调节动物细胞大小的机械化学控制系统

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-11-06 DOI:10.1016/j.ceb.2024.102443

Heather E. Rizzo , Andy L. Zhang , Margaret L. Gardel

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引用次数: 0

摘要

细胞大小的调节来自细胞增殖和新陈代谢途径的物理表现。一方面，这些系统之间的协调产生了世代相传的恒定细胞大小，以维持细胞大小的平衡。然而，细胞大小的主动调控对生理学和在单个生物体内建立细胞大小的广泛差异至关重要，并通过由无数内在和外在线索调控的物理和生化途径来实现。在这篇综述中，我们将探讨阐明动物细胞体积的机械生物学调控及其与新陈代谢和增殖途径的协调的最新数据。

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Mechanochemical control systems regulating animal cell size

Cell size regulation arises from physical manifestations of cell proliferation and metabolic pathways. On one hand, coordination between these systems yields a constant cell size over generations to maintain cell size homeostasis. However, active regulation of cell size is crucial to physiology and to establish broad variation of cell sizes within an individual organism, and is accomplished via physical and biochemical pathways modulated by myriad intrinsic and extrinsic cues. In this review, we explore recent data elucidating the mechanobiological regulation of the volume of animal cells and its coordination with metabolic and proliferative pathways.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.