Turkish Journal of Gastroenterology最新文献_第7页

Cirrhosis in Transition: Emerging Concern in a Post-Pandemic World. 转型期肝硬化：大流行后世界的新关注。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-30 DOI: 10.5152/tjg.2024.0201251

Dilara Turan Gökçe, Meral Akdoğan

引用次数: 0

Diagnostic Performance of Deep Learning Applications in Hepatocellular Carcinoma Detection Using Computed Tomography Imaging. 深度学习在肝细胞癌计算机断层成像诊断中的应用。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-30 DOI: 10.5152/tjg.2024.24538

Enes Şahin, Ozan Can Tatar, Mehmet Eşref Ulutaş, Sertaç Ata Güler, Turgay Şimşek, Nihat Zafer Turgay, Nuh Zafer Cantürk

{"title":"Diagnostic Performance of Deep Learning Applications in Hepatocellular Carcinoma Detection Using Computed Tomography Imaging.","authors":"Enes Şahin, Ozan Can Tatar, Mehmet Eşref Ulutaş, Sertaç Ata Güler, Turgay Şimşek, Nihat Zafer Turgay, Nuh Zafer Cantürk","doi":"10.5152/tjg.2024.24538","DOIUrl":"10.5152/tjg.2024.24538","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a prevalent cancer that significantly contributes to mortality globally, primarily due to its late diagnosis. Early detection is crucial yet challenging. This study leverages the potential of deep learning (DL) technologies, employing the You Only Look Once (YOLO) architecture, to enhance the detection of HCC in computed tomography (CT) images, aiming to improve early diagnosis and thereby patient outcomes. We used a dataset of 1290 CT images from 122 patients, segmented according to a standard 70:20:10 split for training, validation, and testing phases. The YOLO-based DL model was trained on these images, with subsequent phases for validation and testing to assess the model's diagnostic capabilities comprehensively. The model exhibited exceptional diagnostic accuracy, with a precision of 0.97216, recall of 0.919, and an overall accuracy of 95.35%, significantly surpassing traditional diagnostic approaches. It achieved a specificity of 95.83% and a sensitivity of 94.74%, evidencing its effectiveness in clinical settings and its potential to reduce the rate of missed diagnoses and unnecessary interventions. The implementation of the YOLO architecture for detecting HCC in CT scans has shown substantial promise, indicating that DL models could soon become a standard tool in oncological diagnostics. As artificial intelligence technology continues to evolve, its integration into healthcare systems is expected to advance the accuracy and efficiency of diagnostics in oncology, enhancing early detection and treatment strategies and potentially improving patient survival rates.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"124-130"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cucurbitacin IIa Ameliorates DSS-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Inhibiting PERK/ATF4/CHOP Signaling Pathway. 葫芦素IIa通过增强肠道屏障功能和抑制PERK/ATF4/CHOP信号通路改善dss诱导的溃疡性结肠炎

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-23 DOI: 10.5152/tjg.2024.24449

Yang Yang, Qiong Yang

{"title":"Cucurbitacin IIa Ameliorates DSS-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Inhibiting PERK/ATF4/CHOP Signaling Pathway.","authors":"Yang Yang, Qiong Yang","doi":"10.5152/tjg.2024.24449","DOIUrl":"10.5152/tjg.2024.24449","url":null,"abstract":"Background/aims: The primary intent of this manuscript is to ascertain the effect of cucurbitacin IIa on ulcerative colitis (UC) and illustrate the potential mechanisms based on intestinal barrier function and the PERK/ATF4/CHOP signaling pathway.Materials and methods: The UC mouse model was constructed by drinking 3% dextran sulfate sodium (DSS) for 1 week. The colonic tissues were stained with HE to assess pathological changes. The enzyme linked immunosorbent assay was used to measure myeloperoxidase (MPO) activity and levels of IL-1β, IL-6, and TNF-α. The western blot and immunohistochemistry methods were performed to analyze the expressions of PERK/ATF4/CHOP pathway-associated proteins. The quantitative real-time polymerase chain reaction (qRT-PCR) and immunofluorescence analysis were carried out to determine the expressions of ZO-1, claudin-1, occludin mRNA, and protein.Results: In comparison with the model group, cucurbitacin IIa obviously increased body weight and colon length, reduced disease activity index value and MPO activity, and ameliorated the degree of histopathological damage. Inflammatory factor levels were considerably reduced in the cucurbitacin IIa-intervention groups compared to the model group. The western blot and immunohistochemistry results indicated that, compared with the model group, cucurbitacin IIa significantly abolished the protein expressions of p-PERK, p-eIF2α, ATF4, and CHOP. The results of qRT-PCR and immunofluorescence revealed that cucurbitacin IIa greatly elevated the expressions of ZO-1, claudin-1, occludin mRNA and protein.Conclusion: Cucurbitacin IIa dramatically ameliorates DSS-induced UC symptoms via suppressing the PERK/ATF4/CHOP pathway and reinforcing enteric barrier function.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"229-240"},"PeriodicalIF":1.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures. 代谢功能障碍相关脂肪变性肝病的转录组关联研究鉴定相关基因特征

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-23 DOI: 10.5152/tjg.2024.24326

Jianxiu Wang, Qian Gao

{"title":"Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures.","authors":"Jianxiu Wang, Qian Gao","doi":"10.5152/tjg.2024.24326","DOIUrl":"10.5152/tjg.2024.24326","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered the most widespread chronic liver condition globally. Genome-wide association studies (GWAS) have pinpointed several genetic loci correlated to MASLD, yet the biological significance of these loci remains poorly understood. Initially, we applied Functional Mapping and Annotation (FUMA) to conduct a functional annotation of the MASLD GWAS summary statistics, which included data from 3242 cases and 707 631 controls. Additionally, a MASLD transcriptome association study (TWAS) was conducted utilizing FUSION software in combination with the genotype-tissue expression project (GTEx-v8) expression weight set to identify susceptibility genes. Furthermore, to elucidate the observed correlations, we carried out conditional and joint analyses, probabilistic causal fine-mapping of TWAS signals, summary data-based Mendelian randomization (SMR), and phenome-wide association analyses. Following functional annotation analysis, we identified 4 genetic risk loci, annotated 6 lead single nucleotide polymorphisms (SNPs), 27 independent significant SNPs, and 511 candidate SNPs. TWAS also found four genes related to MASLD, including MAU2 sister chromatid cohesion factor (MAU2), EPH receptor A2 (EPHA2), GATA zinc finger domain containing 2A (GATAD2A), and transmembrane 6 superfamily member 2 (TM6SF2). Moreover, fine mapping of TWAS signatures identified 13 causal genes associated with MASLD that were located at 3 genetic risk loci, but SMR results could not rule out the possibility that the relationship between significant genes and MASLD was caused by a linkage disequilibrium structure. Our study found new significantly associated genes for MASLD and highlighted the ability of TWAS to identify and prioritize potentially pathogenic genes.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 5","pages":"280-292"},"PeriodicalIF":1.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing the Power of AI for Enhanced Diagnosis and Treatment of Hepatocellular Carcinoma. 利用人工智能增强肝细胞癌的诊断和治疗。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-16 DOI: 10.5152/tjg.2024.24325

Ting Jin, Mengchen Luo, Feng Chen, Jin Bai, Jin Ding

引用次数: 0

Terlipressin-Induced Skin Necrosis of 3 Cases: Should We Concern? 特利加压素致皮肤坏死3例：我们应该关注吗？

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-16 DOI: 10.5152/tjg.2024.24408

Ömer Küçükdemirci, Ahmet Bektaş

引用次数: 0

WISP1 Inhibits Hepatocellular Carcinoma Cell Proliferation by Promoting CyclinD1 Ubiquitination and Downregulating its Expression. WISP1通过促进CyclinD1泛素化并下调其表达抑制肝癌细胞增殖。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-16 DOI: 10.5152/tjg.2024.23524

Jinlong Yan, Jun Wen Hu, Na Cheng, Nuoya Li, Anqi Xin, Zhipeng Wu, Zhengyi Wu, Jun Lei, Shouhua Zhang, Jinping Yao

{"title":"WISP1 Inhibits Hepatocellular Carcinoma Cell Proliferation by Promoting CyclinD1 Ubiquitination and Downregulating its Expression.","authors":"Jinlong Yan, Jun Wen Hu, Na Cheng, Nuoya Li, Anqi Xin, Zhipeng Wu, Zhengyi Wu, Jun Lei, Shouhua Zhang, Jinping Yao","doi":"10.5152/tjg.2024.23524","DOIUrl":"https://doi.org/10.5152/tjg.2024.23524","url":null,"abstract":"Background/aims: Hepatocellular carcinoma (HCC), a leading cause of cancer-related deaths, is often linked to dysregulated cell cycle proteins. This study focuses on the role of WISP1 in modulating Cyclin D1, a key cell cycle regulator, in HCC.Materials and methods: The study used HCCLM3 and Hep3B cells to assess the expression of Cyclin D1 and cell proliferation following the treatment of WISP1. This was achieved through Western blot, qRT-PCR, and EdU assays. Additionally, animal studies were conducted to evaluate the effects of WISP1 treatment on Cyclin D1 expression and cell proliferation.Results: Overexpression of WISP1 in HCC cells led to a marked decrease in Cyclin D1 protein levels and reduced cell proliferation. WISP1 influences Cyclin D1 through post-translational modifications, particularly ubiquitination and proteasomal degradation.Conclusion: The findings revealed that WISP1’s modulation of Cyclin D1 plays a critical role in inhibiting HCC cell growth, highlighting a potential therapeutic target for HCC treatment.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"247-254"},"PeriodicalIF":1.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144038504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Role of miR-499a-5p in the Development of Gastric Cancer. miR-499a-5p在胃癌发生发展中的功能作用

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-16 DOI: 10.5152/tjg.2024.24429

Cuiling Lu, Chengwang Guo, Cuihua Wu, Zhang Liping, Xiaoling Liu, Shoucun Guo

{"title":"Functional Role of miR-499a-5p in the Development of Gastric Cancer.","authors":"Cuiling Lu, Chengwang Guo, Cuihua Wu, Zhang Liping, Xiaoling Liu, Shoucun Guo","doi":"10.5152/tjg.2024.24429","DOIUrl":"10.5152/tjg.2024.24429","url":null,"abstract":"Gastric cancer (GC) is a highly prone malignant tumor, which has attracted wide attention. This study investigated the expression and clinical value of miR-499a-5p in GC. A total of 105 patients with GC were included in this study. Simultaneously, 55 patients with benign stomach disorders and 45 healthy subjects were enrolled as controls. Real-time quantitative polymerase chain reaction was used to determine the expression of miR-499a-5p. The receiver operating characteristic curve was used to assess the diagnostic value of miR-499a-5p in GC. Kaplan-Meier and logistic analyses were used to evaluate the association between miR-499a-5p and GC prognosis. The levels of miR-499a-5p are markedly downregulated in GC and have a high diagnostic value. miR-499a-5p is closely linked to pathological features of GC. Overexpression of miR-499a-5p inhibits GC cell growth, migration, and invasion. Furthermore, miR499a-5p is also related to GC and 5-year survival, and is a risk factor for GC death. The levels of miR-499a-5p were markedly downregulated in GC and related to GC pathological features. It has the potential to become a biomarker for the diagnosis of GC.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 1","pages":"45-52"},"PeriodicalIF":1.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11736815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142958370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low Expression of FAM96B is Associated with Poor Prognosis in Hepatocellular Carcinoma. FAM96B低表达与肝细胞癌预后不良相关

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-16 DOI: 10.5152/tjg.2024.24198

Yuqun Tang, Liangke Tang, Haijian Du, Chaosheng Wu, Zhuangxiong Wang, Guanshui Luo, Ke He

{"title":"Low Expression of FAM96B is Associated with Poor Prognosis in Hepatocellular Carcinoma.","authors":"Yuqun Tang, Liangke Tang, Haijian Du, Chaosheng Wu, Zhuangxiong Wang, Guanshui Luo, Ke He","doi":"10.5152/tjg.2024.24198","DOIUrl":"10.5152/tjg.2024.24198","url":null,"abstract":"Background/aims: Recently, studies on FAM96B functions mainly focused on its role in maintaining the normal physiological function of cells. However, the clinical implications of FAM96B in hepatocellular carcinoma (HCC) are still unclear.Materials and methods: FAM96B mRNA expression was detected in human HCC tissues and the matched nontumorous tissues by quantitative real-time reverse transcription (qRT-PCR) and then validated in The Cancer Genome Atlas (TCGA) database. Immunohistochemistry assay (IHC) was performed on all 137 cases of HCC samples to examine the protein level of FAM96B. Subsequently, the associations between FAM96B expression and clinicopathological parameters and prognosis were further analyzed.Results: The mRNA level of FAM96B was found to be significantly lower in HCC tissues compared to non-tumorous tissues, as observed in both the local hospital and TCGA database.Immunohistochemistry assay analysis revealed a decrease in FAM96B expression in 78 out of 137 cases, which was significantly associated with larger tumor size, higher Barcelona clinic liver cancer or Child stage, and early distant metastasis. Patients with low FAM96B levels tended to have an unfavorable disease-free and overall survival. Moreover, FAM96B was identified as an independent predictor of patient prognosis in both univariate and multivariate survival analyses. Mechanistically, FAM96B was found to inhibit cancer progression by inducing apoptosis in liver cancer cells and inhibiting their growth.Conclusion: Our findings provide the first evidence suggesting the involvement of FAM96B in the progression of HCC. Additionally, FAM96B could potentially serve as a marker for tumor recurrence and prognosis in HCC patients.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"1 1","pages":"255-262"},"PeriodicalIF":1.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001444/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142856125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liver Transplantation for Autoimmune Hepatitis: 20 Years of Tertiary Centre Experience. 肝移植治疗自身免疫性肝炎：20年三级中心经验。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-16 DOI: 10.5152/tjg.2024.24464

Osman Sağlam, Muhsin Murat Muhip Harputluoğlu, Yılmaz Bilgiç, Sezai Yılmaz, Fatma Hilal Yağın, Cumali Efe

{"title":"Liver Transplantation for Autoimmune Hepatitis: 20 Years of Tertiary Centre Experience.","authors":"Osman Sağlam, Muhsin Murat Muhip Harputluoğlu, Yılmaz Bilgiç, Sezai Yılmaz, Fatma Hilal Yağın, Cumali Efe","doi":"10.5152/tjg.2024.24464","DOIUrl":"10.5152/tjg.2024.24464","url":null,"abstract":"Background/aims: We analyzed the frequency of complications and survival rates in patients with autoimmune hepatitis (AIH) who underwent liver transplantation at a high-volume transplant center.Materials and methods: Patients who underwent transplantation for AIH at the İnönü University Liver Transplantation Institute between January 2002 and December 2021 were included. Patients with a confirmed diagnosis of AIH, without concomitant chronic liver disease, were included in the study.Results: We included 51 patients (31 female) with a median age of 38.5 years (18-65 years). The 12-month and 60-month survival rates were 86.3% and 80.9%, respectively. During a median 2.22 years follow-up, 9 patients died. Six patients died due to systemic infection, 1 due to biliary complications, and 2 patients due to graft rejection. Autoimmune hepatitis recurrence developed in 6 (11%) patients. Overall, biliary complications developed in 56% (28/51) of patients following liver transplantation, and graft rejection occurred in 22% (11/51) of patients.Conclusion: Our results suggest that the outcome of AIH following liver transplantation is good, with a survival rate of up to 80%. Posttransplant biliary complications are common; therefore, close follow-up is necessary.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"1 1","pages":"145-151"},"PeriodicalIF":1.4,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142855993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0