Nanoscale Research Letters最新文献

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Curcumin mediates glutathione depletion via metal–organic framework nanocarriers to enhance cisplatin chemosensitivity on esophageal cancer 姜黄素通过金属-有机框架纳米载体介导谷胱甘肽耗损,增强顺铂对食管癌的化疗敏感性
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-12-11 DOI: 10.1186/s11671-024-04168-5
Yunhao Sun, Kaijun Ying, Jian Sun, Limin Qiu, Yao Wang, Mingming Ji, Lulu Zhou, Jinjin Chen
{"title":"Curcumin mediates glutathione depletion via metal–organic framework nanocarriers to enhance cisplatin chemosensitivity on esophageal cancer","authors":"Yunhao Sun,&nbsp;Kaijun Ying,&nbsp;Jian Sun,&nbsp;Limin Qiu,&nbsp;Yao Wang,&nbsp;Mingming Ji,&nbsp;Lulu Zhou,&nbsp;Jinjin Chen","doi":"10.1186/s11671-024-04168-5","DOIUrl":"10.1186/s11671-024-04168-5","url":null,"abstract":"<div><p>Cisplatin (CDDP) is the primary drug used in the initial treatment of esophageal cancer (EC). However, its side effects and resistance can limit its effectiveness in clinical therapy. Curcumin (Cur)-mediated glutathione (GSH) depletion can reverse resistance, enhance the chemosensitivity of CDDP, and further improve the efficacy of platinum-containing chemotherapy in the treatment of esophageal cancer. However, it is also faced with problems of poor water solubility and low bioavailability in vivo, which severely hinders cancer treatments. In order to address these issues, we developed a novel nanotherapeutic system called CDCZA, combining Cur/CDDP/Cu/ZIF8@Au to enhance chemotherapy through GSH depletion and chemodynamic therapy through self-produced H<sub>2</sub>O<sub>2</sub>. Cu and CDDP were precisely co-loaded into Cu/ZIF8 nanoparticles using a one-pot method, then ultra-small gold nanoparticles mimicking glucose oxidase (Au nanoparticles) were embedded in the outer shell to create the CDCZA nano system. The released Cur could notably decrease intracellular GSH content and thus improve the chemosensitivity of CDDP, resulting in severe cellular apoptosis. And the Au nanoparticles effectively enabled chemodynamic therapy enhancement by accelerating the depletion of β-D-glucose into H<sub>2</sub>O<sub>2</sub>. As a result, the CDCZA nanoparticles showed increased tumor accumulation and improved antitumor effectiveness in a model of EC. Taken together, this work provides a new idea for the clinical design of efficient treatment reagents for EC.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04168-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gold nanoparticle encapsulated hybrid MOF: synthesis, characterization, and co-drug delivery of 5-fluorouracil and curcumin 金纳米颗粒封装杂化MOF: 5-氟尿嘧啶和姜黄素的合成、表征和联合给药
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-12-11 DOI: 10.1186/s11671-024-04152-z
Pranita Rananaware, Parimal Pandit, Varsha Brahmkhatri
{"title":"Gold nanoparticle encapsulated hybrid MOF: synthesis, characterization, and co-drug delivery of 5-fluorouracil and curcumin","authors":"Pranita Rananaware,&nbsp;Parimal Pandit,&nbsp;Varsha Brahmkhatri","doi":"10.1186/s11671-024-04152-z","DOIUrl":"10.1186/s11671-024-04152-z","url":null,"abstract":"<div><p>The unique features of Metal–Organic Frameworks (MOFs), including structural flexibility, high surface area, and variable pore size, have drawn attention in cancer therapy. However, despite advances in surface functionalization, engineering structural features, and porosity, achieving controlled release, stability, scalability, and toxicity remains a challenge. The current study reports gold nanoparticle (AuNP) encapsulated dual metal–organic frameworks (MOFs) comprising zeolitic imidazolate (ZIF8) and cobalt-imidazole (ZIF67) by a simple precipitation method for dual drug delivery applications. This combination associates the advantages of AuNPs and MOFs, creating a potent platform for cancer theranostics that combines diagnosis and treatment into one unit. The synthesized composite (AuNPs@ZIF-8/ZIF-67) is functionalized with Folic acid (FA) and loaded with the anticancer agents Curcumin (C) and 5-fluorouracil (5-FU) for co-drug delivery The synthesized composites, namely Au/ZIF8, Au/ZIF8/ZIF67/FA, Au/ZIF8/ZIF67/FA/5-FU, and Au/ZIF8/ZIF67/FA/5-FU/C were characterized using diverse analytical techniques such as FESEM, XRD, FTIR, TEM, and BET. The characterization methods showed that the hybrid MOF structure was stable and intact after AuNP encapsulation and drug loading. The dual MOF composite exhibits a better affinity for loading C and 5-FU with 60% and 40% drug loading capacity, respectively. The simultaneous drug release studies suggest that AuNPs@ZIF-8/ZIF-67 are more responsive to the acidic pH and show a higher cumulative drug release of 5FU and C at the lower value of pH 5. For further validation, the release kinetics data were fitted into the Korsmeyer-Peppas model in the current study. The observed value of n which is less than 0.5 suggests the pseudo-Fickian diffusion mechanism for drug release, demonstrating long-term release of 5FU and C from Au/ZIF8/ZIF67/FA/5-FU/C. The targeted drug delivery system is anticipated to display synergistic therapeutic efficacy from the combined effect of the two anticancer agents and the pH-responsive nature of ZIF systems.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04152-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in dorzolamide hydrochloride delivery: harnessing nanotechnology for enhanced ocular drug delivery in glaucoma management 盐酸多唑胺给药的进展:利用纳米技术增强青光眼治疗中的眼部药物给药
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-12-10 DOI: 10.1186/s11671-024-04154-x
Sagar R. Pardeshi, Amol D. Gholap, Navnath T. Hatvate, Khushmita D. Gharat, Jitendra B. Naik, Abdelwahab Omri
{"title":"Advances in dorzolamide hydrochloride delivery: harnessing nanotechnology for enhanced ocular drug delivery in glaucoma management","authors":"Sagar R. Pardeshi,&nbsp;Amol D. Gholap,&nbsp;Navnath T. Hatvate,&nbsp;Khushmita D. Gharat,&nbsp;Jitendra B. Naik,&nbsp;Abdelwahab Omri","doi":"10.1186/s11671-024-04154-x","DOIUrl":"10.1186/s11671-024-04154-x","url":null,"abstract":"<div><p>Dorzolamide hydrochloride (DRZ) is a carbonic anhydrase inhibitor utilized in managing elevated intraocular pressure (IOP) associated with glaucoma. However, its clinical effectiveness is hindered by a short half-life, low residence time, and the need for frequent dosing, highlighting the necessity for innovative delivery systems. This work reviews recent advancements in DRZ delivery, particularly focusing on cyclodextrin complexation and nanotechnology applications. It explores the potential of cyclodextrin derivatives to enhance DRZ’s bioavailability. DRZ cyclodextrin complexes or nanoparticulate systems maintain high drug concentrations in the eye while minimizing irritation and viscosity-related issues. Nanotechnology introduces nanoparticle-based carriers such as polymeric nanoparticles, solid lipid nanoparticles, liposomes, niosomes, and nanoemulsions. These formulations enable sustained drug release, improved corneal permeation, and enhanced patient compliance. Clinical trials have shown that DRZ nanoparticle eye drops and nanoliposome formulations offer efficacy comparable to conventional therapies, with the potential for better tolerability. Overall, this review highlights significant progress in DRZ delivery systems, suggesting their potential to transform glaucoma treatment by addressing current limitations and improving therapeutic outcomes.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04154-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of essential oils inclusion complexes: a nanotechnology approach with enhanced thermal and light stability 精油包合物的开发:具有增强热稳定性和光稳定性的纳米技术方法
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-12-08 DOI: 10.1186/s11671-024-04158-7
Fernanda Ramalho Procopio, Ramon Peres Brexó, Luis Eduardo Sousa Vitolano, Maria Eduarda da Mata Martins, Maria Eduarda de Almeida Astolfo, Stanislau Bogusz Junior, Marcos David Ferreira
{"title":"Development of essential oils inclusion complexes: a nanotechnology approach with enhanced thermal and light stability","authors":"Fernanda Ramalho Procopio,&nbsp;Ramon Peres Brexó,&nbsp;Luis Eduardo Sousa Vitolano,&nbsp;Maria Eduarda da Mata Martins,&nbsp;Maria Eduarda de Almeida Astolfo,&nbsp;Stanislau Bogusz Junior,&nbsp;Marcos David Ferreira","doi":"10.1186/s11671-024-04158-7","DOIUrl":"10.1186/s11671-024-04158-7","url":null,"abstract":"<div><p>Essential oils (EOs) are volatile compounds that may have antimicrobial and antioxidant properties. Despite their potential application, low water solubility and chemical instability are limiting factors. Nanoencapsulation processes can overcome this problem, protecting against external factors and promoting a moderate release. Therefore, the objective of the present study was to encapsulate <i>Cymbopogon citratus</i> (CC) and <i>Origanum vulgare</i> (OV) essential oils in β-cyclodextrin (βCD) complexes. Different ratios (w/w) between βCD and EOs (96:4, 92:8, 90:10, 88:12) were tested, seeking greater entrapment efficiency. The particles were characterized by yield, entrapment efficiency, size distribution, morphology, crystallinity, infrared spectroscopy, and thermal behavior. Furthermore, the thermal (70 °C) and photochemical (UV) stability of the free and encapsulated EO was evaluated for 48 h. The results showed that the βCD-CC 90:10 and βCD-OV 90:10 formulations presented greater entrapment efficiency. Crystalline structures of varying sizes (200 to 800 nm), trapezoidal shape, and tendency to aggregation were obtained. Changes in the βCD crystalline organization and the suppression of characteristic free oil absorption bands suggest the EO entrapment. Regarding stability results, βCD-CC remained constant when CC showed losses of 20% (photodegradation) and 60% (thermal degradation) after 48 h of stress exposure. Free OV showed slight variations in absorbance over time, while βCD-OV remained constant over 24 h (thermal degradation) and maintained 60% of oil over 48 h of photo exposure. Furthermore, OV and CC demonstrate color change over time, while βCD-OV and βCD-CC remained constant. The results demonstrate that nanoencapsulation can be an interesting tool for protecting EOs.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04158-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142790369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing agriculture with functional NM: “pathways to sustainable and smart farming technologies” 用功能性纳米技术推进农业:“通往可持续和智能农业技术的道路”
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-12-05 DOI: 10.1186/s11671-024-04144-z
Mir Waqas Alam, Pir Mohammad Junaid, Yonis Gulzar, Buzuayehu Abebe, Mohammed Awad, S. A. Quazi
{"title":"Advancing agriculture with functional NM: “pathways to sustainable and smart farming technologies”","authors":"Mir Waqas Alam,&nbsp;Pir Mohammad Junaid,&nbsp;Yonis Gulzar,&nbsp;Buzuayehu Abebe,&nbsp;Mohammed Awad,&nbsp;S. A. Quazi","doi":"10.1186/s11671-024-04144-z","DOIUrl":"10.1186/s11671-024-04144-z","url":null,"abstract":"<div><p>The integration of nanotechnology in agriculture offers a transformative approach to improving crop yields, resource efficiency, and ecological sustainability. This review highlights the application of functional NM, such as nano-formulated agrochemicals, nanosensors, and slow-release fertilizers, which enhance the effectiveness of fertilizers and pesticides while minimizing environmental impacts. By leveraging the unique properties of NM, agricultural practices can achieve better nutrient absorption, reduced chemical runoff, and improved water conservation. Innovations like nano-priming can enhance seed germination and drought resilience, while nanosensors enable precise monitoring of soil and crop health. Despite the promising commercial potential, significant challenges persist regarding the safety, ecological impact, and regulatory frameworks for nanomaterial use. This review emphasizes the need for comprehensive safety assessments and standardized risk evaluation protocols to ensure the responsible implementation of nanotechnology in agriculture.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04144-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142778518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Citric acid based (CQDs/TiO2) nanocomposites against SARS-COV-2: theoretical, photocatalytic and computational studies 柠檬酸基(CQDs/TiO2)纳米复合材料抗SARS-COV-2:理论、光催化和计算研究
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-12-02 DOI: 10.1186/s11671-024-04117-2
Joina Gunjan Singh, Ankit Kumar Singh, Nurul Hidayah Mohamad Idris, Nattasa Kitchawengkul, Purim Jarujamrus, Hooi Ling Lee, Maria Grishina, Nadezhda Palko, Prateek Pathak, Amita Verma
{"title":"Citric acid based (CQDs/TiO2) nanocomposites against SARS-COV-2: theoretical, photocatalytic and computational studies","authors":"Joina Gunjan Singh,&nbsp;Ankit Kumar Singh,&nbsp;Nurul Hidayah Mohamad Idris,&nbsp;Nattasa Kitchawengkul,&nbsp;Purim Jarujamrus,&nbsp;Hooi Ling Lee,&nbsp;Maria Grishina,&nbsp;Nadezhda Palko,&nbsp;Prateek Pathak,&nbsp;Amita Verma","doi":"10.1186/s11671-024-04117-2","DOIUrl":"10.1186/s11671-024-04117-2","url":null,"abstract":"<div><p>In the last decade, carbon quantum dots (CQDs), a novel class of carbon-based nanomaterials, have received increasing attention due to their distinct properties. Carbon Quantum Dots/Titanium Dioxide (CQDs/TiO<sub>2</sub>) Nanocomposites were reported as potent compounds against SARS-COV-2. In this manuscript, citric acid is the carbon precursor used to synthesize carbon quantum dots (CQDs). Using a green approach, the synthesized CQD fabricates the Carbon Quantum Dots/Titanium Dioxide (CQDs/TiO2) Nanocomposites. Synthesized composites were characterized by using a UV–visible spectrophotometer, Fourier-transformed infrared (FTIR) spectrometry, X-ray diffractometry (XRD), and Scanning electron microscopy with energy dispersive X-ray analysis (SEM–EDX). Methylene blue was used to check the Photocatalytic activity of synthesized (CQDs/TiO<sub>2</sub>) nanocomposites of different concentrations. Computational modeling of agglomerates of CQD and TiO2 nanoparticles with the formula TiO<sub>2</sub>…….. Ti<sub>253</sub>O<sub>506</sub> demonstrated two stages of the nanocomposite formation, including the formation of agglomerates with the neutral and salt-like structures with the total gain in the Gibbs free energy − 38.397 kcal/mole. In silico, Molecular docking studies of citric acid were evaluated against SARS-COV-2 protein to understand their mechanism and key amino acid interactions along with standard drug remdesivir. The photocatalytic activity of CQDs/TiO<sub>2</sub> showed extremely promising results. Based on this study, the proposed mechanism of action of these compounds is reported. A detailed investigation of CQDs/TiO<sub>2</sub> against SARS-CoV-2 is needed, which is another part of the research in our next manuscript.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04117-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142761824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hybrid layer-by-layer assembly of AuNPs/NSF composite for electrochemical detection of miRNA-196a 逐层混合组装 AuNPs/NSF 复合材料,用于电化学检测 miRNA-196a
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-11-26 DOI: 10.1186/s11671-024-04127-0
Jun Ji, Gaofan Shi, Jiayi Jiang, Shu Wu, Haoyuan Su, Hongzhi Pan, Dongdong Zeng
{"title":"Hybrid layer-by-layer assembly of AuNPs/NSF composite for electrochemical detection of miRNA-196a","authors":"Jun Ji,&nbsp;Gaofan Shi,&nbsp;Jiayi Jiang,&nbsp;Shu Wu,&nbsp;Haoyuan Su,&nbsp;Hongzhi Pan,&nbsp;Dongdong Zeng","doi":"10.1186/s11671-024-04127-0","DOIUrl":"10.1186/s11671-024-04127-0","url":null,"abstract":"<div><p>Detection of microRNA-196a (miRNA-196a) is crucial in cancer research, enabling early diagnosis and providing guidance for individualized treatment. In this work, we employed a naturally occurring negatively charged nano silk fibroin (NSF) with high mechanical properties, biocompatibility, and conductivity to be encapsulated with a positively charged gold nanoparticles (AuNPs) were used as film-forming materials for electrostatic layer-by-layer self-assembly to modify the working electrode of the screen-printed carbon electrode (SPCE). Under the optimized experimental conditions, the uniformly distributed AuNPs on the surface of the multilayer film modified SPCE (AuNPs/NSF)<sub>5.5</sub>/SPCE combined with the sulfhydryl-modified capture probe cp-DNA through gold-sulfur bonds. Furthermore, miRNA-196a is specifically captured through complementary base pairing to achieve highly sensitive and specific detection. (AuNPs/NSF)<sub>5.5</sub>/SPCE electrode can detect miRNA-196a in a concentration range of 1.0 × 10<sup>−13</sup> to 1.0 × 10<sup>−6</sup> M, and the calculated detection limit is 4.63 × 10<sup>−14</sup> M when the signal-to-noise ratio is 3. The obtained results showed that the (AuNPs/NSF)<sub>5.5</sub>/SPCE has excellent selectivity and good stability over time.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04127-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solid-state hydrogen storage materials 固态储氢材料
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-11-26 DOI: 10.1186/s11671-024-04137-y
M. R. Kalibek, A. D. Ospanova, B. Suleimenova, R. Soltan, T. Orazbek, A. M. Makhmet, Kh. S. Rafikova, N. Nuraje
{"title":"Solid-state hydrogen storage materials","authors":"M. R. Kalibek,&nbsp;A. D. Ospanova,&nbsp;B. Suleimenova,&nbsp;R. Soltan,&nbsp;T. Orazbek,&nbsp;A. M. Makhmet,&nbsp;Kh. S. Rafikova,&nbsp;N. Nuraje","doi":"10.1186/s11671-024-04137-y","DOIUrl":"10.1186/s11671-024-04137-y","url":null,"abstract":"<div><p>The increasing global emphasis on sustainable energy alternatives, driven by concerns about climate change, has resulted in a deeper examination of hydrogen as a viable and ecologically safe energy carrier. The review paper analyzes the recent advancements achieved in materials used for storing hydrogen in solid-state, focusing particularly on the improvements made in both physical and chemical storage techniques. Metal–organic frameworks and covalent-organic frameworks are characterized by their porous structures and large surface areas, making them appropriate for physical adsorption. Additionally, the conversation centers on metal hydrides and complex hydrides because of their ability to form chemical bonds (absorption) with hydrogen, leading to substantial storage capacities. The combination of materials that adsorb and absorb hydrogen could enhance the overall efficiency. Moreover, the review discusses recent research, analyzes key factors that influence performance, and discusses the difficulties and strategies for enhancing material efficiency and cost-effectiveness. The provided observations emphasize the critical significance of improved materials in facilitating the transition towards a hydrogen-based economy. Furthermore, it is crucial to highlight the necessity for additional study and development in this vital field.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04137-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142714198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nucleus-targeted Silencer nanoplatform regulating ZEB1-AS1 in head and neck squamous cell carcinoma therapy 在头颈部鳞状细胞癌治疗中调控 ZEB1-AS1 的核靶向 Silencer 纳米平台
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-11-23 DOI: 10.1186/s11671-024-04148-9
Haojie Yang, Yangfan Zhang, Zicong Tan, Zihao Liu, Yingzhe Yan, Qin Li, Phei Er Saw, Ning Liufu, Fengtao Ji
{"title":"Nucleus-targeted Silencer nanoplatform regulating ZEB1-AS1 in head and neck squamous cell carcinoma therapy","authors":"Haojie Yang,&nbsp;Yangfan Zhang,&nbsp;Zicong Tan,&nbsp;Zihao Liu,&nbsp;Yingzhe Yan,&nbsp;Qin Li,&nbsp;Phei Er Saw,&nbsp;Ning Liufu,&nbsp;Fengtao Ji","doi":"10.1186/s11671-024-04148-9","DOIUrl":"10.1186/s11671-024-04148-9","url":null,"abstract":"<div><p>Long noncoding RNAs have emerged as key players in the progression of head and neck squamous cell carcinoma (HNSC). Among them, ZEB1-AS1 was identified as an upregulated candidate in HNSC through comprehensive analysis of RNA-sequencing datasets. Here, elevated ZEB1-AS1 expression was correlated with poor prognosis in HNSC patients. Further investigations demonstrated that downregulation of ZEB1-AS1 induced epithelial-mesenchymal transition and increased sensitivity to cisplatin in Cal27 cells, while its upregulation reversed these effects, underscoring its pivotal role in tumor metastasis and cisplatin resistance in Cal27 cells. Mechanistically, ZEB1-AS1, located in cytoplasm and nucleus, directly regulated the expression of ZEB1, thereby influencing the expression of μ opioid receptor (MOR) and implicating in cancer progression. To advance clinical translation, we employed a nucleus-targeting nanoparticle platform for efficient delivery of a mixture of antisense oligonucleotides and siRNA (Silencer), effectively manipulating ZEB1-AS1 expression in vitro and in vivo. Besides, a predictive model for HNSC patients was developed by analyzing the expression levels of ZEB1-AS1, ZEB1, and MOR in the HNSC datasets. Our study underscored the critical role of ZEB1-AS1 in HNSC and its potential as a therapeutic target. By elucidating its functional mechanisms and utilizing a nucleus-targeting nanoparticle platform for efficient delivery, we proved the potential of ZEB1-AS1-targeted therapies in HNSC. </p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04148-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142691869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bismuth sensitized iron oxide on exfoliated graphene oxide (Bi–Fe2O3@GO) for oxygen evaluation reaction 用于氧气评估反应的剥离氧化石墨烯上的铋敏化氧化铁(Bi-Fe2O3@GO
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-11-23 DOI: 10.1186/s11671-024-04146-x
Akhtar Munir, Shaheer Jamal, Humaira Yasmeen Gondal, Javed Iqbal, Aamir Hussain, Arslan Aziz, Mahammad Nisar, Muhammad Zubair, Abdul Momin, Ali Haider
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