Current Opinion in Cell Biology最新文献_第8页

Molecular architecture of the actin cytoskeleton: From single cells to whole organisms using cryo-electron tomography 肌动蛋白细胞骨架的分子结构：利用低温电子断层扫描技术从单细胞到整个生物体

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-04-11 DOI: 10.1016/j.ceb.2024.102356

Jonathan Schneider , Marion Jasnin

引用次数: 0

The multidimensional roles of intermediate filaments - bridging genetic diversity with form, functions, and targets 中间丝的多维作用--连接遗传多样性与形式、功能和目标

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-04-10 DOI: 10.1016/j.ceb.2024.102354

C. Patrick Lusk, John E. Eriksson

引用次数: 0

Editorial overview: Navigating the landscapes of mechanobiology and cell–cell interactions 编辑综述：在机械生物学和细胞-细胞相互作用的景观中航行

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-04-03 DOI: 10.1016/j.ceb.2024.102353

Staffan Strömblad, Yasuyuki Fujita

引用次数: 0

Machines, mechanics and mechanisms of cells and tissues 细胞和组织的机械、力学和机理

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-03-23 DOI: 10.1016/j.ceb.2024.102346

Anne Straube, Kandice Tanner

引用次数: 0

Organelle adaptations in response to mechanical forces during tumour dissemination 肿瘤扩散过程中细胞器对机械力的适应性反应

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-03-12 DOI: 10.1016/j.ceb.2024.102345

Vittoria Graziani , Eva Crosas-Molist , Samantha L. George , Victoria Sanz-Moreno

{"title":"Organelle adaptations in response to mechanical forces during tumour dissemination","authors":"Vittoria Graziani , Eva Crosas-Molist , Samantha L. George , Victoria Sanz-Moreno","doi":"10.1016/j.ceb.2024.102345","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102345","url":null,"abstract":"<div><p>Cell migration plays a pivotal role in various biological processes including cancer dissemination and successful metastasis, where the role of mechanical signals is increasingly acknowledged. This review focuses on the intricate mechanisms through which cancer cells modulate their migratory strategies via organelle adaptations in response to the extracellular matrix (ECM). Specifically, the nucleus and mitochondria emerge as pivotal mediators in this process. These organelles serve as sensors, translating mechanical stimuli into rapid metabolic alterations that sustain cell migration. Importantly, prolonged exposure to such stimuli can induce transcriptional or epigenetic changes, ultimately enhancing metastatic traits. Deciphering the intricate interplay between ECM properties and organelle adaptations not only advances our understanding of cytoskeletal dynamics but also holds promise for the development of innovative anti-metastatic therapeutic strategies.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102345"},"PeriodicalIF":7.5,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000243/pdfft?md5=20520a4520c714f72e6bb8fa77c730b5&pid=1-s2.0-S0955067424000243-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140113872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outside Back Cover 封底外侧

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-03-12 DOI: 10.1016/S0955-0674(24)00031-0

引用次数: 0

Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues 将布里渊显微镜技术整合到细胞和组织多模态机械制图中的优势

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-03-11 DOI: 10.1016/j.ceb.2024.102341

Chenchen Handler , Claudia Testi , Giuliano Scarcelli

{"title":"Advantages of integrating Brillouin microscopy in multimodal mechanical mapping of cells and tissues","authors":"Chenchen Handler , Claudia Testi , Giuliano Scarcelli","doi":"10.1016/j.ceb.2024.102341","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102341","url":null,"abstract":"<div><p>Recent research has highlighted the growing significance of the mechanical properties of cells and tissues in the proper execution of physiological functions within an organism; alterations to these properties can potentially result in various diseases. These mechanical properties can be assessed using various techniques that vary in spatial and temporal resolutions as well as applications. Due to the wide range of mechanical behaviors exhibited by cells and tissues, a singular mapping technique may be insufficient in capturing their complexity and nuance. Consequently, by utilizing a combination of methods–multimodal mechanical mapping–researchers can achieve a more comprehensive characterization of mechanical properties, encompassing factors such as stiffness, modulus, viscoelasticity, and forces. Furthermore, different mapping techniques can provide complementary information and enable the exploration of spatial and temporal variations to enhance our understanding of cellular dynamics and tissue mechanics. By capitalizing on the unique strengths of each method while mitigating their respective limitations, a more precise and holistic understanding of cellular and tissue mechanics can be obtained. Here, we spotlight Brillouin microscopy (BM) as a noncontact, noninvasive, and label-free mechanical mapping modality to be coutilized alongside established mechanical probing methods. This review summarizes some of the most widely adopted individual mechanical mapping techniques and highlights several recent multimodal approaches demonstrating their utility. We envision that future studies aim to adopt multimodal techniques to drive advancements in the broader realm of mechanobiology.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"88 ","pages":"Article 102341"},"PeriodicalIF":7.5,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140103519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Engines of change: Nonmuscle myosin II in mechanobiology 变革的引擎：机械生物学中的非肌肉肌球蛋白 II

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-03-04 DOI: 10.1016/j.ceb.2024.102344

Marina Garrido-Casado, Gloria Asensio-Juárez, Vanessa C. Talayero, Miguel Vicente-Manzanares

{"title":"Engines of change: Nonmuscle myosin II in mechanobiology","authors":"Marina Garrido-Casado, Gloria Asensio-Juárez, Vanessa C. Talayero, Miguel Vicente-Manzanares","doi":"10.1016/j.ceb.2024.102344","DOIUrl":"https://doi.org/10.1016/j.ceb.2024.102344","url":null,"abstract":"<div><p>The emergence of mechanobiology has unveiled complex mechanisms by which cells adjust intracellular force production to their needs. Most communicable intracellular forces are generated by myosin II, an actin-associated molecular motor that transforms adenosine triphosphate (ATP) hydrolysis into contraction in nonmuscle and muscle cells. Myosin II-dependent force generation is tightly regulated, and deregulation is associated with specific pathologies. Here, we focus on the role of myosin II (nonmuscle myosin II, NMII) in force generation and mechanobiology. We outline the regulation and molecular mechanism of force generation by NMII, focusing on the actual outcome of contraction, that is, force application to trigger mechanosensitive events or the building of dissipative structures. We describe how myosin II-generated forces drive two major types of events: modification of the cellular morphology and/or triggering of genetic programs, which enhance the ability of cells to adapt to, or modify, their microenvironment. Finally, we address whether targeting myosin II to impair or potentiate its activity at the motor level is a viable therapeutic strategy, as illustrated by recent examples aimed at modulating cardiac myosin II function in heart disease.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"87 ","pages":"Article 102344"},"PeriodicalIF":7.5,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067424000231/pdfft?md5=8a506b8bb2567b96124253e9f8a84a74&pid=1-s2.0-S0955067424000231-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140024114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in label-free imaging and quantification techniques for the study of lipid droplets in cells 用于研究细胞中脂滴的无标记成像和量化技术的最新进展

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-02-29 DOI: 10.1016/j.ceb.2024.102342

Hyeonwoo Kim , Seungeun Oh , Seongsoo Lee , Kwang suk Lee , YongKeun Park

引用次数: 0

Editorial overview: Functional specialization of the cytoskeleton in diverse cell types 编辑综述：不同细胞类型中细胞骨架的功能特化

IF 7.5 2区生物学

Current Opinion in Cell Biology Pub Date : 2024-02-23 DOI: 10.1016/j.ceb.2024.102343

Adele Marston, Matthew J. Tyska

引用次数: 0