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Membrane fusion and fission during eukaryogenesis 真核生物发生过程中的膜融合与裂变
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-14 DOI: 10.1016/j.ceb.2023.102321
Héctor Romero , Pablo S. Aguilar , Martin Graña , Mauricio Langleib , Virginia Gudiño , Benjamin Podbilewicz
{"title":"Membrane fusion and fission during eukaryogenesis","authors":"Héctor Romero ,&nbsp;Pablo S. Aguilar ,&nbsp;Martin Graña ,&nbsp;Mauricio Langleib ,&nbsp;Virginia Gudiño ,&nbsp;Benjamin Podbilewicz","doi":"10.1016/j.ceb.2023.102321","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102321","url":null,"abstract":"<div><p><span>All eukaryotes can be traced back to a single shared ancestral lineage that emerged from interactions between different prokaryotic cells. Current models of eukaryogenesis describe various selective forces and evolutionary mechanisms that contributed to the formation of eukaryotic cells. Central to this process were significant changes in cellular structure, resulting in the configuration of a new cell type characterized by internal membrane compartments. Additionally, eukaryogenesis results in a life cycle that relies on cell–cell fusion. We discuss the potential roles of proteins involved in remodeling cellular membranes, highlighting two critical stages in the evolution of eukaryotes: the internalization of symbiotic partners and a scenario wherein the emergence of sexual reproduction is linked to a </span>polyploid ancestor generated by cell–cell fusion.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102321"},"PeriodicalIF":7.5,"publicationDate":"2024-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139436092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Decoding the cell nucleus 解码细胞核
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-13 DOI: 10.1016/j.ceb.2023.102319
Hiroshi Kimura, Melike Lakadamyali
{"title":"Decoding the cell nucleus","authors":"Hiroshi Kimura,&nbsp;Melike Lakadamyali","doi":"10.1016/j.ceb.2023.102319","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102319","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102319"},"PeriodicalIF":7.5,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139434276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Local cellular interactions: From signaling to mechanics across development, evolution, and disease 局部细胞相互作用：从信号传递到力学，跨越发育、进化和疾病。
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-12 DOI: 10.1016/j.ceb.2023.102312
Anna Bigas, David Sprinzak
{"title":"Local cellular interactions: From signaling to mechanics across development, evolution, and disease","authors":"Anna Bigas,&nbsp;David Sprinzak","doi":"10.1016/j.ceb.2023.102312","DOIUrl":"10.1016/j.ceb.2023.102312","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102312"},"PeriodicalIF":7.5,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139433199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scaling the cellular frontier: Mechanobiology, tissue dynamics and function 拓展细胞前沿：机械生物学、组织动力学和功能
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-11 DOI: 10.1016/j.ceb.2023.102318
JoAnn Trejo, Giorgio Scita
{"title":"Scaling the cellular frontier: Mechanobiology, tissue dynamics and function","authors":"JoAnn Trejo,&nbsp;Giorgio Scita","doi":"10.1016/j.ceb.2023.102318","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102318","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102318"},"PeriodicalIF":7.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139419319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cellular stress management by caspases Caspases 对细胞压力的管理
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-11 DOI: 10.1016/j.ceb.2023.102314
Luis Alberto Baena-Lopez, Li Wang, Franz Wendler
{"title":"Cellular stress management by caspases","authors":"Luis Alberto Baena-Lopez,&nbsp;Li Wang,&nbsp;Franz Wendler","doi":"10.1016/j.ceb.2023.102314","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102314","url":null,"abstract":"<div><p>Cellular stress plays a pivotal role in the onset of numerous human diseases. Consequently, the removal of dysfunctional cells, which undergo excessive stress-induced damage via various cell death pathways, including apoptosis, is essential for maintaining organ integrity and function. The evolutionarily conserved family of cysteine-aspartic-proteases, known as caspases, has been a key player in orchestrating apoptosis. However, recent research has unveiled the capability of these enzymes to govern fundamental cellular processes without triggering cell death. Remarkably, some of these non-lethal functions of caspases may contribute to restoring cellular equilibrium in stressed cells. This manuscript discusses how caspases can function as cellular stress managers and their potential impact on human health and disease. Additionally, it sheds light on the limitations of caspase-based therapies, given our still incomplete understanding of the biology of these enzymes, particularly in non-apoptotic contexts.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102314"},"PeriodicalIF":7.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067423001631/pdfft?md5=db1271685c984bf5448da0454692c701&pid=1-s2.0-S0955067423001631-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139419320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent developments in membrane traffic and lipid dynamics 膜交通和脂质动力学的最新发展
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-11 DOI: 10.1016/j.ceb.2023.102320
Aurélien Roux, Karin Reinisch
{"title":"Recent developments in membrane traffic and lipid dynamics","authors":"Aurélien Roux,&nbsp;Karin Reinisch","doi":"10.1016/j.ceb.2023.102320","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102320","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102320"},"PeriodicalIF":7.5,"publicationDate":"2024-01-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139419321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells 利用生理环境工程推进人类多能干细胞肾脏类器官模型的发展
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-09 DOI: 10.1016/j.ceb.2023.102306
Anisha Pahuja , Iphigénie Goux Corredera , Daniel Moya-Rull , Elena Garreta , Nuria Montserrat
{"title":"Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells","authors":"Anisha Pahuja ,&nbsp;Iphigénie Goux Corredera ,&nbsp;Daniel Moya-Rull ,&nbsp;Elena Garreta ,&nbsp;Nuria Montserrat","doi":"10.1016/j.ceb.2023.102306","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102306","url":null,"abstract":"<div><p>During embryogenesis, the mammalian kidney arises because of reciprocal interactions between the ureteric bud (UB) and the metanephric mesenchyme (MM), driving UB branching and nephron induction. These morphogenetic processes involve a series of cellular rearrangements that are tightly controlled by gene regulatory networks and signaling cascades. Here, we discuss how kidney developmental studies have informed the definition of procedures to obtain kidney organoids from human pluripotent stem cells (hPSCs). Moreover, bioengineering techniques have emerged as potential solutions to externally impose controlled microenvironments for organoid generation from hPSCs. Next, we summarize some of these advances with major focus On recent works merging hPSC-derived kidney organoids (hPSC-kidney organoids) with organ-on-chip to develop robust models for drug discovery and disease modeling applications. We foresee that, in the near future, coupling of different organoid models through bioengineering approaches will help advancing to recreate organ-to-organ crosstalk to increase our understanding on kidney disease progression in the human context and search for new therapeutics.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102306"},"PeriodicalIF":7.5,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067423001552/pdfft?md5=6a83ca5dd82695172d308db1fd2ae20e&pid=1-s2.0-S0955067423001552-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139399101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Staying away from the breaking point: Probing the limits of epithelial cell elimination 远离爆发点探索上皮细胞消除的极限
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-09 DOI: 10.1016/j.ceb.2023.102316
Romain Levayer
{"title":"Staying away from the breaking point: Probing the limits of epithelial cell elimination","authors":"Romain Levayer","doi":"10.1016/j.ceb.2023.102316","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102316","url":null,"abstract":"<div><p>Epithelial tissues are dramatically remodelled during embryogenesis and tissue homeostasis and yet need to maintain their sealing properties to sustain their barrier functions at any time. Part of these remodellings involve the elimination of a large proportion of cells through apoptosis. Cell extrusion, the remodelling steps leading to seamless dying cell expulsion, helps to maintain tissue cohesion. However, there is an intrinsic limit in the system that can only accommodate a certain proportion/rate of cell elimination as well as certain spatiotemporal distributions. What are then the critical conditions leading to epithelial rupture/tear/sealing defects upon cell elimination and which mechanisms ensure that such limits are never reached? In this short review, I document the conditions in which epithelial rupture has been observed, including in the contexts of epithelial cell death, and the mechanical parameters influencing tissue rupture, and review feedback mechanisms which help to keep the epithelia away from the breaking point.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102316"},"PeriodicalIF":7.5,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067423001655/pdfft?md5=8125d644e639a06f73711311329e8e2f&pid=1-s2.0-S0955067423001655-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139399102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome Jagged介导的发育和疾病：对 Alagille 综合征的机理认识和治疗意义
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-09 DOI: 10.1016/j.ceb.2023.102302
Jan Mašek , Emma R. Andersson
{"title":"Jagged-mediated development and disease: Mechanistic insights and therapeutic implications for Alagille syndrome","authors":"Jan Mašek ,&nbsp;Emma R. Andersson","doi":"10.1016/j.ceb.2023.102302","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102302","url":null,"abstract":"<div><p>Notch signaling controls multiple aspects of embryonic development and adult homeostasis. Alagille syndrome is usually caused by a single mutation in the <em>jagged canonical Notch ligand 1</em> (<em>JAG1</em>), and manifests with liver disease and cardiovascular symptoms that are a direct consequence of <em>JAG1</em> haploinsufficiency. Recent insights into Jag1/Notch-controlled developmental and homeostatic processes explain how pathology develops in the hepatic and cardiovascular systems and, together with recent elucidation of mechanisms modulating liver regeneration, provide a basis for therapeutic efforts. Importantly, disease presentation can be regulated by genetic modifiers, that may also be therapeutically leverageable. Here, we summarize recent insights into how Jag1 controls processes of relevance to Alagille syndrome, focused on Jag1/Notch functions in hepatic and cardiovascular development and homeostasis.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102302"},"PeriodicalIF":7.5,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0955067423001515/pdfft?md5=c78e646746629bb2e80ac407ec9dbfed&pid=1-s2.0-S0955067423001515-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139399056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems 细胞外基质动力学：跨长度尺度和系统的细胞迁移的关键调节器
IF 7.5 2区 生物学
Current Opinion in Cell Biology Pub Date : 2024-01-05 DOI: 10.1016/j.ceb.2023.102309
Dharma Pally , Alexandra Naba
{"title":"Extracellular matrix dynamics: A key regulator of cell migration across length-scales and systems","authors":"Dharma Pally ,&nbsp;Alexandra Naba","doi":"10.1016/j.ceb.2023.102309","DOIUrl":"https://doi.org/10.1016/j.ceb.2023.102309","url":null,"abstract":"<div><p>The interactions between cells and their surrounding extracellular matrix (ECM) are dynamic and play critical roles in cell migration during development, health, and diseases. Recent advances have highlighted the complexity and diversity of ECM compositions, or “matrisomes”, of tissues resulting in ECMs of different physical, mechanical, and biochemical properties. Investigating the effects of these properties on cell-ECM interactions in the context of cell migration have led to a better understanding of the principles underlying tissue morphogenesis, wound healing, immune response, or cancer metastasis. These new insights into the interplay between ECM dynamics and cell migration can lead to the identification of unique opportunities for therapeutic interventions.</p></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"86 ","pages":"Article 102309"},"PeriodicalIF":7.5,"publicationDate":"2024-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139108966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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