线粒体自噬起始机制的研究进展。

IF 6 2区生物学 Q1 CELL BIOLOGY

Current Opinion in Cell Biology Pub Date : 2025-03-20 DOI:10.1016/j.ceb.2025.102493

Catharina Küng , Michael Lazarou , Thanh Ngoc Nguyen

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引用次数: 0

摘要

线粒体自噬是一种重要的溶酶体降解途径，它可以去除受损或不需要的线粒体，以维持细胞和生物体的稳态。自噬如何在线粒体周围形成自噬体的机制已经引起了人们的极大兴趣，因为它们可能是自噬诱导疗法的潜在靶点。线粒体自噬起始可以由各种自噬受体或接头驱动，这些自噬受体或接头响应不同的细胞和线粒体刺激，从线粒体损伤到代谢重布线。这篇综述将涵盖我们对有丝自噬如何启动的理解的最新进展，并通过这样做揭示自噬体形成如何开始的机制可塑性。

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Advances in mitophagy initiation mechanisms

Mitophagy is an important lysosomal degradative pathway that removes damaged or unwanted mitochondria to maintain cellular and organismal homeostasis. The mechanisms behind how mitophagy is initiated to form autophagosomes around mitochondria have gained a lot of interest since they can be potentially targeted by mitophagy-inducing therapeutics. Mitophagy initiation can be driven by various autophagy receptors or adaptors that respond to different cellular and mitochondrial stimuli, ranging from mitochondrial damage to metabolic rewiring. This review will cover recent advances in our understanding of how mitophagy is initiated, and by doing so reveal the mechanistic plasticity of how autophagosome formation can begin.

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来源期刊

Current Opinion in Cell Biology 生物-细胞生物学

CiteScore

14.60

自引率

1.30%

发文量

审稿时长

93 days

期刊介绍： Current Opinion in Cell Biology (COCEBI) is a highly respected journal that specializes in publishing authoritative, comprehensive, and systematic reviews in the field of cell biology. The journal's primary aim is to provide a clear and readable synthesis of the latest advances in cell biology, helping specialists stay current with the rapidly evolving field. Expert authors contribute to the journal by annotating and highlighting the most significant papers from the extensive body of research published annually, offering valuable insights and saving time for readers by distilling key findings. COCEBI is part of the Current Opinion and Research (CO+RE) suite of journals, which leverages the legacy of editorial excellence, high impact, and global reach to ensure that the journal is a widely read resource integral to scientists' workflow. It is published by Elsevier, a publisher known for its commitment to excellence in scientific publishing and the communication of reproducible biomedical research aimed at improving human health. The journal's content is designed to be an invaluable resource for a diverse audience, including researchers, lecturers, teachers, professionals, policymakers, and students.