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Neurofilaments: Novel findings and future challenges 神经丝：新发现与未来挑战
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-02-23 DOI: 10.1016/j.ceb.2024.102326
Jessy V. van Asperen, Farah Kotaich, Damien Caillol, Pascale Bomont
{"title":"Neurofilaments: Novel findings and future challenges","authors":"Jessy V. van Asperen,&nbsp;Farah Kotaich,&nbsp;Damien Caillol,&nbsp;Pascale Bomont","doi":"10.1016/j.ceb.2024.102326","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102326","url":null,"abstract":"<div><p>Neurofilaments (NFs) are abundant cytoskeletal proteins that emerge as a critical hub for cell signalling within neurons. As we start to uncover essential roles of NFs in regulating microtubule and organelle dynamics, nerve conduction and neurotransmission, novel discoveries are expected to arise in genetics, with NFs identified as causal genes for various neurodegenerative diseases. This review will discuss how the latest advances in fundamental and translational research illuminate our understanding of NF biology, particularly their assembly, organisation, transport and degradation. We will emphasise the notion that filaments are not one entity and that future challenges will be to apprehend their diverse composition and structural heterogeneity and to scrutinize how this regulates signalling, sustains neuronal physiology and drives pathophysiology in disease.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102326"},"PeriodicalIF":7.5,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S095506742400005X/pdfft?md5=1f746678e923bd9ed8f0c346566d4c88&pid=1-s2.0-S095506742400005X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GFAP-isoforms in the nervous system: Understanding the need for diversity 神经系统中的 GFAP 异构体：了解多样性的必要性
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-02-23 DOI: 10.1016/j.ceb.2024.102340
Alexandra J.E.M. de Reus , Onur Basak , Werner Dykstra , Jessy V. van Asperen , Emma J. van Bodegraven , Elly M. Hol
{"title":"GFAP-isoforms in the nervous system: Understanding the need for diversity","authors":"Alexandra J.E.M. de Reus ,&nbsp;Onur Basak ,&nbsp;Werner Dykstra ,&nbsp;Jessy V. van Asperen ,&nbsp;Emma J. van Bodegraven ,&nbsp;Elly M. Hol","doi":"10.1016/j.ceb.2024.102340","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102340","url":null,"abstract":"<div><p>Glial fibrillary acidic protein (GFAP) is an intermediate filament (IF) protein expressed in specific types of glial cells in the nervous system. The expression of GFAP is highly regulated during brain development and in neurological diseases. The presence of distinct GFAP-isoforms in various cell types, developmental stages, and diseases indicates that GFAP (post-)transcriptional regulation has a role in glial cell physiology and pathology. GFAP-isoforms differ in sub-cellular localisation, IF-network assembly properties, and IF-dynamics which results in distinct molecular interactions and mechanical properties of the IF-network. Therefore, GFAP (post-)transcriptional regulation is likely a mechanism by which radial glia, astrocytes, and glioma cells can modulate cellular function.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102340"},"PeriodicalIF":7.5,"publicationDate":"2024-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S095506742400019X/pdfft?md5=915b4e26af64b8f5673c1cf4a06a330d&pid=1-s2.0-S095506742400019X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139941824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytoskeletal crosstalk: A focus on intermediate filaments 细胞骨架串联：聚焦中间丝
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-02-14 DOI: 10.1016/j.ceb.2024.102325
Lucas Pradeau-Phélut , Sandrine Etienne-Manneville
{"title":"Cytoskeletal crosstalk: A focus on intermediate filaments","authors":"Lucas Pradeau-Phélut ,&nbsp;Sandrine Etienne-Manneville","doi":"10.1016/j.ceb.2024.102325","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102325","url":null,"abstract":"<div><p>The cytoskeleton, comprising actin microfilaments, microtubules, and intermediate filaments, is crucial for cell motility and tissue integrity. While prior studies largely focused on individual cytoskeletal networks, recent research underscores the interconnected nature of these systems in fundamental cellular functions like adhesion, migration, and division. Understanding the coordination of these distinct networks in both time and space is essential. This review synthesizes current findings on the intricate interplay between these networks, emphasizing the pivotal role of intermediate filaments. Notably, these filaments engage in extensive crosstalk with microfilaments and microtubules through direct molecular interactions, cytoskeletal linkers, and molecular motors that form molecular bridges, as well as via more complex regulation of intracellular signaling.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102325"},"PeriodicalIF":7.5,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000048/pdfft?md5=3adb817461ca180128329464dc799860&pid=1-s2.0-S0955067424000048-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139732505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nuclear mechanotransduction on skin stem cell fate regulation 核机械传导对皮肤干细胞命运调控的影响
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-02-10 DOI: 10.1016/j.ceb.2024.102328
Leah C. Biggs , Yekaterina A. Miroshnikova
{"title":"Nuclear mechanotransduction on skin stem cell fate regulation","authors":"Leah C. Biggs ,&nbsp;Yekaterina A. Miroshnikova","doi":"10.1016/j.ceb.2024.102328","DOIUrl":"10.1016/j.ceb.2024.102328","url":null,"abstract":"<div><p>Mammalian skin is a highly dynamic and regenerative organ that has long been recognized as a mechanically active composite of tissues withstanding daily compressive and tensile forces that arise from body movement. Importantly, cell- and tissue-scale mechanical signals are critical regulators of skin morphogenesis and homeostasis. These signals are sensed at the cellular periphery and transduced by mechanosensitive proteins within the plasma membrane to the cytoskeletal networks, and eventually into the nucleus to regulate chromatin organization and gene expression. The role of each of these nodes in producing a coherent mechanoresponse at both cell- and tissue-scales is emerging. Here we focus on the key cytoplasmic and nuclear mechanosensitive structures that are critical for the mammalian skin development and homeostatic maintenance. We propose that the mechanical state of the skin, in particular of its nuclear compartment, is a critical rheostat that fine-tunes developmental and homeostatic processes essential for the proper function of the organ.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102328"},"PeriodicalIF":7.5,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139716598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell competition and the regulation of protein homeostasis 细胞竞争与蛋白质平衡调节
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-02-01 DOI: 10.1016/j.ceb.2024.102323
Shruthi Krishnan, Pranab K. Paul, Tristan A. Rodriguez
{"title":"Cell competition and the regulation of protein homeostasis","authors":"Shruthi Krishnan,&nbsp;Pranab K. Paul,&nbsp;Tristan A. Rodriguez","doi":"10.1016/j.ceb.2024.102323","DOIUrl":"10.1016/j.ceb.2024.102323","url":null,"abstract":"<div><p>The process of embryonic development involves remarkable cellular plasticity, which governs the coordination between cells necessary to build an organism. One role of this plasticity is to ensure that when aberrant cells are eliminated, growth adjustment occurs so that the size of the tissue is maintained. An important regulator of cellular plasticity that ensures cellular cooperation is a fitness-sensing mechanism termed cell competition. During cell competition, cells with defects that lower fitness but do not affect viability, such as those that cause impaired signal transduction, slower cellular growth, mitochondrial dysregulation or impaired protein homeostasis, are killed when surrounded by fitter cells. This is accompanied by the compensatory proliferation of the surviving cells. The underlying factors and mechanisms that demarcate certain cells as less fit than their neighbouring cells and losers of cell competition are still relatively unknown. Recent evidence has pointed to mitochondrial defects and proteotoxic stress as important hallmarks of these loser cells. Here, we review recent advances in this area, focussing on the role of mitochondrial activity and protein homeostasis as major mechanisms determining competitive cell fitness during development and the importance of cell proteostasis in determining cell fitness.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102323"},"PeriodicalIF":7.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000024/pdfft?md5=da1a74245db4e1bba21b104a6ec31f16&pid=1-s2.0-S0955067424000024-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139663828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outside Back Cover 封底外侧
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-02-01 DOI: 10.1016/S0955-0674(24)00016-4
{"title":"Outside Back Cover","authors":"","doi":"10.1016/S0955-0674(24)00016-4","DOIUrl":"https://doi.org/10.1016/S0955-0674(24)00016-4","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102337"},"PeriodicalIF":7.5,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139719237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanotransduction through protein stretching 通过蛋白质拉伸实现机械传导
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-31 DOI: 10.1016/j.ceb.2024.102327
Yanyu Guo , Jie Yan , Benjamin T. Goult
{"title":"Mechanotransduction through protein stretching","authors":"Yanyu Guo ,&nbsp;Jie Yan ,&nbsp;Benjamin T. Goult","doi":"10.1016/j.ceb.2024.102327","DOIUrl":"10.1016/j.ceb.2024.102327","url":null,"abstract":"<div><p>Cells sense and respond to subtle changes in their physicality, and via a myriad of different mechanosensitive processes, convert these physical cues into chemical and biochemical signals. This process, called mechanotransduction, is possible due to a highly sophisticated machinery within cells. One mechanism by which this can occur is via the stretching of mechanosensitive proteins. Stretching proteins that contain force-dependent regions results in altered geometry and dimensions of the connections, as well as differential spatial organization of signals bound to the stretched protein. The purpose of this mini-review is to discuss some of the intense recent activity in this area of mechanobiology that strives to understand how protein stretching can influence signaling outputs and cellular responses.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102327"},"PeriodicalIF":7.5,"publicationDate":"2024-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000061/pdfft?md5=f6f79bd8ab5ad15a97f94f2047b6d349&pid=1-s2.0-S0955067424000061-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139649236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Forced back into shape: Mechanics of epithelial wound repair 被迫恢复原状：上皮伤口修复机制
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-30 DOI: 10.1016/j.ceb.2024.102324
Shu En Lim , Pablo Vicente-Munuera , Yanlan Mao
{"title":"Forced back into shape: Mechanics of epithelial wound repair","authors":"Shu En Lim ,&nbsp;Pablo Vicente-Munuera ,&nbsp;Yanlan Mao","doi":"10.1016/j.ceb.2024.102324","DOIUrl":"10.1016/j.ceb.2024.102324","url":null,"abstract":"<div><p>Wound repair, the closing of a hole, is inherently a physical process that requires the change of shape of materials, in this case, cells and tissues. Not only is efficient and accurate wound repair critical for restoring barrier function and reducing infection, but it is also critical for restoring the complex three-dimensional architecture of an organ. This re-sculpting of tissues requires the complex coordination of cell behaviours in multiple dimensions, in space and time, to ensure that the repaired structure can continue functioning optimally. Recent evidence highlights the importance of cell and tissue mechanics in 2D and 3D to achieve such seamless wound repair.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102324"},"PeriodicalIF":7.5,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000036/pdfft?md5=cc0e596cf06119edac3571daa2a23904&pid=1-s2.0-S0955067424000036-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
All the small things: Nanoscale matrix alterations in aging tissues 细微之处见真章老化组织中的纳米级基质变化
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-25 DOI: 10.1016/j.ceb.2024.102322
Avery Rui Sun , Ranmadusha M. Hengst , Jennifer L. Young
{"title":"All the small things: Nanoscale matrix alterations in aging tissues","authors":"Avery Rui Sun ,&nbsp;Ranmadusha M. Hengst ,&nbsp;Jennifer L. Young","doi":"10.1016/j.ceb.2024.102322","DOIUrl":"10.1016/j.ceb.2024.102322","url":null,"abstract":"<div><p>Cellular aging stems from multifaceted intra- and extracellular molecular changes that lead to the gradual deterioration of biological function. Altered extracellular matrix (ECM) properties that include biochemical, structural, and mechanical perturbations direct cellular- and tissue-level dysfunction. With recent advancements in high-resolution imaging modalities and nanomaterial strategies, the importance of nanoscale ECM features has come into focus. Here, we provide an updated window into micro- to nano-scale ECM properties that are altered with age and in age-related disease, and the impact these altered small-scale ECM properties have on cellular function. We anticipate future impactful research will incorporate nanoscale ECM features in the design of new biomaterials and call on the tissue biology field to work collaboratively with the nanomaterials community.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102322"},"PeriodicalIF":7.5,"publicationDate":"2024-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000012/pdfft?md5=51b6140dcaf12c685dbef3afc9565051&pid=1-s2.0-S0955067424000012-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139553437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lamins: The backbone of the nucleocytoskeleton interface 拉明斯核细胞骨架界面的骨架
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-22 DOI: 10.1016/j.ceb.2023.102313
Joan M. Sobo , Nicholas S. Alagna , Sean X. Sun , Katherine L. Wilson , Karen L. Reddy
{"title":"Lamins: The backbone of the nucleocytoskeleton interface","authors":"Joan M. Sobo ,&nbsp;Nicholas S. Alagna ,&nbsp;Sean X. Sun ,&nbsp;Katherine L. Wilson ,&nbsp;Karen L. Reddy","doi":"10.1016/j.ceb.2023.102313","DOIUrl":"10.1016/j.ceb.2023.102313","url":null,"abstract":"<div><p><span><span>The nuclear lamina<span> (NL) is a crucial component of the inner nuclear membrane (INM) and consists of </span></span>lamin<span> filaments and associated proteins. Lamins are type V intermediate filament proteins essential for maintaining the integrity and mechanical properties of the nucleus. In human cells, ‘B-type’ lamins (lamin B1 and lamin B2) are ubiquitously expressed, while ‘A-type’ lamins (lamin A, lamin C, and minor isoforms) are expressed in a tissue- and development-specific manner. Lamins homopolymerize to form filaments that localize primarily near the INM, but A-type lamins also localize to and function in the </span></span>nucleoplasm<span>. Lamins play central roles in the assembly, structure, positioning, and mechanics of the nucleus, modulating cell signaling and influencing development, differentiation, and other activities. This review highlights recent findings on the structure and regulation of lamin filaments, providing insights into their multifaceted functions, including their role as “mechanosensors”, delving into the emerging significance of lamin filaments as vital links between cytoskeletal and nuclear structures, chromatin organization, and the genome.</span></p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102313"},"PeriodicalIF":7.5,"publicationDate":"2024-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139543307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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