SMC 介导的染色体组织：环状挤压能解释这一切吗？

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2024-11-26 DOI:10.1016/j.ceb.2024.102447

Tatsuya Hirano, Kazuhisa Kinoshita

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引用次数: 0

摘要

近年来，作为由染色体结构维持蛋白（SMC）复合物（如凝聚素和粘合素）介导的染色体组织的一般机制，环挤压引起了广泛关注。尽管有越来越多的证据支持这一机制，但目前尚未完全确定环挤压是否或如何在生理条件下运行，也未确定细胞中是否有任何替代或额外的 SMC 介导的机制。在这篇综述中，我们总结了文献中提出的非环路挤压机制，并澄清了尚未解决的问题，以进一步丰富我们对 SMC 蛋白复合物如何工作的理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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SMC-mediated chromosome organization: Does loop extrusion explain it all?

In recent years, loop extrusion has attracted much attention as a general mechanism of chromosome organization mediated by structural maintenance of chromosomes (SMC) protein complexes, such as condensin and cohesin. Despite accumulating evidence in support of this mechanism, it is not fully established whether or how loop extrusion operates under physiological conditions, or whether any alternative or additional SMC-mediated mechanisms operate in the cell. In this review, we summarize non-loop extrusion mechanisms proposed in the literature and clarify unresolved issues to further enrich our understanding of how SMC protein complexes work.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.