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Current Opinion in Cell Biology最新文献

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Biogenesis, function and evolution of the archaeal S-layer 古细菌s层的生物发生、功能和进化
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-29 DOI: 10.1016/j.ceb.2025.102534
Shamphavi Sivabalasarma , Marleen van Wolferen , Sonja-Verena Albers , Arthur Charles-Orszag
{"title":"Biogenesis, function and evolution of the archaeal S-layer","authors":"Shamphavi Sivabalasarma ,&nbsp;Marleen van Wolferen ,&nbsp;Sonja-Verena Albers ,&nbsp;Arthur Charles-Orszag","doi":"10.1016/j.ceb.2025.102534","DOIUrl":"10.1016/j.ceb.2025.102534","url":null,"abstract":"<div><div>The archaeal S-layer represents one of the most ancient and versatile cell surface structures, playing critical roles in maintaining cellular integrity, mediating environmental interactions, and enabling cellular flexibility. Recent advances in structural biology, including cryo-electron microscopy and computational tools like AlphaFold, have unveiled the structural intricacies and diversity of these proteinaceous layers. This review highlights the biogenesis, structural assembly, evolutionary adaptations, and functional roles of archaeal S-layers, focusing on model organisms such as <em>Sulfolobus acidocaldarius</em> and <em>Haloferax volcanii</em>. Additionally, we discuss outstanding questions and future directions for the study of archaeal cell envelopes.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102534"},"PeriodicalIF":6.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The power of connections: Recent advances in understanding the regulation of mitochondrial dynamics by membrane contact sites 连接的力量：通过膜接触位点理解线粒体动力学调节的最新进展
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-28 DOI: 10.1016/j.ceb.2025.102535
Jason C. Casler, Laura L. Lackner
{"title":"The power of connections: Recent advances in understanding the regulation of mitochondrial dynamics by membrane contact sites","authors":"Jason C. Casler,&nbsp;Laura L. Lackner","doi":"10.1016/j.ceb.2025.102535","DOIUrl":"10.1016/j.ceb.2025.102535","url":null,"abstract":"<div><div>The continuous remodeling of the mitochondrial network through fusion, fission, transport, and turnover events, collectively known as mitochondrial dynamics, is essential for the maintenance of mitochondrial metabolic and genomic health. While the primary molecular machines that mediate these processes were discovered decades ago, the regulation of mitochondrial dynamics clearly involves additional factors. A major breakthrough came from the discovery that sites of close apposition between organelles, known as membrane contact sites (MCSs), serve as critical regulators of organelle function. MCSs between mitochondria and the ER are now universally recognized as important regulatory hubs of mitochondrial dynamics. Despite this, there are still many unknowns pertaining to the mechanisms by which MCSs influence mitochondrial dynamics. In this review, we describe recent progress identifying novel protein and lipid components that regulate mitochondrial dynamics and emphasize clear gaps in our understanding of how mitochondrial dynamics are coordinated at MCSs. Finally, we conclude by discussing progress towards defining the highly biomedically relevant, but enigmatic, role of mitochondrial dynamics in the preservation of mitochondrial DNA integrity.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102535"},"PeriodicalIF":6.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Chromosomal instability in development and disease: Beyond cancer evolution 发育和疾病中的染色体不稳定性：超越癌症进化
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-28 DOI: 10.1016/j.ceb.2025.102537
Marco Milán
{"title":"Chromosomal instability in development and disease: Beyond cancer evolution","authors":"Marco Milán","doi":"10.1016/j.ceb.2025.102537","DOIUrl":"10.1016/j.ceb.2025.102537","url":null,"abstract":"<div><div>Chromosomal instability (CIN), an increased rate of changes in chromosome structure and number, has been classically associated with human disease as a way of evolving the cancer genome. In recent years, three additional research lines concerning the impact of CIN on human disease have been consolidated. First, beyond the generation of genomic copy number heterogeneity, CIN acts as a source of tumor growth, metastasis, and malignancy through additional mechanisms. Second, CIN is pervasive in early human development, and the resulting aneuploid cells are selectively removed from the fetus to give rise to healthy births. Third, CIN is associated with mosaic variegated aneuploidy, a rare familial disease that compromises brain development and contributes to tumor formation. Here, I will review recent advances in these three topics, with a particular focus on the use of model systems and organisms to understand the increasing impact of CIN on human biology and disease.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102537"},"PeriodicalIF":6.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Overview - Membrane traffic; orchestrating the symphony of life 编辑综述-膜交通；谱写生命的交响曲
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-28 DOI: 10.1016/j.ceb.2025.102532
Robert G. Parton, Lois S. Weisman
{"title":"Editorial Overview - Membrane traffic; orchestrating the symphony of life","authors":"Robert G. Parton,&nbsp;Lois S. Weisman","doi":"10.1016/j.ceb.2025.102532","DOIUrl":"10.1016/j.ceb.2025.102532","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102532"},"PeriodicalIF":6.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mitotic signalling in progenitor cells: Integrating cell division with cell specification 祖细胞中的有丝分裂信号：整合细胞分裂与细胞规格
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-27 DOI: 10.1016/j.ceb.2025.102542
Torcato Martins , Yuu Kimata
{"title":"Mitotic signalling in progenitor cells: Integrating cell division with cell specification","authors":"Torcato Martins ,&nbsp;Yuu Kimata","doi":"10.1016/j.ceb.2025.102542","DOIUrl":"10.1016/j.ceb.2025.102542","url":null,"abstract":"<div><div>Mitotic signalling mediated by cell cycle regulators (CCRs) is pivotal for coordinating cell division and fate specification across metazoans. CCRs, including cyclin-dependent kinases and ubiquitin ligases, use post-translational modifications for rapid, dynamic regulation of the cell cycle, ensuring its unidirectionality and integration with fate determination. This review explores recent findings that further elucidate CCRs’ noncanonical functions, particularly in progenitor cells. Advancements in quantitative <em>in vivo</em> imaging, precise genome editing, and single-cell omics have provided unprecedented spatiotemporal resolution into the mechanisms through which CCRs regulate asymmetric cell division, epigenetic regulation, and cell cycle variations. The evolution of CCRs underscores their crucial role in integrating cellular and developmental signals in multicellular organisms, with implications for disease and therapeutic strategies.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102542"},"PeriodicalIF":6.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144147528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Condensate-membrane interactions shape membranes, tune cytoskeletal assembly, and localize mRNAs 凝聚膜相互作用形成膜，调整细胞骨架组装，并定位mrna
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-26 DOI: 10.1016/j.ceb.2025.102540
Wilton T. Snead
{"title":"Condensate-membrane interactions shape membranes, tune cytoskeletal assembly, and localize mRNAs","authors":"Wilton T. Snead","doi":"10.1016/j.ceb.2025.102540","DOIUrl":"10.1016/j.ceb.2025.102540","url":null,"abstract":"<div><div>Biomolecular condensates have emerged as essential subcellular compartments. Although condensates organize biochemistry without a delimiting membrane, condensates frequently interact with membrane surfaces in diverse cellular contexts. Condensates and membranes reciprocally modulate each other, inducing membrane shape changes, establishing domains of distinct lipid composition, and catalyzing reactions within condensates. Here I discuss recent advancements in our understanding of the condensate-membrane interface, with a focus on membrane shaping, lipid organization, cytoskeletal regulation, and mRNA transport. I conclude by suggesting research avenues that may uncover new functions for membrane-associated condensates, with emphasis on the understudied role of RNA in the condensate-membrane interface.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102540"},"PeriodicalIF":6.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Actin in mitochondrial regulation and mechanometabolic crosstalk 肌动蛋白在线粒体调控和机械代谢串扰中的作用
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-26 DOI: 10.1016/j.ceb.2025.102539
Peng Shi , Yuhan Zhang , Congying Wu
{"title":"Actin in mitochondrial regulation and mechanometabolic crosstalk","authors":"Peng Shi ,&nbsp;Yuhan Zhang ,&nbsp;Congying Wu","doi":"10.1016/j.ceb.2025.102539","DOIUrl":"10.1016/j.ceb.2025.102539","url":null,"abstract":"<div><div>Mitochondria undergo dynamic adaptations to cellular energy demands, changing morphology and function, through active interactions with other cellular organelles and the cytoskeletons. With advances in light and electron microscopy, actin probes for live-cell imaging, as well as proximity labeling, subtle and transient actin structures associated with mitochondria have been resolved and examined, which opened a new era for the understanding of architectural and mechanical regulation of organelles and metabolism. Here, we first review the recent findings that elucidate the actin–mitochondrion interactions in regulating mitochondrial dynamics (including fission, fusion and trafficking), and cristae architecture. Further, we discuss the functional consequences accompanying these morphological changes, which link cellular metabolism to the cytoskeleton and mechanotransduction through direct or indirect organelle control. Moreover, we summarize the avant-garde techniques for probing mitochondrion-associated actin, including new ways to visualize mitochondria–actin interaction in the cytosol and within the mitochondria, methods to identify the molecular components mediating actin–mitochondria crosstalk, and techniques for reconstructing the 3D ultrastructure of actin–mitochondrion interaction. Finally, we conclude pressing issues in this exciting field, calling for interdisciplinary efforts in examine actin–mitochondrion interactions at micro and macro levels. The dynamics and structural integrity of mitochondria are essential for energy metabolism and signal transduction, while their abnormalities lead to mitochondrial dysfunction and severe disease. This review aims to provide a comprehensive perspective on the emerging roles of the actin cytoskeleton in shaping mitochondrial morphology, structure, and functions, providing new angles to understand mitochondria-related diseases.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102539"},"PeriodicalIF":6.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New players on lipid droplets: Their regulations and functions 脂滴的新参与者：它们的调节和功能
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-24 DOI: 10.1016/j.ceb.2025.102541
Huimin Pan , Honggang Su , Xun Huang
{"title":"New players on lipid droplets: Their regulations and functions","authors":"Huimin Pan ,&nbsp;Honggang Su ,&nbsp;Xun Huang","doi":"10.1016/j.ceb.2025.102541","DOIUrl":"10.1016/j.ceb.2025.102541","url":null,"abstract":"<div><div>Lipid droplets (LDs) are highly conserved organelles found across a wide range of organisms, from prokaryotic to eukaryotes. LD proteins are a diverse group of proteins that are associated with LDs, regulating various aspects of LD function, such as storage, mobilization, and interactions with other organelles. Recent research in LD proteins has uncovered a broader range of physiological and pathological roles of LDs, extending beyond their traditional function in lipid metabolism. In this review, we summarize the mechanisms behind LD protein targeting and explore the discovery of new players on LDs, highlighting their specific contributions to cellular function. These discoveries significantly deepen our understanding of LD biology.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102541"},"PeriodicalIF":6.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Outside Back Cover 外封底
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-24 DOI: 10.1016/S0955-0674(25)00093-6
{"title":"Outside Back Cover","authors":"","doi":"10.1016/S0955-0674(25)00093-6","DOIUrl":"10.1016/S0955-0674(25)00093-6","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102555"},"PeriodicalIF":6.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New directions in epithelial mechanoadaptation 上皮细胞机械适应的新方向
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-24 DOI: 10.1016/j.ceb.2025.102536
Julia Eckert , Virgile Viasnoff , Alpha S. Yap
{"title":"New directions in epithelial mechanoadaptation","authors":"Julia Eckert ,&nbsp;Virgile Viasnoff ,&nbsp;Alpha S. Yap","doi":"10.1016/j.ceb.2025.102536","DOIUrl":"10.1016/j.ceb.2025.102536","url":null,"abstract":"<div><div>Cells are active mechanical objects: they are subject to forces, exert force, and interpret changes in force as biological information. We now understand much about how this occurs at the molecular and single-cell level. We also appreciate that mechanobiology gains even greater complexity when it operates at the multicellular level of tissues and organisms. Here, cells exert forces on other cells within tissues to support morphogenesis and homeostasis; but these forces must also be accommodated to ensure that tissue integrity is preserved. Cell–cell adhesion junctions play important roles in transmitting, resisting, as well as detecting mechanical forces in coherent tissues. In this brief article we consider how epithelia adapt to mechanical stresses, focusing on recent developments in understanding the sources of force and new mechanisms for adherens junctions and desmosomes in mechanotransduction.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102536"},"PeriodicalIF":6.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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