发布求助
文献互助 智能选刊 最新文献

Current Opinion in Cell Biology最新文献

筛选
英文 中文
Structuring of the endolysosomal system by HOPS and CORVET tethering complexes HOPS和CORVET系带复合物构建内溶酶体系统
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-04 DOI: 10.1016/j.ceb.2025.102504
Christian Ungermann , Arne Moeller
{"title":"Structuring of the endolysosomal system by HOPS and CORVET tethering complexes","authors":"Christian Ungermann ,&nbsp;Arne Moeller","doi":"10.1016/j.ceb.2025.102504","DOIUrl":"10.1016/j.ceb.2025.102504","url":null,"abstract":"<div><div>Eukaryotic cells depend on their endolysosomal system for membrane protein and organelle turnover, plasma membrane quality control, or regulation of their nutrient uptake. All material eventually ends up in the lytic environment of the lysosome for cellular recycling. At endosomes and lysosomes, the multisubunit complexes CORVET and HOPS tether membranes by binding both their cognate Rab GTPase and specific membrane lipids. Additionally, they carry one Sec1/Munc18-like subunit at their center and thus promote SNARE assembly and, subsequently, bilayer mixing. Recent structural and functional analysis provided insights into their organization and suggested how these complexes combine tethering with fusion catalysis. This review discusses the function and structural organization of HOPS and CORVET in the context of recent studies in yeast and metazoan cells.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102504"},"PeriodicalIF":6.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic structure of the cytoplasm 细胞质的动态结构
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-04-04 DOI: 10.1016/j.ceb.2025.102507
Hyojun Kim, Morgan Delarue
{"title":"Dynamic structure of the cytoplasm","authors":"Hyojun Kim,&nbsp;Morgan Delarue","doi":"10.1016/j.ceb.2025.102507","DOIUrl":"10.1016/j.ceb.2025.102507","url":null,"abstract":"<div><div>The cytoplasm is a dense and complex milieu in which a plethora of biochemical reactions occur. Its structure is not understood so far, albeit being central to cellular functioning. In this review, we highlight a novel perspective in which the physical properties of the cytoplasm are regulated in space and time and actively contribute to cellular function. Furthermore, we underscore recent findings that the dynamic formation of local assemblies within the cytoplasm, such as condensates and polysomes, serves as a key regulator of mesoscale cytoplasmic dynamics.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102507"},"PeriodicalIF":6.0,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143767876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural insights into traffic through the Golgi complex 高尔基大厦交通结构分析
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-03-28 DOI: 10.1016/j.ceb.2025.102505
Bryce A. Brownfield , J. Christopher Fromme
{"title":"Structural insights into traffic through the Golgi complex","authors":"Bryce A. Brownfield ,&nbsp;J. Christopher Fromme","doi":"10.1016/j.ceb.2025.102505","DOIUrl":"10.1016/j.ceb.2025.102505","url":null,"abstract":"<div><div>The Golgi complex is the central sorting station of eukaryotic cells. Several unique trafficking pathways direct the transport of proteins between the Golgi and the endoplasmic reticulum, plasma membrane, and endolysosomal system. In this review we highlight several recent studies that use structural biology approaches to discover and characterize novel mechanisms cells use to control the flow of traffic through the Golgi. These studies provide important new insights into how activation of Arf and Rab GTPases is regulated, how cargo proteins are sorted during vesicle biogenesis, and how vesicle tethers identify their target compartments.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102505"},"PeriodicalIF":6.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143716174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in mitophagy initiation mechanisms 线粒体自噬起始机制的研究进展。
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-03-20 DOI: 10.1016/j.ceb.2025.102493
Catharina Küng , Michael Lazarou , Thanh Ngoc Nguyen
{"title":"Advances in mitophagy initiation mechanisms","authors":"Catharina Küng ,&nbsp;Michael Lazarou ,&nbsp;Thanh Ngoc Nguyen","doi":"10.1016/j.ceb.2025.102493","DOIUrl":"10.1016/j.ceb.2025.102493","url":null,"abstract":"<div><div>Mitophagy is an important lysosomal degradative pathway that removes damaged or unwanted mitochondria to maintain cellular and organismal homeostasis. The mechanisms behind how mitophagy is initiated to form autophagosomes around mitochondria have gained a lot of interest since they can be potentially targeted by mitophagy-inducing therapeutics. Mitophagy initiation can be driven by various autophagy receptors or adaptors that respond to different cellular and mitochondrial stimuli, ranging from mitochondrial damage to metabolic rewiring. This review will cover recent advances in our understanding of how mitophagy is initiated, and by doing so reveal the mechanistic plasticity of how autophagosome formation can begin.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102493"},"PeriodicalIF":6.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
License to drive: Receptor-mediated ER exit of proteins and lipids 驾驶执照：受体介导的蛋白质和脂质内质网出口。
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-03-20 DOI: 10.1016/j.ceb.2025.102501
Xiao Wang , Tiantian Li , Yusong Guo , Xiao-Wei Chen
{"title":"License to drive: Receptor-mediated ER exit of proteins and lipids","authors":"Xiao Wang ,&nbsp;Tiantian Li ,&nbsp;Yusong Guo ,&nbsp;Xiao-Wei Chen","doi":"10.1016/j.ceb.2025.102501","DOIUrl":"10.1016/j.ceb.2025.102501","url":null,"abstract":"<div><div>The secretory pathway, which begins at the endoplasmic reticulum (ER) through the COPII complex, is responsible for transporting proteins and lipid carriers to various destined cellular compartments or extracellular space. The fundamental mechanism by which the COPII operates is evolutionarily conserved. Nevertheless, the vast diversity of mammalian cargos poses significant challenges to the secretory pathway, especially considering the intricate physiology <em>in vivo</em>. Particularly, certain physiologically essential cargos, including procollagen and lipoproteins, appear to be oversized for these canonical carriers, implying the need for additional sophisticated regulation at the onset step so-called ER exit. Emerging evidence highlights the critical role of cargo receptors in selective sorting for ER export, illuminating the complex biology of the trafficking dynamics, which holds broad implications for human health and diseases.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102501"},"PeriodicalIF":6.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143674912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Organizing principles underlying COPII-mediated transport copii介导转运的组织原则
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-03-10 DOI: 10.1016/j.ceb.2025.102492
Julia R. Flood, Caitlin A. Mendina, Anjon Audhya
{"title":"Organizing principles underlying COPII-mediated transport","authors":"Julia R. Flood,&nbsp;Caitlin A. Mendina,&nbsp;Anjon Audhya","doi":"10.1016/j.ceb.2025.102492","DOIUrl":"10.1016/j.ceb.2025.102492","url":null,"abstract":"<div><div>The early secretory pathway governs the transport of thousands of secreted and transmembrane proteins and lipids from the endoplasmic reticulum (ER) to juxtaposed ER-Golgi Intermediate Compartments (ERGIC). This process is largely directed by Coat Protein complex II (COPII), which accumulates on distinct, ribosome-free ER subdomains (transitional ER) to generate highly curved transport intermediates of various sizes and shapes. The rate of secretory flux from the ER can vary significantly, depending on cell type, environmental cues, and other factors, but the mechanisms that regulate COPII-mediated trafficking have been slow to emerge. Here, we focus on recent progress that has contributed to our understanding of how the early secretory pathway is structured to facilitate the export of cargoes from the ER into a chasm approximately 300–500-nm in size, prior to fusion with ERGIC membranes without the aid of cytoskeletal elements to guide their journey.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102492"},"PeriodicalIF":6.0,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
High-dimensional signalling analysis of organoids 类器官的高维信号分析
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-03-09 DOI: 10.1016/j.ceb.2025.102488
Aurélie Dobric, Christopher J. Tape
{"title":"High-dimensional signalling analysis of organoids","authors":"Aurélie Dobric,&nbsp;Christopher J. Tape","doi":"10.1016/j.ceb.2025.102488","DOIUrl":"10.1016/j.ceb.2025.102488","url":null,"abstract":"<div><div>Cellular phenotypes are regulated by dynamic signalling processes that involve proteins, post-translational modifications, epigenetic events, and transcriptional responses. Functional perturbation studies are required to understand cell signalling mechanisms and organoids have recently emerged as scalable biomimetic models amenable to large-scale perturbation. Here, we review the recent advances in high-dimensional analysis of cell signalling in organoids. Single-cell technologies provide cell-type specific analysis of multiple biochemical modalities, enabling a deeper understanding of the signalling mechanisms driving cell-fate dynamics. Emerging multimodal techniques are further revealing coordination between signalling layers and are poised to increase our mechanistic understanding of cell signalling.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102488"},"PeriodicalIF":6.0,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143576799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Multifaceted regulation of asymmetric cell division by the actin cytoskeleton 肌动蛋白细胞骨架对不对称细胞分裂的多方面调控
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-03-07 DOI: 10.1016/j.ceb.2025.102491
Peishan Yi , Guangshuo Ou , Wei Li
{"title":"Multifaceted regulation of asymmetric cell division by the actin cytoskeleton","authors":"Peishan Yi ,&nbsp;Guangshuo Ou ,&nbsp;Wei Li","doi":"10.1016/j.ceb.2025.102491","DOIUrl":"10.1016/j.ceb.2025.102491","url":null,"abstract":"<div><div>Asymmetric cell division (ACD) is essential for generating cell diversity in multicellular eukaryotes, yet the underlying mechanisms remain largely unresolved. Well-established models of ACD, such as microtubule-based spindle displacement in <em>Caenorhabditis elegans</em> embryos and preprophase band assembly in plants provide valuable insights but fail to fully explain asymmetry establishment in others. In this article, we discuss how actin-dependent mechanisms govern ACD in model systems, highlighting emerging commonalities and differences. Given its broad impact, the actin cytoskeleton may play a more significant role in ACD than currently recognized, serving as a fundamental component during organismal development across kingdoms.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102491"},"PeriodicalIF":6.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aneuploidy as a cancer vulnerability 作为癌症易发因素的非整倍体
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-03-06 DOI: 10.1016/j.ceb.2025.102490
Jinghui Cao , Cai Liang , Hongtao Yu
{"title":"Aneuploidy as a cancer vulnerability","authors":"Jinghui Cao ,&nbsp;Cai Liang ,&nbsp;Hongtao Yu","doi":"10.1016/j.ceb.2025.102490","DOIUrl":"10.1016/j.ceb.2025.102490","url":null,"abstract":"<div><div>Aneuploidy is prevalent in cancer and has complicated roles in tumorigenesis. Paradoxically, artificially engineered aneuploidy in normal cells reduces cellular fitness by inducing proteotoxic and genotoxic stresses. A better molecular understanding of the multifaceted roles of aneuploidy in cancer evolution offers promising avenues for future cancer therapies. Here, we discuss the patterns and consequences of aneuploidy in human cancer. We highlight recent efforts to explore aneuploidy as a cancer vulnerability and new interventions that exploit this vulnerability for cancer treatment.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102490"},"PeriodicalIF":6.0,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143561959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial overview: Cell dynamics across biological length scales 编辑概述：跨越生物长度尺度的细胞动力学
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-03-03 DOI: 10.1016/j.ceb.2025.102489
Matthew L. Kutys, Robert Grosse
{"title":"Editorial overview: Cell dynamics across biological length scales","authors":"Matthew L. Kutys,&nbsp;Robert Grosse","doi":"10.1016/j.ceb.2025.102489","DOIUrl":"10.1016/j.ceb.2025.102489","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102489"},"PeriodicalIF":6.0,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143551726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信