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Current Opinion in Cell Biology最新文献

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Outside Back Cover 外封底
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-24 DOI: 10.1016/S0955-0674(25)00093-6
{"title":"Outside Back Cover","authors":"","doi":"10.1016/S0955-0674(25)00093-6","DOIUrl":"10.1016/S0955-0674(25)00093-6","url":null,"abstract":"","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"94 ","pages":"Article 102555"},"PeriodicalIF":6.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New directions in epithelial mechanoadaptation 上皮细胞机械适应的新方向
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-24 DOI: 10.1016/j.ceb.2025.102536
Julia Eckert , Virgile Viasnoff , Alpha S. Yap
{"title":"New directions in epithelial mechanoadaptation","authors":"Julia Eckert ,&nbsp;Virgile Viasnoff ,&nbsp;Alpha S. Yap","doi":"10.1016/j.ceb.2025.102536","DOIUrl":"10.1016/j.ceb.2025.102536","url":null,"abstract":"<div><div>Cells are active mechanical objects: they are subject to forces, exert force, and interpret changes in force as biological information. We now understand much about how this occurs at the molecular and single-cell level. We also appreciate that mechanobiology gains even greater complexity when it operates at the multicellular level of tissues and organisms. Here, cells exert forces on other cells within tissues to support morphogenesis and homeostasis; but these forces must also be accommodated to ensure that tissue integrity is preserved. Cell–cell adhesion junctions play important roles in transmitting, resisting, as well as detecting mechanical forces in coherent tissues. In this brief article we consider how epithelia adapt to mechanical stresses, focusing on recent developments in understanding the sources of force and new mechanisms for adherens junctions and desmosomes in mechanotransduction.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102536"},"PeriodicalIF":6.0,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144131356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The tri-molecular interaction controlling plant cell structure 控制植物细胞结构的三分子相互作用
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-23 DOI: 10.1016/j.ceb.2025.102538
Preet Manchanda, Anja Geitmann
{"title":"The tri-molecular interaction controlling plant cell structure","authors":"Preet Manchanda,&nbsp;Anja Geitmann","doi":"10.1016/j.ceb.2025.102538","DOIUrl":"10.1016/j.ceb.2025.102538","url":null,"abstract":"<div><div>The plant cell wall is a dynamic envelope crucial for cell structure. Recent insights highlight the pivotal roles of RAPID ALKALINIZATION FACTOR (RALF) peptides, LEUCINE-RICH REPEAT EXTENSINS (LRX), and the FERONIA (FER) receptor kinase in maintaining cell wall integrity. This tri-molecular complex, along with other membrane receptors, modulates cell wall mechanics through interactions with de-methylesterified homogalacturonan (HG) in a feedback-controlled manner along with other intra-cellular responses. Through the characterization of this complex, critical questions have emerged regarding the mechanistic details of RALF-induced HG modulation, the mechanosensing role of FER, and the structural roles of extensins in modulating cell wall dynamics. This review underscores the intricate feedback mechanisms involved in the maintenance of cell wall integrity and cellular growth dynamics, offering strategies to enhance crop productivity.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102538"},"PeriodicalIF":6.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design principles and feedback mechanisms in organelle size control 细胞器尺寸控制的设计原理和反馈机制
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-21 DOI: 10.1016/j.ceb.2025.102533
Deb Sankar Banerjee , Shiladitya Banerjee
{"title":"Design principles and feedback mechanisms in organelle size control","authors":"Deb Sankar Banerjee ,&nbsp;Shiladitya Banerjee","doi":"10.1016/j.ceb.2025.102533","DOIUrl":"10.1016/j.ceb.2025.102533","url":null,"abstract":"<div><div>Intracellular organelles are essential for cellular architecture and function, and their size regulation is critical for maintaining cellular homeostasis. Organelle size often scales with cell size, governed by mechanisms that integrate resource allocation, stochastic dynamics, and feedback controls. Here we review these underlying biophysical principles of organelle size control, including the limiting pool hypothesis, stochastic assembly processes, and feedback-driven growth dynamics. We discuss how negative feedback motifs stabilize size, while positive feedback can amplify growth and maintain size under specific conditions. Additionally, we discuss recent advances in modeling size control for organelles with nucleation and fission-fusion dynamics. By integrating experimental observations with theoretical insights, this review provides a conceptual understanding of the design principles governing organelle size regulation in dynamic cellular environments.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102533"},"PeriodicalIF":6.0,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144106116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives 重新定义增强子作用：从结构、基因组和单分子角度的见解
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-16 DOI: 10.1016/j.ceb.2025.102527
David Llères , Andres Cardozo Gizzi , Marcelo Nollmann
{"title":"Redefining enhancer action: Insights from structural, genomic, and single-molecule perspectives","authors":"David Llères ,&nbsp;Andres Cardozo Gizzi ,&nbsp;Marcelo Nollmann","doi":"10.1016/j.ceb.2025.102527","DOIUrl":"10.1016/j.ceb.2025.102527","url":null,"abstract":"<div><div>This review explores recent emerging insights into enhancer action, focusing on underexplored aspects such as the physical size of regulatory elements, the stochasticity of transcription factor binding and chromatin structure, and the role of nonlinear processes in reconciling longstanding discrepancies between theoretical models and experimental observations. Together, these insights provide a nuanced view of enhancer biology, highlighting the complexity of gene regulation and the need for innovative methodologies to further decode enhancer mechanisms.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102527"},"PeriodicalIF":6.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mechano-metabolism on the rise 机械代谢在上升
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-16 DOI: 10.1016/j.ceb.2025.102529
Sirio Dupont
{"title":"Mechano-metabolism on the rise","authors":"Sirio Dupont","doi":"10.1016/j.ceb.2025.102529","DOIUrl":"10.1016/j.ceb.2025.102529","url":null,"abstract":"<div><div>Cells respond to the physical and geometrical tissue properties by multiple mechanotransduction mechanisms that can profoundly influence cells' decision-making, extending to cell metabolism. This review incorporates the most recent findings on this topic, organized along the idea that the mechano-metabolic connection serves three main functions, namely to inform systemic metabolism on the general functioning of a tissue/organ, to tune cells’ energy production with the mechanical requirements imposed by their surroundings, and to coordinate cell metabolism with cell fate choices induced in response to mechanical cues. This connection highlights the pervasive influence of mechanical cues on cell activity, opens interesting questions on its physiological and pathological roles, and lays the foundations for exploiting the mechano-metabolism axis to design new therapeutic approaches.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102529"},"PeriodicalIF":6.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144068043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exploring the cell nucleus: From chromosome structure to single-cell omics 探索细胞核：从染色体结构到单细胞组学
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-16 DOI: 10.1016/j.ceb.2025.102530
Tatsuo Fukagawa, Maria Elena Torres-Padilla
{"title":"Exploring the cell nucleus: From chromosome structure to single-cell omics","authors":"Tatsuo Fukagawa,&nbsp;Maria Elena Torres-Padilla","doi":"10.1016/j.ceb.2025.102530","DOIUrl":"10.1016/j.ceb.2025.102530","url":null,"abstract":"<div><div>The cell nucleus is a fascinating organelle. The myriad of fundamental processes that ensure that the genetic information is read correctly and faithfully transmitted provides a rich subject of research across time scales and model systems. Topics ranging from chromosome ‘metascale’ organization and division, enabled by molecular machineries like the kinetochore, to the organization of the genome that ensues cell division during interphase, which enables fine tuning of gene regulation, are subjects that we cover in the ‘Cell Nucleus’ issue of <em>Current Opinion in Cell Biology</em>.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102530"},"PeriodicalIF":6.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144071655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acidification on the plasma membrane 质膜酸化
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-15 DOI: 10.1016/j.ceb.2025.102531
Ewan MacDonald , Ludger Johannes , Christian Wunder
{"title":"Acidification on the plasma membrane","authors":"Ewan MacDonald ,&nbsp;Ludger Johannes ,&nbsp;Christian Wunder","doi":"10.1016/j.ceb.2025.102531","DOIUrl":"10.1016/j.ceb.2025.102531","url":null,"abstract":"<div><div>The pH balance between extracellular and intracellular space is crucial for a multitude of cellular processes. Real-time observation of pH fluctuations in the range 4–9 in live cells and tissues in a sensitive, non-invasive manner has become feasible with advances in pH quantification by organic dyes, genetically encoded fluorescent proteins, and DNA-based probes. We discuss mechanisms through which pH affects cell cycle, transcription, senescence, neurotransmission, glycolipid-lectin driven endocytosis, tissue remodelling, immune responses, and GPCR signalling. Growth factor-stimulated acidification of the extracellular space notably triggers enzymatic reactions like desialylation at the plasma membrane that control processes involving cell migration and bone resorption. Research into the role of pH in cellular physiology continues to be a fertile ground for discovery that underscores its fundamental importance.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102531"},"PeriodicalIF":6.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143947246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alzheimer's disease and vascular biology – A focus on the procoagulant state 阿尔茨海默病和血管生物学-对促凝状态的关注
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-09 DOI: 10.1016/j.ceb.2025.102528
Marta Casquero-Veiga , Carlos Ceron , Marta Cortes-Canteli
{"title":"Alzheimer's disease and vascular biology – A focus on the procoagulant state","authors":"Marta Casquero-Veiga ,&nbsp;Carlos Ceron ,&nbsp;Marta Cortes-Canteli","doi":"10.1016/j.ceb.2025.102528","DOIUrl":"10.1016/j.ceb.2025.102528","url":null,"abstract":"<div><div>Alzheimer's disease (AD) is characterized by a multifactorial pathophysiology. Beyond its classical hallmarks, growing evidence highlights vascular contributions, including hemostatic dysregulation and a prothrombotic state in AD. This review focuses on recent findings concerning two key blood clot components–fibrin(ogen) and platelets–and their roles in AD pathology, including fibrinogen's abnormal accumulation in the AD brain, its interaction with amyloid-β, together with the associated impacts on clot stability, vascular occlusion, and neuroinflammation; and the potential switch of platelets along the AD continuum from protective to deleterious. This review provides an update on the interplay between vascular dysfunction and AD, underscoring the need for comprehensive integrative research to address AD's complexity and advocating for personalized approaches to tackle this multifaceted disorder.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102528"},"PeriodicalIF":6.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143923555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signals from the extracellular matrix: Region- and sex-specificity in cardiac aging 来自细胞外基质的信号：心脏老化的区域和性别特异性
IF 6 2区 生物学
Current Opinion in Cell Biology Pub Date : 2025-05-09 DOI: 10.1016/j.ceb.2025.102524
Md. Faris H. Ramli , Brian A. Aguado , Jennifer L. Young
{"title":"Signals from the extracellular matrix: Region- and sex-specificity in cardiac aging","authors":"Md. Faris H. Ramli ,&nbsp;Brian A. Aguado ,&nbsp;Jennifer L. Young","doi":"10.1016/j.ceb.2025.102524","DOIUrl":"10.1016/j.ceb.2025.102524","url":null,"abstract":"<div><div>During aging, the cardiac extracellular matrix (ECM) undergoes gradual remodeling that reduces the heart's ability to function. Specific ECM changes cause alterations in cellular signaling pathways, eliciting maladaptive responses. Here, we provide insight into the current knowledge of how age-specific ECM changes contribute to altered ligand–receptor interactions, dysregulated mechanotransduction, and the propagation of pro-fibrotic signaling cascades that underpin dysfunction. We also highlight regional and sex differences that new biomolecular and bioengineered technologies have recently uncovered. We call for new biomaterial strategies that mimic spatiotemporal and sex-specific ECM alterations to equip researchers with the tools to unravel complex cellular signaling events. We believe this can be achieved through interdisciplinary cooperation amongst researchers spanning matrix biology, biomaterials, spatial omics, and biomedical engineering.</div></div>","PeriodicalId":50608,"journal":{"name":"Current Opinion in Cell Biology","volume":"95 ","pages":"Article 102524"},"PeriodicalIF":6.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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