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Antimicrobial membranes based on polycaprolactone:pectin blends reinforced with zeolite faujasite for cloxacillin-controlled release
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2025-01-14 DOI: 10.1186/s11671-024-04161-y
Bárbara Bernardi, João Otávio Donizette Malafatti, Ailton José Moreira, Andressa Cristina de Almeida Nascimento, Juliana Bruzaca Lima, Lilian Aparecida Fiorini Vermeersch, Elaine Cristina Paris
{"title":"Antimicrobial membranes based on polycaprolactone:pectin blends reinforced with zeolite faujasite for cloxacillin-controlled release","authors":"Bárbara Bernardi,&nbsp;João Otávio Donizette Malafatti,&nbsp;Ailton José Moreira,&nbsp;Andressa Cristina de Almeida Nascimento,&nbsp;Juliana Bruzaca Lima,&nbsp;Lilian Aparecida Fiorini Vermeersch,&nbsp;Elaine Cristina Paris","doi":"10.1186/s11671-024-04161-y","DOIUrl":"10.1186/s11671-024-04161-y","url":null,"abstract":"<div><p>Multifunctional membranes applied to biomedical materials become attractive to support the biological agents and increase their properties. In this study, biopolymeric fibers based on polycaprolactone (PCL) and pectin (PEC) were reinforced with faujasite zeolite (FAU) for cloxacillin antibiotic (CLX) loading. FAU with a high specific surface area (347 ± 8 m<sup>2</sup> g<sup>−1</sup>), high crystallinity and particles with a diameter of up to 100 nm were produced under optimized synthesis conditions (100 °C/4 h). Zeolites were incorporated into polymeric nanofibers to be a cloxacillin (CLX) carrier in wound treatment, using electrospinning as an efficient synthesis method. The fibers produced showed good mechanical resistance and the incorporation of CLX was proven by assays to inhibit the growth of <i>Staphylococcus aureus</i> bacteria. The controlled release of CLX in different pH conditions, which simulate the wound environment, was carried out for up to 229 h, achieving a released CLX concentration of up to 6.18 ± 0.02 mg L<sup>−1</sup>. These results prove that obtaining a hybrid fiber (polymer-zeolite) to incorporate drugs to be released in a controlled manner was successfully achieved. The bactericidal activity of this material shows that its use for measured applications could be an alternative to conventional methods.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04161-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142976356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integration of silver nanostructures in wireless sensor networks for enhanced biochemical sensing 在无线传感器网络中集成银纳米结构,增强生化传感。
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2025-01-13 DOI: 10.1186/s11671-024-04159-6
M. Sahaya Sheela, S. Kumarganesh, Binay Kumar Pandey, Mesfin Esayas Lelisho
{"title":"Integration of silver nanostructures in wireless sensor networks for enhanced biochemical sensing","authors":"M. Sahaya Sheela,&nbsp;S. Kumarganesh,&nbsp;Binay Kumar Pandey,&nbsp;Mesfin Esayas Lelisho","doi":"10.1186/s11671-024-04159-6","DOIUrl":"10.1186/s11671-024-04159-6","url":null,"abstract":"<div><p>Integrating noble metal nanostructures, specifically silver nanoparticles, into sensor designs has proven to enhance sensor performance across key metrics, including response time, stability, and sensitivity. However, a critical gap remains in understanding the unique contributions of various synthesis parameters on these enhancements. This study addresses this gap by examining how factors such as temperature, growth time, and choice of capping agents influence nanostructure shape and size, optimizing sensor performance for diverse conditions. Using silver nitrate and sodium borohydride, silver seed particles were created, followed by controlled growth in a solution containing additional silver ions. The size and morphology of the resulting nanostructures were regulated to achieve optimal properties for biochemical sensing in wireless sensor networks. Results demonstrated that embedding these nanostructures in Polyvinyl Alcohol (PVA) matrices led to superior stability, maintaining 93% effectiveness over 30 days compared to 70% in Polyethylene Glycol (PEG). Performance metrics revealed significant improvements: reduced response times (1.2 ms vs. 1.5 ms at zero analyte concentration) and faster responses at higher analyte levels (0.2 ms). These outcomes confirm that higher synthesis temperatures and precise shape control contribute to larger, more stable nanostructures.The enhanced stability and responsiveness underscore the potential of noble metal nanostructures for scalable and durable sensor applications, offering a significant advancement over current methods.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04159-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Crystal growth, structural phase transitions and optical gap evolution of FAPb(Br1-xClx)3 hybrid perovskites (FA: formamidinium ion, CH(NH2)2+) FAPb(Br1-xClx)3混合包晶的晶体生长、结构相变和光隙演化(FA:甲脒离子,CH(NH2)2+)。
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2025-01-13 DOI: 10.1186/s11671-024-04179-2
Carlos A. López, Oscar Fabelo, Carmen Abia, María T. Fernández-Diaz, José A. Alonso
{"title":"Crystal growth, structural phase transitions and optical gap evolution of FAPb(Br1-xClx)3 hybrid perovskites (FA: formamidinium ion, CH(NH2)2+)","authors":"Carlos A. López,&nbsp;Oscar Fabelo,&nbsp;Carmen Abia,&nbsp;María T. Fernández-Diaz,&nbsp;José A. Alonso","doi":"10.1186/s11671-024-04179-2","DOIUrl":"10.1186/s11671-024-04179-2","url":null,"abstract":"<div><p>Chemically tuned organic–inorganic hybrid halide perovskites based on bromide and chloride anions CH(NH<sub>2</sub>)<sub>2</sub>Pb(Br<sub>1−<i>x</i></sub>Cl<sub><i>x</i></sub>)<sub>3</sub> (CH(NH<sub>2</sub>)<sub>2</sub><sup>+</sup>: formamidinium ion, FA) have been crystallized and investigated by neutron powder diffraction (NPD), single crystal X-ray diffraction (SCXRD), scanning electron microscopy (SEM) and UV–vis spectroscopy. FAPbBr<sub>3</sub> and FAPbCl<sub>3</sub> experience successive phase transitions upon cooling, lowering the symmetry from cubic to orthorhombic phases; however, these transitions are not observed for the mixed halide phases, probably due to compositional disorder. The band-gap engineering brought about by the chemical doping of FAPb (Br<sub>1-<i>x</i></sub>Cl<sub><i>x</i></sub>)<sub>3</sub> perovskites (x = 0.0, 0.33, 0.5, 0.66 and 1.0) can be controllably tuned: the gap progressively increases with the concentration of Cl<sup>−</sup> ions from 2.17 to 2.91 eV at room temperature, presenting a nonlinear behavior. This study provides an improved understanding of the structural and optical properties of these appealing hybrid perovskites.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04179-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Insights into semi-continuous synthesis of iron oxide nanoparticles (IONPs) via thermal decomposition of iron oleate
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2025-01-07 DOI: 10.1186/s11671-024-04167-6
Egon Götz Höfgen, Sulalit Bandyopadhyay
{"title":"Insights into semi-continuous synthesis of iron oxide nanoparticles (IONPs) via thermal decomposition of iron oleate","authors":"Egon Götz Höfgen,&nbsp;Sulalit Bandyopadhyay","doi":"10.1186/s11671-024-04167-6","DOIUrl":"10.1186/s11671-024-04167-6","url":null,"abstract":"<p>The increasing demand for magnetic iron oxide nanoparticles (IONPs) in biomedicine necessitates efficient and scalable production methods. Thermal decomposition offers excellent tailoring of the particle properties but its discontinuous batch-operation is restricting scale-up and industrial application. To overcome these challenges, several studies have demonstrated semi-continuous thermal decomposition by slowly injecting the precursor, though only half of them produce magnetite IONPs and even fewer use iron oleate precursors. The available studies are limited, often focusing on single synthesis variables and a comprehensive mapping of the physicochemical properties to reaction conditions is missing. Here we present our investigation of semi-continuous thermal decomposition of iron oleate as a route for the synthesis of magnetic IONPs. We achieved the semi-continuous synthesis of spherical IONPs with properties matching those obtained via the conventional heat-up method. We explored the the effect of multiple synthesis variables, namely addition rate, dwell time, iron oleate amount, oleic acid amount, temperature and consistently report magnetic saturation of our samples. We found that the dwell time seemingly has a stronger effect on particle sizes and magnetic saturation than the addition speed, within moderate addition rates, and further are we the first to report the effect of reaction temperature on semi-continuous synthesis. The iron oleate precursor obtained from salt exchange was employed without pretreatment or dilution thereby facilitating a streamlined synthesis process. An oxidative phase transfer was used to mitigate the key challenge of hydrophobicity of oleate-capped IONPs, enabling their potential use in biomedical applications. Our work advances the understanding of of synthesis-property relationships of IONPs by demonstrating the translation of established synthesis protocols into more efficient and scalable processes through which it provides insights for developing and optimizing future production protocols for various applications.</p>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04167-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142939019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on the electrical and optical conductivity of barium-nickel ferrite nanoparticles doped with Zn
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2025-01-06 DOI: 10.1186/s11671-024-04180-9
Sadiq H. Khoreem, A. H. AL-Hammadi
{"title":"Studies on the electrical and optical conductivity of barium-nickel ferrite nanoparticles doped with Zn","authors":"Sadiq H. Khoreem,&nbsp;A. H. AL-Hammadi","doi":"10.1186/s11671-024-04180-9","DOIUrl":"10.1186/s11671-024-04180-9","url":null,"abstract":"<div><p>The study highlights the significant effects of Zn ions concentration on the optical properties of BaNi<sub>2-x</sub>Zn<sub>x</sub>Fe<sub>16</sub>O<sub>27</sub> ferrites, emphasizing the tunability of the band gap through Zn doping and explores their potential to enhance their optical properties. The barium-nickel ferrite powder, with the composition BaNi<sub>2−x</sub>Zn<sub>x</sub>Fe<sub>16</sub>O<sub>27</sub>, was synthesized using the ceramic method. The effects of Zn doping were analyzed using X-ray diffraction (XRD) and UV‒visible (UV–Vis) spectroscopy. XRD confirmed a pure single-phase W-type hexagonal structure, with an increase in both grain size and lattice constant proportional to the Zn content. The optical properties were assessed through UV‒visible spectroscopy, revealing an increaseing of the band gap with increasing Zn concentration, confirming material’s semiconducting behavior.All optical constants, exhibited consistent variation with increasing Zn substitution.. Additionally, both electrical and optical conductivities increased with rising photon energy, while the conductivity peak decreased with higher Zn content. The electric susceptibility was found to decrease as Zn concentration increased. The results indicate that Zn doping leads to significant changes in lattice parameters, crystallite size, and bandgap energy, suggesting potential applications in optoelectronics, photonics devices, and energy storage.\"</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04180-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction: Prospects and challenges of nanomaterials in sustainable food preservation and packaging: a review
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2025-01-06 DOI: 10.1186/s11671-024-04174-7
Ritesh Pattnaik, Sandeep Kumar Panda, Soumyadeep Biswas, Sayanti De, Subhra Satahrada, Subrat Kumar
{"title":"Correction: Prospects and challenges of nanomaterials in sustainable food preservation and packaging: a review","authors":"Ritesh Pattnaik,&nbsp;Sandeep Kumar Panda,&nbsp;Soumyadeep Biswas,&nbsp;Sayanti De,&nbsp;Subhra Satahrada,&nbsp;Subrat Kumar","doi":"10.1186/s11671-024-04174-7","DOIUrl":"10.1186/s11671-024-04174-7","url":null,"abstract":"","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04174-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142938766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Merits photocatalytic activity of rGO/zinc copper ferrite magnetic nanocatalyst for photodegradation of methylene blue (MB) dye
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2025-01-04 DOI: 10.1186/s11671-024-04162-x
Osama H. Abuzeyad, Ahmed M. El-Khawaga, Hesham Tantawy, Mohamed Gobara, Mohamed A. Elsayed
{"title":"Merits photocatalytic activity of rGO/zinc copper ferrite magnetic nanocatalyst for photodegradation of methylene blue (MB) dye","authors":"Osama H. Abuzeyad,&nbsp;Ahmed M. El-Khawaga,&nbsp;Hesham Tantawy,&nbsp;Mohamed Gobara,&nbsp;Mohamed A. Elsayed","doi":"10.1186/s11671-024-04162-x","DOIUrl":"10.1186/s11671-024-04162-x","url":null,"abstract":"<div><p>The world is now facing a water scarcity crisis due to waste, pollution, and uneven distribution of freshwater resources, which are limited. Thus, the creation of innovative, economical, and effective methods for purifying water is crucial. Here, the photo-assisted degradation of methylene blue (MB) dye under visible light and UV was achieved by using RGO photocatalyst loaded with Zn<sub>0.5</sub>Cu<sub>0.5</sub>Fe<sub>2</sub>O<sub>4</sub> in three different loaded 10%, 20%, and 30% called MRGO 10, MRGO 20, and MRGO 30. Furthermore, all prepared samples was characterized by X-ray diffraction (XRD), fourier transformation infrared (FTIR), transmission electron microscope (TEM), vibrating sample magnetometer (VSM) and Raman analysis. After 40 min, the high photocatalytic efficacy effectively eliminated about 95.2% of the 10 ppm MB using 20 mg of MRGO 20 NPs at pH9 Visible light. From the results, the photocatalytic activity of MRGO 20 reduced to 54.6% after five cycles of methylene blue (MB) dye degradation. The produced samples' observed efficacy in both UV and visible light may encourage continued research into more effective photocatalysts for the filtration of water.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04162-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142925638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
TiO2–ZnO functionalized low-cost ceramic membranes from coal fly ash for the removal of tetracycline from water under visible light
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2025-01-03 DOI: 10.1186/s11671-024-04178-3
Lawrence Sawunyama, Opeyemi A. Oyewo, Seshibe S. Makgato, Mokgadi F. Bopape, Damian C. Onwudiwe
{"title":"TiO2–ZnO functionalized low-cost ceramic membranes from coal fly ash for the removal of tetracycline from water under visible light","authors":"Lawrence Sawunyama,&nbsp;Opeyemi A. Oyewo,&nbsp;Seshibe S. Makgato,&nbsp;Mokgadi F. Bopape,&nbsp;Damian C. Onwudiwe","doi":"10.1186/s11671-024-04178-3","DOIUrl":"10.1186/s11671-024-04178-3","url":null,"abstract":"<div><p>Hybrid wastewater treatment systems offer viable solutions to enhance the removal of complicated contaminants from aqueous system. This innovation has opened new avenues for advanced wastewater treatment processes. Herein, a novel TiO<sub>2</sub>–ZnO functionalized coal fly ash-based ceramic membrane was fabricated by utilizing a combined pressing and sintering method. The intrinsic properties of the functionalized membranes were characterized and their chemical and physical properties such as chemical stability, mechanical stability, water absorption, and porosity were established. The shape, crystallinity, thermal characteristics, and functional groups present were also determined using SEM, XRD, TGA, and FTIR studies, respectively. The results showed that the ceramic membrane functionalized with 0.5 g of TiO<sub>2</sub>–ZnO and sintered at 850 °C exhibited the best thermal, and chemical stability, and possessed the required porosity for ultrafiltration applications. Photocatalytic degradation of tetracycline (TC) as a model pollutant was examined and the optimum efficiency of 77% was achieved within 100 min of visible irradiation using the functionalized membrane. Moreso, the functionalized membrane was found to be stable with 73% degradation efficiency after 5 consecutive cycles of reusability study, showing negligible loss of efficiency. The scale-up of photocatalytic ceramic membranes and their utilization in real industrial applications will confirm their robustness.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04178-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Solid lipid nanoparticles for increased oral bioavailability of acalabrutinib in chronic lymphocytic leukaemia
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-12-30 DOI: 10.1186/s11671-024-04157-8
Swagata Sinha, Punna Rao Ravi, Makarand Somvanshi, S. R. Rashmi
{"title":"Solid lipid nanoparticles for increased oral bioavailability of acalabrutinib in chronic lymphocytic leukaemia","authors":"Swagata Sinha,&nbsp;Punna Rao Ravi,&nbsp;Makarand Somvanshi,&nbsp;S. R. Rashmi","doi":"10.1186/s11671-024-04157-8","DOIUrl":"10.1186/s11671-024-04157-8","url":null,"abstract":"<div><p>Acalabrutinib (ACP) is a first-line treatment for chronic lymphocytic leukemia but suffers from poor and variable oral bioavailability due to its pH-dependent solubility, CYP3A4 metabolism, and P-gp efflux. Thus, the objective of this study was to improve the solubility and dissolution behaviour, in turn enhancing bioavailability, by formulating solid lipid nanoparticles (SLNs). ACP loaded SLNs (ACP-SLNs) were prepared via solvent-free hot emulsification followed by a double sonication process. A combination of glyceryl di-behenate and stearyl palmitate along with Tween 80 was used as the lipid phase to dissolve ACP. A 1% w/v Poloxomer188 solution served as the aqueous phase. The optimized ACP-SLNs were spherical in shape and had particle size of 234.7–257.5 nm, PDI of 0.261–0.320 and loading efficiency of 18.70 ± 1.78%. A typical biphasic release pattern was observed from ACP-SLNs in the in vitro dissolution studies under gastrointestinal and plasma pH conditions (&gt; 90% drug release at pH 4.5 ± 0.2, 6.8 ± 0.2 (representing GIT), and 7.4 ± 0.2 (representing plasma) at 8, 16 and 24 h, respectively). The freeze-dried product was stable when stored at 5 °C for over 6 months. Compared with the bulk drug suspension, the ACP-SLNs suspension resulted in 2.29-fold increase in oral bioavailability and more importantly 2.46-fold increase in the distribution of drug to spleen. Additionally, inhibition of lymph production and flow by administering cycloheximide resulted in 46.01% decrease in the overall absorption of ACP-SLNs, indicating the significance of lymphatic uptake process in the oral absorption of ACP-SLNs.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04157-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biogenic synthesized CuO nanoparticles and 5-fluorouracil loaded anticancer gel for HeLa cervical cancer cells
IF 5.5 3区 材料科学
Nanoscale Research Letters Pub Date : 2024-12-27 DOI: 10.1186/s11671-024-04166-7
Gouranga Dutta, Santhosh Kumar Chinnaiyan, Thirunavukkarasu Palaniyandi, Abimanyu Sugumaran, Damodharan Narayanasamy
{"title":"Biogenic synthesized CuO nanoparticles and 5-fluorouracil loaded anticancer gel for HeLa cervical cancer cells","authors":"Gouranga Dutta,&nbsp;Santhosh Kumar Chinnaiyan,&nbsp;Thirunavukkarasu Palaniyandi,&nbsp;Abimanyu Sugumaran,&nbsp;Damodharan Narayanasamy","doi":"10.1186/s11671-024-04166-7","DOIUrl":"10.1186/s11671-024-04166-7","url":null,"abstract":"<div><p>Cervical cancer remains a significant health challenge in developing countries are high due to low HPV vaccination rates, delayed diagnosis, and restricted healthcare access. Metal nanomaterials, such as copper oxide (CuO) nanoparticles (NPs), have shown significant promise in cancer therapy due to their ability to induce apoptosis. 5-Fluorouracil (5-Fu) enhances the cytotoxic effect against cervical cancer, working synergistically with CuO NPs to maximize the therapeutic impact while potentially reducing the 5-Fu's systemic side effects. This study explores the synergistic therapeutic potential of green-synthesized CuO NPs combined with 5-Fu in a gel formulation for targeted anticancer activity against HeLa cervical cancer cells. CuO NPs were synthesized using <i>Trichosanthes dioica</i> dried seeds extract and incorporated into a pectin-xanthan gum-based gel. The green-synthesized CuO NPs exhibited a zeta potential of −23.7 mV, a particle size of approximately 26 nm, and spherical morphology. Characterization studies, including FTIR, viscosity, spreadability, pH, and stability assessments, confirmed the gel's suitability for vaginal delivery. <i>In-vitro</i> drug release showed xanthan gum extended the release up to 8 h. The MTT assay revealed PXFCu6 gel's IC<sub>50</sub> at 11.82 ± 0.22 μg/mL, significantly more cytotoxic to HeLa cells, being 3.62 times potent than CuO NPs (IC<sub>50</sub>: 42.8 ± 0.24 μg/mL) and 1.63 times potent than 5-Fu alone (IC<sub>50</sub>: 19.3 ± 0.49 μg/mL). The antibacterial assay showed no inhibition for the plain gel, but <i>T. dioica</i>-mediated CuO NPs exhibited inhibition of 22.35 ± 4.9 mm. PXFCu6 gel had the more potent inhibition at 52.05 ± 1.37 mm against <i>Escherichia coli</i> growth. The PXFCu6 gel showed better stability at 4 °C, maintaining viscosity, pH, and drug release, unlike 25 °C where a mild degradation occurred. This research highlights the potential of the CuO NPs-5-Fu gel as a novel, effective therapeutic strategy for cervical cancer treatment.</p><h3>Graphical abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"19 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-024-04166-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142889726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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