Association Between High-Sensitivity C-Reactive Protein Levels and Metabolic Dysfunction-Associated Steatotic Liver Disease and Liver Fibrosis Risk: A Study Based on NHANES Data.

IF 1.6 4区 医学 Q4 GASTROENTEROLOGY & HEPATOLOGY
Chaolong Xu, Kai Wang, Zhiming Peng, Peng Chen, Chengchen Zhang, Xianyi Zeng, Chenghao Tan, Yunchen Huang
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Abstract

Background/Aims: High-sensitivity C-reactive protein (hs-CRP) is a known inflammatory biomarker linked to various metabolic disorders. This study sought to examine the association between hs-CRP levels and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver fibrosis (LF). Materials and Methods: Data from 2787 participants of the 2017-2020 National Health and Nutrition Examination Survey were analyzed. The evaluation of liver steatosis and fibrosis was performed using transient elastography. Furthermore, logistic regression models were applied to examine the correlation between 4 categorized levels of hs-CRP and the risks of MASLD and LF. Results: Compared to individuals with hs-CRP ≤3 mg/L, those with hs-CRP levels of 3.01-6 mg/L, 6.01-10 mg/L, and ≥10.01 mg/L exhibited markedly increased risks of MASLD, with odds ratios and 95% CI of 2.229 (1.892-2.625), 2.474 (1.982-3.090), and 3.175 (2.497-4.037), respectively. The receiver operating characteristic and calibration curves of the model validated the significant association of higher hs-CRP levels with increased MASLD and LF risk. Conclusion: Elevated hs-CRP levels are prominently associated with increased risks of MASLD and LF. High-sensitivity C-reactive protein could serve as a potential biomarker for identifying and managing MASLD and related fibrosis risks.

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高敏感性c反应蛋白水平与代谢功能障碍相关的脂肪变性肝病和肝纤维化风险之间的关联:基于NHANES数据的研究
背景/目的:高敏c反应蛋白(hs-CRP)是一种已知的炎症生物标志物,与多种代谢紊乱有关。本研究旨在探讨hs-CRP水平与代谢功能障碍相关脂肪变性肝病(MASLD)和肝纤维化(LF)风险之间的关系。材料与方法:对2017-2020年全国健康与营养调查2787名参与者的数据进行分析。肝脂肪变性和肝纤维化的评估采用瞬时弹性成像。此外,应用logistic回归模型检验hs-CRP 4种分类水平与MASLD和LF风险之间的相关性。结果:与hs-CRP≤3 mg/L的人群相比,hs-CRP水平为3.01-6 mg/L、6.01-10 mg/L和≥10.01 mg/L的人群发生MASLD的风险明显增加,优势比为2.229(1.892-2.625)、2.474(1.982-3.090)和3.175(2.497-4.037)。受试者工作特征和模型校准曲线验证了hs-CRP水平升高与MASLD和LF风险增加的显著相关性。结论:hs-CRP水平升高与MASLD和LF风险增加显著相关。高灵敏度c反应蛋白可作为识别和管理MASLD及相关纤维化风险的潜在生物标志物。
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来源期刊
Turkish Journal of Gastroenterology
Turkish Journal of Gastroenterology 医学-胃肠肝病学
CiteScore
1.90
自引率
0.00%
发文量
127
审稿时长
6 months
期刊介绍: The Turkish Journal of Gastroenterology (Turk J Gastroenterol) is the double-blind peer-reviewed, open access, international publication organ of the Turkish Society of Gastroenterology. The journal is a bimonthly publication, published on January, March, May, July, September, November and its publication language is English. The Turkish Journal of Gastroenterology aims to publish international at the highest clinical and scientific level on original issues of gastroenterology and hepatology. The journal publishes original papers, review articles, case reports and letters to the editor on clinical and experimental gastroenterology and hepatology.
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