Sergio F. Flores-Correa, L. M. León Hilario, I. A. Ramos-Pérez, Andres A. Reynoso
{"title":"Length-flexible strategies for efficient SERS performance in gold-nanorod-gapped nanoantennas","authors":"Sergio F. Flores-Correa, L. M. León Hilario, I. A. Ramos-Pérez, Andres A. Reynoso","doi":"10.1186/s11671-025-04228-4","DOIUrl":"10.1186/s11671-025-04228-4","url":null,"abstract":"<div><p>Surface-enhanced Raman spectroscopy (SERS) using gold-nanorod-dimer nanoantennas has shown great potential in various applications. This reflects in their large values of the customary figure of merit of SERS: the enhancement factor (EF), which is essentially the fourth power of the electric field integrated at the gap, the location at which target molecules are to be sensed. However, fabrication errors in the nanorod lengths can lead to significant variations in the enhancement factor, resulting in performance limitations whenever low values of EF are encountered. Here, we report both design and procedural strategies to address this issue. First, we show that by reducing the nanorod diameter from 360 to 260 nm, the EF minima can be avoided for any nanorod length, mitigating the impact of fabrication errors. In addition, we explore the influence of incident wave polarization and orientation on the EF. Our simulations reveal that by tilting the excitation away from normal incidence, it is possible to substantially enhance EF under conditions that would otherwise exhibit low enhancement. In particular, this includes the case of 360 nm diameter. These findings expand the fabrication tolerance and broaden the range of usability of gold-nanorod-dimer nanoantennas, enabling more robust and reliable SERS performance. Importantly, we also show that these strategies also apply to nanoantennas with covered nanorod ends, which are of particular interest for realizing hybrid devices that combine SERS with electrical transport measurements.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04228-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dongmei Hu, Qing Wu, Yujun Yang, Yan Wang, Yanhao Li, Haixiang Chen, Liang Tang, Xiang Mao, Zhenyu Wang
{"title":"Bioinspired Fe3O4@Ag@ indocyanine green/adenosine triphosphate nanoenzyme in synergistic antibacterial performance","authors":"Dongmei Hu, Qing Wu, Yujun Yang, Yan Wang, Yanhao Li, Haixiang Chen, Liang Tang, Xiang Mao, Zhenyu Wang","doi":"10.1186/s11671-025-04232-8","DOIUrl":"10.1186/s11671-025-04232-8","url":null,"abstract":"<div><p>Metal-based nanoenzymes with excellent biocompatibility and stable chemical properties are an effective antimicrobial agent against bacterial resistance due to their radical-mediated catalysis. In this work, due to the pH of most bacterial infection sites being close to neutral, targeting the problem of Fe<sub>3</sub>O<sub>4</sub>@Ag difficulty in maintaining the catalytic activity of nanoenzymes in neutral environments, we prepare a novel multifunctional Fe<sub>3</sub>O<sub>4</sub>@Ag@ indocyanine green/adenosine triphosphate peroxidase nanoenzymes for synergistic antibacterial activity. ICG (Indocyanine Green) and ATP (Adenosine triphosphate) are adsorbed on the surface of Fe<sub>3</sub>O<sub>4</sub>@Ag through electrostatic adsorption to form its structure. The cell viability remained above 90%, indicating its good biocompatibility. By complexing ATP with nanoenzymes to participate in single electron transfer and binding with Fe (II), ATP promotes the sudden release of hydroxyl radical (·OH) from the system, successfully transferring Fe<sub>3</sub>O<sub>4</sub>@Ag the peroxidase activity of nanoenzymes extends to neutral pH. By utilizing ICG as a photosensitizer and a sonosensitizer, under the combined treatment of near-infrared light and ultrasound, the photodynamic therapy (PDT)/photothermal therapy (PTT)/sonodynamic therapy (SDT) functions can be achieved, achieving multifunctional synergistic antibacterial effects. In a neutral environment, its bactericidal efficiency against Gram negative (<i>Escherichia coli</i>) and Gram positive (<i>Staphylococcus aureus</i>) is 99.9% and 99.7%, respectively, providing a new multi-mode synergistic antibacterial strategy for bacterial infections.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div><div><p>Metal based nanoenzymes with excellent biocompatibility and stable chemical properties are an effective antimicrobial agent against bacterial resistance due to their radical mediated catalysis. The prepared multifunctional Fe<sub>3</sub>O<sub>4</sub>@Ag@ICG/ATP exhibit peroxidase nanoenzymes perform ance for synergistic antibacterial activity. ICG and ATP are adsorbed on the surface of Fe<sub>3</sub>O<sub>4</sub>@Ag through electrostatic adsorption to form its structure</p></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04232-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Development of an innovative low-temperature PEALD process for stress-compensated TiO2 and SiO2 multilayer anti-reflective coatings","authors":"Duy Thanh Cu, Kuan-Yu Ko, Wen-Hao Cho, Chao-Te Lee, Meng-Chi Li, Chien-Cheng Kuo","doi":"10.1186/s11671-025-04238-2","DOIUrl":"10.1186/s11671-025-04238-2","url":null,"abstract":"<div><p>This study presents a low-temperature plasma-enhanced atomic layer deposition (PEALD) technique for fabricating high-performance, stress-reduced anti-reflective coatings (ARCs). To the best of our knowledge, this is the first extensive study on titanium dioxide (TiO<sub>2</sub>)/silicon dioxide (SiO<sub>2</sub>) stacking with PEALD at such a low temperature of 70 °C, which may help to overcome high-temperature deposition issues and mechanical stress for polymer substrates. Despite the presence of impurities in the low-temperature deposited films, the measured extinction coefficient (k < 10<sup>–4</sup>) indicates negligible optical absorption in both TiO<sub>2</sub> and SiO<sub>2</sub> layers, ensuring optimal performance for ARCs. Stress compensation is observed between tensile TiO<sub>2</sub> films (≈ 220 MPa) and compressive SiO<sub>2</sub> films (≈ − 35 MPa). For multi-layer ARCs, this combination strategy leads to a very low total stress of 48 MPa, which is a big step forward for stress control in optical coatings. This stress-reduction effect remains effective even when the thickness difference reaches up to 9.6%. This consistency has been demonstrated in real-world applications, where achieving an ideal level of thinness can be challenging. The optimized process at 150 W plasma power produces high-quality optics with an average reflectivity of 0.35% in the visible range while maintaining low stress, a significant achievement in low temperature deposited optical coatings. The choice of common, cost-effective materials like SiO<sub>2</sub> and TiO<sub>2</sub> makes this approach easily scalable for industrial use and can see the future of manufacturing ARCs for various applications. These films are characterized by a low density of defects and an amorphous structure with the smoothness of their surface being close to one atomic monolayer (≈ 0.2 nm), which indicates their high optical quality, comparable to films deposited at high temperatures. The low-temperature PEALD presented in this work not only pushes the boundary in advanced optical coatings but also enlarges the capacity in coating temperature-sensitive substrates and complex 3D structures. This innovation paves the way for applications in bendable electronics, high-performance optical components, and next generation display devices.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04238-2.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143688324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. C. Pardo, F. Pasadas, A. Medina-Rull, M. G. Palomo, S. Ortiz-Ruiz, E. G. Marin, A. Godoy, F. G. Ruiz
{"title":"Comprehensive analysis and exploratory design of graphene-based subharmonic mixers operating at the gigahertz band","authors":"M. C. Pardo, F. Pasadas, A. Medina-Rull, M. G. Palomo, S. Ortiz-Ruiz, E. G. Marin, A. Godoy, F. G. Ruiz","doi":"10.1186/s11671-025-04221-x","DOIUrl":"10.1186/s11671-025-04221-x","url":null,"abstract":"<div><p>Ambipolar conductance in graphene field-effect transistors (GFETs), and in particular their quasi-quadratic I–V transfer characteristic, makes these devices excellent candidates for exploiting subharmonic mixing at high frequencies. Several realizations have already demonstrated the ability of GFETs to compete with, or even improve, state-of-the-art mixers based on traditional technologies. Nonetheless, a systematic analysis of the influence on performance of both circuit design and technological aspects has not been conducted yet. In this work, we present a comprehensive assessment of the conversion losses by means of applying radio-frequency circuit design techniques in terms of filtering and matching, along with the impact stemming from physical and geometric variations of a fabricated graphene technology.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04221-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative toxicity and environmental impact assessments of sonochemically-synthesized CuO and Zn-doped CuO nanoparticles using zebrafish and LCA tools","authors":"Beatrice Negrini, Pamela Floris, Christian D’Abramo, Seyed Ahmad Aldaghi, Mattia Costamagna, Massimo Perucca, Melissa Saibene, Ilana Perelshtein, Anita Colombo, Patrizia Bonfanti, Paride Mantecca","doi":"10.1186/s11671-025-04225-7","DOIUrl":"10.1186/s11671-025-04225-7","url":null,"abstract":"<div><p>Nanomaterials (NMs), including nanoparticles (NPs), offer promising potential in achieving the European Commission’s Green Deal goals of climate-neutral, zero-pollution and circular economy. Metal oxide NPs display antimicrobial properties, with efficacy also towards antimicrobial-resistant bacteria. Nevertheless, the increasing manufacture, use and unintended release of NMs particularly in aquatic compartments, raises concerns about their environmental sustainability and safety towards non-target organisms. Within the Safe and Sustainable by Design framework, this study compares toxicity and environmental impacts of sonochemically synthesized water-based CuO and Zn-doped CuO NPs. Zebrafish embryos were exploited in a high-throughput developmental and behavioral screening to investigate nanosafety. The Fish Embryo acute Toxicity test was used to assess the NPs aquatic toxicity potential, while behaviour was addressed by tracking embryos activity. The Life Cycle Assessment (LCA) methodology was implemented through the OpenLCA software to evaluate the environmental footprint of the NPs synthesis. Our findings showed no significative lethality at the tested concentrations (0.01–100 mg/L) (LC<sub>50 wCuO</sub> > > 100 mg/L), with the exception of ZnCuO NPs 100 mg/L (LC<sub>50 ZnCuO</sub> = 123 mg/L). Sub-lethality occurred as delayed hatching, partially recovered by Zn-doping, and embryo development. LCA highlighted the dominant role of electricity (which represented 47 to 98% of the total impacts) and copper acetate (37–94%) consumption in the environmental impacts of the NPs synthesis, emphasizing the importance of optimizing energy and chemical use to minimize environmental burden. This research supports the safe and sustainable design of nano-enabled antimicrobials and underscores the need for an approach comprehensive of both risk assessment and LCA in nanotechnology development.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04225-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akshita Thakur, Hema K. Alajangi, Akanksha Sharma, Euimin Hwang, Akhil Khajuria, Laxmi Kumari, Pradeep Kumar Jaiswal, Yong-beom Lim, Gurpal Singh, Ravi Pratap Barnwal
{"title":"Stigmurin encapsulated PLA–PEG ameliorates its therapeutic potential, antimicrobial and antiproliferative activities","authors":"Akshita Thakur, Hema K. Alajangi, Akanksha Sharma, Euimin Hwang, Akhil Khajuria, Laxmi Kumari, Pradeep Kumar Jaiswal, Yong-beom Lim, Gurpal Singh, Ravi Pratap Barnwal","doi":"10.1186/s11671-025-04224-8","DOIUrl":"10.1186/s11671-025-04224-8","url":null,"abstract":"<div><p>In light of growing global challenge posed by antimicrobial resistance, it is very important to explore alternatives that can target pathogenic microorganisms. One such strategy involves the use of antimicrobial peptides (AMPs) and Stigmurin is one such AMP present in Brazilian scorpion <i>Tityus stigmurus</i> which possesses antimicrobial, antiproliferative and antiparasitic activity. The study commenced with successful synthesis and characterization of Stigmurin and its analogues, designated S1 and S2. Studies on Stigmurin and its analogues have demonstrated that analogues exhibit enhanced antimicrobial efficacy but often lead to increased hemolysis, limiting their therapeutic application. To prevent the associated toxicity of these peptides, PLA–PEG di-block copolymer was synthesised to prepare nanoparticles (E-WT, E1, and E2) with an average diameter of approximately 160–180 nm. The core of the research involved evaluating the antimicrobial (<i>Bacillus subtilis</i>), antibiofilm (<i>B. subtilis</i> and <i>Pseudomonas aeruginosa</i>), antiproliferative (HEK293 and RAW264.7) and hemolytic activity of the peptides. In addition to the experimental work, in silico analysis using structural models was conducted to further understand their potential interactions. The findings demonstrated that the analogue peptides exhibit enhanced antimicrobial and antibiofilm activity compared to the wild-type Stigmurin. Moreover, encapsulating the peptides in PLA–PEG nanoparticles maintained the antimicrobial activity against <i>B. subtilis</i>. Further, encapsulation significantly reduced hemolysis as well as cytotoxicity by 10–20%, thereby improving their safety profile.</p><h3>Graphical abstract</h3><div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04224-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Sahu, U. K. Panigrahi, Debashree Nayak, Shamima Hussain, P. Mallick
{"title":"Structural, optical and magnetic properties of CuO/α-Fe2O3 nanocomposites: effect of Fe concentration and annealing temperature","authors":"B. Sahu, U. K. Panigrahi, Debashree Nayak, Shamima Hussain, P. Mallick","doi":"10.1186/s11671-025-04222-w","DOIUrl":"10.1186/s11671-025-04222-w","url":null,"abstract":"<div><p>The impact of annealing temperature (500, 600, and 700 °C) and Fe concentration on the formation of 5, 10 and 20 at.% Fe-doped CuO was investigated using structural, optical, and magnetic characterizations. XRD and Raman studies confirmed the presence of both CuO and α-Fe<sub>2</sub>O<sub>3</sub> in the composite samples. The broadening of the multiphoton transition mode in the Raman spectra with increasing Fe concentration and annealing temperature could be associated with the defects. FESEM analysis showed that the sample’s morphology changed from non-homogeneous, irregularly shaped flake-like particles to nearly spherical particles with increased Fe concentration. Optical characterization suggested that the samples’ higher optical band gap energy (> 3 eV) could result from the quantum confinement effect. Photoluminescence analysis revealed that the rise of annealing temperature from 500 to 600 °C led to a shift in the emission coordinates from the near-green to the blue region. All the samples showed a clear hysteresis loop at room temperature indicating the ferromagnetic nature. The maximum coercivity of 777 Oe and highest remanent magnetization of 2.06 emu/g was found for the 20% Fe-doped CuO annealed at 700 °C. On the other hand, the 5% Fe-doped CuO samples exhibited an exchange bias field of ~ 31 Oe at 300 K.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04222-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143581084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Linlin Zhuang, Ying Zhao, Jingyi Shen, Li Sun, Pan Hao, Jianbo Yang, Yu Zhang, Qiuping Shen
{"title":"Advances in porcine epidemic diarrhea virus research: genome, epidemiology, vaccines, and detection methods","authors":"Linlin Zhuang, Ying Zhao, Jingyi Shen, Li Sun, Pan Hao, Jianbo Yang, Yu Zhang, Qiuping Shen","doi":"10.1186/s11671-025-04220-y","DOIUrl":"10.1186/s11671-025-04220-y","url":null,"abstract":"<div><p>Porcine epidemic diarrhea (PED) is a highly contagious intestinal disease caused by the porcine epidemic diarrhea virus (PEDV). The economic impact of PEDV on the global pig industry has been significant, resulting in considerable losses. This paper presents a review of the latest research progress on PEDV genome, molecular epidemiology, vaccine development, and molecular detection methods. It was determined that the genetic diversity of the PEDV spike (<i>S</i>) gene was closely associated with the epidemiological trend of PEDV. The prevalence of <i>S</i> gene variants of different genotypes exhibited variability across regions and pig populations. Epidemiological analyses have demonstrated that PEDV can be transmitted via multiple routes, including direct contact, airborne aerosol, and water source contamination. With regard to vaccine research, the available vaccines can be classified into several categories, including live-attenuated vaccines, inactivated vaccines, subunit vaccines, bacterial vector vaccines, viral vector vaccines, mRNA vaccines, etc. Each of these has distinctive characteristics in terms of immunogenicity, protection efficiency, and safety. Molecular detection methods, including PCR-based methods, isothermal amplification techniques, immunological assays, and biosensors, play an important role in the diagnosis and monitoring of PEDV. Furthermore, this paper examines the current developments in PEDV research and identifies the key areas of future investigation. The objective of this paper is to establish a theoretical foundation for the prevention and control strategies of PED, and to provide a point of reference for further research on the genomics, epidemiology, vaccine development and detection methods of PEDV.</p></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04220-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143533264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Irshad Ahamad, Masood Nadeem, M. Moshahid Alam Rizvi, Tasneem Fatma
{"title":"Bio-fabricated silver nanoparticles: therapeutic evaluation as a potential nanodrug against cervical and liver cancer cells","authors":"Irshad Ahamad, Masood Nadeem, M. Moshahid Alam Rizvi, Tasneem Fatma","doi":"10.1186/s11671-025-04212-y","DOIUrl":"10.1186/s11671-025-04212-y","url":null,"abstract":"<div><p>Nanobiotechnology has grown rapidly and is now widely used in the diagnosis and treatment of modern diseases. Biosynthesized silver nanoparticles (AgNPs) are eco-friendly, cost-effective, biocompatible route, and have biomedical properties at minimal concentrations. In the present study extract of cyanobacterium (<i>Anabaena variabilis</i>) was utilized to synthesize facile, reliable AgNPs, further biosynthesized AgNPs were characterized by physicochemical techniques. The atomic force microscope study confirmed the shape of AgNPs while the scanning electron microscopy study revealed 17 to 35 nm in the size range. The zeta potential value of -19.5 mV demonstrated the repulsion effect between the particles, which prevents their aggregations while the heating stability of AgNPs was confirmed by Thermogravimetry differential thermal analysis. Another important characteristic, such as elemental constituent of AgNPs was determined by inductively coupled plasma mass spectrometry and was observed 94.24, 95.19, 97.06, and 99.34% of silver present in their respective concentrations of AgNPs. In vitro cytotoxicity of AgNPs was screened on HeLa, SiHa, (Cervical carcinoma), and HepG2 (Human hepatocellular carcinoma), cell lines. To evaluate the biocompatibility of AgNPs immortalized human embryonic kidney (HEK-293) cell line was used. The IC<sub>50</sub> values of AgNPs are were observed as 23.76 ± 2.4 µg/mL, 11.21 ± 1.7 µg/mL, and 22.27 ± 1.8 µg/mL against HeLa, SiHa and HepG2 cell lines respectively. AgNPs demonstrated the biocompatible nature against HEK-293 cells, Normal cell line (HEK-293) cytotoxicity results showed exhibited ≥ 95% cell viability at all the concentrations. During the DAPI (4’,6-diamidino-2-phenylindole) staining study IC<sub>50</sub> dose of AgNPs on cancer cell lines (HeLa, SiHa, and HepG2) showed nuclear morphological alterations which indicate the DNA damage and apoptosis in cancer cells. AgNPs treated cancer cells increased the cells number in the S phase while decreased the number of cells in the G0-G1 and G2/M phases of the cell cycle in all three cancer cells compared to the control.</p><h3>Graphical Abstract</h3>\u0000<div><figure><div><div><picture><source><img></source></picture></div></div></figure></div></div>","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04212-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Retraction Note: Poly(γ-glutamic acid)-coated lipoplexes loaded with Doxorubicin for enhancing the antitumor activity against liver tumors","authors":"Na Qi, Bo Tang, Guang Liu, Xingsi Liang","doi":"10.1186/s11671-025-04187-w","DOIUrl":"10.1186/s11671-025-04187-w","url":null,"abstract":"","PeriodicalId":51136,"journal":{"name":"Nanoscale Research Letters","volume":"20 1","pages":""},"PeriodicalIF":5.5,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://link.springer.com/content/pdf/10.1186/s11671-025-04187-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143480913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}