Nanomedicine approaches to enhance the effectiveness of meropenem: a strategy to tackle antimicrobial resistance

IF 5.5 3区材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Nanoscale Research Letters Pub Date : 2025-04-01 DOI:10.1186/s11671-025-04244-4

Yohannes Mengesha

{"title":"Nanomedicine approaches to enhance the effectiveness of meropenem: a strategy to tackle antimicrobial resistance","authors":"Yohannes Mengesha","doi":"10.1186/s11671-025-04244-4","DOIUrl":null,"url":null,"abstract":"<div><p>Meropenem, a carbapenem typically reserved for treating severe infections, has encountered resistance from certain bacteria, including multidrug-resistant (MDR) strains of <i>Pseudomonas aeruginosa (P. aeruginosa)</i> and <i>Klebsiella pneumonia (K. pneumonia</i>). Nanoparticles (NPs) have emerged as a promising strategy to combat drug-resistant bacteria. By targeting specific biosynthetic and enzymatic pathways and penetrating bacterial membranes, NPs can function as antibiotic delivery systems (nanocarriers) or exhibit intrinsic antibacterial properties. When combined with various types of nanoparticles–such as lipid- and polymer-based NPs, metallic NPs, silica NPs, nanoemulsions, niosomes, carbon NPs, and nanocomposites–meropenem has shown enhanced effectiveness in overcoming resistance to MDR bacteria and reducing adverse effects. However, several challenges persist, including scaling up industrial production, ensuring safety and favorable toxicity profiles, and addressing the limited availability of in vivo evidence. This review explores nanoparticle strategies to combat resistance to meropenem.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04244-4.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanoscale Research Letters","FirstCategoryId":"88","ListUrlMain":"https://link.springer.com/article/10.1186/s11671-025-04244-4","RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

Abstract

Meropenem, a carbapenem typically reserved for treating severe infections, has encountered resistance from certain bacteria, including multidrug-resistant (MDR) strains of Pseudomonas aeruginosa (P. aeruginosa) and Klebsiella pneumonia (K. pneumonia). Nanoparticles (NPs) have emerged as a promising strategy to combat drug-resistant bacteria. By targeting specific biosynthetic and enzymatic pathways and penetrating bacterial membranes, NPs can function as antibiotic delivery systems (nanocarriers) or exhibit intrinsic antibacterial properties. When combined with various types of nanoparticles–such as lipid- and polymer-based NPs, metallic NPs, silica NPs, nanoemulsions, niosomes, carbon NPs, and nanocomposites–meropenem has shown enhanced effectiveness in overcoming resistance to MDR bacteria and reducing adverse effects. However, several challenges persist, including scaling up industrial production, ensuring safety and favorable toxicity profiles, and addressing the limited availability of in vivo evidence. This review explores nanoparticle strategies to combat resistance to meropenem.

查看原文本刊更多论文

提高美罗培南有效性的纳米医学方法：一种应对抗菌素耐药性的策略

美罗培南是一种碳青霉烯类药物，通常用于治疗严重感染，但它遇到了某些细菌的耐药性，包括铜绿假单胞菌（P. aeruginosa）和肺炎克雷伯菌（K. pneumonia）的多重耐药菌株。纳米颗粒（NPs）已经成为对抗耐药细菌的一种很有前途的策略。通过靶向特定的生物合成和酶促途径并穿透细菌膜，NPs可以作为抗生素递送系统（纳米载体）或表现出固有的抗菌特性。当与各种类型的纳米颗粒（如脂质和聚合物基纳米颗粒、金属纳米颗粒、二氧化硅纳米颗粒、纳米乳液、乳质体、碳纳米颗粒和纳米复合材料）结合使用时，美罗南在克服耐多药耐药细菌耐药性和减少不良反应方面表现出更强的有效性。然而，一些挑战仍然存在，包括扩大工业生产，确保安全性和有利的毒性特征，以及解决体内证据的有限可用性。这篇综述探讨了纳米颗粒对抗美罗培南耐药性的策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nanoscale Research Letters 工程技术-材料科学：综合

CiteScore

11.30

自引率

0.00%

发文量

110

审稿时长

48 days

期刊介绍： Nanoscale Research Letters (NRL) provides an interdisciplinary forum for communication of scientific and technological advances in the creation and use of objects at the nanometer scale. NRL is the first nanotechnology journal from a major publisher to be published with Open Access.