Turkish Journal of Gastroenterology最新文献

{"title":"Transplant Indications in Polycystic Liver and Kidney Disease","authors":"Sandra Perez-Prado, Abid Suddle","doi":"10.5152/tjg.2026.26217","DOIUrl":"10.5152/tjg.2026.26217","url":null,"abstract":"<p><p>Polycystic liver and kidney disease encompasses a spectrum of inherited disorders ,primarily autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (ADPLD). Although many patients remain asymptomatic for decades, a subset develops debilitating complications, including massive hepatomegaly, recurrent cyst infections, malnutrition, and progressive renal dysfunction. Diagnosis relies on imaging criteria and genetic testing. ADPKD is most commonly associated with PKD1 and PKD2 mutations, whereas ADPLD is associated with PRKCSH and SEC63 mutations. Magnetic resonance imaging provides optimal assessment of cyst distribution, liver volume, and complications. Disease severity classifications, such as Schnelldorfer classification, guide therapeutic decision-making. Liver transplantation is the only definitive treatment for severe symptomatic PLD. Primary indications include recurrent cyst infections refractory to medical therapy, massive hepatomegaly with significant impairment of quality of life, malnutrition, and portal hypertension. Patient-reported instruments, including PLD-Q and POLCA, questionnaires, provide objective measures of symptom burden and aid in transplant candidacy assessment. In patients with concurrent renal insufficiency (estimated glomerular filtration rate <30 mL/min/1.73 m2), combined liver–kidney transplantation may improve outcomes and confer potential immunoprotective benefits for the renal graft. Despite favorable posttransplant outcomes—including 5-year survival rates exceeding 80%—variation in listing criteria persists, highlighting the need for standardized, evidence-based guidelines. Multidisciplinary evaluation and individualized management remain essential to optimize clinical outcomes in this complex patient population.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Effect of Endoscopic Mucosal Needle Aspiration Combined with Anhydrous Alcohol in the Treatment of Pneumatosis Cystoides Intestinalis.","authors":"Tingxu Yang, Wenjuan Feng, Yan Ma, Haixia Wang","doi":"10.5152/tjg.2026.25322","DOIUrl":"10.5152/tjg.2026.25322","url":null,"abstract":"<p><strong>Background/aims: </strong>To evaluate the clinical efficacy and safety of endoscopic mucosal needle aspiration combined with intracapsular anhydrous alcohol injection for colonic pneumatosis cystoides intestinalis (PCI).</p><p><strong>Materials and methods: </strong>In this single-center, quasi-randomized comparative study, 86 patients diagnosed with colonic PCI and treated between April 2021 and April 2023 were allocated to a control group (needle aspiration alone, n = 43) or an observation group (needle aspiration plus alcohol injection, n = 43). Therapeutic efficacy, recurrence rate, complications, and postoperative satisfaction were compared between the two groups.</p><p><strong>Results: </strong>No immediate or short-term complications were observed, including bleeding, perforation, obstruction, or infection. Longer follow-up is needed to assess the late adverse events. At 3 months after treatment, the overall efficacy rate was significantly higher in the observation group (100%, 43/43) than in the control group (88.37%, 38/43; χ2 = 5.309, P = .021). No recurrence was observed in the observation group, whereas 5 cases (11.63%) recurred in the control group (χ2 = 5.309, P = .021). Furthermore, postoperative satisfaction was markedly higher in the observation group (95.35%) compared with the control group (79.07%).</p><p><strong>Conclusion: </strong>Endoscopic mucosal needle aspiration combined with intracapsular anhydrous alcohol injection was technically feasible. No immediate or short-term complications were observed. These findings suggest potential short-term benefit, but larger, multicenter studies with longer follow-up are needed to confirm effectiveness and late adverse events.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Frequency of Pancreatic Exocrine Insufficiency Among Patients with Abdominal Pain, Bloating, and Malodorous Flatus: Hidden Pancreatic Insufficiency","authors":"Gizem Sultan Kürtül, Orhan Sezgin, Damla Hazal Sucu","doi":"10.5152/tjg.2026.25746","DOIUrl":"10.5152/tjg.2026.25746","url":null,"abstract":"<p><strong>Background/aims: </strong>Pancreatic exocrine insufficiency (PEI) is a condition characterized by impaired digestion and absorption resulting from insufficient exocrine secretion of the pancreas. The current study aimed to determine the prevalence, clinical characteristics, and associated risk factors of PEI in patients presenting to the gastroenterology outpatient clinic with common gastrointestinal complaints such as abdominal pain, dyspepsia, and defecation disorders.</p><p><strong>Materials and methods: </strong>Three hundred ten symptomatic patients were retrospectively evaluated using demographic data, biochemical markers, the PEI Questionnaire, and fecal elastase-1 (FE-1) levels. PEI was defined as an FE-1 level <200 μg/mL, with levels <100 μg/mL indicating severe deficiency.</p><p><strong>Results: </strong>PEI was identified in 45.8% (n = 142) of the cohort, with 43% classified as severe. PEI was significantly more common in males (P = .024). Key comorbidities associated with PEI included diabetes mellitus, hypertension, hyperlipidemia, and prior gastric or pancreatic surgery. Abdominal pain, bloating, and particularly malodorous flatus (odds ratio = 3.705) were strong predictors of PEI. Severe PEI was associated with significantly lower hemoglobin and vitamin D levels. Sixty-five percent of patients with PEI had prior symptoms but had not been diagnosed.</p><p><strong>Conclusion: </strong>PEI is highly prevalent among patients with non-specific gastrointestinal (GI) symptoms and is frequently underdiagnosed. Clinicians should maintain a high index of suspicion, particularly in patients with metabolic comorbidities or prior GI surgeries.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382230/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using Hepatitis B Surface Antigen-Positive Donors in Liver Transplantation: Outcomes, Prophylaxis, and Monitoring with a Focus on Hepatitis B Virus-Naive Recipients","authors":"Ali Emre Bardak, Aafeen Mujeeb, Ayse Eylul Donmez, Nazli Begum Ozturk, Eda Yildiz, Hemeesh Tandel, Merih Deniz Toruner, Merve Gurakar, Behnam Saberi, Nilay Danis, Ahmet Gurakar","doi":"10.5152/tjg.2026.26018","DOIUrl":"10.5152/tjg.2026.26018","url":null,"abstract":"<p><p>Liver transplantation (LT) remains the only definitive treatment for end-stage liver disease and selected hepatic malignancies. However, persistent organ shortages continue to drive high waitlist mortality worldwide. Hepatitis B virus (HBV)-positive donors, including hepatitis B surface antigen (HBsAg)-positive and anti-hepatitis B core antibody-positive (HBsAg-negative) donors, represent an increasingly important but historically underused resource. The introduction of high-barrier nucleos(t)ide analogs, the selective use of hepatitis B immunoglobulin, and pre- and posttransplant vaccination have markedly reduced viral transmission, enabling safe transplantation in both HBV-immune and selected HBV-naive recipients. Regional guidelines and consensus statements, including those from the American Society of Transplantation, European Association for the Study of the Liver, American Association for the Study of Liver Diseases, and Asian Pacific Association for the Study of the Liver, support individualized, risk-directed prophylaxis and posttransplant surveillance. Ethical considerations, particularly informed consent and risk-benefit discussions in the setting of organ scarcity, remain central to clinical decision-making. Large cohort studies demonstrate comparable graft and patient survival with HBV-negative grafts, along with economic advantages and expansion of the donor pool. However, evidence in HBV-naive recipients remains limited, with most data derived from immune or previously infected recipients, highlighting the need for careful patient selection and robust prophylaxis. Available evidence on the use of HBsAg-positive donors in HBV-naive recipients is obtained predominantly from cadaveric donor transplantation, as experience with HBsAg-positive living donors remains limited. This narrative review summarizes current evidence on the use of HBsAg-positive grafts in LT, with a focus on HBV-naive recipients, based predominantly on cadaveric donor experience.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":1.6,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-452-3p Targets Adenomatous Polyposis Coli to Regulate the Malignant Phenotypes and Prognosis of Esophageal Cancer.","authors":"Dian Lin, Yaqiong Xie, Yaxi Song, Miao He, Xingwu Huang","doi":"10.5152/tjg.2026.26023","DOIUrl":"10.5152/tjg.2026.26023","url":null,"abstract":"<p><strong>Background/aims: </strong>Esophageal cancer is a common malignancy of the digestive tract worldwide, with extremely poor prognosis in advanced stages. miR-452-3p regulates multiple tumors and may contribute to the development and progression of esophageal cancer. The current study aims to examine the correlation between miR-452-3p expression and prognosis in esophageal cancer and further investigate the potential molecular mechanisms by which miR-452-3p regulates the malignant phenotype of esophageal cancer cells.</p><p><strong>Materials and methods: </strong>A total of 155 pairs of esophageal cancer tissues and adjacent normal tissue samples were collected. Reverse Transcription Quantitative PCR was used to detect the expression levels of miR-452-3p and adenomatous polyposis coli (APC). Survival analyses were performed using Kaplan-Meier and Cox regression analyses. The effects of miR-452-3p on the biological behavior of esophageal cancer cells were assessed through in vitro experiments. Additionally, dual-luciferase reporter gene assays and rescue experiments were performed to confirm the regulatory relationship between miR-452-3p and APC.</p><p><strong>Results: </strong>The miR-452-3p expression is upregulated in esophageal cancer. Elevated miR-452-3p expression is closely related to the clinical pathological characteristics and poor prognosis of esophageal cancer and serves as an independent prognostic risk factor. Functional experiments demonstrate that miR-452-3p overexpression enhances the malignant biological behavior of esophageal cancer cells. miR-452-3p directly targets APC. Silencing APC reverses the inhibitory effect of miR-452-3p inhibitor on the malignant phenotype.</p><p><strong>Conclusion: </strong>miR-452-3p promotes esophageal cancer progression by targeting APC, and patients with low levels of miR-452-3p exhibit favorable prognosis.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148018474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Evaluation of Serum Hepcidin and Fecal Calprotectin for Disease Activity Assessment in Inflammatory Bowel Disease.","authors":"Pırıl Akıncıoğlu, Ülkü Dağlı, Ebru Koca","doi":"10.5152/tjg.2026.25774","DOIUrl":"10.5152/tjg.2026.25774","url":null,"abstract":"<p><strong>Background/aims: </strong>Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic inflammatory disorder commonly associated with iron deficiency anemia and anemia of chronic disease. Hepcidin is a key regulator of iron homeostasis, increasing in response to inflammation and decreasing in iron deficiency. This study evaluated the relationship between serum hepcidin and fecal calprotectin levels and examined the potential role of hepcidin in assessing disease activity and differentiating anemia subtypes.</p><p><strong>Materials and methods: </strong>The study included 29 patients with IBD with active disease, 45 in remission, and 34 controls; all participants were evaluated at Başkent University Ankara Hospital in 2014. Complete blood count, serum hepcidin, ferritin, serum iron, total ironbinding capacity (TIBC), C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) were analyzed in all participants. Fecal calprotectin was additionally measured in patients.</p><p><strong>Results: </strong>Hepcidin levels were significantly higher in patients with both active disease and in remission compared with controls (P < .05). Hepcidin levels were negatively correlated with hemoglobin, hematocrit, and ferritin and positive correlated with TIBC and ESR (P < .05). Fecal calprotectin levels were significantly higher in patients with active disease and were positively correlated with CRP and clinical activity scores (P < .01). However, no significant correlation was found between hepcidin and fecal calprotectin (P > .025).</p><p><strong>Conclusion: </strong>Fecal calprotectin was strongly associated with disease activity, whereas hepcidin was not, suggesting that hepcidin may have limited utility for disease activity assessment. Hepcidin may primarily reflect systemic iron metabolism and anemia of inflammation. Further studies are needed to clarify its clinical role.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin (Acetylsalicylic Acid) Exerts Antineoplastic Effects on Bile Duct Carcinoma Cells Through Modulation of COX-2/ EGFR, AMPK, and IGF-1R Signaling Pathways.","authors":"Yoonchan Lee, Jin Lee, Eun Mi Hong, Kyong Joo Lee, Se Woo Park, Dong Hee Koh","doi":"10.5152/tjg.2026.25775","DOIUrl":"10.5152/tjg.2026.25775","url":null,"abstract":"<p><strong>Background/aims: </strong>Bile duct carcinoma (BDC) is a highly aggressive malignancy. While epidemiological evidence suggests that acetylsalicylic acid (ASA [aspirin]) reduces BDC risk, the underlying molecular mechanisms have not been fully elucidated. This investigation explored the antineoplastic mechanisms of ASA in BDC cells.</p><p><strong>Materials and methods: </strong>The human BDC cell line SNU-245 was used in all experiments. Cell viability was determined using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays, whereas apoptosis and caspase-3 levels were evaluated using enzyme-linked immunosorbent assay. Protein expression was analyzed using Western blotting and immunofluorescence. Functional pathway interactions were investigated using siRNA-mediated gene silencing.</p><p><strong>Results: </strong>ASA reduced cell viability and increased apoptosis markers, accompanied by increased Bax and p53 expression and decreased Bcl-2 levels. ASA treatment reduced cyclooxygenase-2 (COX-2) expression and decreased epidermal growth factor receptor (EGFR)levels. COX-2 knockdown markedly attenuated deoxycholic acid (DCA)-induced EGFR phosphorylation, whereas EGFR silencing partially reduced DCA-induced COX-2 expression. These results suggest reciprocal signaling interactions, with COX-2 exerting a relatively stronger upstream influence. ASA increased phosphorylation of AMP-activated protein kinase at threonine 172 (AMPKᵀʰʳ¹⁷²) and reduced insulin like growth factor-1 receptor (IGF-1R)/insulin receptor substrate-1 (IRS-1) signaling and decreased mammalian target of rapamycin (mTOR) phosphorylation. ASA also attenuated epidermal growth factor (EGF)-induced changes in epithelial-mesenchymal transition- related markers, including preservation of E-cadherin and reduction of N-cadherin expression.</p><p><strong>Conclusion: </strong>In this in vitro model, ASA exposure was associated with coordinated modulation of multiple cell-survival-related signaling pathways in BDC cells, including COX-2/EGFR signaling, AMPK activation, and IGF-1R-mediated mTOR regulation. These findings provide mechanistic insight into the potential antineoplastic effects of ASA and support further translational studies in BDC.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13247861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147876564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abdominal Cocoon Syndrome: A Rare Condition That Causes Diagnostic Challenges","authors":"Zekiye Nur Harput, Orhan Sezgin, Feramuz Demir Apaydın, Enver Reyhan","doi":"10.5152/tjg.2026.25642","DOIUrl":"10.5152/tjg.2026.25642","url":null,"abstract":"","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-05-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13382231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148037455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Sleep Quality and Postcolonoscopy Pain.","authors":"Haci Bolat, Tugba Tolu, Haluk Tarık Kani","doi":"10.5152/tjg.2026.26044","DOIUrl":"10.5152/tjg.2026.26044","url":null,"abstract":"<p><strong>Background/aims: </strong>Postcolonoscopy pain remains a key determinant of patient satisfaction and willingness to undergo repeat procedures. Patient-related factors influencing postprocedural pain are not fully understood, and the role of sleep quality has not been systematically elucidated. This study aimed to investigate the association between sleep quality and postcolonoscopy abdominal pain in a real-world cohort.</p><p><strong>Materials and methods: </strong>This single-center, prospective observational cohort study included adults aged 18-80 years undergoing diagnostic or surveillance colonoscopy. All procedures were performed by a single experienced endoscopist under standardized conditions. Psychological and sleep-related parameters were assessed using validated instruments, including the Beck Depression Inventory, State- Trait Anxiety Inventory, Van Dream Anxiety Scale, and Pittsburgh Sleep Quality Index. Pain intensity was measured using a Visual Analog Scale at 0 minutes, 30 minutes, 6 hours, and 24 hours after the procedure. Associations between psychometric measures and pain scores were analyzed using Spearman's correlation.</p><p><strong>Results: </strong>A total of 103 patients were included (mean age, 54.7 ± 12.4 years; 45.6% female). Postcolonoscopy pain was most prominent 0 minutes after the procedure and decreased progressively over time. Poor sleep quality was significantly associated with higher pain intensity at 6 hours after colonoscopy (r = 0.239, P = .015). Anxiety and depressive symptom severity scores were not associated with pain intensity; however, a prior clinical diagnosis of depression was associated with higher postprocedural pain scores. Higher pain scores were also observed in patients with incomplete procedures, gastrointestinal symptoms, and postprocedural dissatisfaction (P < .05).</p><p><strong>Conclusion: </strong>Sleep quality may represent an important patient-related factor influencing early postcolonoscopy pain perception. Consideration of sleep and psychosocial factors alongside routine clinical evaluation may help improve the understanding of postprocedural pain variability and enhance patient-centered endoscopy care. Cite this article as: Bolat H, Tolu T, Kani HT. Association between sleep quality and postcolonoscopy pain. Turk J Gastroenterol. 2026;37(8):839-848.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"839-848"},"PeriodicalIF":2.3,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13455510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miR-3678-3p Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating Phosphatase and Tensin Homolog.","authors":"Jinjun Zhang, Ci Cheng, Taiyu Li","doi":"10.5152/tjg.2026.25836","DOIUrl":"10.5152/tjg.2026.25836","url":null,"abstract":"<p><strong>Background/aims: </strong>Esophageal squamous cell carcinoma (ESCC) is a gastrointestinal malignancy characterized by high invasiveness. The current study aimed to evaluate the role of miR-3678-3p in ESCC and its potential mechanisms.</p><p><strong>Materials and methods: </strong>The study included 109 ESCC patients. The miR-3678-3p expression in ESCC tissues and cells was quantified. The association between miR-3678-3p and ESCC severity and adverse prognosis was evaluated. The target relationship between miR- 3678-3p, phosphatase and tensin homolog (PTEN) was confirmed. The effects of miR 3678-3p and PTEN on ESCC cell function were analyzed.</p><p><strong>Results: </strong>ESCC tissues and cells exhibited elevated expression of miR-3678-3p. Elevated miR-3678-3p expression was significantly associated with malignant clinical features in ESCC, including larger tumor size, advanced tumor-node-metastasis staging, higher lymph node metastasis, and poor tumor differentiation. High miR-3678-3p expression served as a predictor of shorter overall survival. miR-3678-3p targeted and regulated PTEN. miR-3678-3p knockdown significantly suppressed the malignant progression of ESCC cells, whereas silencing of PTEN reversed these effects. miR-3678-3p and PTEN jointly participated in the development of ESCC.</p><p><strong>Conclusion: </strong>miR-3678-3p serves as a promising prognostic marker for predicting the severity and adverse outcomes of ESCC. miR- 3678-3p promotes ESCC progression by targeting PTEN.</p>","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13247857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}