Nanoscale Research Letters最新文献

{"title":"Xanthatin nanocrystals exert anti-inflammatory properties against TNFα-primed 2D monolayers and in 3D spheroids of human HT29 colorectal cancer cells","authors":"Aleksandra Berenguer Roque,&nbsp;Alain Zgheib,&nbsp;Suslebys Salomon-Izquierdo,&nbsp;Amanda Manso Peña,&nbsp;Luis A. Osoria Alfonso,&nbsp;Janet Piloto-Ferrer,&nbsp;Borhane Annabi","doi":"10.1186/s11671-025-04257-z","DOIUrl":"10.1186/s11671-025-04257-z","url":null,"abstract":"<div><p>Poor water-solubility of emerging new chemotherapeutic drugs lead to low absorption and tissue bioavailability. Improved drug delivery has therefore recently been achieved through the versatile physico-chemical properties of nanocrystals (NCs) in targeted cancer therapies. Here, nanocrystalization was used with xanthatin, a not highly water-soluble natural sesquiterpene lactone compound that possesses anti-tumour properties and which was recently investigated for potential use in the treatment of cancer and autoimmune diseases. Given that tumour-promoting inflammation is a hallmark of colorectal cancer (CRC), and that epidemiological studies associated inflammatory biomarkers to CRC poor prognosis and therapy resistance, the anti-inflammatory properties of xanthatin NCs were assessed in 2D monolayers and in 3D spheroids of a human HT29 CRC cell model. The 3D spheroids being a model recapitulating a cancer stem cells and chemoresistant phenotype. HT29 2D monolayer cell response was first tested against four pro-inflammatory inducers including phorbol-12-myristate-13-acetate, tumour necrosis factor alpha (TNFα), transforming growth factor beta, and Concanavalin A. Of these inducers, HT29 cell response to TNFα resulted in the most elevated expression of cyclooxygenase (COX)-2 which was prevented by commercial xanthatin along with the phosphorylation of the extracellular signal-regulated kinase 1/2 and of IkappaB (IκB). Alteration of 3D spheroids formation and of the inflammatory/immunity transcriptomic signature was also found better altered by xanthatin NCs in comparison to commercial xanthatin and the isolated molecule. Collectively, our data indicate that xanthatin nanocrystallization did not alter the potential in vitro anti-inflammatory and anticancer properties of xanthatin against a 3D CRC chemoresistance cellular model. These properties make NCs a significant advancement in the field of cancer theranostics to improve patient outcomes.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04257-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transmission electron microscopy analysis of UV laser implanted gold nanoparticles and their influence on photoluminescence enhancement from silicon nanocrystals","authors":"Lukas Janos Richter,&nbsp;Ulrich Ross,&nbsp;Michael Seibt,&nbsp;Jürgen Ihlemann","doi":"10.1186/s11671-025-04263-1","DOIUrl":"10.1186/s11671-025-04263-1","url":null,"abstract":"<div><p>The photoluminescence of silicon nanocrystals is significantly enhanced via laser-based implantation of gold nanoparticles into silicon suboxide. This study is to explore in detail the nanoscale interactions between silicon nanocrystals embedded in the oxide matrix and gold nanoparticles through transmission electron microscopy. The influence of gold nanoparticle size and distance from the silicon nanocrystals is investigated and correlated with photoluminescence enhancement. A more than threefold enhancement in photoluminescence of silicon nanocrystals is observed, depending on the size and separation distance of the gold nanoparticles, demonstrating the efficiency of this straightforward and rapid laser-based method.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04263-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144073784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single tin-vacancy center in nanoscale diamond","authors":"Masanori Fujiwara,&nbsp;Masanao Ohori,&nbsp;Frederick Tze Kit So,&nbsp;Yuto Makino,&nbsp;Naoya Morioka,&nbsp;Izuru Ohki,&nbsp;Ryuji Igarashi,&nbsp;Masahiro Nishikawa,&nbsp;Norikazu Mizuochi","doi":"10.1186/s11671-025-04256-0","DOIUrl":"10.1186/s11671-025-04256-0","url":null,"abstract":"<div><p>Group-IV color centers in diamonds are promising not only as spin–photon interfaces for quantum networks but also as multicolor photoluminescence probes and all-optical temperature sensors for biological research. Therefore, generating group-IV color centers in detonation nanodiamonds (DNDs), the smallest class of diamond nanocrystals, has become a research focal point. This approach holds potential for the noninvasive introduction of diamond sensors into living cell organelles, enabling sensing of local structural and temperature changes with minimal disturbance. Following the successful generation of silicon- and germanium-vacancy centers in DNDs, the generation of tin-vacancy (SnV) centers was investigated. Similar to other group-IV color centers, the SnV centers exhibit strong photoluminescence. In addition, the SnV center offers a long spin coherence time compared with those of silicon- and germanium-vacancy centers. However, the strain induced by large Sn atoms poses substantial challenges for generating SnV centers in ultrasmall nanodiamonds. In this study, Sn-doped DNDs with a mean particle size of ~ 5 nm were subjected to a 3 days boiling acid treatment, which led to sharp zero-phonon lines of SnV centers at ~ 620 nm in the photoluminescence spectra. Photon autocorrelation measurements further revealed the presence of single SnV centers in these DNDs.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04256-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143949666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interface and strain energy driven variant selection in lamellar Ti–Al alloys","authors":"Zan Zhang,&nbsp;Jicheng Zhuo,&nbsp;Kunning Niu,&nbsp;Haiwei Zhang,&nbsp;Peng Sang,&nbsp;Shenglong Wang,&nbsp;Yongsheng Li","doi":"10.1186/s11671-025-04258-y","DOIUrl":"10.1186/s11671-025-04258-y","url":null,"abstract":"<div><p>The microstructure-property is essential important and complicated to be explored in metals. A novel multi-variant γ phase with nano-lamella incorporating multi-interface microstructure brings the special strength-ductility in Ti–Al alloys, the formation and selection of multi-variant interfaces are attractive questions. The phase-field simulations reveal the interface priority selection in the nucleation of γ variant with three kinds of interface, twin boundary (TB), pseudo-twin boundary (PTB) and ordered domain boundary (ODB), the low ratio of TB at nucleation stage transforms to the large ratio at growth stage, the interface elastic strain energy drives the γ variant selection. The findings reveal the role of interface elastic strain in facilitating the preferential development of specific γ variant, correlating an increase in TB with the escalation of elastic strain energy.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04258-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tunable properties of silver (Ag) substituted BaFe2O4 nanoparticles for photovoltaic (PV) applications","authors":"Irum Shahid Khan,&nbsp;Iftikhar Hussain Gul","doi":"10.1186/s11671-025-04261-3","DOIUrl":"10.1186/s11671-025-04261-3","url":null,"abstract":"<div><p>In this work, Ba_1-xAg_xFe₂O₄ (x = 0.0, 0.2, 0.3, 0.5) nanoparticles have been prepared using the sol–gel auto-combustion method providing the pioneering investigation of substitution of silver into barium ferrite, that is often associated with magnetic applications. A broad inspection has been performed on structural, magneto-electric, dielectric, and optical properties uncovering potential of Ag incorporated barium ferrite nano particles using X-ray diffraction, Vibrating sample magnetometer, Multiferroic system, Impedance Analyzer, UV visible diffuse reflectance spectroscopy, Fluorescence spectrophotometer and Photoluminescence (PL) system. The chemical bonding and functional groups of all samples were explored by Fourier transform infrared spectrometer as well as with RAMAN spectroscopy. The slight turn in orthorhombic structure from (Pnma 62) to (Bb21m 36) was detected from pure BaFe₂O₄ particles to Ag concentrated samples and also illustrated in 3D visualization. The formation of spherical nanoparticles (46-32 nm) with designed composition (Ba_0.8Ag_0.2Fe₂O₄, Ba_0.7Ag_0.3Fe₂O₄, Ba_0.5Ag_0.5Fe₂O₄) which was confirmed by Scanning electron microscopy and Energy dispersive x-ray spectroscopy separately. The maximum magnetization value of 22.3 emu/g was revealed by the Ba_0.5Ag_0.5Fe₂O₄ sample. The lowest energy band gap value of 1.5–1.8 eV was achieved by pristine and Ba_0.7Ag_0.3Fe₂O₄ making it eligible to operate within the ideal region of solar cell efficiency with reduced recombination losses. The PL emission intensity was also observed in the visible spectrum at 573–576 nm for Ag concentrated samples suggesting that material can efficiently absorb and release light in the solar spectrum’s most useful region. Significant leakage current was indicated by the PE loop with high conductivity, indicating that the material has reduced resistance and enhanced charge transport. Simulating solar illumination was used to evaluate the photovoltaic performance of nanoparticles, producing response curves for photocurrent and dark current revealing the improved photo current with Ag infusion. The valuable results of Ag-infused barium ferrites for dielectric, optical, and photovoltaic capabilities offered a fresh concept for using magnetic nanoparticles modified by silver as an encouraging development in the PV applications.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04261-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility analysis and development trend of nanomaterials for the treatment of pancreatic cancer","authors":"Jingyao Zhu,&nbsp;Yue Li,&nbsp;Xiaoqing Li,&nbsp;Yong Wang,&nbsp;Qixiang Liu,&nbsp;Yang Yang,&nbsp;HongJian Guan","doi":"10.1186/s11671-025-04259-x","DOIUrl":"10.1186/s11671-025-04259-x","url":null,"abstract":"<div><p>Pancreatic cancer is a highly aggressive disease that poses a significant threat to human health. Although conventional chemotherapy remains an effective treatment, it is often associated with severe side effects, underscoring the need for more effective cancer therapies. In this study, we analyzed the keywords of past studies, the countries with the highest number of publications, the leading journals, prominent authors, and collaborations between countries, authors, and journals, as well as the impact factors of relevant literature. The aim was to explore the trends in the use of nanomaterials for the treatment of pancreatic cancer, enabling researchers to review past achievements and gain a better understanding of future research directions. Relevant research articles were sourced from core Web of Science databases, and VOSviewer and CiteSpace visualization tools were employed to reveal the intrinsic links between the information. Research on the use of nanomaterials for the therapy of pancreatic cancer has been growing since the twenty-first century, particularly from 2018 to the present. The United States has become a leader in this field, with the highest number of publications and the most published authors. Additionally, a 2018 study published in Nature demonstrated that patients with insufficient CD8 + T-cell infiltration in the pancreatic cancer tumor microenvironment (TME) had significantly lower survival rates (HR = 2.5, p &lt; 0.001). And CSF1R inhibitors combined with a PD-1 antibody resulted in 60% tumor shrinkage in a mouse model. These findings suggest that research on the tumor microenvironment and immunotherapy is poised to be a key focus of future studies, offering new hope for pancreatic cancer patients.</p><h3>Graphical Abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04259-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143938167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid assembly of highly ordered DNA origami lattices at mica surfaces","authors":"Bhanu Kiran Pothineni,&nbsp;Jörg Barner,&nbsp;Guido Grundmeier,&nbsp;David Contreras,&nbsp;Mario Castro,&nbsp;Adrian Keller","doi":"10.1186/s11671-025-04254-2","DOIUrl":"10.1186/s11671-025-04254-2","url":null,"abstract":"<div><p>The surface-assisted assembly of DNA origami lattices is a potent method for creating molecular lithography masks. Lattice quality and assembly kinetics are controlled by various environmental parameters, including the employed surface, the assembly temperature, and the ionic composition of the buffer, with optimized parameter combinations resulting in highly ordered lattices that can span surface areas of several cm². Established assembly protocols, however, employ assembly times ranging from hours to days. Here, the assembly of highly ordered hexagonal DNA origami lattices at mica surfaces is observed within few minutes using high-speed atomic force microscopy (HS-AFM). A moderate increase in the DNA origami concentration enables this rapid assembly. While forming a regular lattice takes 10 min at a DNA origami concentration of 4 nM, this time is shortened to about 2 min at a concentration of 6 nM. Increasing the DNA origami concentration any further does not result in shorter assembly times, presumably because DNA origami arrival at the mica surface is diffusion-limited. Over short length scales up to 1 µm, lattice order is independent of the DNA origami concentration. However, at larger length scales of a few microns, a DNA origami concentration of 10 nM yields slightly better order than lower and higher concentrations. Therefore, 10 nM can be considered the optimum concentration for the rapid assembly of highly ordered DNA origami lattices. These results thus represent an important step toward the industrial-scale application of DNA origami-based lithography masks.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04254-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143913890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular drug delivery systems based on nanotechnology: a comprehensive review for the treatment of eye diseases","authors":"Rahul Dev Bairagi,&nbsp;Raiyan Rahman Reon,&nbsp;Md Mahbub Hasan,&nbsp;Sumit Sarker,&nbsp;Dipa Debnath,&nbsp;Md. Tawhidur Rahman,&nbsp;Sinthia Rahman,&nbsp;Md. Amirul Islam,&nbsp;Md. Abu Talha Siddique,&nbsp;Bishwajit Bokshi,&nbsp;Md. Mustafizur Rahman,&nbsp;Amit Kumar Acharzo","doi":"10.1186/s11671-025-04234-6","DOIUrl":"10.1186/s11671-025-04234-6","url":null,"abstract":"<div><p>Ocular drug delivery is a significant challenge due to the intricate anatomy of the eye and the various physiological barriers. Conventional therapeutic approaches, while effective to some extent, often fall short in effectively targeting ocular diseases, resulting in suboptimal therapeutic outcomes due to factors such as poor ocular bioavailability, frequent dosing requirements, systemic side effects, and limited penetration through ocular barriers. This review elucidates the eye’s intricate anatomy and physiology, prevalent ocular diseases, traditional therapeutic modalities, and the inherent pharmacokinetic and pharmacodynamic limitations associated with these modalities. Subsequently, it delves into nanotechnology-based solutions, presenting breakthroughs in nanoformulations such as nanocrystals, liposomes, dendrimers, and nanoemulsions that have demonstrated enhanced drug stability, controlled release, and deeper ocular penetration. Additionally, it explores a range of nanosized carriers, including nano-structured lipid carriers, hydrogels, nanogels, nanoenzymes, microparticles, conjugates, exosomes, nanosuspensions, viral vectors, and polymeric nanoparticles, and their applications. Unique insights include emerging innovations such as nanowafers and transcorneal iontophoresis, which indicate paradigm shifts in non-invasive ocular drug delivery. Furthermore, it sheds light on the advantages and limitations of these nanotechnology-based platforms in addressing the challenges of ocular drug delivery. Though nano-based drug delivery systems are drawing increasing attention due to their potential to enhance bioavailability and therapeutic efficacy, the review ends up emphasizing the imperative need for further research to drive innovation and improve patient outcomes in ophthalmology.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04234-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Harnessing optical forces with advanced nanophotonic structures: principles and applications","authors":"Geze Gao,&nbsp;Tianhua Shao,&nbsp;Tianyue Li,&nbsp;Shuming Wang","doi":"10.1186/s11671-025-04252-4","DOIUrl":"10.1186/s11671-025-04252-4","url":null,"abstract":"<div><p>Non-contact mechanical control of light has given rise to optical manipulation, facilitating diverse light-matter interactions and enabling pioneering applications like optical tweezers. However, the practical adoption of versatile optical tweezing systems remains constrained by the complexity and bulkiness of their optical setups, underscoring the urgent requirement for advancements in miniaturization and functional integration. In this paper, we present innovations in optical manipulation within the nanophotonic domain, including fiber-based and metamaterial tweezers, as well as their emerging applications in manipulating cells and artificial micro-nano robots. Furthermore, we explore interdisciplinary on-chip devices that integrate photonic crystals and optofluidics. By merging optical manipulation with the dynamism of nanophotonics and metamaterials, this work seeks to chart a transformative pathway for the future of optomechanics and beyond.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04252-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143902752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Layer-by-layer coating strategy to functionalize the magnetic nanoparticles for their multi-functionalization","authors":"Jing Liu,&nbsp;Ye Chen,&nbsp;Hongjie Huang,&nbsp;Feixiong Chen","doi":"10.1186/s11671-025-04250-6","DOIUrl":"10.1186/s11671-025-04250-6","url":null,"abstract":"<div><p>Magnetic nanoparticles (MNPs) hold significant potential for a wide range of applications, however, surface modification or bio-conjugation of MNPs often leads to their aggregation and instability. To address this, we proposed a facile method using a layer-by-layer (LbL) coating technique with polyallylamine hydrochloride (PAH) and poly(styrene sulfonic acid) sodium salt (PSS), so as to maintain the dispersion stability and functionality of MNPs. This method enabled us to develop the powerful MNPs towards to their use in the electrochemical biosensor, by combining both the redox probes (ferrocene (Fc), anthraquinone (AQ), or monocarboxymethylene blue (MB)) and bio-probes (IgG). The redox molecules were effectively anchored to the MNPs under the organic solvents, while such functionalized MNPs surface were subsequently protected by the LbL coating process prior to dispersing in high ionic strength solutions (e.g. Phosphate-buffered saline). And the out-layer of polyelectrolyte shell allowed biomolecules to attach to the MNP surface without chemical cross-linking. Our results demonstrated that the TEM size of MNPs@Fc, MNP@AQ and MNP@MB after LbL coating were characterized as 11.0 ± 2.0 nm, 10.5 ± 2.1 nm and 12.4 ± 2.2 nm and these developed redox MNPs of MNPs@Fc, MNPs@AQ and MNPs@MB were characterized by square wave voltammetry (SWV) with their redox intensity of 0.64 ± 0.10 µA, 23.25 ± 0.73 µA and 0.48 ± 0.13 µA, respectively. In addition, the binding efficiency of adsorption between the MNPs and IgG was up to 78%, evidenced by SDS-PAGE gel analysis. This facile method offered a versatile and effective way to functionalize MNPs, combining redox and biological properties for potential applications in disease diagnosis and point-of-care diagnostics.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04250-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143900736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}