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Outside Back Cover 外封底
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-07-22 DOI: 10.1016/S0955-0674(25)00115-2
{"title":"Outside Back Cover","authors":"","doi":"10.1016/S0955-0674(25)00115-2","DOIUrl":"10.1016/S0955-0674(25)00115-2","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102577"},"PeriodicalIF":6.0,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679055","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging phylogenetic diversity: Cellular dynamics in non-model organisms 利用系统发育多样性：非模式生物的细胞动力学
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-07-19 DOI: 10.1016/j.ceb.2025.102568
Sarah L. Guest , Arthur T. Molines
{"title":"Leveraging phylogenetic diversity: Cellular dynamics in non-model organisms","authors":"Sarah L. Guest ,&nbsp;Arthur T. Molines","doi":"10.1016/j.ceb.2025.102568","DOIUrl":"10.1016/j.ceb.2025.102568","url":null,"abstract":"<div><div>Cell biologists use a severely undersampled population of eukaryotes as model organisms to infer cellular processes across an immense diversity. In consequence, mechanisms are defined in only a few lineages. Here, we highlight cellular behaviors not observed in model organisms. We describe examples (multicellular and protistan) from several major supergroups (TSAR, Haptista, Archaeplastida, Amorphea, Excavates), focusing on species for which quantified dynamic measurements are available. Through these examples, we discuss how these behaviors and underlying dynamics matter for the cell biology community. We aim to increase the awareness of such organisms and familiarize readers with the diversity of behaviors present in nature. By expanding the bestiary of organisms available to researchers, we can obtain a better picture of eukaryotic cells' features and capabilities.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"Article 102568"},"PeriodicalIF":6.0,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144663243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cytoskeletal scaffolding of NaVs and KVs in neocortical pyramidal neurons: Implications for neuronal signaling and plasticity 新皮质锥体神经元中nav和kv的细胞骨架支架：对神经元信号传导和可塑性的影响
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-07-16 DOI: 10.1016/j.ceb.2025.102570
Carina C. Elvira , Paul M. Jenkins
{"title":"Cytoskeletal scaffolding of NaVs and KVs in neocortical pyramidal neurons: Implications for neuronal signaling and plasticity","authors":"Carina C. Elvira ,&nbsp;Paul M. Jenkins","doi":"10.1016/j.ceb.2025.102570","DOIUrl":"10.1016/j.ceb.2025.102570","url":null,"abstract":"<div><div>The initiation and propagation of action potentials (APs) depend on the precise localization of voltage-gated sodium (Na<sub>V</sub>) and potassium (K<sub>V</sub>) channels in neurons. In neocortical pyramidal neurons, Na<sub>V</sub>1.2 and Na<sub>V</sub>1.6 are key at the axon initial segment (AIS) and nodes of Ranvier (noR), driving AP initiation and propagation. Na<sub>V</sub>1.2 also supports AP backpropagation in the soma and dendrites. Ankyrin-G anchors these channels at the AIS and noR, while new findings reveal that ankyrin-B scaffolds Na<sub>V</sub>1.2 in dendrites. This review highlights how ankyrins stabilize Na<sub>V</sub> and K<sub>V</sub> channels across neuronal domains, ensuring proper function crucial for excitability, synaptic plasticity, and signaling. Recent findings explore how ankyrins differentially localize Na<sub>V</sub>1.2 and Na<sub>V</sub>1.6, with implications for understanding neurological disorders linked to disrupted channel localization.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"Article 102570"},"PeriodicalIF":6.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144633763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Controlling cell architecture with protein design 用蛋白质设计控制细胞结构
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-07-15 DOI: 10.1016/j.ceb.2025.102569
Jessica A. Cross , Derek N. Woolfson , Mark P. Dodding
{"title":"Controlling cell architecture with protein design","authors":"Jessica A. Cross ,&nbsp;Derek N. Woolfson ,&nbsp;Mark P. Dodding","doi":"10.1016/j.ceb.2025.102569","DOIUrl":"10.1016/j.ceb.2025.102569","url":null,"abstract":"<div><div>Cells depend on a complex and precisely regulated subcellular organization, largely driven by the cytoskeleton and motor proteins that control intracellular transport. This review explores innovative strategies to manipulate cellular architecture using targeted protein design and engineering of cytoskeletal elements and molecular motors. We highlight advances in inducible dimerization techniques, which enable precise control over cytoskeletal dynamics through light- and small-molecule-sensitive domains. In addition, we discuss modifications to motor proteins that alter directionality, processivity, and cargo specificity, providing insights into their roles in cellular transport. Rapid advances in <em>de novo</em> protein design offer new tools to hijack natural cytoskeletal machinery and create synthetic elements for cellular architecture, including membraneless organelles and synthetic cytoskeletal tracks. This research promises to deepen our understanding of cellular organization, uncover regulatory mechanisms, and provide new proteins for therapeutic applications and synthetic cell development.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"Article 102569"},"PeriodicalIF":6.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer-associated fibroblasts as mediators of tissue microenvironment remodeling in cancer 癌症相关成纤维细胞作为癌症组织微环境重塑的介质
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-07-14 DOI: 10.1016/j.ceb.2025.102567
Fernanda G. Kugeratski , Emily J. Kay , Sara Zanivan
{"title":"Cancer-associated fibroblasts as mediators of tissue microenvironment remodeling in cancer","authors":"Fernanda G. Kugeratski ,&nbsp;Emily J. Kay ,&nbsp;Sara Zanivan","doi":"10.1016/j.ceb.2025.102567","DOIUrl":"10.1016/j.ceb.2025.102567","url":null,"abstract":"<div><div>Cancer-associated fibroblasts (CAFs) are a multifunctional cell population of solid tumors that substantially remodel the tumor microenvironment (TME). The combination of single-cell and spatial technologies with elegant mouse models and analysis of patient samples is enabling unprecedented advances in the characterization of CAF origins, heterogeneity, and functions within the TME. As such, the field is now evolving to delineate tissue-specific subpopulations of CAFs, their markers, and the biological context in which each subset presents with a tumor-promoting or a tumor-restraining function. In this timely review, we discuss recent advances in CAF biology in the context of emerging areas of interest in the field of anticancer therapy: immunotherapy, metabolism, and extracellular vesicles. We also highlight the substantial role of CAFs in modulating the immune microenvironment and the recent advances in targeting CAFs for cancer treatment.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"Article 102567"},"PeriodicalIF":6.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mathematical modelling of cancer cell evolution and plasticity 癌细胞进化和可塑性的数学建模
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-07-09 DOI: 10.1016/j.ceb.2025.102558
Chloé Colson, Frederick JH. Whiting, Ann-Marie Baker, Trevor A. Graham
{"title":"Mathematical modelling of cancer cell evolution and plasticity","authors":"Chloé Colson,&nbsp;Frederick JH. Whiting,&nbsp;Ann-Marie Baker,&nbsp;Trevor A. Graham","doi":"10.1016/j.ceb.2025.102558","DOIUrl":"10.1016/j.ceb.2025.102558","url":null,"abstract":"<div><div>In this review, we argue that mathematical modelling is an essential tool for understanding cancer cell evolution and phenotypic plasticity. We show that mathematical models enable us to reconstruct time-dependent tumour evolutionary dynamics from temporally-restricted biological data. In their ability to capture complex biological processes, they also serve as a means for <em>in silico</em> experimentation. In particular, they allow us to investigate different biological hypotheses and generate experimentally-testable predictions about underlying mechanisms of phenotype evolution and treatment resistance. Finally, mathematical models can reveal which biological data is informative, and, in combination with our understanding of which biological hypotheses need to be tested, they can guide experimental and clinical trial design.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102558"},"PeriodicalIF":6.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144580438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signaling mechanisms in the reactivation of quiescent neural stem cells in Drosophila 果蝇静止神经干细胞再激活的信号机制
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-07-07 DOI: 10.1016/j.ceb.2025.102566
Mahekta R. Gujar , Hongyan Wang
{"title":"Signaling mechanisms in the reactivation of quiescent neural stem cells in Drosophila","authors":"Mahekta R. Gujar ,&nbsp;Hongyan Wang","doi":"10.1016/j.ceb.2025.102566","DOIUrl":"10.1016/j.ceb.2025.102566","url":null,"abstract":"<div><div>Neural stem cells (NSCs) play a central role in the nervous system development and regeneration. In the adult mammalian brain, most NSCs remain in a quiescent state, but they can exit quiescence and become active, leading to the generation of new neurons. Maintaining a balance between NSC quiescence and activation is important for adult neurogenesis. Similar to their mammalian counterparts, <em>Drosophila</em> NSCs transition between quiescence and reactivation. This review summarizes the latest insights into the molecular processes driving the reactivation of quiescent NSCs in the <em>Drosophila</em> larval brain. We focus on recent advances in stem cell niches, cytoskeletal proteins, and both transcriptional and posttranslational regulations during NSC reactivation, as well as a new regeneration model in the <em>Drosophila</em> brain.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"Article 102566"},"PeriodicalIF":6.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144571104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arp2/3-complex regulation – Novel insights and open questions arp2 /3-复杂的规则-新颖的见解和开放的问题
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-25 DOI: 10.1016/j.ceb.2025.102565
Theresia E.B. Stradal , Micaela Boiero Sanders , Peter Bieling
{"title":"Arp2/3-complex regulation – Novel insights and open questions","authors":"Theresia E.B. Stradal ,&nbsp;Micaela Boiero Sanders ,&nbsp;Peter Bieling","doi":"10.1016/j.ceb.2025.102565","DOIUrl":"10.1016/j.ceb.2025.102565","url":null,"abstract":"<div><div>Arp2/3 complex is a central actin filament generator driving numerous motile processes in cells. It was originally isolated from Acanthamoeba approx. 30 years ago. It is highly conserved throughout eukaryotic life and composed of 7 subunits, two of which are actin related proteins, ARP2 and ARP3. Since then the modalities of its regulation were continuously unraveled, bringing about a large number of proteins that affect its activity. We here set out to briefly review our current knowledge and identify open questions that demand answers and add new twists, advancing our understanding to reflect physiological complexity.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102565"},"PeriodicalIF":6.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144480114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of left–right symmetry breaking across scales 跨尺度的左右对称破缺机制
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-21 DOI: 10.1016/j.ceb.2025.102564
Nikoloz Tsikolia , Dinh Thach Lam Nguyen , Yee Han Tee
{"title":"Mechanisms of left–right symmetry breaking across scales","authors":"Nikoloz Tsikolia ,&nbsp;Dinh Thach Lam Nguyen ,&nbsp;Yee Han Tee","doi":"10.1016/j.ceb.2025.102564","DOIUrl":"10.1016/j.ceb.2025.102564","url":null,"abstract":"<div><div>Establishment of left–right (LR) asymmetry relies on a multistep interplay of molecular signaling and physical processes. Initial LR symmetry breaking in several model vertebrates was shown to take place at the LR organizer (LRO) where chiral rotation of monocilia produces a leftward fluid flow. Subsequent bending of sensory cilia triggers Pkd2-channel–mediated calcium transients which in turn are required for induction of asymmetrical signaling upstream of morphological asymmetries, emphasizing the role of mechanosensation in flow detection. Crucially, unidirectional flow and its detection were suggested to require cellular-scale asymmetries including planar cell polarity–mediated posterior position and ultrastructural chirality of motile cilia as well as asymmetric Pkd2 localization within sensory cilia. Alternative mechanisms of LR symmetry breaking operate in models like the chick embryo, where asymmetry of gene expression is preceded by leftward primitive node rotation suggesting mechanisms based on cytoskeletal chirality known from invertebrate models including <em>Caenorhabditis elegans</em> and fruit fly. Investigation of chirality at the cellular level suggests that chirality of components of cytoskeleton, particularly actin filaments, is amplified by distinct modules based i.e. on formin-actin and myosin-actin interactions which drive intracellular swirling and cortical flow, providing a basis for LR asymmetry. Cellular chirality can organize LR asymmetry of multicellular behavior as observed in the chiral alignment of fibroblasts. The integration of molecular, cellular, and tissue-scale chirality highlights conserved and divergent mechanisms underpinning LR symmetry breaking across species. Unraveling these processes may illuminate pathways connecting cytoskeletal dynamics to organismal asymmetry, offering insights into development and evolution.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102564"},"PeriodicalIF":6.0,"publicationDate":"2025-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macropinocytosis: Molecular mechanisms and regulation 巨量红细胞增多症：分子机制和调控
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-17 DOI: 10.1016/j.ceb.2025.102563
Hui Tu , Haibin Wang , Huaqing Cai
{"title":"Macropinocytosis: Molecular mechanisms and regulation","authors":"Hui Tu ,&nbsp;Haibin Wang ,&nbsp;Huaqing Cai","doi":"10.1016/j.ceb.2025.102563","DOIUrl":"10.1016/j.ceb.2025.102563","url":null,"abstract":"<div><div>Macropinocytosis is a conserved pathway for non-selective bulk uptake of extracellular fluid. It plays important roles in various cellular processes, including nutrient acquisition in <em>Dictyostelium</em> and cancer cells and antigen sampling by immune cells. This process is initiated by localized actin polymerization, which drives the formation of membrane protrusions that close to generate macropinosomes. Once formed, macropinosomes undergo maturation and traffic through the endolysosomal system for cargo degradation, whereas non-degradable material is exocytosed. Recent studies have uncovered conserved regulatory networks controlling macropinosome formation and maturation. This review provides an overview of these pathways, highlighting key molecular regulators and their coordinated responses to environmental signals. We also examine the interplay between macropinocytosis and cell migration, discussing potential mechanisms that balance these processes to optimize cellular function.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102563"},"PeriodicalIF":6.0,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144298873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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