.2026.26551","DOIUrl":"https://doi.org/10.5152/tjg.2026.26551","url":null,"abstract":"","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149013225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}