新皮质锥体神经元中nav和kv的细胞骨架支架：对神经元信号传导和可塑性的影响

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-07-16 DOI:10.1016/j.ceb.2025.102570

Carina C. Elvira , Paul M. Jenkins

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引用次数: 0

摘要

动作电位（ap）的产生和传播依赖于神经元中电压门控钠（NaV）和钾（KV）通道的精确定位。在新皮质锥体神经元中，NaV1.2和NaV1.6是轴突初始段（AIS）和Ranvier节点（noR）的关键，驱动AP的发生和传播。NaV1.2还支持AP在体细胞和树突中的反向传播。锚蛋白g将这些通道锚定在AIS和noR上，而新发现表明锚蛋白b在树突上支架NaV1.2。这篇综述强调了锚蛋白如何稳定跨神经元域的NaV和KV通道，确保适当的功能对兴奋性、突触可塑性和信号传导至关重要。最近的研究结果探讨了锚定蛋白如何不同地定位NaV1.2和NaV1.6，这对理解与通道定位中断相关的神经系统疾病具有重要意义。

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Cytoskeletal scaffolding of NaVs and KVs in neocortical pyramidal neurons: Implications for neuronal signaling and plasticity

The initiation and propagation of action potentials (APs) depend on the precise localization of voltage-gated sodium (Na_V) and potassium (K_V) channels in neurons. In neocortical pyramidal neurons, Na_V1.2 and Na_V1.6 are key at the axon initial segment (AIS) and nodes of Ranvier (noR), driving AP initiation and propagation. Na_V1.2 also supports AP backpropagation in the soma and dendrites. Ankyrin-G anchors these channels at the AIS and noR, while new findings reveal that ankyrin-B scaffolds Na_V1.2 in dendrites. This review highlights how ankyrins stabilize Na_V and K_V channels across neuronal domains, ensuring proper function crucial for excitability, synaptic plasticity, and signaling. Recent findings explore how ankyrins differentially localize Na_V1.2 and Na_V1.6, with implications for understanding neurological disorders linked to disrupted channel localization.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.