发布求助
文献互助 智能选刊 最新文献

Current Opinion in Cell Biology最新文献

筛选
英文 中文
Nuclear biophysics: Spatial coordination of transcriptional dynamics? 核生物物理学：转录动力学的空间协调？
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-14 DOI: 10.1016/j.ceb.2025.102561
Tae Yeon Yoo , Bernardo Gouveia , Daniel Needleman
{"title":"Nuclear biophysics: Spatial coordination of transcriptional dynamics?","authors":"Tae Yeon Yoo ,&nbsp;Bernardo Gouveia ,&nbsp;Daniel Needleman","doi":"10.1016/j.ceb.2025.102561","DOIUrl":"10.1016/j.ceb.2025.102561","url":null,"abstract":"<div><div>A great deal is known about biochemical aspects of transcription, but we still lack an understanding of how transcription is causally regulated in space and time. A major unanswered question is the extent to which transcription at different locations in the nucleus are independent from each other or, instead, are spatially coordinated. We propose two classes of models of coordination: 1) the shared environment model, in which neighboring loci exhibit coordinated transcriptional dynamics due to sharing the same local biochemical environment; 2) the mechanical crosstalk model, in which forces propagate from one actively transcribing locus to affect transcription of another. Determining the prevalence of the spatial coordination of transcription, and the underlying mechanisms when it occurs, is an exciting challenge in nuclear biophysics.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102561"},"PeriodicalIF":6.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in single-cell omics: Transformative applications in basic and clinical research 单细胞组学进展：在基础和临床研究中的变革性应用
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-14 DOI: 10.1016/j.ceb.2025.102548
Mohammed Inayatullah , Anuj Kumar Dwivedi , Vijay K. Tiwari
{"title":"Advances in single-cell omics: Transformative applications in basic and clinical research","authors":"Mohammed Inayatullah ,&nbsp;Anuj Kumar Dwivedi ,&nbsp;Vijay K. Tiwari","doi":"10.1016/j.ceb.2025.102548","DOIUrl":"10.1016/j.ceb.2025.102548","url":null,"abstract":"<div><div>Recent advancements in single-cell RNA sequencing, spatial transcriptomics, and multi-omics integration have enabled researchers to dissect complex tissues and identify distinct cell populations with unique functional states. This review discusses the application of single-cell omics in diverse fields, including cancer research and developmental biology, showcasing how they reveal insights into cellular interactions, disease mechanisms, and therapeutic responses. Notable studies illustrate the potential of single-cell approaches to uncover novel biomarkers and therapeutic targets, particularly in heterogeneous diseases such as cancer and neurodevelopmental disorders. Furthermore, the review emphasizes the importance of integrating single-cell data with computational models to enhance our understanding of cellular dynamics and microenvironmental influences. Overall, this review underscores the critical role of single-cell omics in advancing our knowledge of biology and its applications in clinical settings, paving the way for personalized medicine.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102548"},"PeriodicalIF":6.0,"publicationDate":"2025-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144289029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
From brain-sparing to prioritised tumour growth: Insights into tumour-host interactions 从脑保留到肿瘤优先生长：对肿瘤-宿主相互作用的见解
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-13 DOI: 10.1016/j.ceb.2025.102560
Qian Dong , Louise Y. Cheng
{"title":"From brain-sparing to prioritised tumour growth: Insights into tumour-host interactions","authors":"Qian Dong ,&nbsp;Louise Y. Cheng","doi":"10.1016/j.ceb.2025.102560","DOIUrl":"10.1016/j.ceb.2025.102560","url":null,"abstract":"<div><div>Cellular responses to their environment are shaped not only by genetic composition but also by interactions with neighbouring cells. Beyond local interactions, inter-organ crosstalk has emerged as a crucial mechanism coordinating tissue growth and function. In this review, we discuss recent findings, mainly using <em>Drosophila</em> as a model system to investigate how organs compete for resources under metabolic stress. This mechanism ensures the prioritized growth of essential organs during development and the growth of tumours at the expense of other tissues and host fitness. Together, these studies offered valuable insights into how inter-organ communications via secreted factors and host resource reallocation are important in affecting tissue fitness and driving disease progression.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102560"},"PeriodicalIF":6.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144280464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolution of the cytoskeleton: Emerging clues from the diversification and specialisation of archaeal cytoskeletal proteins 细胞骨架的进化：从古细菌细胞骨架蛋白的多样化和特化中出现的线索
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-12 DOI: 10.1016/j.ceb.2025.102557
Hannah J. Brown, Vinaya D. Shinde, Leonardo Bosi, Iain G. Duggin
{"title":"Evolution of the cytoskeleton: Emerging clues from the diversification and specialisation of archaeal cytoskeletal proteins","authors":"Hannah J. Brown,&nbsp;Vinaya D. Shinde,&nbsp;Leonardo Bosi,&nbsp;Iain G. Duggin","doi":"10.1016/j.ceb.2025.102557","DOIUrl":"10.1016/j.ceb.2025.102557","url":null,"abstract":"<div><div>Recent research in archaeal cell biology has revealed a remarkable diversity of cytoskeletal proteins related to those found in bacteria and eukaryotes, such as the tubulin, actin, and ESCRT protein superfamilies, and archaea-specific proteins that self-assemble and have been implicated in cytoskeletal roles. Here, we outline an emerging view that the archaeal cytoskeleton has several conceptual ties to the sophisticated eukaryotic cytoskeleton. We highlight that duplication and specialisation of protein function is common among archaeal cytoskeletal systems, and that some paralogues show coordinated, opposing functions in the regulation of cell morphogenesis and structural homeostasis. Furthermore, the presence of homologues of eukaryotic cytoskeletal regulators in Asgard archaea, the closest known relatives of eukaryotes, underscores further linkages between eukaryotic and increasingly sophisticated archaeal cytoskeletal systems.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102557"},"PeriodicalIF":6.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Apical constriction in morphogenesis: From actomyosin architecture to regulatory networks 形态发生中的顶端收缩：从肌动球蛋白结构到调控网络
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-12 DOI: 10.1016/j.ceb.2025.102562
Samara N. Ranie , Melanie D. White
{"title":"Apical constriction in morphogenesis: From actomyosin architecture to regulatory networks","authors":"Samara N. Ranie ,&nbsp;Melanie D. White","doi":"10.1016/j.ceb.2025.102562","DOIUrl":"10.1016/j.ceb.2025.102562","url":null,"abstract":"<div><div>Apical constriction is a key morphogenetic process driving tissue remodelling throughout life, including early developmental events. Once thought to occur through uniform actomyosin ring contraction, it is now recognized as a dynamic process with diverse actomyosin architectures across species, tissues, and cell types. Regulation of apical constriction involves multiple scales, from tissue mechanics to junctional remodelling and protein trafficking. New studies are revealing how this process is controlled through actomyosin cortex organization, cytoskeletal–junctional interactions, and junctional protein levels. Considering how variable actomyosin structures are integrated with emerging regulatory pathways across different models will be crucial. Advances in <em>in vivo</em> live imaging promise deeper insights into the regulatory networks coordinating actomyosin dynamics and apical constriction, shedding light on its role in shaping tissues during development.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102562"},"PeriodicalIF":6.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
E-Cadherin: A conductor of cellular signaling 钙粘蛋白：细胞信号传导的导体
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-12 DOI: 10.1016/j.ceb.2025.102559
Rachel J. Kehrberg, Kris A. DeMali
{"title":"E-Cadherin: A conductor of cellular signaling","authors":"Rachel J. Kehrberg,&nbsp;Kris A. DeMali","doi":"10.1016/j.ceb.2025.102559","DOIUrl":"10.1016/j.ceb.2025.102559","url":null,"abstract":"<div><div>Upon engagement of E-cadherin or when mechanical force is applied, E-cadherin recruits cytoskeletal proteins and triggers various signal transduction cascades including PI3K, Src, Rho family GTPases, kinases, YAP/TAZ, AMPK, and other metabolic enzymes. These cascades modulate E-cadherin's stability, viscosity, and its connection to the actin cytoskeleton, thereby reinforcing cell–cell adhesion.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102559"},"PeriodicalIF":6.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of organelle architecture on oocyte developmental potential 细胞器结构对卵母细胞发育潜能的影响
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-11 DOI: 10.1016/j.ceb.2025.102556
Elvira Nikalayevich, Noemi Zollo, Marie-Hélène Verlhac
{"title":"Impact of organelle architecture on oocyte developmental potential","authors":"Elvira Nikalayevich,&nbsp;Noemi Zollo,&nbsp;Marie-Hélène Verlhac","doi":"10.1016/j.ceb.2025.102556","DOIUrl":"10.1016/j.ceb.2025.102556","url":null,"abstract":"<div><div>Oocytes are female gametes specialized in storing maternal RNAs, proteins, lipids, and metabolites essential for embryonic development after fertilization, sometimes for decades in humans. To support this extended lifespan, oocytes have evolved mechanisms to organize specialized organelles. This review highlights recent discoveries on how oocytes regulate mRNA and protein accumulation, storage, and degradation over time. Additionally, we explore advances in understanding cytoplasmic activity and remodeling, particularly the role of cortex mechanical properties in fine-tuning organelle distribution and function to ensure proper oocyte development.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102556"},"PeriodicalIF":6.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
“Cancer progression through systemic signaling viewed from Drosophila” “从果蝇的系统信号看癌症进展”
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-11 DOI: 10.1016/j.ceb.2025.102545
Masato Enomoto , Shizue Ohsawa
{"title":"“Cancer progression through systemic signaling viewed from Drosophila”","authors":"Masato Enomoto ,&nbsp;Shizue Ohsawa","doi":"10.1016/j.ceb.2025.102545","DOIUrl":"10.1016/j.ceb.2025.102545","url":null,"abstract":"<div><div>Cancers develop through local interactions between tumor cells and neighboring cells within the tissue micro environment, while distinct organs regulate cancer progression and suppression via systemic factors. Recent studies in <em>Drosophila</em> have revealed systemic signaling pathways that influence tumor development. This review summarizes the mechanisms by which organ-derived molecules remotely trigger tumor growth and suppression. Additionally, we discuss how tumors dysregulate various organ systems, leading to animal mortality.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102545"},"PeriodicalIF":6.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in spying on cell signaling with fluorescent biosensors 荧光生物传感器探测细胞信号的最新进展
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-10 DOI: 10.1016/j.ceb.2025.102546
Qian-yi Zhang , Sohum Mehta , Jin Zhang
{"title":"Recent advances in spying on cell signaling with fluorescent biosensors","authors":"Qian-yi Zhang ,&nbsp;Sohum Mehta ,&nbsp;Jin Zhang","doi":"10.1016/j.ceb.2025.102546","DOIUrl":"10.1016/j.ceb.2025.102546","url":null,"abstract":"<div><div>Cells routinely orchestrate the activities of diverse biochemical pathways to sustain cellular function and proliferation, as exemplified by their ability to faithfully convert extracellular signals into specific intracellular responses. The dynamic nature of intracellular signaling calls for appropriate tools to capture these complex molecular events. Recent advances in genetically encoded biosensor engineering are revolutionizing our ability to dissect the molecular mechanisms regulating signaling activities with unprecedented resolution. Here, we present a timely update on novel biosensor designs and highlight recent applications where biosensor imaging yielded breakthrough insights into the spatiotemporal dynamics of GPCR signaling and cell cycle regulation.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102546"},"PeriodicalIF":6.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144242831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nutrient sensing and signalling of specific amino acids: Insights from Drosophila study 特定氨基酸的营养感知和信号传导：来自果蝇研究的见解
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-06-07 DOI: 10.1016/j.ceb.2025.102547
Ayano Oi , Fumiaki Obata
{"title":"Nutrient sensing and signalling of specific amino acids: Insights from Drosophila study","authors":"Ayano Oi ,&nbsp;Fumiaki Obata","doi":"10.1016/j.ceb.2025.102547","DOIUrl":"10.1016/j.ceb.2025.102547","url":null,"abstract":"<div><div>Maintaining amino acid (AA) homeostasis is necessary for organisms. To achieve this, organisms have evolved various signalling pathways regulated by sensing general or specific AA levels. Recently, advances in genetic and dietary manipulation have shed light upon how these AA signalling pathways regulate organismal physiology, metabolism, behaviour, and lifespan. However, elucidating the detailed mechanisms by which each AA is sensed and influences an animal's life is challenging. In some model organisms such as <em>Drosophila melanogaster</em>, chemically defined diet has been developed to manipulate single nutrients, which enables us to study the organismal response to dietary restriction of particular AAs. In this review, we aim to discuss the latest findings on animals' responses to dietary AAs, with a focus on recent studies in <em>Drosophila</em>.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102547"},"PeriodicalIF":6.0,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144229901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信