Multifaceted regulation of asymmetric cell division by the actin cytoskeleton

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-03-07 DOI:10.1016/j.ceb.2025.102491

Peishan Yi , Guangshuo Ou , Wei Li

引用次数: 0

Abstract

Asymmetric cell division (ACD) is essential for generating cell diversity in multicellular eukaryotes, yet the underlying mechanisms remain largely unresolved. Well-established models of ACD, such as microtubule-based spindle displacement in Caenorhabditis elegans embryos and preprophase band assembly in plants provide valuable insights but fail to fully explain asymmetry establishment in others. In this article, we discuss how actin-dependent mechanisms govern ACD in model systems, highlighting emerging commonalities and differences. Given its broad impact, the actin cytoskeleton may play a more significant role in ACD than currently recognized, serving as a fundamental component during organismal development across kingdoms.

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肌动蛋白细胞骨架对不对称细胞分裂的多方面调控

在多细胞真核生物中，不对称细胞分裂（ACD）是产生细胞多样性的必要条件，但其潜在机制在很大程度上仍未得到解决。成熟的ACD模型，如秀丽隐杆线虫胚胎中基于微管的纺锤体位移和植物的前期带组装，提供了有价值的见解，但不能完全解释其他不对称的建立。在本文中，我们讨论了作用蛋白依赖机制如何在模型系统中控制ACD，突出了新出现的共性和差异。鉴于其广泛的影响，肌动蛋白细胞骨架可能在ACD中发挥比目前认识到的更重要的作用，作为跨王国生物体发育的基本组成部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.