{"title":"Analytical solution of nano-concrete-epoxy interaction area considering static equilibrium","authors":"Md. Foisal Haque","doi":"10.1186/s11671-024-04083-9","DOIUrl":"10.1186/s11671-024-04083-9","url":null,"abstract":"<div><p>This research proposes an analytical solution of the nano-concrete-epoxy interaction area within nano crack region of the reinforced concrete beam by applying Newton’s third law in static equilibrium. For deriving the governing equation, the imaginary beam with free ends (no support) is considered within nano crack region. This imaginary beam is acted along the imaginary line of concrete-epoxy interface. Newton’s third law is applicable for deriving the governing equation because of assuming the absence of frictional and other external forces. The parametric study is performed for implementing the proposed formula of nano interactive area considering variable nano crack depths and thicknesses. The nano interactive area is increased gradually with the increment of depths and thicknesses based on the parametric study because of linear functionality of interactive area and geometry of nano crack region. The maximum interactive area is found to be 314 nm<sup>2</sup> at 0.6 ratio of depths and thicknesses of the nano crack. The incremental differences in interactive area between the crack depth or thickness ratios of 0.1 and 0.6 are found to be 25.4% and 1.6% for variations of the crack depth and thickness ratios, respectively. So, the crack depth shows higher impact on the interaction area compared to the thickness of the crack. However, there is a scope for enhancing this research in future by deriving closed-formed analytical formulations to consider appropriate boundary conditions.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04083-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142224556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akhil Khajuria, Hema K. Alajangi, Akanksha Sharma, Harinder Kaur, Prakriti Sharma, Sushmita Negi, Laxmi Kumari, Manisha Trivedi, Ashok Kumar Yadav, Robin Kumar, Rajeev Singh Raghuvanshi, Indu Pal Kaur, Rajeev K. Tyagi, Pradeep Kumar Jaiswal, Yong-beom Lim, Ravi Pratap Barnwal, Gurpal Singh
{"title":"Theranostics: aptamer-assisted carbon nanotubes as MRI contrast and photothermal agent for breast cancer therapy","authors":"Akhil Khajuria, Hema K. Alajangi, Akanksha Sharma, Harinder Kaur, Prakriti Sharma, Sushmita Negi, Laxmi Kumari, Manisha Trivedi, Ashok Kumar Yadav, Robin Kumar, Rajeev Singh Raghuvanshi, Indu Pal Kaur, Rajeev K. Tyagi, Pradeep Kumar Jaiswal, Yong-beom Lim, Ravi Pratap Barnwal, Gurpal Singh","doi":"10.1186/s11671-024-04095-5","DOIUrl":"10.1186/s11671-024-04095-5","url":null,"abstract":"<div><p>Breast cancer is one of the leading causes of death among women globally, making its diagnosis and treatment challenging. The use of nanotechnology for cancer diagnosis and treatment is an emerging area of research. To address this issue, multiwalled carbon nanotubes (MWCNTs) were ligand exchanged with butyric acid (BA) to gain hydrophilic character. The successful functionalization was confirmed by FTIR spectroscopy. Surface morphology changes were observed using SEM, while TEM confirmed the structural integrity of the MWCNTs after functionalization. Particle size, zeta potential, and UV spectroscopy were also performed to further characterize the nanoparticles. The breast cancer aptamer specific to Mucin-1 (MUC-1) was then conjugated with the functionalized MWCNTs. These MWCNTs successfully targeted breast cancer cells (MDA-MB-231) as examined by cellular uptake studies and exhibited a reduction in cancer-induced inflammation, as evidenced by gene transcription (qPCR) and protein expression (immunoblotting) levels. Immunoblot and confocal-based immunofluorescence assay (IFA) indicated the ability of CNTs to induce photothermal cell death of MDA-MB-231 cells. Upon imaging, cancer cells were effectively visualized due to the MWCNTs’ ability to act as magnetic resonance imaging (MRI) contrast agents. Additionally, MWCNTs demonstrated photothermal capabilities to eliminate bound cancer cells. Collectively, our findings pave the way for developing aptamer-labeled MWCNTs as viable “theranostic alternatives” for breast cancer treatment.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04095-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Therapeutic effect of targeted antioxidant natural products","authors":"Sohini Mukherjee, Hitesh Chopra, Rajat Goyal, Sihao Jin, Zhenzhen Dong, Tanmoy Das, Tanima Bhattacharya","doi":"10.1186/s11671-024-04100-x","DOIUrl":"10.1186/s11671-024-04100-x","url":null,"abstract":"<div><p>The exploration of targeted therapy has proven to be a highly promising avenue in the realm of drug development research. The human body generates a substantial amount of free radicals during metabolic processes, and if not promptly eliminated, these free radicals can lead to oxidative stress, disrupting homeostasis and potentially contributing to chronic diseases and cancers. Before the development of contemporary medicine with synthetic pharmaceuticals and antioxidants, there was a long-standing practice of employing raw, natural ingredients to cure a variety of illnesses. This practice persisted even after the active antioxidant molecules were known. The ability of natural antioxidants to neutralise excess free radicals in the human body and so prevent and cure a wide range of illnesses. The term \"natural antioxidant\" refers to compounds derived from plants or other living organisms that have the ability to control the production of free radicals, scavenge them, stop free radical-mediated chain reactions, and prevent lipid peroxidation. These compounds have a strong potential to inhibit oxidative stress. Phytochemicals (antioxidants) derived from plants, such as polyphenols, carotenoids, vitamins, and others, are central to the discussion of natural antioxidants. Not only may these chemicals increase endogenous antioxidant defenses, affect communication cascades, and control gene expression, but they have also shown strong free radical scavenging properties. This study comprehensively summarizes the primary classes of natural antioxidants found in different plant and animal source that contribute to the prevention and treatment of diseases. Additionally, it outlines the research progress and outlines future development prospects. These discoveries not only establish a theoretical groundwork for pharmacological development but also present inventive ideas for addressing challenges in medical treatment.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04100-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142188226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ruby Dhiman, Nancy Bazad, Riya Mukherjee, Himanshu, Gunjan, Elcio Leal, Saheem Ahmad, Kirtanjot Kaur, V. Samuel Raj, Chung-Ming Chang, Ramendra Pati Pandey
{"title":"Enhanced drug delivery with nanocarriers: a comprehensive review of recent advances in breast cancer detection and treatment","authors":"Ruby Dhiman, Nancy Bazad, Riya Mukherjee, Himanshu, Gunjan, Elcio Leal, Saheem Ahmad, Kirtanjot Kaur, V. Samuel Raj, Chung-Ming Chang, Ramendra Pati Pandey","doi":"10.1186/s11671-024-04086-6","DOIUrl":"10.1186/s11671-024-04086-6","url":null,"abstract":"<div><p>Breast cancer (BC) remains a leading cause of morbidity and mortality among women worldwide, with triple-negative breast cancer (TNBC) posing significant treatment challenges due to its aggressive phenotype and resistance to conventional therapies. Recent advancements in nanocarrier technology offer promising solutions for enhancing drug delivery, improving bioavailability, and increasing drug accumulation at tumor sites through targeted approaches. This review delves into the latest innovations in BC detection and treatment, highlighting the role of nanocarriers like polymeric micelles, liposomes, and magnetic nanoparticles in overcoming the limitations of traditional therapies. Additionally, the manuscript discusses the integration of cutting-edge diagnostic tools, such as multiplex PCR-Nested Next-Generation Sequencing (mPCR-NGS) and blood-based biomarkers, which are revolutionizing early detection and molecular profiling of BC. The convergence of these technologies not only enhances therapeutic outcomes but also paves the way for personalized medicine in BC management. This comprehensive review underscores the potential of nanocarriers in transforming BC treatment and emphasizes the critical importance of early detection in improving patient prognosis.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11380656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142147033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miguel de Jesus Oliveira Santos, Jéssica Teles-Souza, Renata Freitas de Araújo-Calumby, Robert L. Copeland Jr, Henrique Rodrigues Marcelino, Deise Souza Vilas-Bôas
{"title":"Advances, limitations and perspectives in the use of celecoxib-loaded nanocarriers in therapeutics of cancer","authors":"Miguel de Jesus Oliveira Santos, Jéssica Teles-Souza, Renata Freitas de Araújo-Calumby, Robert L. Copeland Jr, Henrique Rodrigues Marcelino, Deise Souza Vilas-Bôas","doi":"10.1186/s11671-024-04070-0","DOIUrl":"10.1186/s11671-024-04070-0","url":null,"abstract":"<div><p>Cancer is highlighted as a major global health challenge in the XXI century. The cyclooxygenase-2 (COX-2) enzyme rises as a widespread tumor progression marker. Celecoxib (CXB) is a selective COX-2 inhibitor used in adjuvant cancer therapy, but high concentrations are required in humans. In this sense, the development of nanocarriers has been proposed once they can improve the biopharmaceutical, pharmacokinetic and pharmacological properties of drugs. In this context, this article reviews the progress in the development of CXB-loaded nanocarriers over the past decade and their prospects. Recent advances in the field of CXB-loaded nanocarriers demonstrate the use of complex formulations and the increasing importance of in vivo studies. The types of CXB-loaded nanocarriers that have been developed are heterogeneous and based on polymers and lipids together or separately. It was found that the work on CXB-loaded nanocarriers is carried out using established techniques and raw materials, such as poly (lactic-co-glicolic acid), cholesterol, phospholipids and poly(ethyleneglycol). The main improvements that have been achieved are the use of cell surface ligands, the simultaneous delivery of different synergistic agents, and the presence of materials that can provide imaging properties and other advanced features. The combination of CXB with other anti-inflammatory drugs and/or apoptosis inducers appears to hold effective pharmacological promise. The greatest advance to date from a clinical perspective is the ability of CXB to enhance the cytotoxic effects of established chemotherapeutic agents.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11379842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preparation irinotecan hydrochloride loaded PEGylated liposomes using novel method supercritical fluid and condition optimized by Box–Behnken design","authors":"Misagh Mohammadi, Mehrnaz Karimi, Farhad Raofie","doi":"10.1186/s11671-024-04071-z","DOIUrl":"10.1186/s11671-024-04071-z","url":null,"abstract":"<div><p>A semi-synthetic camptothecin derivative known as irinotecan hydrochloride is frequently used to treat colorectal cancer, including colorectal adenocarcinoma and lung cancers involving small cells. Irinotecan has a very short half-life; therefore, continuous infusions are required to keep the drug’s blood levels at therapeutic levels, which could produce cumulative toxicities. Effective delivery techniques, including liposomes, have been developed to address these shortcomings. In this study, a continuous supercritical fluid approach dubbed Expansion Supercritical Fluid into an aqueous solution, in which the pressure decreases rapidly but remains over the critical pressure, is proposed to manufacture polyethylene glycolylated (PEGylated) liposomes carrying irinotecan hydrochloride. To accomplish this, PEGylated liposomes were created using a Box–Behnken design, and the operating parameters (flow rate, temperature, and pressure drop) were optimized. Encapsulation efficiency, mean size, and prepared liposome count were 94.6%, 55 nm, and 758 under ideal circumstances. Additionally, the stability of the PEGylated liposome was investigated during 8 weeks, and also PEGylated liposome-loaded irinotecan release profile was compared to conventional liposomes and free irinotecan, and a constant drug release was seen after the first burst release from liposomes.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11377383/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142141909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"FS-iTFET: advancing tunnel FET technology with Schottky-inductive source and GAA design","authors":"Jyi-Tsong Lin, Wei-Heng Tai","doi":"10.1186/s11671-024-04096-4","DOIUrl":"10.1186/s11671-024-04096-4","url":null,"abstract":"<div><p>In this paper, we introduce a novel Forkshape nanosheet Inductive Tunnel Field-Effect Transistor (FS-iTFET) featuring a Gate-All-Around structure and a full-line tunneling heterojunction channel. The overlapping gate and source contact regions create a strong and uniform electric field in the channel. Furthermore, the metal–semiconductor Schottky junction in the intrinsic source region induces the required carriers without the need for doping. This innovative design achieves both a steeper subthreshold swing (<i>SS</i>) and a higher ON-state current (<i>I</i><sub>ON</sub>). Using calibration-based simulations with Sentaurus TCAD, we compare the performance of three newly designed device structures: the conventional Nanosheet Tunnel Field-Effect Transistor (NS-TFET), the Nanosheet Line-tunneling TFET (NS-LTFET), and the proposed FS-iTFET. Simulation results show that, compared to the traditional NS-TFET, the NS-LTFET with its full line-tunneling structure improves the average subthreshold swing (<i>SS</i><sub>AVG</sub>) by 19.2%. More significantly, the FS-iTFET, utilizing the Schottky-inductive source, further improves the <i>SS</i><sub>AVG</sub> by 49% and achieves a superior <i>I</i><sub>ON</sub>/<i>I</i><sub>OFF</sub> ratio. Additionally, we explore the impact of Trap-Assisted Tunneling on the performance of the three different integrations. The FS-iTFET consistently demonstrates superior performance across various metrics, highlighting its potential in advancing tunnel field-effect transistor technology.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tanaka Ndongwe, Angel-Alberta Zhou, Nelisa Paidamwoyo Ganga, Nyaradzo Matawo, Unami Sibanda, Tinotenda Vanessa Chidziwa, Bwalya A. Witika, Rui W. M. Krause, Gauta Gold Matlou, Xavier Siwe-Noundou
{"title":"The use of nanomaterials as drug delivery systems and anticancer agents in the treatment of triple-negative breast cancer: an updated review (year 2005 to date)","authors":"Tanaka Ndongwe, Angel-Alberta Zhou, Nelisa Paidamwoyo Ganga, Nyaradzo Matawo, Unami Sibanda, Tinotenda Vanessa Chidziwa, Bwalya A. Witika, Rui W. M. Krause, Gauta Gold Matlou, Xavier Siwe-Noundou","doi":"10.1186/s11671-024-04089-3","DOIUrl":"10.1186/s11671-024-04089-3","url":null,"abstract":"<div><p>Triple-negative breast cancer (TNBC) is characterised by the lack or low expression of estrogen, progesterone, and human epidermal growth factor receptor 2 receptors. TNBC has a high recurrence rate, swiftly metastasizes, and has a high mortality rate. Subsequently, the increase in cases of TNBC has signaled the need for treatment strategies with improved drug delivery systems. New diagnostic approaches, chemical entities, formulations particular those in the nanometric range have emerged after extensive scientific research as alternative strategies for TNBC treatment. As compared to contemporary cancer therapy, nanoparticles offer peculiar tunable features namely small size, shape, electrical charge, magnetic and fluorescent properties. Specifically in targeted drug delivery, nanoparticles have been demonstrated to be highly efficient in encapsulating, functionalization, and conjugation. Presently, nanoparticles have ignited and transformed the approach in photodynamic therapy, bioimaging, use of theranostics and precision medicine delivery in breast cancer. Correspondingly, recent years have witnessed a drastic rise in literature pertaining to treatment of TNBC using nanomaterials. Subsequently, this manuscript aims to present a state-of-the-art of nanomaterials advance on TNBC treatment; the ubiquitous utility use of nanomaterials such as liposomes, dendrimers, solid lipid nanomaterials, gold nanomaterials and quantum dots as anticancer agents and drug delivery systems in TNBC.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11372008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Electrocatalytic ethanol oxidation reaction: recent progress, challenges, and future prospects","authors":"Jasvinder Kaur, Ram K. Gupta, Anuj Kumar","doi":"10.1186/s11671-024-04067-9","DOIUrl":"10.1186/s11671-024-04067-9","url":null,"abstract":"<div><p>Direct ethanol fuel cells (DEFCs) have been widely considered as a feasible power conversion technology for portable and mobile applications. The economic feasibility of DEFCs relies on two conditions: a notable reduction in the expensive nature of precious metal electrocatalysts and a simultaneous remarkable improvement in the anode's long-term performance. Despite the considerable progress achieved in recent decades in Pt nanoengineering to reduce its loading in catalyst ink with enhanced mass activity, attempts to tackle these problems have yet to be successful. During the ethanol oxidation reaction (EOR) at the anode surface, Pt electrocatalysts lose their electrocatalytic activity rapidly due to poisoning by surface-adsorbed reaction intermediates like CO. This phenomenon leads to a significant loss in electrocatalytic performance within a relatively short time. This review provides an overview of the mechanistic approaches during the EOR of noble metal-based anode materials. Additionally, we emphasized the significance of many essential factors that govern the EOR activity of the electrode surface. Furthermore, we provided a comprehensive examination of the challenges and potential advancements in electrocatalytic EOR.</p><h3>Graphic abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pooja V. Nagime, Nishat M. Shaikh, Sohel B. Shaikh, Chandrakant D. Lokhande, Vinod V. Patil, Sheeba Shafi, Dwi Marlina Syukri, Vijay R. Chidrawar, Ashwini Kumar, Sudarshan Singh
{"title":"Facile synthesis of silver nanoparticles using Calotropis procera leaves: unraveling biological and electrochemical potentials","authors":"Pooja V. Nagime, Nishat M. Shaikh, Sohel B. Shaikh, Chandrakant D. Lokhande, Vinod V. Patil, Sheeba Shafi, Dwi Marlina Syukri, Vijay R. Chidrawar, Ashwini Kumar, Sudarshan Singh","doi":"10.1186/s11671-024-04090-w","DOIUrl":"10.1186/s11671-024-04090-w","url":null,"abstract":"<div>\u0000 \u0000 <p>The alarming rise of pathogen antibiotic resistance presents a major global health challenge and demands a novel way to control the microbial infections. Simultaneously, nanotechnology has found numerous uses in electrical as well as electronic systems, including timing, filtering, power factor adaptation, and capacitors for energy storage. This work investigates the synthesis and characterization of a silver nanoparticle (AgNPs) utilizing <i>Calotropis procera</i> (CPL) leaf extract. The optimization of synthesis process and the reduction of nanoparticles (NPs) were validated by UV–visible spectroscopy. AgNPs' was exhaustively characterized for morphology, crystallinity, zeta-potential, and structural properties. The produced NPs demonstrated a wide range of characteristics, such as antioxidant, antidiabetic, antibacterial, and antifungal effects. Furthermore, remarkable electrochemical performance was indicated by the CPL-AgNPs electrode, which has mesoporous, clustered sphere-shaped particles onto a flexible stainless-steel substrate. This highlights the electrode's potential in energy storage applications. Copper monosulfide served as the anode and CPL-AgNPs as the cathode electrode in tested hybrid supercapacitor devices, which proved remarkable specific capacitances, high specific energy, and exceptionally high specific power. In order to address the twin challenges of antimicrobial resistance alongside advanced energy storage, this study provides a novel and thorough analysis of the basic electrochemistry as well biological properties of AgNPs, clarifying their potential storage of charges mechanisms and biomedical applications.</p>\u0000 <span>AbstractSection</span>\u0000 Graphical abstract\u0000 <div><figure><div><div><picture><source><img></source></picture></div></div></figure></div>\u0000 \u0000 </div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11371983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}