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Current Opinion in Cell Biology最新文献

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New insights into signaling networks coordinating epidermal stem cell regulation in skin regeneration and aging 在皮肤再生和衰老中协调表皮干细胞调节的信号网络的新见解。
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-10-07 DOI: 10.1016/j.ceb.2025.102594
Mizuho Ishikawa , Hung Manh Phung , Thisakorn Dumrongphuttidecha , Aiko Sada
{"title":"New insights into signaling networks coordinating epidermal stem cell regulation in skin regeneration and aging","authors":"Mizuho Ishikawa ,&nbsp;Hung Manh Phung ,&nbsp;Thisakorn Dumrongphuttidecha ,&nbsp;Aiko Sada","doi":"10.1016/j.ceb.2025.102594","DOIUrl":"10.1016/j.ceb.2025.102594","url":null,"abstract":"<div><div>The skin is a dynamic, regenerative organ capable of withstanding diverse internal and external stresses, supported by tissue-resident stem cells. A complex signaling network regulates interactions between epidermal stem cells, dermal cells, immune cells, and the extracellular matrix to maintain tissue integrity. Disruptions in these signaling pathways can impair cellular communication, alter stem cell lineage commitment, and compromise epidermal stem cell identity, ultimately resulting in a loss of coordinated tissue function. In this review, we highlight recent insights into three key signaling factors—metabolic, mechanical, and inflammatory cues—that regulate epidermal stem cell behavior during homeostasis, regeneration, and aging. We further discuss how dysregulation of these pathways contributes to pathological skin remodeling and explore emerging intervention strategies targeting signaling molecules to restore epidermal stem cell function and skin health.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"97 ","pages":"Article 102594"},"PeriodicalIF":4.3,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145253534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KASH proteins transform from passive tethers to dynamic conductors of motor-driven nuclear dynamics. KASH蛋白从被动系绳转变为动力驱动核动力学的动态导体。
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-10-01 Epub Date: 2025-08-10 DOI: 10.1016/j.ceb.2025.102578
G W Gant Luxton, Selin Gümüşderelioğlu, Kassandra M Ori-McKenney, Daniel A Starr, Richard J McKenney
{"title":"KASH proteins transform from passive tethers to dynamic conductors of motor-driven nuclear dynamics.","authors":"G W Gant Luxton, Selin Gümüşderelioğlu, Kassandra M Ori-McKenney, Daniel A Starr, Richard J McKenney","doi":"10.1016/j.ceb.2025.102578","DOIUrl":"10.1016/j.ceb.2025.102578","url":null,"abstract":"<p><p>Nuclear-cytoskeletal coupling orchestrates critical cellular processes from migration to tissue organization. At the core of this machinery, outer nuclear membrane Klarsicht/ANC-1/SYNE homology (KASH) proteins function as sophisticated molecular conductors rather than simple structural tethers. This review examines three principles redefining these versatile proteins: specialized interfaces for selective microtubule motor protein recruitment that orchestrate diverse chromosomal and nuclear dynamics, coordination of multiple cytoskeletal systems through simultaneous engagement with actin and microtubules, and tissue-specific regulation that explains the diverse KASH protein-related disease manifestations. This framework provides insights into conditions from muscular dystrophy to neurodegeneration and suggests targeted therapeutic opportunities.</p>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"102578"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144823153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From images to understanding: Advances in deep learning for cellular dynamics analysis 从图像到理解：细胞动力学分析的深度学习进展。
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-10-01 DOI: 10.1016/j.ceb.2025.102585
Benjamin Woodhams , Virginie Uhlmann
{"title":"From images to understanding: Advances in deep learning for cellular dynamics analysis","authors":"Benjamin Woodhams ,&nbsp;Virginie Uhlmann","doi":"10.1016/j.ceb.2025.102585","DOIUrl":"10.1016/j.ceb.2025.102585","url":null,"abstract":"<div><div>Deep learning (DL) has revolutionized bioimage analysis, enabling unprecedented insights into cellular dynamics. This review provides an overview of state-of-the-art DL approaches for quantifying cellular dynamics from 2D microscopy images, considering the three fundamental steps in dynamics analysis: identifying objects in space through segmentation, connecting them through time via tracking, and extracting meaningful measurements from their resulting trajectories. We highlight how recent methodological innovations in DL are complementing more classical, long-established algorithms, and discuss emerging trends as well as the importance of ensuring that DL-powered cellular dynamics analysis remains scientifically sound and accessible. By discussing methodological advances and pointing to available practical tools, this review aims to bridge the gap between computational expertise and biological applications, providing guidance to help navigate this rapidly evolving field and identify approaches that are relevant to specific research questions.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"97 ","pages":"Article 102585"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145214123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of cellular fitness and cell competition: Towards an integrated view. 细胞适应和细胞竞争的机制：迈向一个综合的观点。
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-10-01 Epub Date: 2025-08-09 DOI: 10.1016/j.ceb.2025.102571
Jules Lavalou, Karyna Kulakova, Yogaspoorthi J Subramaniam, Eugenia Piddini
{"title":"Mechanisms of cellular fitness and cell competition: Towards an integrated view.","authors":"Jules Lavalou, Karyna Kulakova, Yogaspoorthi J Subramaniam, Eugenia Piddini","doi":"10.1016/j.ceb.2025.102571","DOIUrl":"10.1016/j.ceb.2025.102571","url":null,"abstract":"<p><p>Cell competition is a fundamental mechanism of tissue quality control that enables the selective elimination of less fit, mis-specified, diseased or aged cells. By shaping tissue composition, it plays a critical role in development, organismal health and a wide range of physiological and pathological contexts, including cancer. As its biological significance continues to grow, elucidating the molecular mechanisms underlying cell competition is essential for advancing our understanding of tissue biology, disease progression and future therapeutic strategies. In this review, we highlight recently identified, evolutionarily conserved pathways that govern cell competition through metabolites and systemic signals, proteostasis and mechanical exchange. By integrating findings across species and pathways, we reveal how these distinct mechanisms may intersect and coordinate to determine competitive outcomes, providing a conceptual framework to inform and guide future research.</p>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"102571"},"PeriodicalIF":4.3,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144818112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic regulation of cell death signaling 细胞死亡信号的动态调控
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-09-26 DOI: 10.1016/j.ceb.2025.102583
Asma Majoul , Ana J. Garcia-Saez
{"title":"Dynamic regulation of cell death signaling","authors":"Asma Majoul ,&nbsp;Ana J. Garcia-Saez","doi":"10.1016/j.ceb.2025.102583","DOIUrl":"10.1016/j.ceb.2025.102583","url":null,"abstract":"<div><div>There are many ways for a cell to die, but each cell only dies once, causing an inherent variability that results from common triggers activating interconnected signaling networks that diverge at key decision points during cell death initiation, progression, and execution. Despite the death of each cell being a unique biomolecular event, shared features allow us to categorize the process depending on the pathways activated and their outcomes. Here we outline core concepts about the dynamic interplay between cell death pathways, focusing on apoptosis, necroptosis, pyroptosis, and ferroptosis. We highlight unresolved decision points, including the dynamics of pore formation and the points of no return. We also discuss conceptual commonalities across systems and outline key recent developments that refine our understanding of the dynamic regulation of cell death.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"97 ","pages":"Article 102583"},"PeriodicalIF":4.3,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modeling cytoskeletal and cell dynamics 模拟细胞骨架和细胞动力学
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-09-25 DOI: 10.1016/j.ceb.2025.102584
Christoph Anton , Franziska Lautenschläger , Rhoda J. Hawkins
{"title":"Modeling cytoskeletal and cell dynamics","authors":"Christoph Anton ,&nbsp;Franziska Lautenschläger ,&nbsp;Rhoda J. Hawkins","doi":"10.1016/j.ceb.2025.102584","DOIUrl":"10.1016/j.ceb.2025.102584","url":null,"abstract":"<div><div>Here we give an overview of recent theoretical and experimental work on modeling the mechanics and dynamics of the cytoskeleton. The cytoskeleton is a multicomponent, complex and active material that is essential to cell mechanics and dynamics. We focus on one of the main components of this material, namely actin filaments. We discuss these filaments and their interactions with other proteins within the cytoskeleton. To fully understand the cytoskeleton, it is important to consider both theoretical and experimental work in calculo, in silico, in vitro, in vivo, and in situ. We review the current state of knowledge and look forward to further work to come on aspects not yet understood.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"97 ","pages":"Article 102584"},"PeriodicalIF":4.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Roles of molecular motors in insulin-secreting beta cells 分子马达在胰岛素分泌β细胞中的作用
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-09-22 DOI: 10.1016/j.ceb.2025.102582
Syed N. Barmaver, Guoqiang Gu, Irina Kaverina
{"title":"Roles of molecular motors in insulin-secreting beta cells","authors":"Syed N. Barmaver,&nbsp;Guoqiang Gu,&nbsp;Irina Kaverina","doi":"10.1016/j.ceb.2025.102582","DOIUrl":"10.1016/j.ceb.2025.102582","url":null,"abstract":"<div><div>Pancreatic β cells are essential for glucose homeostasis through the regulated secretion of insulin in response to rising glucose levels. A critical component of this process is the precise and timely positioning of insulin secretory granules (ISGs) at the secretion sites on the plasma membrane. This positioning is mediated by molecular motors that transport ISGs along cytoskeletal tracks, including microtubules (MTs) and actin filaments. Despite their importance, the roles of molecular motors in insulin-secreting β cells remain incompletely understood. In this review, we summarize current findings on the involvement of molecular motors both in ISG transport, directly regulating granule availability for secretion, and in the organization of other subcellular structures, thereby indirectly influencing secretion. These indirect roles include kinesin-1-mediated microtubule sliding that configures the β cell-specific MT network, the spatial organization of calcium channels, and mitochondrial positioning, among others. We also draw parallels between β cells and neurons, proposing that insights from neuronal motor protein studies can guide future research directions in β cell biology.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"97 ","pages":"Article 102582"},"PeriodicalIF":4.3,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145119922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cell signaling across scales in health and disease 健康和疾病中的细胞信号传导
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-09-13 DOI: 10.1016/j.ceb.2025.102581
Victoria Sanz-Moreno, Boon Chuan Low
{"title":"Cell signaling across scales in health and disease","authors":"Victoria Sanz-Moreno,&nbsp;Boon Chuan Low","doi":"10.1016/j.ceb.2025.102581","DOIUrl":"10.1016/j.ceb.2025.102581","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"97 ","pages":"Article 102581"},"PeriodicalIF":4.3,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outside Back Cover 外封底
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-09-09 DOI: 10.1016/S0955-0674(25)00130-9
{"title":"Outside Back Cover","authors":"","doi":"10.1016/S0955-0674(25)00130-9","DOIUrl":"10.1016/S0955-0674(25)00130-9","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"Article 102592"},"PeriodicalIF":4.3,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechanisms of transmembrane domain recognition during endoplasmic reticulum quality control 内质网质量控制中跨膜结构域识别的机制
IF 4.3 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-08-22 DOI: 10.1016/j.ceb.2025.102580
Nikita Sergejevs, Pedro Carvalho
{"title":"Mechanisms of transmembrane domain recognition during endoplasmic reticulum quality control","authors":"Nikita Sergejevs,&nbsp;Pedro Carvalho","doi":"10.1016/j.ceb.2025.102580","DOIUrl":"10.1016/j.ceb.2025.102580","url":null,"abstract":"<div><div>Misfolded proteins can be toxic to cells, and their accumulation is a hallmark of diseases such as neurodegeneration. Normally, protein homeostasis is maintained by quality control processes that eliminate misfolded proteins. In the endoplasmic reticulum (ER), misfolded proteins are eliminated through endoplasmic reticulum–associated degradation (ERAD). This process is mediated by ubiquitin ligase complexes that recognize substrates in the membrane and lumen of the ER and retrotranslocate them to the cytosol to mediate their ubiquitination for subsequent degradation by the proteasome. While the recognition of luminal substrates is well understood, how ERAD complexes specifically identify and select aberrant membrane proteins remains poorly defined. Here, we review examples of intramembrane substrate recognition during ERAD and discuss the principles involved.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"96 ","pages":"Article 102580"},"PeriodicalIF":4.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144885419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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