Turkish Journal of Gastroenterology最新文献_第2页

Six-Month Outcomes of Endoscopic Intragastric Balloon Therapy: A Prospective Single-Center Study. 内镜胃内球囊治疗的六个月结果：一项前瞻性单中心研究。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-05-20 DOI: 10.5152/tjg.2025.25043

Mahmut Yüksel, Kerem Kenarlı, Fırathan Sarıaltın, Emine Sena Sözen, Ahmet Akbay, Erdoğan Deniz, Kübra Köken, Çağdaş Erdoğan, Mevlüt Hamamcı, Hasan Tankut Köseoğlu

{"title":"Six-Month Outcomes of Endoscopic Intragastric Balloon Therapy: A Prospective Single-Center Study.","authors":"Mahmut Yüksel, Kerem Kenarlı, Fırathan Sarıaltın, Emine Sena Sözen, Ahmet Akbay, Erdoğan Deniz, Kübra Köken, Çağdaş Erdoğan, Mevlüt Hamamcı, Hasan Tankut Köseoğlu","doi":"10.5152/tjg.2025.25043","DOIUrl":"10.5152/tjg.2025.25043","url":null,"abstract":"Background/Aims: Obesity is a growing global health challenge associated with increased morbidity and mortality. Intragastric balloon therapy has emerged as a minimally invasive alternative for weight management in patients unsuitable for bariatric surgery or as a bridging intervention. This study evaluates the efficacy, safety, and metabolic impacts of intragastric balloon therapy in a prospective cohort. \u0000\u0000Materials and Methods: A total of 65 patients underwent endoscopic intragastric balloon therapy between October 2023 and January 2025. Comprehensive baseline evaluations included body weight, body mass index, and computed tomography analysis of visceral and subcutaneous fat tissue thickness. Patients were followed up at 2 and 6 months post procedure. Statistical analysis was performed to assess weight loss, metabolic changes, and safety outcomes. \u0000\u0000Results: Of the initial cohort, 62 patients (mean age: 37.89 years; 75.4% female) completed the study. The median body weight decreased significantly from 104.5 kg pre-procedure to 88 kg at 6 months (P < .001). Body mass index values similarly declined, with a mean reduction from 37.59 to 32.79 kg/m2 (P < .001). Significant decreases in subcutaneous and visceral fat tissue thickness were observed (P < .001 and P = .032, respectively). Only 1 patient (1.5%) required early balloon removal due to nausea, with no other major complications reported. \u0000\u0000Conclusion: Intragastric balloon therapy is an effective and safe intervention for short-term weight loss, with significant reductions in adipose tissue. Further research is needed to evaluate its long-term efficacy and metabolic benefits.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"1 1","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the Editor: A Rare Case of Upper Gastrointestinal Bleeding due to Amyloidosis. 致编辑：一例罕见的上消化道淀粉样变性出血病例。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-05-20 DOI: 10.5152/tjg.2025.24476

Ali Karataş, Halit Kandemir, Gülden Bilican, Mehmet Cindoruk, Tarkan Karakan

引用次数: 0

Total Metabolic Syndrome Score in Addition To FIB-4 Score May Be Useful in Predicting Advanced Fibrosis in Metabolic Dysfunction-Associated Steatotic Liver Disease. 除FIB-4评分外，总代谢综合征评分可能有助于预测代谢功能障碍相关脂肪变性肝病的晚期纤维化。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-05-20 DOI: 10.5152/tjg.2025.25058

Burcu Gurbuz, Bahadir Koylu, Onur Keskin

引用次数: 0

The Knockdown of USP34 Inhibits the Progression of Hepatocellular Carcinoma by Accelerating c-Myc Degradation. 敲低USP34通过加速c-Myc降解抑制肝细胞癌的进展

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-04-21 DOI: 10.5152/tjg.2025.24335

Hailiang Liu, Xile Wei, Ye Nie, Jianshan Liu, Ming Fan

{"title":"The Knockdown of USP34 Inhibits the Progression of Hepatocellular Carcinoma by Accelerating c-Myc Degradation.","authors":"Hailiang Liu, Xile Wei, Ye Nie, Jianshan Liu, Ming Fan","doi":"10.5152/tjg.2025.24335","DOIUrl":"https://doi.org/10.5152/tjg.2025.24335","url":null,"abstract":"Background/aims: The function and mechanism of ubiquitin-specific protease 34 (USP34) in hepatocellular carcinoma (HCC) were explored to provide new molecular targets for treating HCC.Materials and methods: In the present study, bioinformatics techniques, quantitative real-time polymerase chain reaction, and western blot were used to detect the level of USP34 in HCC tissues and cell lines. Small interfering RNA of USP34 was transfected into HCC cells, and then Cell Counting Kit-8 (CCK-8) assay, wound healing assay, and transwell assay were performed to verify the proliferation, migration and invasion of HCC cells. Enzyme-linked immunosorbent assay was utilized to assess the glycolysis level in HCC cells. Co-immunoprecipitation was used to evaluate the ubiquitination level of cellular Myc (c-Myc).Results: The expression of USP34 was upregulated in HCC patients and strongly associated with worse outcomes. Meanwhile, interference with USP34 suppressed the proliferation, migration, and invasion of HCC cells. In addition, silencing of USP34 reduced the glucose uptake, lactate production and ATP content in HCC cells, as well as downregulated the expression levels of glycolysis-related proteins (hexokinase 2, glucose transporter 1, pyruvate kinase M2, and lactate dehydrogenase A). Furthermore, the knockdown of USP34 enhanced the ubiquitination level of c-Myc and increased the degradation of c-Myc. Overexpression of c-Myc reverted the inhibitory effects of si-USP34 on the malignant biological behavior in HCC cells.Conclusion: The USP34 regulates aerobic glycolysis and inhibits the progression of HCC by accelerating c-Myc ubiquitinated degradation.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144004743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study. 揭示免疫特性与肝细胞癌之间的因果关系：来自双向孟德尔随机化研究的见解。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-04-21 DOI: 10.5152/tjg.2025.24558

Jie Li, Gechun Wang, Xiaonan Xiang, Jiaguo Wang

{"title":"Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study.","authors":"Jie Li, Gechun Wang, Xiaonan Xiang, Jiaguo Wang","doi":"10.5152/tjg.2025.24558","DOIUrl":"https://doi.org/10.5152/tjg.2025.24558","url":null,"abstract":"Background/aims: Hepatocellular carcinoma (HCC) is significantly influenced by the immune system, which plays a key role in its development, progression, treatment, and prognosis. While observational studies have revealed correlations between circulating immune traits and HCC, their genetic basis and causal links remain unclear. This study aims to investigate the genetic associations and bidirectional causal relationships between immune traits and HCC risk using Mendelian randomization (MR) approaches.Materials and methods: Genome-wide association study summary statistics from the FinnGen cohort (R9, including 453 HCC cases and 287137 controls) were used to perform a bidirectional two-sample MR analysis. The causal effects of immune traits on HCC, as well as reverse causality, were assessed. Sensitivity analyses, including heterogeneity and pleiotropy tests, were used to ensure the robustness and validity of the results.Results: Thirty-nine immune traits were identified to be significantly associated with HCC risk. Elevated levels of 10 immune traits were positively associated with increased HCC risk, while the abundance of 29 immune traits was inversely correlated with HCC incidence. Furthermore, the reverse MR analysis revealed significant causal effects of HCC on 11 immune traits.Conclusion: This study provides strong evidence of genetic links between systematic immune cell profiles and HCC, shedding light on the mechanisms underlying its onset and progression. These findings identify potential immune biomarkers for early diagnosis and immune-targeted therapies.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PPARγ Activates Autophagy by Suppressing the PI3K-AKT1-FOXO3 Signaling Pathway and thus Alleviates Hepatic Ischemia-Reperfusion Injury. PPARγ通过抑制PI3K-AKT1-FOXO3信号通路激活自噬，从而减轻肝缺血再灌注损伤。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-04-21 DOI: 10.5152/tjg.2025.24529

Xinyu Liu, Hengguan Cui, Xianqing Song, Weixing Shen, Bin Yan

{"title":"PPARγ Activates Autophagy by Suppressing the PI3K-AKT1-FOXO3 Signaling Pathway and thus Alleviates Hepatic Ischemia-Reperfusion Injury.","authors":"Xinyu Liu, Hengguan Cui, Xianqing Song, Weixing Shen, Bin Yan","doi":"10.5152/tjg.2025.24529","DOIUrl":"https://doi.org/10.5152/tjg.2025.24529","url":null,"abstract":"Background/aims: Hepatic ischemia-reperfusion injury (HIRI) refers to the damage caused by metabolic imbalance post-ischemia upon reperfusion, often occurring in scenarios like hemorrhagic shock, liver resection, and liver transplantation. Due to the complex nature of the mechanisms underlying metabolic imbalance, specific treatment options are lacking. Peroxisome proliferator activated receptor gamma (PPARγ) is a group of metabolic regulatory receptors that can influence HIRI by regulating autophagy, although the precise mechanism remains contentious.Materials and methods: In vivo and in vitro experiments were conducted to simulate hypoxic conditions, evaluating the effects of PPARγ overexpression plasmids, autophagy inhibitors, phosphatidylinositol 3-kinase (PI3K) activators, and PPARγ agonists on HIRI. The activation status of the PI3K-AKT1-FOXO3 signaling pathway, autophagy levels, inflammatory responses, and liver cell/organ damage were analyzed using western blot, ELISA, flow cytometry, H&E staining, and TUNEL experiments.Results: Peroxisome proliferator activated receptor gamma can mitigate cell damage caused by hypoxia by activating autophagy, with the activation of autophagy being associated with the inhibition of the PI3K-AKT1-FOXO3 signaling pathway. Additionally, pretreatment of mice with the PPARγ agonist rosiglitazone can alleviate HIRI induced by ischemia by inhibiting the activation of the PI3K-AKT1-FOXO3 signaling pathway to induce autophagy.Conclusion: Peroxisome proliferator activated receptor gamma inhibited the PI3K-AKT1-FOXO3 signaling pathway, which in turn activated autophagy to alleviate HIRI.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Huge Gastric Adenoma Composed of Pyloric Gland Adenoma and Foveolar-Type Adenoma with Serrated Dysplasia Cured by Endoscopic Submucosal Dissection. 内镜下粘膜夹层术治疗由幽门腺腺瘤和凹窝型腺瘤组成的巨大胃腺瘤伴锯齿状发育不良1例。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-04-21 DOI: 10.5152/tjg.2025.24799

Shuai Han, Shouxin Yin, Zongguo Sun, Shuangshuang Ren, Zhi Wei

引用次数: 0

Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study. 揭示免疫特性与肝细胞癌之间的因果关系：来自双向孟德尔随机化研究的见解。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-04-21 DOI: 10.5152/ tjg.2025.24558

Jie Li, Gechun Wang, Xiaonan Xiang, Jianguo Wang

{"title":"Unraveling the Causal Links Between Immune Traits and Hepatocellular Carcinoma: Insights From a Bi-Directional Mendelian Randomization Study.","authors":"Jie Li, Gechun Wang, Xiaonan Xiang, Jianguo Wang","doi":"10.5152/ tjg.2025.24558","DOIUrl":"https://doi.org/10.5152/ tjg.2025.24558","url":null,"abstract":"Background/Aims: Hepatocellular carcinoma (HCC) is significantly influenced by the immune system, which plays a key role in its development, progression, treatment, and prognosis. While observational studies have revealed correlations between circulating immune traits and HCC, their genetic basis and causal links remain unclear. This study aims to investigate the genetic associations and bidirectional causal relationships between immune traits and HCC risk using Mendelian randomization (MR) approaches. Materials and Methods: Genome-wide association study summary statistics from the FinnGen cohort (R9, including 453 HCC cases and 287137 controls) were used to perform a bidirectional two-sample MR analysis. The causal effects of immune traits on HCC, as well as reverse causality, were assessed. Sensitivity analyses, including heterogeneity and pleiotropy tests, were used to ensure the robustness and validity of the results. Results: Thirty-nine immune traits were identified to be significantly associated with HCC risk. Elevated levels of 10 immune traits were positively associated with increased HCC risk, while the abundance of 29 immune traits was inversely correlated with HCC incidence. Furthermore, the reverse MR analysis revealed significant causal effects of HCC on 11 immune traits. Conclusion: This study provides strong evidence of genetic links between systematic immune cell profiles and HCC, shedding light on the mechanisms underlying its onset and progression. These findings identify potential immune biomarkers for early diagnosis and immune-targeted therapies.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 7","pages":"420-430"},"PeriodicalIF":1.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Serum miR-146a and miR-155 as Predictors of Virological Control After Entecavir Withdrawal in HBeAg-Positive Chronic Hepatitis B Patients. 血清miR-146a和miR-155作为hbeag阳性慢性乙型肝炎患者恩替卡韦停药后病毒学控制的预测因子

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-04-07 DOI: 10.5152/tjg.2025.24685

Ming Li Xu, Li Huan Wang

{"title":"Serum miR-146a and miR-155 as Predictors of Virological Control After Entecavir Withdrawal in HBeAg-Positive Chronic Hepatitis B Patients.","authors":"Ming Li Xu, Li Huan Wang","doi":"10.5152/tjg.2025.24685","DOIUrl":"https://doi.org/10.5152/tjg.2025.24685","url":null,"abstract":"Background/aims: Distinct virological relapse (VR) has occurred after stopping the use of nucleos(t)ide analogues treatment in patients with chronic hepatitis B (CHB) who are positive for Hepatitis B e antigen (HBeAg). Here, we aimed to identify serum miR-146a and miR155 in HBeAg-positive patients with CHB and their relationship with VR after entecavir (ETV) discontinuance.Materials and methods: Ninety-eight patients with CHB and positive for HBeAg before initiating treatment were analyzed. Virological relapse was defined as 2 consecutive examinations (3 months apart) after treatment discontinuance, both showing an HBV DNA load of more than >2000 IU/mL.Results: Compared to control, CHB patients were observed with increases in serum miR-146a and miR-155 before starting ETV treatment (P < .001). There were 52 patients (53.1%) experiencing VR at 12 months after discontinuance of ETV treatment. The VR group was demonstrated with increases in serum miR-146a and miR-155 than the non-VR group before starting ETV treatment (P < .001). Whether at the beginning of ETV discontinuance or at 12 months after ETV discontinuance, the VR group was noted with elevations in serum miR-146a and miR-155 than the non-VR group (P < .001).Conclusion: The findings demonstrated that miR-146a and miR-155 levels in the circulation may be promising assessment tools for identifying sustained-virological responders after ETV discontinuance in CHB patients.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can the Mucosa Heal Histologically in Celiac Disease? What are the Indicators of Remission in Celiac Patients? 乳糜泻黏膜能组织学愈合吗？乳糜泻患者缓解的指标是什么？

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-04-07 DOI: 10.5152/tjg.2025.24518

Berat Ebik, Ferhat Bacaksiz, Mustafa Zanyar Akkuzu, Ahmet Yavuz, Ümit Karabulut, Muhsin Kaya

{"title":"Can the Mucosa Heal Histologically in Celiac Disease? What are the Indicators of Remission in Celiac Patients?","authors":"Berat Ebik, Ferhat Bacaksiz, Mustafa Zanyar Akkuzu, Ahmet Yavuz, Ümit Karabulut, Muhsin Kaya","doi":"10.5152/tjg.2025.24518","DOIUrl":"https://doi.org/10.5152/tjg.2025.24518","url":null,"abstract":"Background/aims: The effect of a gluten-free diet on the small intestinal mucosa in patients with celiac disease (CD) is unclear. The occurrence of mucosal healing and the permanence of villous atrophy in celiac patients under a gluten-free diet were investigated.Material and methods: The symptoms, laboratory values, autoantibody levels, and endoscopic mucosal biopsy samples of 115 celiac patients, 56 of whom were in remission at different time periods since diagnosis, were examined.Results: Although 61.8% of patients said they were compliant with the gluten-free diet, 48.7% were in remission. Sixty-seven percent (n = 77) of patients with CD reported at least one symptom. Only weight loss was associated with disease activity (P = .019). While only 5 (8.9%) of the patients in remission were endoscopically and histopathologically normal, villous atrophy was detected in 69.9% of the patients. Villous atrophy was present in 86% of patients within the first 5 years of diagnosis, while this rate was 59% in patients older than 10 years. Logistic regression analysis showed that compliance with diet (odds ratio [OR]: 4.39; P < .001) and normal endoscopic appearance of the mucosa (OR: 13.01; P < .001) were the strongest predictive factors of remission.Conclusion: Diet compliance and remission rates of celiac patients increase over time. However, histologically, intraepithelial lymphocytosis almost never improves, and villous atrophy persists in most patients even if they comply with the diet. Although the asymptomatic nature of the patients, their autoantibody titers, and their dietary compliance are considered important indicators of remission, these parameters do not clearly reflect the histological status of the mucosa.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.4,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0