Nanoscale Research Letters最新文献

{"title":"Bio-fabricated silver nanoparticles: therapeutic evaluation as a potential nanodrug against cervical and liver cancer cells","authors":"Irshad Ahamad,&nbsp;Masood Nadeem,&nbsp;M. Moshahid Alam Rizvi,&nbsp;Tasneem Fatma","doi":"10.1186/s11671-025-04212-y","DOIUrl":"10.1186/s11671-025-04212-y","url":null,"abstract":"<div><p>Nanobiotechnology has grown rapidly and is now widely used in the diagnosis and treatment of modern diseases. Biosynthesized silver nanoparticles (AgNPs) are eco-friendly, cost-effective, biocompatible route, and have biomedical properties at minimal concentrations. In the present study extract of cyanobacterium (<i>Anabaena variabilis</i>) was utilized to synthesize facile, reliable AgNPs, further biosynthesized AgNPs were characterized by physicochemical techniques. The atomic force microscope study confirmed the shape of AgNPs while the scanning electron microscopy study revealed 17 to 35 nm in the size range. The zeta potential value of -19.5 mV demonstrated the repulsion effect between the particles, which prevents their aggregations while the heating stability of AgNPs was confirmed by Thermogravimetry differential thermal analysis. Another important characteristic, such as elemental constituent of AgNPs was determined by inductively coupled plasma mass spectrometry and was observed 94.24, 95.19, 97.06, and 99.34% of silver present in their respective concentrations of AgNPs. In vitro cytotoxicity of AgNPs was screened on HeLa, SiHa, (Cervical carcinoma), and HepG2 (Human hepatocellular carcinoma), cell lines. To evaluate the biocompatibility of AgNPs immortalized human embryonic kidney (HEK-293) cell line was used. The IC₅₀ values of AgNPs are were observed as 23.76 ± 2.4 µg/mL, 11.21 ± 1.7 µg/mL, and 22.27 ± 1.8 µg/mL against HeLa, SiHa and HepG2 cell lines respectively. AgNPs demonstrated the biocompatible nature against HEK-293 cells, Normal cell line (HEK-293) cytotoxicity results showed exhibited ≥ 95% cell viability at all the concentrations. During the DAPI (4’,6-diamidino-2-phenylindole) staining study IC₅₀ dose of AgNPs on cancer cell lines (HeLa, SiHa, and HepG2) showed nuclear morphological alterations which indicate the DNA damage and apoptosis in cancer cells. AgNPs treated cancer cells increased the cells number in the S phase while decreased the number of cells in the G0-G1 and G2/M phases of the cell cycle in all three cancer cells compared to the control.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04212-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Note: Poly(γ-glutamic acid)-coated lipoplexes loaded with Doxorubicin for enhancing the antitumor activity against liver tumors","authors":"Na Qi,&nbsp;Bo Tang,&nbsp;Guang Liu,&nbsp;Xingsi Liang","doi":"10.1186/s11671-025-04187-w","DOIUrl":"10.1186/s11671-025-04187-w","url":null,"abstract":"","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04187-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in molecular epidemiology and detection methods of pseudorabies virus","authors":"Linlin Zhuang,&nbsp;Jiansen Gong,&nbsp;Jingyi Shen,&nbsp;Ying Zhao,&nbsp;Jianbo Yang,&nbsp;Qingxin Liu,&nbsp;Yu Zhang,&nbsp;Qiuping Shen","doi":"10.1186/s11671-025-04217-7","DOIUrl":"10.1186/s11671-025-04217-7","url":null,"abstract":"<div><p>Pseudorabies (PR), a highly contagious disease caused by the pseudorabies virus (PRV), represents a significant threat to the global swine industry. Despite the success of developed countries in controlling the PRV epidemic through swine pseudorabies eradication programs, wild boars, as a potential source of infection, still require sustained attention and effective control measures. Concurrently, there has been considerable global attention directed towards cases of PRV infection in humans. In consideration of the aforementioned factors, this paper presents a comprehensive review of recent developments in the PRV genome, epidemiology, vaccine research, and molecular detection methods. The epidemiology section presents an analysis of the transmission routes, susceptible animal groups, and geographic distribution of PRV, as well as an examination of the trend of the epidemic in recent years. In the field of vaccine research, the current development of genetically engineered vaccines is emphasized, and the immunogenicity and safety of vaccines are discussed. Moreover, the molecular detection techniques utilized to identify PRV, including immunological methods, nucleic acid detection methods, biosensors, and so forth, are presented in a systematic manner. Finally, this paper presents a comprehensive discussion of the current status of PRV-related research and offers insights into future directions, with the aim of providing a foundation for the scientific prevention and control of PRV.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04217-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial thermal flow control on thermoelectric device by tuning electrode absorptivity","authors":"Sohei Saito,&nbsp;Ayaha Yamamoto,&nbsp;Yu-Jung Lu,&nbsp;Takuo Tanaka,&nbsp;Wakana Kubo","doi":"10.1186/s11671-025-04193-y","DOIUrl":"10.1186/s11671-025-04193-y","url":null,"abstract":"<div><p>Thermoelectric conversion is a direct conversion of thermal energy to electricity, triggered by the Seebeck effect. Typically, the configuration of a thermoelectric device and the absorptivity of both electrodes exhibit symmetrical optical characteristics between the hot and cold ends, and these factors usually are not expected to affect the direction of the thermal gradient. Here, we first demonstrate the ability to reverse the direction of thermal flow across a thermoelectric element by adjusting the absorptivity of electrodes at both ends in an environment with uniform thermal radiation. For example, when the metamaterial or fullerene electrodes were attached to one end a <i>p</i>-type thermoelectric element, they generated output voltages of 19.0 and -4.0 V, respectively, in an environment with uniform thermal radiation at 364 K. Using this insight, we demonstrated power generation on a <span>(pi)</span>-shaped thermoelectric device consisting only of <i>p</i>-type thermoelectric legs by designing the absorptivity of the electrode at each end. Our findings will provide valuable insights as a device guideline for conventional thermoelectric devices.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04193-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of food-simulating liquids and polishing times on the color stability of microhybrid and nanohybrid resin composites","authors":"Muhammet Fidan,&nbsp;Nevin Çankaya","doi":"10.1186/s11671-025-04205-x","DOIUrl":"10.1186/s11671-025-04205-x","url":null,"abstract":"<div><p>The aim of this study was to evaluate the effect of food-simulating liquids and polishing times on the color stability of microhybrid and nanohybrid resin composite materials. One nanohybrid (Compofill) and one microhybrid (Dynamic plus) were used to prepare 120 samples each. Three polishing time subgroups were randomly assigned to each composite group. The polishing groups were treated with a one-step polishing system (Dimanto). Based on food-simulating liquids, the polishing groups were each separated into four subgroups (<i>n</i> = 10): ethanol, heptane, citric acid, and distilled water. Color change was evaluated by immersing the resin composites in liquids simulating food for 7 and 14 days. Three-way ANOVA was used for data analyses. When the color changes of the resin composites were compared, Compofill showed the lowest color change at baseline–7 days and baseline–14 days. In terms of food-simulating media, all times, the immersion in ethanol resulted in higher color variation compared to distilled water and citric acid while heptane showed an intermediate behavior. The nanohybrid composite showed less discoloration than the microhybrid composite. The discoloration of the nanohybrid resins after 7 and 14 days was below the clinically acceptable level. At all times, the increase in polishing time contributed to color stability.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04205-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143455449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Solid‑state hydrogen storage materials","authors":"M. R. Kalibek,&nbsp;A. D. Ospanova,&nbsp;B. Suleimenova,&nbsp;R. Soltan,&nbsp;T. Orazbek,&nbsp;A. M. Makhmet,&nbsp;Kh. S. Rafikova,&nbsp;N. Nuraje","doi":"10.1186/s11671-025-04216-8","DOIUrl":"10.1186/s11671-025-04216-8","url":null,"abstract":"","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04216-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143438637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of peptide nanoparticles for improved diabetes outcomes: insights and opportunities","authors":"Reuben Samson Dangana,&nbsp;Michael Ben Okon,&nbsp;Ikuomola Emmanuel Orire,&nbsp;Idris Olatunji Sanusi,&nbsp;Swase Dominic Terkimbi,&nbsp;Patrick Maduabuchi Aja,&nbsp;Ibrahim Babangida Abubakar,&nbsp;Godwin Anyim","doi":"10.1186/s11671-025-04215-9","DOIUrl":"10.1186/s11671-025-04215-9","url":null,"abstract":"<div><p>This present study carried out a systematic review and meta-analysis of peptide nanoparticles in diabetes management for improved patient outcomes from 2014 to 2024. Different electronic databases, including PubMed, Scopus, Web of Science, ResearchGate, Google Scholar, and the Cochrane Library, were searched for relevant literature using Medical Subject Headings (MeSH) and boolean operators. A total of 317 articles were obtained and include PUBMED (39), Scopus (215), ResearchGate (30), Google Scholar (25), and Cochrane Library (8). From these, 186 duplicate entries were eliminated, while 76 articles were dismissed for some reasons. After scanning the titles, abstracts, and contents of the remaining 55 articles for relevance, 22 articles were eliminated. After a full-text screening using inclusion/exclusion criteria, an additional 11 articles were discarded, while 4 were excluded during the data extraction phase. In the end, seven (7) publications were considered relevant based on the eligibility criteria, representing 2.22%. Results showed that sequential exclusion of the studies did not have a significant impact on the effects of peptide nanoparticles on glucose control, insulin delivery, bioavailability, efficacy, safety, and patient outcomes in diabetes management. Also, peptide nanoparticles had positive improvement on glycemic control, insulin levels, glycated hemoglobin (HbA1C) levels, and overall patient outcomes. The study concludes that peptide nanoparticles harbour the potential to improve diabetes management through enhanced glucose control, insulin delivery, and patient outcomes. However, there is a significant gap in knowledge. Further research is required to understand the long-term safety and efficacy of many of the enlisted nanoparticles. Additionally, future studies should explore a wider range of peptides and proteins for encapsulation, develop delivery systems for larger and conformationally diverse molecules, and improve the oral bioavailability of encapsulated therapeutics. Long-term clinical trials are needed to validate this approach in humans and elucidate the underlying mechanisms for optimal treatment design. If these knowledge gaps are addressed, peptide nanoparticles will unavoidably become a powerful tool for effective management of diabetes along with traditional methods.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04215-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"N-doped graphene oxide nanomaterial: synthesis and application as controlled-release of urea for advancement in modern agriculture","authors":"Tapas Mallik,&nbsp;Srabanti Ghosh,&nbsp;Deepak Ekka","doi":"10.1186/s11671-025-04194-x","DOIUrl":"10.1186/s11671-025-04194-x","url":null,"abstract":"<div><p>Controlled-release fertilizer plays a crucial role in advancing modern agriculture. One promising avenue of research is the utilization of graphene oxide (GO) for controlled-release fertilizer. Here, urea decorated GO (urea@GO) nanomaterial has fabricated through mechanical process and applied for enhance the releasing characteristics of urea by control study. From the experiment, it has seen the nanocomposite (urea@GO) extends the power of the nutrient release period to ≥ 10 h in aqueous media. Where the UV–Vis peak at 560–600 nm shifts towards 400–490 nm by the formation of N-doping. This original and innovative technology holds a significant development for potential crop production. One more advantage is the photochemical dissociation of by-products &amp; residue of GO and the release of non-toxic &amp; eco-friendly species, which are not harmful to crops as well as the health of the environment.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04194-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Controlled growth of citrate-stabilized gold nanoparticles using a semi-continuous seed-mediated route","authors":"Muhammad Bilal,&nbsp;Sulalit Bandyopadhyay","doi":"10.1186/s11671-025-04189-8","DOIUrl":"10.1186/s11671-025-04189-8","url":null,"abstract":"<div><p>Gold nanoparticles (Au NPs) hold unique optical and electronic properties due to their surface plasmon resonance. The size, shape, and surface chemistry of Au NPs are key parameters for altering their optical properties to fine-tune Au NPs for specific applications. We report a size-controlled synthesis of citrate-stabilized Au NPs via the Turkevich method, followed by their growth through a semi-continuous seed-mediated approach. Au NPs of up to 53 nm were synthesized by controlled addition of chloroauric acid (HAuCl₄) to pre-prepared citrate stabilized Au NP seeds. Our approach leverages the residual sodium citrate from the Turkevich reaction to reduce HAuCl₄ during seed-mediated growth of Au NPs. Notably, we observed that a boiling temperature, as opposed to 70 °C, provided better control over nanoparticle size and morphology. Our method addresses several challenges associated with seed-mediated growth by yielding relatively spherical, monodisperse, citrate-stabilized, water-dispersible Au NPs in a single growth step, without sacrificing yield. Furthermore, a kinetics study revealed a continuous increase in particle diameter over the reaction period, hinting at the continuous and uniform growth of Au NPs.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04189-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in macro-bioactive materials enhancing dentin bonding","authors":"Junping Fan,&nbsp;Pei Wang,&nbsp;Shen Wang,&nbsp;Rong Li,&nbsp;Yaoxi Yang,&nbsp;Lei Jin,&nbsp;Yingying Sun,&nbsp;Dongfang Li","doi":"10.1186/s11671-025-04206-w","DOIUrl":"10.1186/s11671-025-04206-w","url":null,"abstract":"<div><p>The long-term stability of dentin bonding is equally crucial for minimally invasive aesthetic restoration. Although the dentin bonding meets clinical standards at the initial stage, its long-term efficacy remains suboptimal owing to the impact of physiological factors. Herein, we present a comprehensive analysis of macro-bioactive materials, including nanomaterials and polymer materials, to improve the longevity of dentin bonding and extend the lifespan of adhesive prosthetics through various mechanisms to achieve sustained and stable dentin bonding effects over an extended period. On the one hand, the macro-bioactive materials directly inhibit the enzymatic activity of matrix metalloproteinases (MMPs) or impede the acidogenic abilities of cariogenic microorganisms, thereby enhancing the local pH within the oral cavity. On the other hand, they indirectly prevent the activation of MMPs, thereby safeguarding the structural integrity of the resin–dentin bonding interface and efficiently improve its long-term stability. Moreover, these macro-bioactive materials establish cross-links with collagen fibers, promoting bionic remineralization and protecting the exposed collagen fibers within the hybrid layer from degradation. These processes ultimately enhance the mechanical properties of the resin–dentin bonding interface and efficiently improve its long-term stability.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04206-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143430956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}