A Review of Natural Products Against Alcoholic Liver Fibrosis.

Abstract

Globally, alcoholic beverages top the charts in both sales and consumption rates. However, prolonged intake of these drinks often leads to hepatic injury, potentially progressing to more severe conditions such as hepatic fibrosis, cirrhosis, and in extreme cases, hepatocellular carcinoma. Over the past 2 decades, pharmacological research has increasingly validated the therapeutic potential of natural botanicals and their bioactive derivatives in the clinical management of hepatic fibrosis. In this review, anti-fibrotic secondary metabolites targeting alcohol-induced liver injury have been systematically analyzed, focusing on their botanical origins, pharmacodynamic profiles, structural characteristics, and mechanistic underpinnings. It provides some reference for developing natural products in the treatment of liver fibrosis in the future.