Arp2/3-complex regulation – Novel insights and open questions

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-06-25 DOI:10.1016/j.ceb.2025.102565

Theresia E.B. Stradal , Micaela Boiero Sanders , Peter Bieling

引用次数: 0

Abstract

Arp2/3 complex is a central actin filament generator driving numerous motile processes in cells. It was originally isolated from Acanthamoeba approx. 30 years ago. It is highly conserved throughout eukaryotic life and composed of 7 subunits, two of which are actin related proteins, ARP2 and ARP3. Since then the modalities of its regulation were continuously unraveled, bringing about a large number of proteins that affect its activity. We here set out to briefly review our current knowledge and identify open questions that demand answers and add new twists, advancing our understanding to reflect physiological complexity.

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arp2 /3-复杂的规则-新颖的见解和开放的问题

Arp2/3复合体是驱动细胞中许多运动过程的中心肌动蛋白丝发生器。它最初是从棘阿米巴原虫中分离出来的。30年前。它在整个真核生命中高度保守，由7个亚基组成，其中两个是肌动蛋白相关蛋白ARP2和ARP3。从那时起，它的调节模式不断被解开，带来了大量影响其活性的蛋白质。在这里，我们将简要回顾我们目前的知识，并确定需要回答的开放性问题，并添加新的曲折，推进我们的理解，以反映生理的复杂性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.