Turkish Journal of Gastroenterology最新文献_第8页

The Effects of Positioning During Colonoscopy on Efficacy and Post-procedure Comfort. 结肠镜检查时体位对疗效及术后舒适度的影响。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-01-06 DOI: 10.5152/tjg.2025.24439

Mustafa Ergin, Gülencan Yumuşak Ergin, Fatih Kıvrakoğlu, Mehmet İbiş

{"title":"The Effects of Positioning During Colonoscopy on Efficacy and Post-procedure Comfort.","authors":"Mustafa Ergin, Gülencan Yumuşak Ergin, Fatih Kıvrakoğlu, Mehmet İbiş","doi":"10.5152/tjg.2025.24439","DOIUrl":"10.5152/tjg.2025.24439","url":null,"abstract":"Background/aims: There are studies with different results on improving effectiveness and patient comfort by increasing lumen distention through positioning during colonoscopy. In our study, we aimed to compare colonoscopy outcomes and post-procedural patient comfort in the left-lateral and right-lateral positions.Materials and methods: A total of 231 patients who underwent screening colonoscopy were included. Patients were randomized to either the left-lateral or the right-lateral position. Patient age, sex, comorbidities, body mass index (BMI) values, times to reach the cecum, ileum intubation rates, total procedure times, and colonoscopy findings were compared. Pain and discomfort after the procedure were evaluated and compared with the visual analog scale (VAS) scores at 30 minutes, 6 hours, and 24 hours.Results: Colonoscopy was performed in the left-lateral position in 129 patients and in the right-lateral position in 102. The distributions of age, sex, comorbidities, and BMI values were similar in both groups. The time to reach the cecum and the total procedure time were similar in both groups. There were no significant differences in the findings detected by colonoscopy. There was no significant difference in the post-procedural VAS scores.Conclusion: ","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 3","pages":"174-182"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11899989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identification of Potential Functional Modules and Diagnostic Genes for Crohn's Disease Based on Weighted Gene Co-expression Network Analysis and LASSO Algorithm. 基于加权基因共表达网络分析和LASSO算法的克罗恩病潜在功能模块和诊断基因的鉴定

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-01-06 DOI: 10.5152/tjg.2025.23605

Ruiquan Wang, Hongqi Zhao

{"title":"Identification of Potential Functional Modules and Diagnostic Genes for Crohn's Disease Based on Weighted Gene Co-expression Network Analysis and LASSO Algorithm.","authors":"Ruiquan Wang, Hongqi Zhao","doi":"10.5152/tjg.2025.23605","DOIUrl":"10.5152/tjg.2025.23605","url":null,"abstract":"Background/aims: Accurate diagnosis of Crohn's disease (CD) is paramount due to its resemblance to other inflammatory bowel diseases. Early and precise diagnosis plays a pivotal role in tailoring personalized treatments, thereby enhancing the quality of life for CD patients.Materials and methods: Differential gene expression analysis was conducted to identify genes from the mRNA expression profiles of CD samples, followed by pathway enrichment analysis. The immune cell infiltration levels of each CD patient sample were assessed. Using weighted gene co-expression network analysis, key gene modules linked to CD were found. Hub gene identification was made easier by the construction of protein-protein interaction networks. Next, utilizing the Least Absolute Shrinkage and Selection Operator on the hub genes in the training set, a diagnostic model was created. The accuracy of the model was then confirmed using a different validation set.Results: Our analysis revealed 651 differentially expressed genes, enriched in leukocyte chemotaxis and inflammation-related pathways. Immunization results showed a higher abundance of T cells CD4 memory resting, macrophages M2, and plasma cells in CD patients. Weighted gene co-expression network analysis linked the turquoise module with macrophages M2. Eight hub genes (APOA1, APOA4, CYP2C8, CYP2C9, CYP2J2, EPHX2, HSD3B1, and LPL) formed the diagnostic model, exhibiting excellent diagnostic performance with area under curve values of 0.94 (training set) and 0.941 (validation set).Conclusion: The CD diagnostic model, based on hub genes, shows exceptional diagnostic accuracy, providing a valuable reference for CD diagnosis.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"209-218"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inflammation and Immune-Based Scores Predict Prognosis for Patients with Hepatocellular Carcinoma: A Pilot Single-Center Study. 基于炎症和免疫的评分预测肝细胞癌患者的预后：一项试点单中心研究。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-01-06 DOI: 10.5152/tjg.2025.24407

Merve Guzel Dirim, Asli Cifcibasi Ormeci, Bilger Cavus, Arzu Poyanli, Kursat Rahmi Serin, Filiz Akyuz, Kadir Demir, Selman Fatih Besisik, Sabahattin Kaymakoglu

{"title":"Inflammation and Immune-Based Scores Predict Prognosis for Patients with Hepatocellular Carcinoma: A Pilot Single-Center Study.","authors":"Merve Guzel Dirim, Asli Cifcibasi Ormeci, Bilger Cavus, Arzu Poyanli, Kursat Rahmi Serin, Filiz Akyuz, Kadir Demir, Selman Fatih Besisik, Sabahattin Kaymakoglu","doi":"10.5152/tjg.2025.24407","DOIUrl":"10.5152/tjg.2025.24407","url":null,"abstract":"Background/aims: Hepatocellular carcinoma (HCC) ranks as a major contributor to cancer-related deaths. Systemic inflammation plays a pivotal role in HCC development and progression. Thus, we aimed to determine the impact of inflammation- and immune-based scores in predicting the prognosis of HCC.Materials and methods: In this retrospective study, patients with HCC were enrolled between 2010 and 2020. The purpose of this retrospective study was to evaluate the impact of various biomarkers, including baseline alpha-fetoprotein (AFP) levels, C-reactive protein (CRP)-albumin-lymphocyte (CALLY) index, neutrophil-to-CRP (N/CRP) ratio, systemic immune-inflammation index (SII), albumin-bilirubin (ALBI) score, neutrophil-to-lymphocyte ratio (NLR), and aspartate aminotransferase (AST)-to-alanine aminotransferase (ALT) (AST/ALT) ratio (AAR), on survival, invasion of vascular tracts, metastasis, and treatment responses.Results: A total of 199 patients with complete (n = 44) and non-complete (n = 145) treatment response groups were enrolled in the study. All scores for the non-complete response group were statistically significant (P < .05). The areas under the curves for predicting a non-complete response group were 0.651, 0.649, 0.636, 0.625, 0.613, 0.609, and 0.600 for AFP, CALLY index, AAR, SII, N/CRP ratio, ALBI score, and NLR, respectively. These results are consistent with the assessment of mortality and HCC progression.Conclusion: Our results indicate that these biomarkers could serve as powerful prognostic tools for HCC.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"219-228"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory Role of IGF2BP2 in Intestinal Mucosal Barrier Dysfunction in Ulcerative Colitis. IGF2BP2在溃疡性结肠炎肠黏膜屏障功能障碍中的调节作用。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-01-06 DOI: 10.5152/tjg.2025.24192

Ruifan Li, Bin Gu, Anli Lv

{"title":"Regulatory Role of IGF2BP2 in Intestinal Mucosal Barrier Dysfunction in Ulcerative Colitis.","authors":"Ruifan Li, Bin Gu, Anli Lv","doi":"10.5152/tjg.2025.24192","DOIUrl":"10.5152/tjg.2025.24192","url":null,"abstract":"Background/aims: Ulcerative colitis (UC), an idiopathic and chronic inflammatory disease, primarily targets the mucosal lining of the colon. This research endeavors to reveal the mechanism of insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) and nuclear receptor coactivator-3 (NCOA3) in UC-induced intestinal mucosal barrier dysfunction.Materials and methods: Dextran sodium sulfate (DSS) was used for UC mouse modeling, followed by an assessment of the disease activity index, intestinal barrier integrity, and intestinal permeability assessment through FITC-glucan assay. microRNA (miR)-222-3p, IGF2BP2, and NCOA3 levels in colon tissues of mice were detected. The targeted binding of miR-222-3p to IGF2BP2 was determined using a dual-luciferase assay. The enrichment of IGF2BP2 or N6-methyladenosine (m6A) on NCOA3 mRNA in YAMC cells was tested by RNA immunoprecipitation and m6A RNA immunoprecipitation assays, and the mRNA stability of NCOA3 was determined after actinomycin D treatment.Results: miR-222-3p was increased while IGF2BP2 and NCOA3 were decreased in the colon tissues of UC mice. IGF2BP2 overexpression effectively alleviated intestinal injury and reinstated the functional integrity of the mucosal barrier in DSS mice. IGF2BP2 recognized and bound to the m6A site of NCOA3 and increased mRNA stability, and miR-222-3p negatively regulated IGF2BP2. NCOA3 downregulation abated the beneficial impact of IGF2BP2 overexpression on DSS mice. miR-222-3p downregulation upregulated IGF2BP2/NCOA3 expression to protect against intestinal mucosal barrier dysfunction.Conclusion: IGF2BP2 was repressed by miR-222-3p, yet IGF2BP2 increased the stability of NCOA3 mRNA via an m6A-dependent pathway, ultimately leading to attenuation of UC-related intestinal mucosal barrier impairment and UC progression.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"269-279"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma. 平均血小板体积是肝细胞癌肝移植患者预后不良的因素。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-01-06 DOI: 10.5152/tjg.2025.24540

Mustafa Şentürk, Volkan İnce, Orhan Üreyen, Kemal Eyvaz, Burak Işık, Brian I Carr, Sezai Yılmaz

{"title":"Mean Platelet Volume Is a Poor Prognostic Factor in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma.","authors":"Mustafa Şentürk, Volkan İnce, Orhan Üreyen, Kemal Eyvaz, Burak Işık, Brian I Carr, Sezai Yılmaz","doi":"10.5152/tjg.2025.24540","DOIUrl":"10.5152/tjg.2025.24540","url":null,"abstract":"Background/aims: Mean platelet volume (MPV) reflects platelet activation. Platelets have an important role in tumor progression and metastasis. In this study, we wanted to investigate the effect of MPV on survival in patients undergoing liver transplantation (LT) for hepatocellular carcinoma (HCC).Materials and methods: All data of 376 patients who underwent LT and pathologically diagnosed with HCC were analyzed. By determining the cut-off of MPV (10.2 fL), 2 groups with high and low MPV were formed. The groups were compared within themselves. Factors affecting survival were determined by univariate and multivariate analysis.Results: When the groups were compared, patients with low MPV had significantly higher platelet counts, larger tumor sizes, lower BMI, and higher recurrence rates. In multivariate analysis, GGT >104, AFP >200 μg/L, largest tumor diameter >5 cm, and lower MPV were found to be independent risk factors that affected the prognosis. Tumor-free survival was significantly worse in the lower MPV group (P = .002).Conclusion: Pre-transplant low MPV may be useful in predicting poor prognosis and a high rate of tumor recurrence in patients with HCC after liver transplantation.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 3","pages":"169-173"},"PeriodicalIF":1.4,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143651691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consider Mitochondrial DNA Rearrangements as a Cause of Idiopathic Pancreatitis. 考虑线粒体DNA重排作为特发性胰腺炎的原因。

IF 1.6 4区医学

Turkish Journal of Gastroenterology Pub Date : 2025-01-06 DOI: 10.5152/tjg.2025.24704

Josef Finsterer, Sounira Mehri

引用次数: 0

Diagnostic Performance of Deep Learning Applications in Hepatocellular Carcinoma Detection Using Computed Tomography Imaging. 深度学习在肝细胞癌计算机断层成像诊断中的应用。

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-30 DOI: 10.5152/tjg.2024.24538

Enes Şahin, Ozan Can Tatar, Mehmet Eşref Ulutaş, Sertaç Ata Güler, Turgay Şimşek, Nihat Zafer Turgay, Nuh Zafer Cantürk

{"title":"Diagnostic Performance of Deep Learning Applications in Hepatocellular Carcinoma Detection Using Computed Tomography Imaging.","authors":"Enes Şahin, Ozan Can Tatar, Mehmet Eşref Ulutaş, Sertaç Ata Güler, Turgay Şimşek, Nihat Zafer Turgay, Nuh Zafer Cantürk","doi":"10.5152/tjg.2024.24538","DOIUrl":"10.5152/tjg.2024.24538","url":null,"abstract":"Hepatocellular carcinoma (HCC) is a prevalent cancer that significantly contributes to mortality globally, primarily due to its late diagnosis. Early detection is crucial yet challenging. This study leverages the potential of deep learning (DL) technologies, employing the You Only Look Once (YOLO) architecture, to enhance the detection of HCC in computed tomography (CT) images, aiming to improve early diagnosis and thereby patient outcomes. We used a dataset of 1290 CT images from 122 patients, segmented according to a standard 70:20:10 split for training, validation, and testing phases. The YOLO-based DL model was trained on these images, with subsequent phases for validation and testing to assess the model's diagnostic capabilities comprehensively. The model exhibited exceptional diagnostic accuracy, with a precision of 0.97216, recall of 0.919, and an overall accuracy of 95.35%, significantly surpassing traditional diagnostic approaches. It achieved a specificity of 95.83% and a sensitivity of 94.74%, evidencing its effectiveness in clinical settings and its potential to reduce the rate of missed diagnoses and unnecessary interventions. The implementation of the YOLO architecture for detecting HCC in CT scans has shown substantial promise, indicating that DL models could soon become a standard tool in oncological diagnostics. As artificial intelligence technology continues to evolve, its integration into healthcare systems is expected to advance the accuracy and efficiency of diagnostics in oncology, enhancing early detection and treatment strategies and potentially improving patient survival rates.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":" ","pages":"124-130"},"PeriodicalIF":1.4,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11851832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cirrhosis in Transition: Emerging Concern in a Post-Pandemic World. 转型期肝硬化：大流行后世界的新关注。

IF 1.6 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-30 DOI: 10.5152/tjg.2024.0201251

Dilara Turan Gökçe, Meral Akdoğan

引用次数: 0

Cucurbitacin IIa Ameliorates DSS-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Inhibiting PERK/ATF4/CHOP Signaling Pathway. 葫芦素IIa通过增强肠道屏障功能和抑制PERK/ATF4/CHOP信号通路改善dss诱导的溃疡性结肠炎

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-23 DOI: 10.5152/tjg.2024.24449

Yang Yang, Qiong Yang

{"title":"Cucurbitacin IIa Ameliorates DSS-Induced Ulcerative Colitis via Enhancing Intestinal Barrier Function and Inhibiting PERK/ATF4/CHOP Signaling Pathway.","authors":"Yang Yang, Qiong Yang","doi":"10.5152/tjg.2024.24449","DOIUrl":"10.5152/tjg.2024.24449","url":null,"abstract":"Background/aims: The primary intent of this manuscript is to ascertain the effect of cucurbitacin IIa on ulcerative colitis (UC) and illustrate the potential mechanisms based on intestinal barrier function and the PERK/ATF4/CHOP signaling pathway.Materials and methods: The UC mouse model was constructed by drinking 3% dextran sulfate sodium (DSS) for 1 week. The colonic tissues were stained with HE to assess pathological changes. The enzyme linked immunosorbent assay was used to measure myeloperoxidase (MPO) activity and levels of IL-1β, IL-6, and TNF-α. The western blot and immunohistochemistry methods were performed to analyze the expressions of PERK/ATF4/CHOP pathway-associated proteins. The quantitative real-time polymerase chain reaction (qRT-PCR) and immunofluorescence analysis were carried out to determine the expressions of ZO-1, claudin-1, occludin mRNA, and protein.Results: In comparison with the model group, cucurbitacin IIa obviously increased body weight and colon length, reduced disease activity index value and MPO activity, and ameliorated the degree of histopathological damage. Inflammatory factor levels were considerably reduced in the cucurbitacin IIa-intervention groups compared to the model group. The western blot and immunohistochemistry results indicated that, compared with the model group, cucurbitacin IIa significantly abolished the protein expressions of p-PERK, p-eIF2α, ATF4, and CHOP. The results of qRT-PCR and immunofluorescence revealed that cucurbitacin IIa greatly elevated the expressions of ZO-1, claudin-1, occludin mRNA and protein.Conclusion: Cucurbitacin IIa dramatically ameliorates DSS-induced UC symptoms via suppressing the PERK/ATF4/CHOP pathway and reinforcing enteric barrier function.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 4","pages":"229-240"},"PeriodicalIF":1.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12001508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143781853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures. 代谢功能障碍相关脂肪变性肝病的转录组关联研究鉴定相关基因特征

IF 1.4 4区医学

Turkish Journal of Gastroenterology Pub Date : 2024-12-23 DOI: 10.5152/tjg.2024.24326

Jianxiu Wang, Qian Gao

{"title":"Transcriptome-Wide Association Study of Metabolic Dysfunction-Associated Steatotic Liver Disease Identifies Relevant Gene Signatures.","authors":"Jianxiu Wang, Qian Gao","doi":"10.5152/tjg.2024.24326","DOIUrl":"10.5152/tjg.2024.24326","url":null,"abstract":"Metabolic dysfunction-associated steatotic liver disease (MASLD) is considered the most widespread chronic liver condition globally. Genome-wide association studies (GWAS) have pinpointed several genetic loci correlated to MASLD, yet the biological significance of these loci remains poorly understood. Initially, we applied Functional Mapping and Annotation (FUMA) to conduct a functional annotation of the MASLD GWAS summary statistics, which included data from 3242 cases and 707 631 controls. Additionally, a MASLD transcriptome association study (TWAS) was conducted utilizing FUSION software in combination with the genotype-tissue expression project (GTEx-v8) expression weight set to identify susceptibility genes. Furthermore, to elucidate the observed correlations, we carried out conditional and joint analyses, probabilistic causal fine-mapping of TWAS signals, summary data-based Mendelian randomization (SMR), and phenome-wide association analyses. Following functional annotation analysis, we identified 4 genetic risk loci, annotated 6 lead single nucleotide polymorphisms (SNPs), 27 independent significant SNPs, and 511 candidate SNPs. TWAS also found four genes related to MASLD, including MAU2 sister chromatid cohesion factor (MAU2), EPH receptor A2 (EPHA2), GATA zinc finger domain containing 2A (GATAD2A), and transmembrane 6 superfamily member 2 (TM6SF2). Moreover, fine mapping of TWAS signatures identified 13 causal genes associated with MASLD that were located at 3 genetic risk loci, but SMR results could not rule out the possibility that the relationship between significant genes and MASLD was caused by a linkage disequilibrium structure. Our study found new significantly associated genes for MASLD and highlighted the ability of TWAS to identify and prioritize potentially pathogenic genes.","PeriodicalId":51205,"journal":{"name":"Turkish Journal of Gastroenterology","volume":"36 5","pages":"280-292"},"PeriodicalIF":1.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12070431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143994894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0